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    Öğe
    Assessment of Serum S100 Protein Levels in Patients with Fibromyalgia
    (Clinical & Exper Rheumatology, 2014) Cavas, Husamettin; Oktayoglu, Pelin; Verim, Sabahattin; Em, Serda; Caglayan, Mehmet; Bozkurt, Mehtap; Yildiz, Ismail
    [Abstract Not Available]
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    Öğe
    Association of Neuron-Specific Enolase with Sleep Quality, Cognitive Function And Quality of Life in Patients with Fibromyalgia Syndrome
    (Clinical & Exper Rheumatology, 2014) Verim, Sabahattin; Cavas, Husamettin; Nas, Kemal; Yazmalar, Levent; Batmaz, Ibrahim; Cevik, Remzi
    [Abstract Not Available]
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    Öğe
    A Case of Spondyloepiphyseal Dysplasia Tarda Coexisting With Osteoporosis and Mimicking Spondyloarthropathy
    (Galenos Yayincilik, 2013) Batmaz, Ibrahim; Sariyildiz, Mustafa Akif; Dilek, Banu; Ulu, Mehmet Ali; Verim, Sabahattin; Budulgan, Mahmut; Cevik, Remzi
    Spondyloepiphyseal dysplasia tarda (SEDT), which is characterized by short stature with short trunk, may cause barrel chest, kyphoscoliosis, platyspondyly, coxa vara and genu varum/valgum deformities due to delayed formation of epiphyses. The association of SEDT with osteopenia and osteoporosis has been reported. Chronic back and buttock pain, swelling of the joints and morning stiffness are some of the clinical findings of SEDT which can be confused with inflamatory diseases. In this article, we present a 19-year-old male patient with SEDT who was diagnosed as having spondyloarthropathy because of back and buttock pain and morning stiffness associated with osteoporosis.
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    Fibromyalji hastalarında serum nöron spesifik enolaz düzeylerinin araştırılması
    (2015) Verim, Sabahattin
    Giriş: Fibromyalji sendromu (FMS), yaygın vücut ağrıları ve halsizlikle kendini gösteren kronik ağrı sendromudur ve santral sensitizasyon sendromları arasında yer almaktadır. Nöron spesifik enolaz(NSE) yapılan çalışmalarda nöron hasarıyla ilişkili olduğu tespit edilen bir biyomarkır olup, FMS'nin patofizyolojisindeki rölü çalışılmamıştır. Amaç: Bu çalışmada amacımız, FMS hastalarında serum NSE düzeylerinin etkilenip etkilenmediğini ve yaşam kalitesi, psikolojik durum ve kognitif fonksiyonlarla ilişkisi olup olmadığını değerlendirmekti. Gereç ve yöntem: Çalışmaya Amerikan Romatoloji Derneği (ACR)1990 FMS sınıflandırma kriterlerine göre fibromyalji tanısı konan 55 kadın hasta ve 40 sağlıklı gönüllü kadın alındı. Hasta ve kontrol grubunun demografik özellikleri, yaşam kalitesi ölçekleri( SF-36, fibromyalji etki anketi(FIQ)), psikolojik durum ( beck depresyon ölçeği, durumluluk ve sürekli kaygı ölçeği(STAİ-1, STAİ-2)) uyku kalitesi ölçeği(pitssburg uyku kalitesi anketi(PUKİ)), kognitif disfonksiyon (mini mental test, saat çizme testi ) ölçekleri çalışıldı. Serum NSE düzeyleri ECLİA yöntemi ile çalışıldı. Bulgular: Serum NSE düzeylerinde FMS hastalarında anlamlı farklılık bulunmadı. . FMS hastalarında yaşam kalitesi, uyku ve psikolojik durum skorları kontrol grubuna göre anlamlı olarak farklı bulunurken, kongnitif fonksiyonlarda anlamlı değişiklik bulunmadı. Serum NSE düzeyleri ile yaşam kalitesi, psikolojik durum ve kognitif fonksiyonlar arasında anlamlı ilişki bulunmadı. Sonuç: Bu çalışmada FMS hastalarında NSE düzeylerinde bir değişiklik saptanmadı. Bunun yanında NSE düzeyleriyle klinik parametreler, yaşam kalitesi, psikolojik ve kognitif durum arasında da bir ilişki bulunmadı. Çalışmaya alınan FMS hastalarında kognitif disfonksiyonun olmamasının bu sonuca katkısı olabilir. Daha geniş katlımlı ve kognitif durumun etkilendiği hastaların dahil edildiği çalışmaların yapılması NSE ile FMS arasındaki ilişki konusuna açıklık getirecektir. , Anahtar kelimeler: Fibromiyalji sendromu, yaşam kalitesi, nöron spesifik enolaz, kognitif disfonksiyon, psikolojik durum, uyku kalitesi.
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    Serum levels of neuron-specific enolase in patients with fibromyalgia syndrome: Correlation with cognitive functions, quality of life and psychological state
    (Ios Press, 2017) Verim, Sabahattin; Batmaz, Ibrahim; Yazmalar, Levent; Nas, Kemal; Cavas, Husamettin; Cevik, Remzi
    BACKGROUND: Fibromyalgia syndrome (FMS) is a non-articular rheumatic disorder of unclear etiology, characterized by widespread body pain, fatigue and, psychological complaints OBJECTIVES: To investigate the serum levels of neuron-specific enolase (NSE) in patients with FMS and to evaluate the relationship between cognitive function, quality of life and psychological state. MATERIALS AND METHODS: Fifty-five female patients diagnosed with fibromyalgia according to the American College of Rheumatology (ACR) classification criteria, and 40 healthy female subjects were enrolled in the study. Life quality scale [(Fibromyalgia Impact Questionnaire (FIQ)], psychological state (Beck Depression Scale), and cognitive dysfunction (mini mental test, clock drawing test) scales were used for patients and control subjects. Serum NSE levels were studied using the ECLIA method. RESULTS: No significant differences were found in the serum NSE levels between the FMS patients and the control subjects (p > 0.05). Life quality and psychological state scores were found to be higher in FMS patients relative to the control group (p < 0.001). However, no significant differences were detected in cognitive function (p > 0.05). Significant correlations were not found between the serum NSE levels and quality of life, psychological state and cognitive functions (p > 0.05). CONCLUSION: No significant difference was determined between the groups in terms of NSE levels. Further studies, including larger series, should be carried out to clarify this relationship.
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    Serum relaxin levels in benign hypermobility syndrome
    (Ios Press, 2015) Em, Serda; Oktayoglu, Pelin; Bozkurt, Mehtap; Caglayan, Mehmet; Karakoc, Mehmet; Ucar, Demet; Verim, Sabahattin
    OBJECTIVE: In this study, we investigated the activity of serum relaxin in female patients with benign joint hypermobility syndrome (BJHS), locomotor system findings accompanying BJHS, and its relation to relaxin. METHODS: Into the study, female patients with BJHS and healthy women as the control group were included. The patients were diagnosed by using the Brighton 1998 criteria. Examination of the locomotor system for study groups were performed. Serum relaxin levels of both patient and control group were measured. RESULTS: There were 48 female patients with BJHS and 40 healthy women in the study. With respect to the control group, the level of serum relaxin was higher in the patients (47.1 +/- 20.3, 34.4 +/- 22.1; p > 0.05). Again compared with the control group, arthralgia (p = 0.00), myalgia (p = 0.01), shoulder impingement syndrome (p = 0.05), pes planus (p = 0.01), and hyperkyphosis (p = 0.000) were higher in the patients. The level of relaxin median was significantly higher in the patients with pesplanus and hyperkyphosis than those who did not have them (p = 0.05, p = 0.01, respectively). CONCLUSIONS: Although serum relaxin level is not considered a causative factor for BJHS, the significant increases found in those patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin has a limited and indefinite role in patients with BJHS.