Yazar "Varol, S." seçeneğine göre listele

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    Assesment the role of oxidative stress and efficacy of caffeic acid phenethyl ester (CAPE) on neurotoxicity induced by isoniazid and ethambutol in a rat model
    (Verduci Publisher, 2014) Uzar, E.; Varol, S.; Acar, A.; Firat, U.; Basarslan, S. K.; Evliyaoglu, O.; Yucel, Y.
    OBJECTIVE: The aim of this study were to investigate a role of oxidative stress and the therapeutic efficacy of caffeic acid phenethyl ester (CAPE) in the pathogenesis of neurotoxicity induced by isoniazid and etambutol in a rat model. MATERIALS AND METHODS: Male Sprague-Dawley rats were randomly divided into eight experimental groups: control, INH, ETM, INH+ETM, INH+CAPE, ETM+CAPE, INH+ETM+CAPE, and CAPE treatment group, with ten animals in each group. INH and ETM doses were given orally within tap water for 30 days. CAPE was administered into relevant groups intraperitoneally for 30 days. Brain tissue and sciatic nerve were removed for biochemical and histopathological investigation. RESULTS: In the INH, ETM, and INH+ETM groups, malondialdehyde (MDA) and total oxidant status (TOS) levels were significantly higher than those of the control group (p < 0.05). Also, in these groups, brain total antioxidant capacity (TAC) levels, and superoxide dismutase (SOD) and PON-1 activities were decreased compared with the control group (p < 0.05). By a CAPE supplement within INH and ETM groups, there was a significant decrease in MDA and TOS (p < 0.05). In addition to a significant increase in TAC levels, and SOD and PON-1 activities both in brain and sciatic nerve tissues (p < 0.05). CONCLUSIONS: CAPE may protect against INH- and ETM-induced neurotoxicity in rat brain and sciatic nerve.
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    Detection of borderline dosage of malathion intoxication in a rat's brain
    (Verduci Publisher, 2015) Varol, S.; Basarslan, S. K.; Firat, U.; Alp, H.; Uzar, E.; Arikanoglu, A.; Evliyaoglu, O.
    OBJECTIVE: Humans and other animals are liable to expose to low doses of malathion (MAL). However, experimental studies on its toxic threshold dose and toxic low-dose effects have not been conducted. The aims of this study were to detect the initiation of the toxic effects of sub-acute low doses (2.5, 5, and 10 mg/kg) of MAL by immunohistochemical and biochemical parameters in rat brain. MATERIALS AND METHODS: Twenty-eight rats were randomly assigned into four groups (n=7) including control and three different amounts of MAL-exposed groups (2.5, 5, and 10 mg/kg). RESULTS: On immunohistochemical examination, the number of caspase-3-positive cells in all MAL-exposed groups was significantly higher than in the control group. Consistent with this, the total antioxidant capacity, total oxidant status, and the levels of superoxide dismutase, malondialdehyde, and paraoxanase activity were significantly different in the 5 and 10 mg/kg MAL-exposed groups compared with the control group. Additionally, the total oxidant status and malondialdehyde levels were significantly higher in the 5 and 10 mg/kg MAL-exposed groups compared with those in the 2.5 mg/kg MAL-exposed group. CONCLUSIONS: Our results indicate that over 5 mg/kg MAL exposure may result in dose-dependent oxidative stress, increased caspase-3 activity, and launching to the toxic effects in rat brain.
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    Effects of estrogen, estrogen/progesteron combination and genistein treatments on oxidant/antioxidant status in the brain of ovariectomized rats
    (Verduci Publisher, 2013) Evsen, M. S.; Ozler, A.; Gocmez, C.; Varol, S.; Tunc, S. Y.; Akil, E.; Uzar, E.
    INTRODUCTION: The aim of this study was to investigate the antioxidative effects of estradiol (E), E plus progesteron (P) combination (E/P) and genistein (G) treatment in the brain of ovariectomized (OVX) rats. MATERIALS AND METHODS: Adult female Sprague-Dawley rats were divided into five groups, with each group including ten rats. Rats were anesthetized and bilateral ovariectomy was performed under general anaesthesia in all groups except for the sham operation group. Groups included: Sham-operated, control (OVX), estrogen treated group (OVX+ E), E/P combination group (OVX+ E/P) and G treated group (OVX+ G). Treatments were applied for 8 weeks. The total anti-oxidant status (TAS), total oxidant status (TOS), nitric oxide level (NO), glutathione peroxidase activity (GSH-Px) and oxidative stress index (OSI) were analysed in the brain tissue of rats from each treatment category. RESULTS: Ovariectomy lead to an increase in brain TOS and OSI levels compared to the sham group (p < 0.05). Also, ovariectomy resulted in a decrease in brain TAS levels compared to the sham group that approached statistical significance (p = 0.078). Significant decreases in TOS, OSI, GSH-Px and a significant increases in TAS and NO levels were observed in the E-treatment group compared to the control group (p < 0.001). The E/P combination group exhibited a significantly decreased TOS and OSI and significantly increased TAS and NO levels relative to the control group (p < 0.05). Genistein treatment resulted in a significant decrease in TOS and OSI compared to the control group (p < 0.05). CONCLUSIONS: Oxidative stress markers increase in the brain tissue of OVX rats. Conversely, estradiol, E/P and G supplementation decreases oxidative stress markers and increases antioxidant activity. Using G may prevent neural pathologies result in menopause-related oxidative stress.
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    New inflammatory predictors for cerebral ischemic stroke: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio
    (Wiley-Blackwell, 2014) Akil, E.; Akil, M. A.; Varol, S.; Arslan, D.; Akyuz, A.; Bilik, M. Z.
    [Abstract Not Available]
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    New inflammatory predictors for cerebral ischemic stroke: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio
    (Springer Heidelberg, 2014) Akil, E.; Akil, M. A.; Varol, S.; Arslan, D.; Akyuz, A.; Bilik, M. Z.
    [Abstract Not Available]
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    RELATION BETWEEN ARYLESTERASE ACTIVITY AND PULSE PRESSURE IN PATIENTS WITH A ISCHEMIC STROKE
    (Lippincott Williams & Wilkins, 2017) Ozturk, U.; Ozturk, O.; Varol, S.
    [Abstract Not Available]
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    Relation between electrophysiological findings and diffusion weighted magnetic resonance imaging in ulnar neuropathy in the elbow
    (Wiley-Blackwell, 2012) Altun, Y.; Aygun, S.; Cevik, M. U.; Acar, A.; Varol, S.; Arikanoglu, A.; Onder, H.
    [Abstract Not Available]
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    RELATION BETWEEN PARAOXONASE-1 ACTIVITY AND PULSE PRESSURE IN PATIENTS WITH A ISCHEMIC STROKE
    (Lippincott Williams & Wilkins, 2017) Ozturk, U.; Ozturk, O.; Varol, S.
    [Abstract Not Available]
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    The relationship of the mean platelet volume and C-reactive protein levels with mortality in ischemic stroke patients
    (Verduci Publisher, 2013) Arikanoglu, A.; Yucel, Y.; Acar, A.; Cevik, M. U.; Akil, E.; Varol, S.; Unan, F.
    BACKGROUND AND OBJECTIVES: The relationship of the mean platelet volume (MPV) and C-reactive protein (CRP) values withmortality in patients with ischemic stroke is not clear. Besides, the correlation between CRP and MPV in patients with ischemic stroke has not been adequately studied yet. In the present study, our aim is to investigate the interrelationship of the CRP and MPV parameters together with their influence on mortality in patients with acute ischemic stroke. PATIENTS AND METHODS: Sixty-three patients with acute ischemic stroke have been enrolled in the study. The stroke patients were divided into 2 groups as those who died within the first 10 days and those who survived. The MPV and CRP in both groups have been compared. Also, the MPV obtained from the ischemic stroke patients were compared with the MPV of the healthy volunteers. RESULTS: A statistically significant difference (p = 0.027) was observed between the MPV of the stroke patients (8.6 +/- 1.95 fL) and the control group (7.93 +/- 0.82 fl). The MPV (9.24 +/- 1.98 fL) and CRP (10.8 +/- 7.0 mg/l) of those ischemic stroke patients who died were statistically significantly higher (p < 0.05) than the MPV (8.09 +/- 1.75 fl) and CRP (3.2 +/- 3.5 mg/l) of the patients who survived. There was also a positive correlation between the MPV and CRP of the ischemic stroke patients (r = 0.31, p = 0.029). CONCLUSIONS: The fact that there is a relationship between the MPV and CRP in ischemic stroke patients and that the CRP and MPV are higher in the ischemic stroke patients who died in comparison to those who survived may be an indication of the roles these markers play in the mortality of stroke patients.