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  • Küçük Resim
    Öğe
    1,6-BİS(2-karboksi aldehit fenoksi)bütan ile modifiye edilmiş Amberlit Xad-16 reçinesinden yararlanılarak kurşun, kadmiyum, çinko, bakır ve nikel iyonlarının önderiştirilmeleri ve çözeltiden ayrılmalarının incelenmesi
    (2017) Varhan Oral, Elif; Ziyadanoğulları, Berrin
    Bu çalışmada her biri ayrı ayrı çözelti ortamında bulunan Pb(II), Cd(II), Zn(II), Cu(II) ve Ni(II) iyonları, modifiye Amberlit XAD-16-1,6-bis(2-karboksi aldehit fenoksi)bütan ligandını içeren mini kolon kullanılarak zenginleştirildi ve alevli atomik absorpsiyon spektrometrik yöntem ile tayin edildi. pH, geri alma çözeltisinin türü, derişimi, hacmi ve akış hızı, örnek çözeltisinin hacmi ve akış hızı, sorpsiyon kapasitesi gibi bazı faktörlerin zenginleştirme verimine etkisi araştırıldı. Deneysel olarak belirlenen en uygun şartlarda Pb(II), Cd(II), Zn(II), Cu(II) ve Ni(II) iyonlarının geri kazanma verimleri sırasıyla % 99 ± 1.15, 100 ± 1.40, 98 ± 1.82, 100 ± 2.15, 100 ± 2.70 olarak elde edildi (N=5). Alevli AAS ile tayinlerde gözlenebilme sınırları Pb(II), Cd(II), Zn(II), Cu(II) ve Ni(II) için sırasıyla 1.47, 1.19, 0.11, 0.33, 1.16 ?g/L olarak bulundu (3s,N=20). Yöntemin gerçek numunelere uygulanabilirliğini araştırmak için Na+, K+, Ca2+, Mg2+, Cl- ve SO42- gibi bazı matriks elementlerin geri kazanma verimine etkisi incelendi. Önerilen yöntem, Dicle nehir suyu, Elazığ Maden çayı suyu, trafiğin yoğun olduğu yerlerden alınan otomobil egzos partikülleri, Diyarbakır ilinde yetişen marul ve maydanoz gibi gerçek örneklerde Pb(II), Cd(II), Zn(II), Cu(II) ve Ni(II) iyonlarının tayini için uygulandı ayrıca önerilen yöntemin doğruluğu, standart referans madde analiz edilerek kontrol edildi.
  • Küçük Resim
    Öğe
    A comprehensive study on chemical and biological investigation of thymus brachychilus jalas: A rich source of ursolic and oleanolic acids
    (Taylor & Francis Inc, 2023) Akdeniz, Mehmet; Yiğitkan, Serkan; Yılmaz, Mustafa Abdullah; Yener, İsmail; Varhan Oral, Elif; Fırat, Mehmet; Orhan, İlkay Erdoğan
    The significance of Thymus species in the scientific community is growing steadily due to their extensive utilization in traditional medicine, food industry, and pharmaceutical sector, owing to their abundance in essential oil and phytochemical content, rendering them commercially significant species. The current work focuses on conducting a comprehensive analysis of the ethanol extract and essential oil derived from the root and aerial portions of Thymus brachychilus Jalas, an endemic species that has not been previously investigated. Additionally, a novel GC-MS (gas chromatography-mass spectrometry) technique was developed to quantify the levels of triterpenoids, which are frequently found in many plants, particularly those belonging to the Lamiaceae family. The approach was then used to assess the triterpenoid content of the species. While the phenolic content of the species was determined by LC-MS/MS (liquid chromatography-tandem mass spectrometry), the chemical composition of triterpenoid, essential oil and flavor (aroma) of the plant was determined by GC-MS. Eucalyptol was the primary ingredient in both the essential oil and the flavor, accounting for 11.05% and 12.35%, respectively. In the DPPH and ABTS radical scavenging techniques, the root ethanol extract exhibited the greatest antioxidant activity with IC50 values of 26.70 +/- 0.23 and 19.16 +/- 0.11 mu g/mL, respectively. There was a high level of urease (59.54 +/- 1.67% at 100 mu g/mL) inhibitory activity observed in the root ethanol extract in enzyme inhibition assays, as well as angiotensin (94.80 +/- 0.56%), elastase (40.19 +/- 0.39%), and collagenase (48.26 +/- 0.12%) inhibition in the aerial ethanol extract. Moreover, the MCF-7 cell line for breast cancer had a strong cytotoxic impact when exposed to the essential oil of the species (vitality%: 1.45 +/- 0.01 at 200 mu g/mL. The LC-MS/MS and GC-MS studies revealed that the roots had a significant concentration of rosmarinic acid (15,801 mu g analyte/g extract), but the aerial portions had a substantial quantity of ursolic acid (152,374 mu g analyte/g extract). The plant exhibits potential in the food, cosmetic, and pharmaceutical sectors on account of its elevated levels of rosmarinic and ursolic acid, superior antioxidant capacity, and angiotensin and urease inhibitory effect.