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Öğe The anti-oxidant and anti-apoptotic effects of nebivolol and zofenopril in a model of cerebral ischemia/reperfusion in rats(Pergamon-Elsevier Science Ltd, 2012) Uzar, Ertugrul; Acar, Abdullah; Evliyaoglu, Osman; Firat, Ugur; Kamasak, Kagan; Gocmez, Cuneyt; Alp, HarunThe aim of this experiment was to investigate whether nebivolol and zofenopril have protective effects against oxidative damage and apoptosis induced by cerebral ischemia/reperfusion (I/R). There were seven groups of rats, with each containing eight rats. The groups were: the control group, I/R group, I/R plus zofenopril, I/R plus nebivolol, I/R plus nebivolol and zofenopril. zofenopril only and nebivolol only. Cerebral I/R was induced by clamping the bilateral common carotid artery and through hypotension. The rats were sacrificed 1 h after ischemia, and histopathological and biochemical analyses were carried out on their brains. The total antioxidant capacity was evaluated by using an automated and colorimetric measurement method developed by Erel. I/R produced a significant increase in the levels of total oxidant status and malondialdehyde levels, the number of caspase-3 immunopositive cells and activities of prolidase and paraoxonase in brain when compared with the control group (p<0.05). A significant decrease in brain total antioxidant capacity and nitric oxide levels were found in I/R group when compared with the control group (p<0.05). Both nebivolol and zofenopril treatment prevented decreasing of the total antioxidant capacity and nitric oxide levels, produced by I/R in the brain (p<0.05). Both nebivolol and zofenopril treatment prevented the total oxidant status, malondialdehyde levels, activities of paraoxonase and prolidase from increasing in brains of rats exposed to I/R (p<0.05). In conclusion, both nebivolol and zofenopril protected rats from ischemia-induced brain injury. The protection may be due to the indirect prevention of oxidative stress and apoptosis. (C) 2011 Elsevier Inc. All rights reserved.Öğe Association Between Carpal Tunnel Syndrome and Abdominal Obesity(Turkish Neurological Soc, 2010) Uzar, Ertugrul; Ilhan, Atilla; Ersoy, AlevtinaObjective: Obesity has been suggested as a risk factor for carpal tunnel syndrome (CTS). Previous studies on the association of CTS and obesity have generally considered body mass index (BMI). However, the relationships between CTS and waist circumference or waist-to-hip ratio (WHR), which are known as more sensitive measures for abdominal obesity, have not been studied previously. In this study, it was aimed to evaluate the role of BMI and abdominal obesity in patients with CTS. Materials and Methods: Female patients who applied to the neurology outpatient clinics with pain, numbness, paresthesia, or dysesthesia in the hands were included. The patients were divided into two groups, according to the clinical evaluation, as CTS or non-CTS. CTS diagnosis was electrophysiologically confirmed in 44 patients. Thirty-one subjects who were not diagnosed as CTS electrophysiologically were recruited as the control group. Clinical findings, nerve conduction studies and anthropometric measurements (height, weight, BMI, hip circumference, waist circumference and WHR) of CTS patients were compared with those of the control group. Results: The CTS group had significantly higher BMI, waist circumference and WHR values compared to the control group (for each parameter, p< 0.0001). The rates of obesity in the CTS group were 55.8%, 47.7% and 34.9%, respectively, according to waist circumference, BMI and WHR measurements. In the CTS group, 16% of the patients, who were defined as non-obese according to BMI, were determined as obese according to waist circumference. In the CTS group, significant positive correlations were found between BMI and WHR and median-ulnar sensory interpeak latency of the fourth digit (r= 0.26, p< 0.05; r= 0.25, p< 0.05, respectively). Conclusion: In this study, it was found that abdominal obesity is an important risk factor for CTS, and nerve conduction may be affected by waist circumference, BMI and WHR. In addition to general obesity, abdominal obesity may be an important risk factor for CTS.Öğe Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population(Korean Coll Neuropsychopharmacology, 2016) Yucel, Yavuz; Coskun, Salih; Cengiz, Beyhan; Ozdemir, Hasan H.; Uzar, Ertugrul; Cim, Abdullah; Camkurt, M. AkifObjective: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5 HT) and their respective receptors have been implicated in the patogenesis. Methods: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (-759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system. Results: We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group. Conclusion: This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.Öğe Cryptogenic Isolated Cortical Venous Infarct: A Report of Three Cases(Galenos Publ House, 2011) Uzar, Ertugrul; Ilhan, Atilla; Cakir, Banu; Ersoy, Alevtina; Duzgun, Ulkuhan; Uz, BurakCortical vein infarction without dural sinus involvement is extremely rare. Herein, we present three patients with headache, partial seizure and right-sided numbness. On neurological examination, focal neurologic deficit was not observed in our patients. Magnetic resonance imaging revealed cerebral ischemia which showed as hypointense on T1-weighted images and hyperintense on T2-weighted images that do not follow the boundary of arterial territories, indicating cortical venous infarct. Cortical venous infarct should be suspected in patients who present with sudden onset headache and/or focal epileptic seizures even if there is no neurologic deficit. The diagnosis and treatment of cortical venous infarct should be considered as an emergency because of the high potential for full recovery with anticoagulant treatment.Öğe Diagnostic value of F-wave inversion in patients with early carpal tunnel syndrome(Elsevier Ireland Ltd, 2012) Cevik, Mehmet Ugur; Altun, Yasar; Uzar, Ertugrul; Acar, Abdullah; Yucel, Yavuz; Arikanoglu, Adalet; Varol, SeferRoutine electrophysiological studies usually give normal results in patients with early stage carpal tunnel syndrome (CTS). Diagnostic significance of the F-wave inversion (the median of F-wave minimal latencies (FWML) exceeds a normal ipsilateral ulnar FWML by 1 ms) has not been previously reported in early stage CTS. In this study, our primary aim was to investigate the diagnostic value of F-wave inversion in early stage CTS. Additionally, we aimed to demonstrate any possible relationship between F-wave inversion and symptom scores of the Boston questionnaire and functional capacity in early stage CTS. The study included 60 early stage CTS patients who presented with a median sensory nerve conduction velocity of >= 50 m/s. The symptom severity and functional status of the patients were assessed by using the Boston questionnaire. The control group consisted of 45 healthy volunteers. We compared early stage CTS patients and healthy control subjects in terms of the results obtained from median-ulnar FWML. Existence of F-wave inversion was found in 32 (53.3%) of the early stage CTS patients and in 3 (8.7%) of the healthy controls (p = 0.001). It was also found to be positively correlated with the Boston questionnaire scores (p = 0.001, r = 0.41) and functional capacity scores (p = 0.001, r = 0.41). The sensitivity and specificity of F-wave inversion for the diagnosis of early stage CTS were calculated as 53.3% and 93.3%, respectively. The addition of F-wave inversion measurement to the set of the routine nerve conduction studies can increase the reliability of the electrophysiological studies in patients with early stage CTS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.Öğe Effect of Caffeic Acid Phenethyl Ester on Cerebellar Tissue Damage Secondary to Methanol Intoxication: Experimental Study(Turkish Neurological Soc, 2013) Arikanoglu, Adalet; Yuksel, Hatice; Gocmez, Cuneyt; Uzar, Ertugrul; Acar, Abdullah; Aluclu, Mehmet UfukObjective: Previous studies have shown the role of oxidative stress in methanol neurotoxicity. CAPE is known to have an antioxidant property that is shown in many experimental studies. In this study, we aimed to investigate whether CAPE has a protective effect against oxidative stress observed in the cerebellar tissue in methanol intoxication. Material and Method: In this study, a total of 40 rats were split into 5 groups: control group (n=8), MTX-alone group (n=8), MTX+methanol group (n=8), MTX+methanol+ethanol group (ethanol group) (n=8), and MTX+metanol+CAPE group (CAPE group) (n=8). All the rats except the control group were delivered methotrexate (MTX) therapy (0.3 mg/kg/day, via i. p. route) for 7 days in order to induce methanol toxicity. The control group received no drug therapy. Seven days later, 3 g/kg (i.p.) methanol was delivered in the ethanol and CAPE groups. Four hours after the delivery of methanol, ethanol group received 0.5 g/kg ethanol (i.p.) and CAPE group received 10 mu mol/kg CAPE (i.p.), while the other groups were delivered only saline (i.p.). The rats were decapitated after 8 hours and the cerebellar tissues were removed. PON-1, TAS, and MDA levels were measured in the tissues. Results: MTX-alone group demonstrated decreased TAS and PON-1 levels (p=0.001 and p=0.004, respectively) and increased MDA level (p=0.001), as compared to the control group. When MTX+methanol group was compared with the MTX-alone group, MTX+methanol group was found to have decreased TAS and PON-1 activities (p=0.037 and p=0.046, respectively) and increased MDA level (p=0.022). The ethanol group was found to show a significant decrease in MDA level (p=0.001), as compared with the MTX+methanol group. The CAPE group exhibited increased TAS and PON-1 levels (p=0.001 and p=0.001, respectively) and decreased MDA levels, as compared with the MTX+methanol group. Discussion: Cerebellum demonstrates oxidative stress secondary to methanol intoxication. CAPE therapy is more effective against cerebellar oxidative stress than ethanol therapy.Öğe Effect of lisinopril on oxidative stress in brain tissues of rats with L-Name induced hypertension(Walter De Gruyter Gmbh, 2013) Kirbas, Serkan; Kutluhan, Suleyman; Kirbas, Aynur; Sutcu, Recep; Kocak, Ahmet; Uzar, ErtugrulObjective: Arterial hypertension is often associated with pathologies related with oxidative stress. Angiotensin converting enzyme (ACE) inhibitors have been used as a safe and effective treatment of hypertension and coronary heart disease. However, the significance of ACE inhibitor usage in hypertension-induced cerebrovascular and neurodegenerative diseases is still unknown. In this study, we aimed to investigate the effects of lisinopril, an ACE inhibitor, on oxidative stress and antioxidant enzyme activities in brain tissues of rats with L-NAME (N-omega-Nitro-L-Arginine Methyl Ester hydrochloride) induced hypertension. Methods: Thirty-two Sprague-Dawley rats were divided into four groups: Control, L-NAME, L-NAME plus lisinopril, and only lisinopril. Hypertension was induced by oral administration of the L-NAME (75 mg/kg/day) in drinking water for 6 weeks. Rats were treated with Lisinopril (10 mg/kg/day) for six weeks. Systolic blood pressures were measured at the first, third and sixth weeks by using tail cuff method. Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) activity were measured from the brain tissue. Nitric oxide (NO) levels were measured from plasma. Results: Our results showed that L-NAME leads to an increase in systolic blood pressure of animals. The antihypertensive effect of lisinopril was observed. MDA level was significantly increased, and antioxidant enzymes activities were decreased in L-NAME given group (p<0.05). However, there was no statistically significant differences between the lisinopril given and other groups according to antioxidant enzymes activities (p>0.05). Conclusion: In our study, hypertension led to oxidative damage in brain tissues. Although lisinopril prevents the hypertension induced oxidative damage, direct antioxidant effect was not observed. Further studies are needed in order to gain certainty effect of lisinopril in brain tissue.Öğe Effects of 50 Hz electric field on malondyaldehide and nitric oxide levels in spinal cord of rats at prenatal plus postnatal period(Tubitak Scientific & Technological Research Council Turkey, 2011) Uzar, Ertugrul; Yilmaz, H. Ramazan; Yilmaz, Mustafa; Uz, Efkan; Yurekli, Vedat Ali; Dundar, Bumin; Koyuncuoglu, Hasan RifatAim: The effect of 50 Hz electric field (EF) on developing neural tissues is not known. We aimed to determine whether there would be any oxidative stress effect of 50 Hz EF on developing spinal cord tissues of pup rats by evaluating malondialdehyde (MDA), nitric oxide (NO) levels, and antioxidant enzyme activities such as superoxide dismutase (SOD) and catalase (CAT) measurement. Materials and methods: In the prenatal+postnatal group, the pregnant rat was exposed to continuous EF at 50 Hz 10 kV/s until delivery. Then the female pups of this group (n = 7) were exposed to EF at the same doses and for the same duration until puberty. In the postnatal group, the pregnant rat was unexposed to EF during pregnancy, but the female pups from this group (n = 7) began to be exposed to EF at delivery, and continued to be exposed to EF at 50 Hz EF 10 kV/m for 24 h until puberty. Results: In the prenatal+postnatal group, the MDA and NO levels in the spinal cord tissue of pup rats were significantly higher when compared to the control group. However, in the postnatal group, the MDA and NO levels in the spinal cord tissue of pup rats were not significantly different when compared to the control group. Conclusion: A 50 Hz electric field may cause oxidative stress in the spinal cord of rats in the prenatal+postnatal period.Öğe Effects of Intrathecal Caffeic Acid Phenethyl Ester and Methylprednisolone on Oxidant/Antioxidant Status in Traumatic Spinal Cord Injuries(Thieme Medical Publ Inc, 2015) Gocmez, Cuneyt; Celik, Feyzi; Kamasak, Kagan; Kaplan, Metin; Uzar, Ertugrul; Arikanoglu, Adalet; Evliyaoglu, OsmanPurposeTo examine the effect of intrathecally given caffeic acid phenethyl ester (CAPE) on peroxidation and total oxidant and antioxidant systems, and the effect of intrathecally given methylprednisolone (MP) in spinal cord injury (SCI) models. Materials and MethodsFour groups of 10 rats were formed: (1) Laminectomy, intrathecal saline injection, no SCI (sham: S); (2) Laminectomy, intrathecal saline injection, SCI (control: SCI); (3) Laminectomy, intrathecally given single dose of 3 mg/kg MP, SCISCI (SCI+MP). 4) Laminectomy, intrathecally given single dose of 1 mu g/kg CAPE, SCI (SCI+CAPE). Malondialdehyde (MDA), total oxidant activity (TOA), total antioxidant capacity (TAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) values in the spinal cord tissue were evaluated. ResultsWhen group S and group SCI were compared, MDA, TOA, and SOD parameters increased post-SCI (p<0.01). When compared with group SCI, it was observed that CAPE and MP decreased the MDA, TOA, and SOD levels (p<0.01). This decrease was more pronounced in the SCI+CAPE group. When group S and group SCI were compared, a statistically substantial decrease was observed in the post-SCI TAC levels. When compared with group SCI, it was shown that CAPE and MP treatment substantially increased TAC levels (p<0.001). ConclusionIntrathecal injection of both CAPE and MP inhibits lipid peroxidation and increase of oxidants in SCIs.Öğe Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats(Springer-Verlag Italia Srl, 2012) Uzar, Ertugrul; Alp, Harun; Cevik, Mehmet Ugur; Firat, Ugur; Evliyaoglu, Osman; Tufek, Adnan; Altun, YasarThe aim of this study was to investigate the possible effects of ellagic acid in brain and sciatic nerve tissues of diabetic rats. Also, the impact of ellagic acid on catalase and paraoxonase (PON-1) activities, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and nitric oxide (NO) were examined. The rats were randomly divided into four groups, with eight rats each: Normal controls (not diabetic), only ellagic acid treated (ellagic acid controls, not diabetic), Diabetic controls (streptozotocin, diabetic), ellagic acid-treated diabetic (streptozotocin + ellagic acid). After a 4 week experiment, rats were sacrificed, and biomarkers for oxidative stress in the brain and sciatic nerve tissues of the rats were measured. There was significant depletion in the PON-1, catalase, and TAS levels in the brain and sciatic nerve tissues compared to the control groups (for both parameters, p < 0.05). The values of catalase, PON-1 and TAS reversed back to normal levels in ellagic acid-treated diabetic rats compared to untreated diabetic rats (for both parameters, p < 0.05). The levels of MDA, TOS, NO and, OSI in the brain and sciatic nerve tissues were higher in untreated diabetic rats compared to control group (for both parameters p < 0.05). However, MDA, TOS, OSI, and NO levels were found to be significantly reduced in the ellagic acid-treated diabetic group compared to the untreated diabetic group in these tissues (for both parameters, p < 0.05). In conclusion, the results of the present study suggested that ellagic acid exhibits neuroprotective effects against oxidative damage in diabetic rats.Öğe Evaluation of serum oxidant/antioxidant balance in multiple sclerosis(Springer Heidelberg, 2012) Acar, Abdullah; Cevik, M. Ugur; Evliyaoglu, Osman; Uzar, Ertugrul; Tamam, Yusuf; Arikanoglu, Adalet; Yucel, YavuzThe total oxidative status (TOS)/total anti-oxidative status (TAS) ratio can provide information on an individual's absolute oxidative stress index (OSI). We investigated the alterations in the oxidant-antioxidant balance by measuring the oxidant parameters OSI, TOS, and malondialdehyde (MDA) together with the antioxidant parameters such as TAS, and superoxide dismutase (SOD) in patients with relapsing remitting multiple sclerosis (MS). To our knowledge, this is the first study to evaluate OSI in patients with relapsing remitting MS. 35 ambulatory patients with relapsing-remitting MS (35.8 +/- A 8.7 years) and 32 age- and activity-matched healthy control subjects (35.1 +/- A 3.7 years) that participated in the study. Serum TAS and TOS levels were determined using new automated methods. MS patients had higher concentrations of MDA (151.5 +/- A 51.1 vs. 111.3 +/- A 27.4 nmol/g protein, respectively; p < 0.001), TOS (148.1 +/- A 162.5 vs. 48.3 +/- A 46.4 mmol H2O2 Equiv./g protein, respectively; p = 0.002), OSI (21124 +/- A 32543 vs. 5294 +/- A 5562, respectively; p = 0.008), and SOD (4.5 +/- A 0.7 vs. 3.4 +/- A 0.6 U/L, respectively; p < 0.001) compared with healthy controls. On the other hand, MS patients had lower concentrations of NO (12.3 +/- A 6.9 vs. 17.4 +/- A 2.5 mu mol/g protein, respectively; p < 0.001) and TAS (0.82 +/- A 0.27 vs. 0.26 +/- A 0.15, respectively; p = 0.011) compared with healthy controls. In conclusion, these findings indicate that the oxidative stress plays an important role in the pathogenesis of MS.Öğe The increase of mean platelet volume in patients with Alzheimer disease(Tubitak Scientific & Technological Research Council Turkey, 2014) Koc, Emine Rabia; Uzar, Ertugrul; Cirak, Yasemin; Parlak Demir, Yasemin; Ilhan, AtillaBackground/aim: Vascular risk factors play an important role in the progression of Alzheimer disease (AD). Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV is associated with an increased risk of vascular inflammation. Here we aimed to examine whether MPV could be used as a marker of vascular damage in AD and to discuss the relation between MPV and other vascular risk factors. Materials and methods: A total of 109 outpatients with AD and 81 healthy controls were included in this study. Diagnosis of AD was made according to defined criteria. The Turkish version of the Mini Mental State Examination (MMSE) was used for cognitive assessment. According to the test results, patients were divided into 2 subgroups, mild (MMSE >= 18) and moderate (MMSE < 18), and their MPV levels were compared. Results: MPV levels were higher in the AD group. There was no statistically significant difference between the moderate group and the mild group according to MPV values. Conclusion: Increased MPV in patients with AD may point to platelet dysfunction. MPV is an indicator of increased in vivo platelet activation. Hence, platelets could be the link between vascular risk factors and AD. The assessment of MPV in patients with AD may help identify the patients that could benefit from additional antiplatelet therapy.Öğe The Increase of The Mean Platelet Volume in Patients With Intracerebral Haemorrhage(Galenos Publ House, 2012) Arikanoglu, Adalet; Cevik, Mehmet Ugur; Uzar, Ertugrul; Acar, Abdullah; Akil, Esref; Ekici, Faysal; Tasdemir, NebahatObjective: The mean platelet volume (MPV) is a biomarker of platelet function and activity. The influence of platelet function disorders on the aetiology of intracerebral haemorrhages (ICH) and mortality is not clear yet. The purpose of this study is to investigate the change in the MPV values in patients with ICH and to observe its influence on mortality in a retrospective manner. Material and Method: Sixty-six patients with intracerebral haemorrhage (32 males, 34 females; mean age: 61.9 +/- 16.9) were enrolled in the study. Patients with ICH were divided into two groups as those who died within the first 10 days and those who survived. The MPV values and the haematoma volumes were compared between the groups. Also, the MPV values and platelet counts of the patients with ICH were compared with the values of healthy volunteers from similar age and sex groups (27 males, 17 females; mean age: 59.9 +/- 3.2). Results: The MPV values of the patients with ICH measured within 24 hours following the intracerebral haemorrhage (8.33 +/- 1.27 fl) were statistically significantly higher than the MPV values of the control group (7.76 +/- 1.14 fl) (p=0.018). The platelet counts of the patients with ICH also measured with in the first 24 hours (235.8 +/- 94.9 x 10(3)/mL) were statistically significantly lower than the platelet counts of the control group (279.1 +/- 94.9 x 10(3)/mL) (p=0.022). No statistically significant difference in terms of the MPV values and platelet counts was observed between the patients with ICH who died within the first 10 days and those who survived (p>0.05). However, the difference observed in the haematoma volume between the patients with ICH who died within the first 10 days (31.1 +/- 33.7 ml) and those who survived (8.7 +/- 13.4 ml) was statistically significant (p<0.001). No correlation was found between the haematoma volume and the MPV value in the patients with ICH. Discussion: The increase, observed in the mean platelet volume in patients with ICH, may point to a disorder in the platelet function. No relationship was found between the increase in the MPV and the mortality rates.Öğe Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine(Bmc, 2011) Uzar, Ertugrul; Evliyaoglu, Osman; Toprak, Guelten; Acar, Abdullah; Yucel, Yavuz; Calisir, Tugba; Cevik, Mehmet UgurAsymmetric dimethylarginine (ADMA) has been found as correlated with endothelial dysfunction and oxidative stress. There are few studies regarding ADMA and nitric oxide (NO) levels in patients with migraine and alterations of ADMA and NO levels during migraine attack are not well-known. Therefore, in present study, we aimed to measure NO and ADMA levels in patients with migraine and compare them with the control group to investigate the correlation between migraine, oxidative stress and endothelial dysfunction. The migraine group consisted of 59 patients, including 22 suffering from migraine with aura and 37 suffering from migraine without aura. The control group consisted of 31 healthy volunteers without headache. The patients in migraine group were divided into subgroups based on whether attack period was present or not and whether it was migraine with or without aura. Plasma ADMA levels were measured using an enzyme-linked immunosorbent assay method. Migraine patients had higher concentrations of NO (35.6 +/- A 7.7, 31.0 +/- A 6.2 mu mol/L, respectively, p = 0.005) and ADMA (0.409 +/- A 0.028, 0.381 +/- A 0.044 mu mol/L, respectively, p = 0.001) levels when compared with the healthy controls. During migraine attack, NO and ADMA levels were found to be significantly higher in migraine group as compared to control group (respectively, p = 0.015, p = 0.014). Similarly, NO and ADMA levels in the patients with migraine in the interictal period were found to be significantly higher as compared to control group (p = 0.011, p = 0.003). In conclusion, higher ADMA and NO levels of patients with migraine supported that oxidative stress and endothelial dysfunction may have a role in migraine pathogenesis.Öğe Investigation of Mean Platelet Volume in Patients with Multiple Sclerosis(Turkish Neurological Soc, 2011) Uzar, Ertugrul; Arikanoglu, Adalet; Yucel, Yavuz; Aydin, Birsen; Tanriverdi, Mehmet Halis; Tasdemir, NebahatObjective: Alterations in platelet function have been observed in patients with multiple sclerosis. Mean platelet volume is a marker of the platelet activity and is reported to be increased in vascular diseases. The aim of this retrospective study was to investigate the correlation between mean platelet volume and multiple sclerosis. Materials and Methods: The patient group consisted of 46 multiple sclerosis patients who were presented with multiple sclerosis attacks (males/females: 10/36, mean age: 34.3 +/- 9.4 year). In the multiple sclerosis patients, mean platelet volume values during the attack were compared with the mean platelet volume value after attack. Mean platelet volume values of patients were also compared with those of 38 age/sex-matched healthy individuals (males/females: 14/24, mean age: 36.4 +/- 10.4). Results: No difference was found in mean platelet volume values during the multiple sclerosis attack (8.0 +/- 1.2) versus after the multiple sclerosis attack (7.9 +/- 1.2), and no relation was found between mean platelet volume and Expanded Disability Status Scale (EDSS) parameters (p> 0.05). No difference was found in mean platelet volume values between the multiple sclerosis group (8.1 +/- 1.3) and control group (8.1 +/- 1.1) (p> 0.05). Conclusion: No significant change in mean platelet volume values was seen during the multiple sclerosis attack versus after the multiple sclerosis attack. This finding supports that platelet activation does not play an important role in the multiple sclerosis pathogenesis. However, the relation between multiple sclerosis and mean platelet volume should be investigated prospectively.Öğe Late Onset Ramsay Hunt Syndrome; A Case Report(Cukurova Univ, Fac Medicine, 2013) Tay, Arzu; Tamam, Yusuf; Uzar, ErtugrulRamsay Hunt Syndrome is a rare syndrome with symptoms of facial paralysis accompanied by herpetic vesicles in oropharynx and ear side. Recovery from facial paralysis is generally late and with sequel. In the current case, a 90 year-old man has been admitted to neurology clinics with symptoms of vesicular lesions in hairy skin, left ear auricula, chin and neck which developed after severe pain. His history, clinical and laboratory findings revealed that he had Ramsay Hunt syndrome, which had been treated with intravenous acyclovir and steroid. Facial paralysis quickly responded to the treatment with full recovery.Öğe PLATELET ACTIVATION IN ALZHEIMER'S DISEASE(Elsevier Science Inc, 2014) Koc, Emine R.; Uzar, Ertugrul; Cirak, Yasemin; Demir, Yasemin P.; Ilhan, Atilla[Abstract Not Available]Öğe Primary headaches associated with sexual activity respond to topiramate therapy: a case report(Springer Heidelberg, 2011) Arikanoglu, Adalet; Uzar, ErtugrulPrimary headaches are rarely associated with orgasms. Indomethacin at doses of 25-50 mg/day taken 30-60 minutes prior to sexual activity may prevent headaches. Propranolol and metoprolole have been used for headaches that consistently emerge during frequent sexual activity of any type. It is also known that topiramate is useful for treating migraines, but it is rarely used for other primary headaches. The role of topiramate in the treatment of headaches associated with sexual activity is unclear. Indomethacin and propranolol could not be used in our patient who, besides sexual activity-associated headaches, suffered from gastritis and diabetes mellitus. Thus, topiramate (50 mg/day) was used prophylactically, and sexual activity-associated headaches did not recur during 6 months of topiramate therapy. This is the first report of positive response to topiramate as prophylactic treatment against sexual activity-associated headaches when propranolol and indomethacin are contraindicated.Öğe Protective Effect of Caffeic Acid Phenethyl Ester in Rat Cerebral Ischemia/Reperfusion Damage(Turkish Neurological Soc, 2011) Uzar, Ertugrul; Acar, Abdullah; Firat, Ugur; Evliyaoglu, Osman; Alp, Harun; Tufek, Adnan; Yavuz, CelalObjective: Because oxidative stress is related to cerebral ischemia/reperfusion (I/R) injury, modulation of oxygen free radical production may represent a new approach to the management of cerebral I/R. Caffeic acid phenethyl ester (CAPE) has been determined to have neuroprotective, antioxidant, anti-inflammatory, and anti-apoptotic activities. The aim of this study was to investigate whether CAPE has a protective effect on cerebral I/R damage, and to determine the possible effects of CAPE on total antioxidant/oxidant status. Methods: A total of 30 rats were randomly divided into three groups as control group, I/R group, and I/R + CAPE. Total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) levels and histopathological cellular structures were evaluated in cerebral tissues obtained after the experiment procedure in all groups. Results: In the brain tissue, TOS and OSI levels were found to be significantly increased in the I/R group compared to the controls (p=0.023, p=0.001, respectively). Significantly decreased TAS levels were found in the I/R group compared to the controls (p=0.001). CAPE treatment prevented the increase in TOS and OSI that is produced by cerebral I/R (p=0.041, p=0.001, respectively). TAS was found to be increased in the CAPE + I/R group compared with the I/R group (p=0.002). In the I/R group, the brain sections showed findings of cerebral I/R damage including inflammation, vascular congestion and necrosis (for both variables, p=0.001). These histopathological cerebral damage findings were found to be significantly reduced in the CAPE + I/R group compared to the I/R group (for both parameters, p<0.05). Conclusion: In this study, it was found that oxidative stress had an important role in the pathogenesis of cerebral I/R damage, and histopathological and biochemical evaluations showed significantly decreased I/R damage following CAPE treatment in rats.Öğe Pseudotumor cerebri due to Behcet's disease increased fluid in the perioptic nerve sheath on cranial magnetic resonance imaging(Aves Press Ltd, 2011) Uzar, Ertugrul; Ekici, Faysal; Sahin, Alparslan; Tamam, Yusuf; Acar, Abdullah; Tasdemir, NebahatPseudotumor cerebri is a rare condition of Behcet's disease. Enlargement of optic nerve sheath and increased subarachnoid fluid around the optic nerve are uncommon magnetic resonance (MR) findings of the patients with pseudotumor cerebri. To the best of our knowledge, these findings were not reported in pseudotumor cerebri due to Behcet's disease. Lumboperitoneal shunting surgery may be performed in cases which have visual symptoms and refractory to the medical treatment. In this paper, the relevant clinical and radiological findings were discussed, and a brief overview of therapeutic management was provided.
