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Öğe Cypermethrin-induced histopathological and biochemical changes in Nile tilapia (Oreochromis niloticus), and the protective and recuperative effect of ascorbic acid(Elsevier Science Bv, 2009) Korkmaz, N.; Cengiz, E. I.; Unlu, E.; Uysal, E.; Yanar, M.The objective of this study was to investigate the effects of ascorbic acid on the toxicity of cypermethrin's on histopathological lesions in tissues and protein, glycogen levels in Oreochromis niloticus. Nile tilapia was exposed to 0.22 and 0.44 mu g/l cypermethrin + control diet. 0.22 and 0.44 mu g/l cypermethrin + ascorbic acid supplemented diet for 20 days. The fish were allowed recuperation period of 15 days in pesticide-free water and fed with ascorbic acid suplementation diet. In light microscopic investigation, histopathological lesions were observed in the gill, liver and kidney. The severity of lesions accreted depending on increased pesticide concentration and control diet. Some of the lesions were reversible or at least were less pronounced after recuperation period. Protein levels decreased in some groups after treatment period according to control groups (p < 0.05). The highest depletions in liver, muscle and gill protein levels were found in 0.44 mu g/l cypermethrin + ascorbic acid supplemented diet group (62.23%), in 0.22 mu g/l cypermethrin + control diet group (53.12%) and in 0.44 mu g/l cypermethrin + control diet group (61.87%) after 10 days, respectively. These levels increased at the end of the recuperation period. The highest depletion in liver glycogen levels was found in 0.22 mu g/l cypermethrin + control diet group (50.50%) after 10 days (p < 0.05). At the end of recuperation period, there was no difference between the groups (except 0.22 mu g/l cypermethrin + ascorbic acid supplemented diet group) and controls. The decrease of muscle glycogen, except 0.22 mu g/l cypermethrin + ascorbic acid supplemented diet group, was recorded at the end of 10 and 20 days. In the recuperation period, an increase was observed at all groups. These results revealed that the histopathology, protein and glycogen can work as good indicators of stress of a toxicant on fish. Ascorbic acid serves fish as an antitoxic agent against pesticide toxicity. (C) 2009 Elsevier B.V. All rights reserved.Öğe THE DETAILED EVALUATION OF SUPERNUMERARY TEETH WITH THE AID OF CONE BEAM COMPUTED TOMOGRAPHY(Taylor & Francis Ltd, 2010) Tumen, E. C.; Yavuz, I.; Tumen, D. S.; Hamamci, N.; Berber, G.; Atakul, F.; Uysal, E.The aim of this paper is to demonstrate the application of a recently developed three-dimensional imaging system, cone beam computed tomography, in the detailed evaluation of supernumerary teeth. Two-hundred and twenty three patients with supernumerary teeth (68 females and 155 males) were included in this study. Patients ranged in age from 12 to 25 years. Supernumerary teeth were detected by clinical examination and traditional radiographies. Moreover careful investigation for more details was made with the cone beam computed tomography. Supernumerary teeth which were detected with the examinations of the cone beam computed tomography images were classified according to the number location, shape and eruption rate. The prevalence of supernumerary teeth was determined to be 1.45% of the study population. Males were affected more than females in a ratio of 2.3:1. Supernumerary teeth were most frequently located in 86.2% of the cases in the maxilla; 10.1% in the mandible and 3.7% both in the maxilla and mandible. Supernumerary teeth were most commonly conical in shape (68.8%). One supernumerary tooth was present in 67.7% of the patients, 30.9% had two, and 1.4% had three supernumeraries. Definite and early diagnosis of the supernumerary teeth is very important. Detailed examinations and evaluations of these teeth with three-dimensional images is very benefical in terms of treatment planning and preventing complications which may occurÖğe Effects of Ovariectomy and Bilateral Molar Teetless on Mandibular Condyle of Rat(Medwell Online, 2012) Zengingul, A. I.; Ketani, S.; Karadede, M. I.; Uysal, E.; Ketani, M. A.This study, researchers examined the ovariectomy and bilateral molar teetless of mandibular condyle in rat by histologically and histomorphometrically. In this part of the study, 12 Wistar Albino rats, 120 days old and weighing 200-250 g were used. The rats were divided into three groups, a control and two experimental group. The experimental groups of rats were subjected to ovariectomy in. order to create oestrogen deficiency and bilateral molars extraction. After 35 days of ovariectomy, control and experimental group rats were killed and their mandible condyle removed. The speciemens were stained with Hematoxylin and Eosin (HE) and examined for structure of histologically and histomorphometrically. Histomorphometric analysis; mandibular condyle of control and experimental groups were statistically significant results of the histological layers (p<0.05). It was concluded that ovariectomy application and molar teetless can induce histopathological and histomorphometrically changes in the structure of the condyle.Öğe Effects of seasonal and physiological variations on the serum chemistry, vitamins and thyroid hormone concentrations in sheep(Wiley, 2006) Yokus, B.; Cakir, D. U.; Kanay, Z.; Gulten, T.; Uysal, E.The aim of this study was to investigate the possible effects of the reproductive status and seasonal variations on the serum chemistry and vitamin status and their relationships with the thyroid hormones in Sakiz-Awassi crossbreed sheep. The sheep (n = 34) were divided into two groups. The first group (n = 22) was mated; the second group (n = 12) was not mated. Their serum samples were collected four times a year at the each season and under reproductive status. The periods are 1, early pregnancy (October); 2, late pregnancy (January); 3, lactation (April); and 4, dry season (July). The results of this study indicated that (1) total protein (TP), globulin, cholesterol, creatinine, uric acid and T4/T3 vary with reproductive status but not seasonal variations; (2) alanine aminotransferase, T4, fT4 concentrations in serum vary only with reproductive status; (3) the urea, creatine kinase, lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase, amylase, albumin, triglyceride, VLDL, Vit A-E, T3 and fT3 concentration could vary with both reproductive status and seasonal variations; (4) the glucose, gamma-glutamyl transpeptidase, folate concentrations were altered neither season of the year nor the reproductive status; (5) a single reference interval for folate, gamma-glutamyl transpeptidase (GGT), glucose, TP, globulin, cholesterol, creatinine, uric acid and T4/T3 can be used for both mated and non-mated sheep because of no differences were found due to the reproductive status. Taking the results together suggests that reproductive status and seasonal variations have to be taken into consideration for a correct interpretation of the serum chemistry values of sheep. Nutritional supplements are required for sheep during certain periods to avoid a decline of their performance, which would then represent consequent economic, loses.Öğe Evaluation of the relationship between sagittal anomalies and the presence of third molars in two different periods in Turkish orthodontic patients(Diagnosis Press Ltd, 2008) Hamamci, N.; Basaran, G.; Uysal, E.The purpose of this investigation was to evaluate the existence of third molar germs in orthodontic patients in Turkey, to examine the correlation between the existence of third molars and sagittal maxillomandibular jaw relationships and to compare the presence of third molars in individuals born in the 1970s and 1990s. The subjects were of 450 patients attending the orthodontic clinic Dicle University aged younger than 15 years. The subjects were divided into two groups: Group I, consisted of 150 patients (50 males and 100 females) born between 1975 and 1979, and group 2300 patients (124 males and 176 females) born between 1990 and 1997. Assessments were made from panoramic radiographs and lateral cephalograms. The chi square test were present in 71.5 percent of subjects, (2) a non-significant decrease was determined in the level of third molars present in individuals group 2. (p > 0.05), (3) mandibular third molars were present significantly more often than maxillary third molars(p < 0.001), (4) no statistically significant difference was found among the prevalences of third molars in all Angle classifications in the sagittal plane (p > 0.05) and (5) the percentage of skeletal Class II subjects who had all four third molars was higher than that of skeletal Class III subjects.Öğe Factors affecting morbidity and mortality in gangrenous cholecystitis(Acta Medical Belgica, 2006) Girgin, S.; Gedik, E.; Tacyildiz, I. H.; Akguen, Y.; Bac, B.; Uysal, E.Introduction : Gangrenous cholecystitis is a serious complication of acute cholecystitis. Male gender, older age, leukocytosis, cardio-vascular diseases and diabetes were reported as factors that increase the risk of gangrenous cholecystitis. The aim our study was to determine variables affecting morbidity and mortality as well as to define the independent risk factors in Gangrenous Cholecystitis. Methods : Fifty three patients who had been treated for Gangrenous Cholecystitis were reviewed. The variables are defined as follows : age, gender, systemic diseases, Mannheim Peritonitis index, aspartate aminotransferase, alanine aminotransferase, white blood cell count and type of surgery. In order to determine the independent risk factors that might affect morbidity and mortality in Gangrenous Cholecystitis, we made use of multivariate logistic regression analysis. Results : The independent risk factors affecting on morbidity were age (P = 0.037), existing systemic disease (P 0.047) and >= 29 Mannheim Peritonitis index (P = 0.008), and the independent risk factors affecting on mortality were age (P = 0.046), white blood cell count (P = 0.035). Pre-operative and post-operative third day aspartate aminotransferase and alanine aminotransferase average values were compared, there was a significant difference (P < 0.0001, P < 0.0001 respectively). Conclusions : We found that older age, >= 29 Mannheim Peritonitis index and existence of systemic diseases were independent risk factors affecting morbidity. Older age and lower of white blood cell count were independent risk factors affecting mortality. We believe that further comprehensive studies, involving prospective, multi-center and a large number of patients, are needed.Öğe Incisor trauma in a Turkish preschool population: Prevalence and socio-economic risk factors(F D I World Dental Press Ltd, 2011) Tumen, E. C.; Adiguzel, O.; Kaya, S.; Uysal, E.; Yavuz, I.; Ozdemir, E.; Atakul, F.Objective: This study aimed to assess the prevalence of traumatic injuries of the primary incisors in preschool children from 2 to 5 years old in South-Eastern Anatolia, Turkey. Additionally, the relationship between traumatic dental injuries, parents' education level, family income, size of incisal overjet and the presence of anterior open bite were examined. Basic research design: A cross-sectional survey Clinical settings: Data were collected through oral examinations and structured interviews, and included socio-economic indicators. Participants: A total of 727 children of both genders were included in the study. 122 of these children were aged 2; 183 aged 3; 178 aged 4 and 186 aged 5. Results: The prevalence of dental injuries was 8.0% (n=58). The highest frequency of trauma in the primary teeth was observed at the age of 4. Boys experienced more dental injuries than girls, 12.2% and 4.0%, respectively. The most common crown fracture was in enamel only (57%) followed by crown fracture of enamel and dentin (19%). Conclusion: The prevalence of dental injuries in Turkish preschool children was very low. The children with incisal overjet greater than 5mm and anterior open bite experienced more dental injuries in primary teeth than their counterparts with normal occlusion. Socio-economic indicators were not statistically significantly associated with the occurrence of traumatic dental injuries.Öğe Microleakage of Glass Ionomer based Restorative Materials in Primary Teeth: An In vitro Study(Wolters Kluwer Medknow Publications, 2018) Ayna, B.; Celenk, S.; Atas, O.; Tumen, E. C.; Uysal, E.; Toptanci, I. R.Aim: Using AutoCAD, we examined the microleakage of dye at the edges of primary-teeth restorations using three glass ionomer-based restorative materials. Materials and Methods: A total of 30 extracted noncarious primary molars were used. Class V cavities were adjusted on the buccal surfaces. The teeth were randomly divided into three groups of 10 teeth each as follows: Group A (Ketac Molar), Group B (Photac Fil), and Group C (Dyract XP). All specimens were stored for 24 h at 37 degrees C in distilled water. The teeth were thermocycled 1000 times between 5 degrees C +/- 2 degrees C and 55 degrees C +/- 2 degrees C before immersion in 0.5% basic fuchsin for 24 h. Two mesiodistal cuts of each tooth were photographed under a stereomicroscope equipped with a digital camera. The dye-infiltrated surface area was measured. Statistical evaluations were performed by the Kolmogorov-Smirnov test, Levene test, one-way analysis of variance, and Tukey's honestly significant difference test. Results: The mean microleakage ratio differed significantly among the groups (P < 0.05). Group C exhibited a significantly smaller area (P < 0.001) than the other groups. Group A had a nonsignificantly higher mean microleakage value than Group B (P > 0.05). Conclusions: Polyacid-modified composite resin may be a useful restorative material in primary teeth in terms of minimizing microleakage.Öğe Morphological Changes Caused by Streptozotocin-Induced Diabetes in the Healthy Gingiva of Rats(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2016) Dag, A.; Firat, E. T.; Uysal, E.; Ketani, M. A.; Seker, U.Background and Objective: Epidemiologic and clinical studies have indicated that diabetes is a risk factor for periodontal disease progression. The aim of the present study was to evaluate the morphological changes of gingiva in streptozotocin diabetic rats. Material and Methods: 30 male Wistar rats that weighed 250-300g were used in this study. The animals were randomly divided into 2 groups, one with streptozotocin-induced diabetes and another one with healthy (non-diabetic) animals. All rats were sacrificed after 21 days, and their maxillary first molars with surrounding tissues were observed morphological analyses. Results: In this study, it was observed that the epithelial thickness was greater in the diabetes group, compared to the control group. The statistical comparison of the diabetes and control groups for the thickness of each of the layers of the epithelium demonstrated that the thickness of the keratinized (corneum), granular and basal layers had significantly increased in the diabetic animals. Furthermore, the diabetes group displayed a decrease in the height of the connective tissue papillae, which was found to be statistically insignificant. Another important finding detected in the diabetes group was the congestion of the gingival capillaries, which showed that blood circulation is impaired in diabetes cases. Conclusion: On the basis of the results obtained in this study, it was concluded that streptozotocin-induced diabetes may increase predisposition to periodontal disease by causing morphological changes in the periodontal tissues.Öğe P53 gene exon 4 RFLP polymorphism and relation with severity of disease in patients with coronary artery disease(Blackwell Publishing, 2006) Cakir, D. U.; Yokus, B.; Tekes, S.; Iltimur, K.; Mete, N.; Uysal, E.[Abstract Not Available]Öğe Prevalence of Traumatic Dental Injuries and Associated Factors Among 8 to 12-years-old Schoolchildren in Diyarbakir, Turkey(Wolters Kluwer Medknow Publications, 2017) Tumen, E. C.; Yavuz, I.; Kayd, S.; Uysal, E.; Tumen, D. S.; Ay, Y.; Basaran, G.Background and objectives: This study aimed to assess the prevalence of traumatic injuries of the permanent incisors in public primary schoolchildren from 8 to 12 years old in South-Eastern Anatolia, Turkey. Additionally, the relationship between traumatic dental injuries, parents' education level, family income, size of incisal overjet and the presence of anterior open bite were examined. Materials and methods: Data were collected through oral examinations and structured interviews, and included socio-economic indicators. A total of 2907 children of both genders (1498 boys, 1409 girls) were included in the study. The response rate was 97%. Results: The prevalence of dental injuries was 4.6% (n = 135). The highest frequency of trauma in permanent teeth was observed at the age of 12 (8%). Boys experienced more dental injuries than girls, 5.9% and 3.3% (p = 0.001), respectively. The most commonly reported cause of injuries to the permanent incisors was falls (71.8%), followed by collision with objects or people (17.8%). Maxillary central incisors were the most affected by dental injuries (154, 84.6%). The most common crown fracture was in enamel only (67.58%) followed by crown fracture of enamel and dentin (22.52%). Conclusion: Socio-economic indicators and parents' level of education were not statistically significantly associated with the occurrence of traumatic dental injuries. Factors associated with increased risk of dental injuries in permanent teeth were age, gender, having an incisal overjet greater than 5mm and anterior open bite.Öğe Proton NMR Relaxation in Albumin Solution Doped with Mn(II)(Springer Wien, 2009) Yilmaz, A.; Koylu, M. Z.; Uysal, E.The aim of this study is to obtain further information about the source of proton relaxation in the Mn(II)-human serum albumin complex. For this purpose, proton relaxation rates in albumin solutions 1/T(1) and 1/T(2) were measured versus increasing amounts of manganese [Mn(t)]. The fractions of manganese bound to albumin [Mn(b)] and free manganese [Mn(f)] were then determined from proton relaxation rate enhancement data. Paramagnetic contributions of bound manganese to the observed relaxation rates (1/T(1p)*)(b) and (1/T(2p)*)(b) were also determined. Finally, the (1/T(2p)*)(b)/(1/T(1p)*)(b) ratio was used in a derived equation to estimate an effective correlation time tau. Mean tau value of the complex was found to be in the order of 3 ns, while the hydration number of bound manganese q was estimated to be about 4. The 1/tau was found to be the sum of the inverse values of rotational correlation time 1/tau(r), mean residence time of water in hydration spheres of the complex 1/tau(m), and longitudinal electronic relaxation time of manganese 1/tau(s) in the complex. In conclusion, the relaxation mechanism in albumin solutions containing Mn(II) can be interpreted through dipolar and scalar interactions modulated by tau(r), tau(m) and tau(s). This analysis enables one to get reasonable figures for the tau(r) and q of Mn(II) in albumin solution.Öğe RETROSPECTIVE EVALUATION OF CERVICAL SPINE INJURY VICTIMS PRESENTED TO EMERGENCY DEPARTMENT(Aves, 2007) Ustundag, M.; Orak, M.; Guloglu, C.; Sayhan, M. B.; Uysal, E.OBJECTIVE: In this study we purpose that to research demographic characteristics, complications and trauma origins of emergency department patients with cervical spine injury. METHODS: We scanned emergency patients with cervical spine injury data, retrospectively between January 2004 and February 2007. The patients were categorized into three groups: survived group (Group I), death group (Group II) and neurological deficit group (Group III). RESULTS: We accepted 34 patients with cervical spine injury between January 2004 and February 2007. Age average was 34,5 +/- 15,3(15-65). In this study 25(73,5%) patients were male and 9(26,5%) were female. Our study 24(70,6%) patients were Group I, 4(11,8%) patients were Group II and 6(17,6%) were Group III. In this study 17 patients were passengers and drivers from traffic accidents, 12 patients were falls from flat-roofed houses, 1 patient was pedestrians from traffic accidents and 4 patients were from other causes. The presence of cervical spine collar at the time of admission was 21 patients. Our patients divided three groups according to admission Glasgow Coma Score (GCS). Our study 30 patients were high GCS group (GCS=13-15), 2 patients were moderate GCS group (GCS=9-12) and 2 patients were low GCS group (GCS=3-8). In this study, 10 patients were paraparalysis, 2 patients were paraparesis and 6 patients were tetraparalysis at the time of admission. Our study, 6 patients were C1-C2 fractures, 13 patients were C3-C7 fracture, 1 patient was C1-C2 dislocations and 5 patients were C3-C7 dislocations. However, 6 patients were both C3-C7 fracture and dislocations, 2 patients were both C1-C2 and C3-C7 dislocations, 1 patient was both C1-C2 and C3-C7 fractures. The ratios of the patients having surgical operation and the patients receiving medical therapy were 44,1%(n=15) and 55,9 %(n=19) respectively. CONCLUSION: Cervical spine injury is relatively common in young man. Passengers and drivers from traffic accidents are the most common reason for cervical spine injury. We described that our patients had high ratio C3-C7 fractures and dislocations. At the time of admission not-presence of neurological deficit was found as decreased factors on mortality and morbidity of the patients with Cervical spine injury. Contrary, presence of tetraparalysis was found as increased factors. However presence both C3-C7 fracture and dislocations were found as increased factors on mortality and morbidity.Öğe Three-year clinical evaluation of endodontically treated anterior teeth restored with a polyethylene fibre-reinforced composite(Wiley, 2009) Ayna, B.; Celenk, S.; Atakul, F.; Uysal, E.Polyethylene fibre-reinforced composites (FRCs) have been under development for some time. However, there is a lack of data on the clinical performance of these restorations. The purpose of this descriptive study was to evaluate the clinical performance of endodontically treated anterior teeth restored using polyethylene FRCs. Eighty-seven endodontically treated anterior teeth in 65 patients were restored with polyethylene FRCs. The restorations were placed by three operators. The patients were recalled for examinations every year for up to three years. The restorations were evaluated using modified Ryge and USPHS criteria. A statistical analysis showed no significant difference in marginal irregularity, marginal discolouration, surface texture, wear/anatomic form, fracture and retention, radiographic appearance, or debonding between the baseline and three-year results. Based on our three-year examination results, polyethylene FRC restorations appear to be clinically successful.
