Yazar "Uyar, Ali" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • [ X ]
    Öğe
    Is there a relationship between the liver SUVmax values in FDG-PET/CT imaging and non-alcoholic fatty liver disease score?
    (2021) Yalçın, Kendal; Güzel, Fatih; Kaplan, İhsan; Güzel, Yunus; Taşdemir, Bekir; Uyar, Ali; Tuzcu, Şadiye Altun
    Aim: Non-alcoholic fatty liver disease is one of the most common causes of liver disease worldwide with an estimated prevalence of 20%–30% in adult population. Following the widespread utilization of PET in the evaluation of malignant diseases, F-18 FDG have also been reported to be used in non-malignant processes. The aim of this study is to elucidate whether the FDG SUVmax values determined by PET/CT in different adipose tissue samples and the liver change according to NAFLD score. During our desktop research we did not find any published article therefore, it is the first study in this field. Materials and Method: A total of 230 patients who applied to Dicle University Faculty of Medicine, Department of Nuclear Medicine between March and April 2020 and who have been conducted FDG PET/CT for diagnosis, staging, restaging and evaluation of response to treatment were included in the study. Patients were divided into three groups according to their NAFLD score as patients with fibrosis score <-1,455 (the group in which severe fibrosis was excluded) as group-1, and those with NAFLD score between -1.455-0.676 (inter-mediate score) as group-2. and patients with a NAFLD score >0.676 (severe fibrosis group) group-3. Results: Liver SUVmax levels were found to be significantly higher in group-3 than group-1. No significant difference was observed between group-2 and group-3. SUVmax levels measured from supracalvicular region, posterior scapular region and mesentery region were not different from each other in all three groups. Glucose-corrected liver SUVglu levels were found to be significantly lower in group-1 than group-3 (p=0.001). In terms of liver SUVglu levels, group-1 and group-2 and group-2 and group-3 did not differ statistically from each other. Supracalvicular SUVglu, posterior scapular SUVglu and mesenteric SUVglu groups were not different from each other. Conclusions: The most important result of this study could be elaborated with increased FDG uptake in NAFLD. Liver FDG uptake increases as the severity of NAFLD increases as demonstrated by the NAFLD score.
  • [ X ]
    Öğe
    Local imaging to interpret tumor size in F18 fluorodeoxyglucose positron emission tomography/CT in lung cancers
    (Assoc Medica Brasileira, 2024) Tuzcu, Sadiye Altun; Kaplan, Ihsan; Ibiloglu, Ibrahim; Uyar, Ali; Guzel, Fatih; Guzel, Yunus; Tasdemir, Bekir
    OBJECTIVE: This study aimed to determine the thoracic and extra-thoracic extension of the disease in patients diagnosed with lung cancer and who had whole-body F18-fluorodeoxyglucose positron emission tomography/CT imaging and to investigate whether there is a relationship between tumor size and extrathoracic spread. METHODS: A total of 308 patients diagnosed with lung cancer were included in this study. These 308 patients were first classified as group 1 (SPN 30 mm>longest lesion diameter >= 10 mm) and group 2 (lung mass (longest lesion diameter >= 30 mm), and then the same patients were classified as group 3 (nodular diameter of <= 20 mm) and group 4 (nodular size of >20 mm). Group 1 was compared with group 2 in terms of extrathoracic metastases. Similarly, group 3 was compared with group 4 in terms of frequency of extrathoracic metastases. F18 fluorodeoxyglucose positron emission tomography/CT examination was used to detect liver, adrenal, bone, and supraclavicular lymph node metastasis, besides extrathoracic metastasis. RESULTS: Liver, bone, and extrathoracic metastasis in group 1 was statistically lower than in group 2 (p<0.001, p<0.01, and p=0.03, respectively). Liver, extrathoracic, adrenal, and bone metastasis in group 3 was statistically lower than that in group 4 (p<0.001, p=0.01, and p=0.04, p<0.01, respectively). The extrathoracic extension was observed in only one patient in group 3. In addition, liver, adrenal, and bone metastases were not observed in group 3 patients. CONCLUSION: Positron emission tomography/CT may be more appropriate for cases with a nodule diameter of <= 20 mm. Performing local imaging in patients with a nodule diameter of <= 20 mm could reduce radiation exposure and save radiopharmaceuticals used in positron emission tomography/CT imaging.
  • Küçük Resim
    Öğe
    Prostat kanserli hastalarda 68ga-psma pet-bt volümetrik parametrelerinin tedavi yanıtını öngörmedeki rolü
    (Dicle Üniversitesi, Tıp Fakültesi, 2023) Uyar, Ali; Taşdemir, Bekir
    Amaç: Primer evreleme için Ga-68 PSMA PET/BT ile görüntüleme yapılmış prostat adenokarsinomlu hastalarda ölçülen TL-PSMA, PSMA-TV ve SUVpeak değerlerinin tedavi yanıtını öngörmede rolü olup olmadığını tespit etmeyi amaçladık. Materyal ve Metod: 25 Mart 2019 ile 3 Aralık 2021 tarihleri arasında primer evreleme amaçlı Ga-68 PSMA PET/BT çekimi olan 68 hastanın görüntüleri retrospektif olarak incelendi. Prostat bezi, lenf nodları, kemik ve visseral organ metastazlarına %40 eşik değer ile manuel çizim yapılarak volümetrik parametre verileri elde edildi. Bulgular: TL-PSMA(Kemik) ölçümü, tedaviye yanıtlı ve yanıtsız grup arasında istatistiksel olarak anlamlı düzeyde farklıydı (p=0,049). Ayrıca TL-PSMA ve PSMA-TV parametreleri de tedaviye yanıtlı ve yanıtsız grup arasında istatistiksel olarak anlamlı düzeyde farklılık göstermekteydi (sırasıyla, p=0,02 ve p=0,016). Diğer volümetrik parametreler ve tedavi yanıtı arasında anlamlı olarak ilişki bulamadık. Sonuç: Primer evreleme amacıyla yapılan Ga-68 PSMA PET/BT görüntülemesi ile elde edilen volümetrik parametrelerin prostat adenokarsinomlu hastalarda tedavi yanıtını öngörmede rolü olabileceği tespit edilmiştir. Ancak konunun netlik kazanabilmesi için daha geniş hasta gruplarıyla yapılacak yeni çalışmalara ihtiyaç vardır.
  • [ X ]
    Öğe
    The relationship between 68Ga-PSMA uptake and Gleason Score and PSA levels in patients with prostate cancer
    (MediHealth Academy Yayıncılık, 2021) Altuntuzcu, Şadiye; Taşdemir, Bekir; Kaplan, İhsan; Uyar, Ali; Güzel, Fatih; Güzel, Yunus; Dağgülli, Mansur
    Aim: PSMA expression has been observed in increased levels in patients with high Gleason scores. Current information on Ga-68 PSMA PET/CT shows that primary staging with PET/CT is important in patients with high-risk PC. Ga-68 PSMA PET/CT may also have a place in patients with intermediate risk PC, but only a few data are available at present. In this study, we aimed to elucidate the relationship between PSMA expression value in the prostate gland, total PSA levels and GS in patients diagnosed with prostate cancer. Material and Method: A total of 98 patients who were pathologically diagnosed with prostate cancer that did not receive any treatment and underwent Ga-68 PSMA PET/CT imaging for staging were included in the study. Findings detected in Ga-68 PSMA PET/CT imaging were categorized as prostate, lymph node, bone, and visceral organ. The focal increased PSMA expression values ??observed in the prostate gland were recorded as SUVmax. The patients were divided into two separate groups according to their GS score (GS>7 and GS?7). Correlations between prostate PSMA SUVmax, GS score and total PSA scores were investigated. Results: PSMA SUVmax levels of the group with a Gleason score of >7 were found to be significantly higher than the group with a Gleason score of ?7 (p=0.03). The rates of lymph node metastasis, bone metastasis and visceral organ metastases were found to be significantly higher in the group with a Gleason score >7 compared to the group with a Gleason score ?7. A positive correlation was observed between PSMA SUVmax and Total PSA (r=0.260, p=0.01). A positive correlation was observed between PSMA SUVmax and Gleason score (r=0.260, p=0.01). A positive correlation was observed between total PSA and Gleason score (r=0.320, p=0.001). Conclusion: In conclusion, PSMA SUVmax and Total PSA levels were higher in the group with high Gleason score. There is a positive correlation between PSMA SUVmax and total PSA. Clinicians should be careful in this regard, as the possibility of metastasis will be high in groups with high Gleason scores.