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    Perioperative High-Dose Amiodarone Elevates Nitric Oxide Levels in Patients Undergoing Coronary Artery Bypass Surgery.
    (Allied Acad, 2013) Uysal, Ayhan; Azak, Soner; Colak, M. Cengiz; Burma, Oktay; Ozguler, I. Murat; Ustundag, Bilal; Bayar, Mustafa Kemal
    The aim of the current study was to assess the effects of the Class III antiarrhythmic drug amiodarone on arterial blood Nitric oxide (NO) levels together with malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-px), and catalase (CAT) levels in patients undergoing coronary artery bypass surgery (CABG). Twenty patients undergoing CABG were included in the study. The patients were divided into control and amiodarone groups (n=10 in each group). The patients in group 1 did not receive any drugs. The patients in group II received 4X400 mg/day amiodarone on the day before surgery, 2X600 mg/day amiodarone on the day of surgery, and 2X400 mg/day amiodarone for the first consecutive four days after the surgery. NO, MDA, SOD, GSH-px, and CAT values were measured for biochemical evaluation of oxidative stress before the induction of anesthesia (T-A), before CPB (T-CPB), five minutes after the clamp was removed (T-c), after protamine (T-P), and on postoperative days 1 (T-1), 3 (T-3), and 5 (T-5). Hemodynamic changes of all patients were recorded at before the induction of anesthesia (TA), before CPB (TCPB), after protamine (T-P), and on postoperative day 1 (T1). Amiodarone elevated NO levels at all times during the study period but did not cause changes in MDA, SOD, GSH-px, or CAT. In addition, amiodarone decreased mean pulmonary artery pressure, pulmonary capillary wedge pressure, and heart rate in these patients. No side effect due to drug was observed. Heart rate was found more decreased in amiodarone group at T-1 and T-2 stages when compared with controls (p<0.05). Perioperative high- dose amiodarone might be beneficial for patients who are pulmonary hypertensive and are undergoing CABG.
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    Öğe
    PLASMA TOTAL HOMOCYSTEINE, LIPOPROTEIN (A) AND VON WILLEBRAND FACTOR LEVELS IN ASSESSMENT OF METABOLIC CONTROLS OF CHILDREN WITH TYPE I DIABETES MELLITUS
    (Nobel Ilac, 2014) Ertugrul, Sabahattin; Sen, Yasar; Yilmaz, Erdal; Aydin, Mustafa; Ustundag, Bilal
    Objective: Diabetes is a significant risk factor for early onset of atherosclerosis. In this study, it was aimed to determine whether total homocysteine (tHcy), lipoprotein(a) [Lp(a)] and von Willebrand factor (vWF) levels have an early predictive value like glycolysated hemoglobin (HbA1c) levels in assessment of metabolic condition of children with type I diabetes. Material and Method: Study group consisted of 65 children and adolescents who had type I diabetes but not clinical findings of microvascular and macrovascular complications and 20 healthy children and adolecents with the same age group and gender Blood samples were obtained from diabetic patients, treatments were arranged and patients were followed up (Group I diabetic patients). Patients were re-evaluated at the end of 1 year and blood samples were obtained again (Group H diabetic patients). Results: A statistically significant difference was found between the first (11.1 +/- 3.3 mu mol/L) and the second tHcy levels (10.2 +/- 1.7 mu mol/L) of diabetic patients and tHcy levels of control group (8.9 +/- 2 mu mol/L)(p<0.05 and <0.01, respectively). A statistically significant difference was found between the first (10.4 +/- 5.4 mg/dl) and the second Lp(a) levels (9.0 +/- 4.3 mg/dl) of diabetic patients and Lp(a) levels of control group (5.3 +/- 2.8 mg/dl)(p<0.01 and <0.001, respectively). A statistically significant difference was not found when vWF levels of diabetic groups I and II and control group were compared (p>0.05). A statistically significant positive correlation was found between tHcy and HbA1c, microalbumin in Group I diabetic patients (r=0,389, p=0,02; r=0,286, p=0,034, respectively). A statistically significant positive correlation was found between HbA1c and homocysteine, vWF, microalbumin (r=0,428, p=0,001; r=0,328, p=0,024; r=0,742, p=0,001, respectively) and vWF and microalbumin levels (r=0,560, p=0,001) in Group II diabetic patients. Conclusion: In conclusion, that tHcy and Lp(a) could be beneficial for assessment of metabolic control of diabetes, treatments toward reducing the complications of diabetes or the outcomes of additions to diet.