Yazar "Unal, Mehmet" seçeneğine göre listele

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    Öğe
    Comparison of Renoprotective Effect of Dabigatran With Low-Molecular-Weight Heparin
    (Sage Publications Inc, 2016) Yazici, Suleyman; Karahan, Oguz; Oral, Mehmet Kerem; Bayramoglu, Zehra; Unal, Mehmet; Caynak, Baris; Sagbas, Ertan
    Objective: The susceptibility of tissue to ischemia-reperfusion (I/R) injury is a major obstacle to tissue regeneration and cellular survival. In this study, we investigated the possible renoprotective effect of dabigatran in an experimental renal I/R model. Method: A total of 25 rats were randomly divided into 5 equal groups. The control group was used to obtain basal values of oxidant and antioxidant biomarkers. The sham group was used to obtain renal prolidase and malondialdehyde (MDA) levels after renal ischemia (for 45 minutes) and reperfusion (for 1 hour). A standard diet was followed. Oral 15 mg/kg dabigatran etexilate was administrated to group I, intraperitoneal 250 U/kg enoxaparin sodium was administrated to group II, and intraperitoneal 250 U/kg bemiparin sodium was administrated to group III for 1 week before the renal I/R was performed. Renal tissue samples were obtained during the first hour of reperfusion to detect renal prolidase and MDA levels in these groups, after which the rats were euthanized. Results: Renal prolidase levels were significantly higher in the sham group compared with the control group (1834.2 982.3 U/g protein vs 238.8 +/- 43.6U/g protein; P = .001). Lower prolidase levels were observed in groups II (838.7 +/- 123.8 U/g protein) and III (1012.9 +/- 302.3 U/g protein), and the lowest prolidase levels occurred in group I (533.8 +/- 96.2 U/g protein; P < .05) when compared with the sham group. The MDA levels were significantly lower (P < .05) in groups I, II, and III (163.9 +/- 41.5, 185.4 +/- 51.0, and 138.2 +/- 22.6 mol/g protein, respectively) compared with the sham group. Conclusion: Dabigatran etexilate, a univalent direct thrombin inhibitor, may protect the renal tissue more effectively when compared to low-molecular-weight heparins.
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    Öğe
    Evaluation of stress distribution of a new restorative material and composite resin: a finite-element analysis study
    (Taylor & Francis Ltd, 2017) Dogan, Mehmet Sinan; Demirci, Fatih; Eratilla, Elif; Eratilla, Veysel; Yavuz, Yasemin; Unal, Mehmet
    Glass carbomer cement is a new dental material developed from the traditional glass ionomer cements. It has better mechanical and chemical features when compared to the conventional glass ionomer cements. The purpose of this in silico investigation was to examine the influence of glass carbomer and composite resin materials with class I cavity design on stresses happening in the inlay. Finite-element analysis and three-dimensional modelling were used to examine the stress in the glass carbomer and hybrid composite inlays resulting from a 300-N point load on occlusal surfaces. Two different inlay materials, glass carbomer cement and hybrid composite resin, were evaluated. The maximum von Misses stress values in the composite resin inlays were significantly lower than those in the glass carbomer inlays. The results from this study showed that the resistance of the glass carbomer against the forces was higher than that of the composite resin inlays. The stresses were concentrated mostly at similar regions. The obtained results suggest that glass carbomer may be recommended as a preferred filler restorative material in teeth with much structure loss.
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    Öğe
    Three-dimensional finite-element analysis of two ceramic inlay restorations with different cavity designs
    (Taylor & Francis Ltd, 2015) Guven, Sedat; Akdogan, Mehmet; Oz, Cihan; Dogan, Mehmet Sinan; Unal, Mehmet; Unal, Server; Sahbaz, Cafer
    The aim of this in silico investigation was to examine the influence of two ceramic inlay materials with different cavity designs on stresses in the inlay. Finite-element analysis and three-dimensional modelling were used to examine the stress in ceramic inlays resulting from a 250-N point load on occlusal surfaces. The adhesion properties and von Mises stress values in the enamel, dentin, ceramic materials and cement linings were simulated. Two ceramic inlay materials: porcelain ceramic (Empress II, Ivoclar Vivadent, Liechtenstein) and zirconia ceramic (ICE Zirkon, Zirkonzahn SRL, Gais, Italy), as well as two cavity corner designs: rectangular and rounded, were evaluated. The obtained von Mises stress results indicated that the maximum and minimum forces were concentrated in the enamel and dentin, respectively. The stress values in the dentin and inlay material were similar in the porcelain ceramic and zirconia ceramic groups. However, in the enamel, the stress values in the zirconia ceramic group were significantly lower than those in the porcelain ceramic group. Additionally, cavities with rounded corners were subject to significantly less stress compared to those with rectangular corners. Thus, the zirconia ceramic inlay demonstrated better performance under applied stress, based on the reduced stress values in the tooth structure. Cavities with rounded corners showed less stress than those with rectangular corners, which could be attributed to the enhanced stress distribution capabilities of rounded corners.