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    Niosomes of Nerium oleander extracts: In vitro assessment of bioactive nanovesicular structures
    (Elsevier, 2017) Gunes, Aybike; Guler, Emine; Un, Rabia Nur; Demir, Bilal; Barlas, F. Baris; Yavuz, Murat; Coskunol, Hakan
    Niosomes are known as non-ionic surfactant-based vesicles and have been used quite a lot for medical applications as a novel drug delivery system in recent years. Herein we describe, the preparation and characterization of niosomes containing oleander (Nerium oleander) (ONs) extract as the herbal compound. In this context, niosomal formulations of two different extracts obtained from oleander roots were prepared by a thin film hydration technique using Tween 60 (non-ionic surfactant) with a cholesterol mixture at 1:1 M ratio. These vesicular structures were characterised by various techniques such as atomic force microscopy, zeta potential and dynamic light scattering size measurements. ONs vesicles are less than 100 nm in size with a good physical stability more than 50 days. Initially, total phenolic and flavonoid contents and antioxidant activities of the extracts were investigated. The methanol extract of oleander roots (MOE) showed higher polyphenolic content and exhibits a better antioxidant activity in compared to the hydro-methanol (20% methanol) extract (MOWE). Total phenolic contents in the MOE and MOWE were calculated as 64.51 +/- 0.945 mu g/mg and 65.05 +/- 0.37 mu g/mg gallic acid equivalents, respectively. Encapsulation efficiencies of the vesicles were found as 16.2% for MON (contain MOE) and 13.24% for MWON (contain MOWE). The significant linear correlation Was confirmed between the antioxidant activity and total phenolic content of extracts as well as ONs. Cell based cytotoxic activities of methanol extract and MON formulations were also assessed via KIT assay using Hela and A549 cell lines. (C) 2016 Elsevier B.V. All rights reserved.
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    Phyto-Niosomes: In Vitro Assessment of the Novel Nanovesicles Containing Marigold Extract
    (Taylor & Francis As, 2015) Un, Rabia Nur; Barlas, F. Baris; Yavuz, Murat; Seleci, Didem Ag; Seleci, Muharrem; Gumus, Z. Pinar; Guler, Emine
    Herbal compounds, so-called phytoconstituents, illustrate poor absorption by living cells. Phytosomes are advanced form of herbal compounds that show higher absorption rate and bioavailability, which results better than conventional plant extracts. Niosomes, which are made of nonionic surfactants, create better chemical and stability conditions besides lipid vesicles. This study covers the preparation, characterization and cell culture applications of phyto-niosomes of Marigold extract. Before the encapsulation process, extracts of selected plants were prepared and the extract that presents best bioactivity was chosen. The resulting phyto-niosomes were characterized and their biological activities including cytotoxicity, wound healing and antioxidant activity were investigated.