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Öğe Assesment of Paediatric Varicella Pneumonia(Univ West Indies Faculty Medical Sciences, 2016) Aktar, F.; Tekin, R.; Bektas, M. S.; Kostu, M.; Aktar, S.; Gunes, A.; Uluca, U.Background: The objective of the study was to determine the clinical presentation, diagnosis, treatment, and respiratory complications of varicella zoster pneumonia (VZP) in children. Material and methods: Relevant data, age, gender, month of admission, demographic data, past medical and family histories, physical findings during admission, laboratory findings, treatments given, and outcome of these treatments with diagnosis of varicella pneumonia were collected retrospectively. Results: In a two-year period, 15 cases were identified and their data were analysed. Eight patients were male (53%) and seven were female (43%). The mean age was 4.7 +/- 3.7 months. Twelve cases (80%) were under six months of age and nine patients (60%) had household contact with persons with chicken pox infection. After onset of the chicken pox rash, the mean time for development of respiratory symptoms was 3.5 +/- 1.0 days. The mean hospital stay was 13 +/- 1.8 days and ranged from 9-17 days. The persisting fever, fatigue, and cough episodes were major presenting symptoms upon admission in almost all the patients. All patients received acyclovir and non-specific pneumonia treatment and all recovered. None of the children were previously immunized against varicella. Conclusions: Varicella zoster pneumonia should be considered in patients with prolonged fever and accompanying cough in patients with chicken pox. Probably the best approach would be a trial of high dose acyclovir treatment in children who develop VZP.Öğe Evaluation of children with juvenile idiopathic arthritis in southeastern Turkey: a single center experience(Lithographia, 2015) Sen, V; Ece, A.; Uluca, U.; Yel, S.; Tan, I; Karabel, D.; Yildirim, B.Background: The aim of this study was to investigate the disease characteristics of children with juvenile idiopathic arthritis (JIA) in southeast Turkey. Methods: The International League of Associations for Rheumatology (ILAR) criteria were used to diagnose JIA. Hospital records of the Pediatric Rheumatology Unit, of the Dicle University Hospital, were reviewed retrospectively and demographic, clinical and laboratory data were recorded. Results: Totally 213 children (103 boys, 110 girls), with an age range of 1.6-18 years were enrolled. The mean age of the disease onset was 8.1 years. Polyarticular type was the most common (42.3%) presentation. The frequencies of other JIA subtypes were as follows: oligoarticular 37.1%, systemic 8.9%, enthesitis-related arthritis (ERA) 10.8% and psoriatic arthritis 0.9%. The knees (74.2%) and ankles (54.0%) were the most commonly affected joints. Uveitis was found in 4.2% of patients. Anti-nuclear antibodies were positive in 11.7% and HLA-B27 in 2.8% of patients. Active disease was seen in 57 (26.7%) patients at the last visit. Conclusion: In the present study, polyarticular JIA was the predominant subtype and there were fewer patients with positive ANA or uveitis compared to previous studies.Öğe Evaluation Of Three Patients With Haemorrhagic Diathesis Which Are Intracranial Haemorrhage(Wiley, 2015) Uluca, U.; Soker, M.; Yel, S.; Gocmez, C.; Tayfun, F.; Karabel, D.; Arpa, A.[Abstract Not Available]Öğe FeNO levels in children with asthma and other diseases of the lung(Verduci Publisher, 2013) Kelekci, S.; Sen, V.; Yolbas, I.; Uluca, U.; Tan, I.; Gurkan, M. F.BACKGROUND: Prolonged cough in children is one of the major complaints seen in hospitals. It is difficult to make a proper diagnosis and start the appropriate treatment. Fraction of exhaled nitric oxide (FeNO) measurement is a valuable non-invasive diagnostic tool in determining the cause of prolonged cough in children. Although there are several studies on asthma and COPD, there is a lack of them on other lung diseases such as tuberculosis, bronchiectasia, bronchiolitis obliterans (BO), and pneumonia. PATIENTS AND METHODS: In this study, pretreatment FeNO levels of patients with various lung diseases were measured and results from the sick patient groups were compared with the results from the control group. RESULTS: Pre-treatment FeNO levels in BO, asthma, and tuberculosis patient groups were higher than in the control group (p < 0.001). There was no significant difference between the acute bacterial pneumonia and bronchiectasia groups, and the control group (p > 0.05). CONCLUSIONS: FeNO measurement is a highly important guiding tool in diagnosis and treatment of various lung diseases.Öğe Hypertrophic Cardiomyopathy as a Clinical Component of Congenital Cytomegalovirus Infection(Univ West Indies Faculty Medical Sciences, 2016) Demir, F.; Yilmazer, M. M.; Dalli, S.; Yolbas, I.; Uluca, U.; Bilici, M.; Turan, M. I.We report hypertrophic cardiomyopathy in a newborn with congenital cytomegalovirus infection. The neonate had distinct signs of congenital cytomegalovirus infection including petechiae, jaundice, intracranial calcifications, cerebral ventriculomegaly and chorioretinitis together with hypertrophic cardiomyopathy. Following determination of anti-cytomegalovirus IgM, viral DNA was also isolated from the plasma of the patient by polymerase chain reaction. Although cytomegalovirus is a relatively frequent cause of myocarditis in childhood, it was rarely reported to be associated with cardiac abnormalities such as structural heart disease, atrioventricular block, or dilated cardiomyopathy. To our knowledge, this is the first case with congenital cytomegalovirus infection and hypertrophic cardiomyopathy.Öğe The relationships between clinical outcome and the levels of total antioxidant capacity (TAC) and coenzyme Q (CoQ10) in children with pandemic influenza (H1N1) and seasonal flu(Verduci Publisher, 2012) Kelekci, S.; Evliyaoglu, O.; Sen, V.; Yolbas, I.; Uluca, U.; Tan, I.; Gurkan, M. F.BACKGROUND AND AIM, This study was planned to evaluate the relationships between the levels of total antioxidant capacity (TAC) and Coenzyme 0 (Coal 0) and clinical outcome in hospitalized children with pandemic influenza (H1N1). Serum copper (Cu) and zinc (Zn) levels were also determined to evaluate the changings of oxidative stress's enzyme activities depending on their cofactor concentrations. PATIENTS AND METHODS, Children with suspected H1N1 virus infection were hospitalized and nasal swabs were sent to laboratory for confirmation of H1N1 by rRT-PCR assay. Age and sex matched 31 healthy children were included as Control Group. Total antioxidant capacity and CoQ10 were determined by spectrophotometry and HPLC, respectively, and Cu and Zn were determined using atomic absorption spectrometer. RESULTS, Totally 28 children had H1N1 and 37 children had seasonal influenza (SI). TAC, CoQ10 and Zn levels were found to be significantly decreased in H1N1 patients (1.01 +/- 0.19, 752.2 +/- 163, 69 +/- 27, respectively) compared to Control Group (1.64 +/- 0.36, 934 +/- 21, 92 +/- 4, respectively). Seasonal Influenza group had significantly decreased TAC and Zn levels (1.31 +/- 0.27, 78 +/- 34 respectively) compared with control group (1.64 +/- 0.36, 92 +/- 41, respectively). CoQ10 levels were also found as decreased in H1N1 compared to seasonal influenza (752.2 +/- 163 vs 1022 +/- 199, p = 0.003). There was a significant correlation between CoQ10 levels of sera and chest radiographic findings of patients with H1N1 pneumonia. No significant differences were found in serum Cu levels between patients with H1N1 and SI or control group (150 +/- 45 vs 127 +/- 37, p = 0.215). CONCLUSIONS, Pandemic influenza infection had increased oxidative stress compared to the seasonal influenza.
