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Öğe THE ASSESMENT OF LONG TERM OUTCOMES IN HBSAG NEGATIVE RENAL TRANSPLANT RECIPIENTS WHO WERE TRANSPLANTED FROM HBSAG POSITIVE DONORS(Wiley-Blackwell, 2015) Yilmaz, Vural Taner; Ulger, Burak Veli; Aliosmanoglu, Ibrahim; Erbis, Halil; Tuna, Yasar; Akbas, Halide; Ozdem, Sebahat[Abstract Not Available]Öğe Assessment of Long-Term Outcomes in Hbs Ag-Negative Renal Transplant Recipients Transplanted from Hbs Ag-Positive Donors(Int Scientific Information, Inc, 2015) Yilmaz, Vural Taner; Ulger, Burak Veli; Aliosmanoglu, Ibrahim; Erbis, Halil; Tuna, Yasar; Akbas, Halide; Ozdem, SebahatBackground: The aim of this study was to evaluate the long-term outcomes of renal transplantation from Hbs Ag-positive donors to Hbs Ag-negative recipients. Material/Methods: A total of 78 patients who underwent renal transplantation in our clinic between January 2006 and May 2014 were included in the study. Patients were divided into 2 groups: Group 1: Donor Hbs Ag (+) (n=26, Hbs Ab (-), Hbe Ag (-), Hbe Ab (+), Hbc Ig total (+) and HBV DNA (+), male/female (M/F): 16 (61.5%)/10 (38.5%), and Group 2: Donor Hbs Ag (-) (n=52, M/F: 41 (78.8%)/11 (21.2%). Hbs Ab levels were similar in recipients in both groups. Data were collected retrospectively. Analyses were performed by using SPSS 20.0 software, and patient and graft survival were measured by using Kaplan-Meier survival curve and compared by using the log-rank test. Results: Demographic data were similar in the 2 groups. The rate of acute Hepatitis B infection was significantly higher in Group 1 than in Group 2 [n=3 (11.5%) vs. n=0 (0%), respectively, p=0.012]. Acute hepatitis B attacks were detected in vaccinated patients. Graft survival rates (groups 1 and 2, respectively; at 1st, 3rd, 5th and 8th years: 95% vs. 96%, 95% vs. 94%, 85% vs. 88%, 85% vs. 82%, p=0.970) and patient survival rates (p=0.098), acute rejection rates (p=0.725), delayed graft function, chronic allograft dysfunction, new-onset diabetes after transplantation (NODAT), cytomegalovirus infection, and the need for postoperative dialysis and plasmapheresis were similar between groups. Conclusions: Our study revealed that the risk of developing acute hepatitis B was higher in patients renally transplanted from Hbs Ag (+) donors, but the other clinical outcomes were similar between groups.Öğe Effect of Intraperitoneal Curcumin Instillation on Postoperative Peritoneal Adhesions(Karger, 2015) Turkoglu, Ahmet; Gul, Mesut; Yuksel, Hatice Kurt; Alabalik, Ulas; Ulger, Burak Veli; Uslukaya, Omer; Avci, YahyaObjective: The aim of this study was to determine the effect of curcumin on adhesion formation in a rat cecum abrasion model. Materials and Methods: Thirty Wistar rats were randomized into three groups; the control group received saline, the curcumin group received 10 mg/kg of curcumin after cecal abrasion, and in the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were assessed blindly using a standardized scale, and histopathological samples were taken and examined. Results: There were no incisional hernias or wound dehiscences in any animals of the three groups. A comparison of adhesion scores showed a significant difference between the curcumin (median = 1) and the control group (median = 2; p < 0.05). The grade of inflammation of the curcumin (median = 1) and the sham (median = 0) group was significantly lower than that of the control group (median = 3; p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham (48.3 +/- 11.8 mu g/mg) and the curcumin (63.8 +/- 13.9 mu g/mg) group compared to the control group (85.7 +/- 22.1 mu g/mg; p < 0.05). Conclusion: These data suggest that curcumin, administered intraperitoneally, was effective in the prevention of peritoneal adhesion formation. (C) 2014 S. Karger AG, BaselÖğe The effects of sulforaphane on the liver and remote organ damage in hepatic ischemia-reperfusion model formed with pringle maneuver in rats(Elsevier, 2015) Oguz, Abdullah; Kapan, Murat; Kaplan, Ibrahim; Alabalik, Ulas; Ulger, Burak Veli; Uslukaya, Omer; Turkoglu, AhmetBackground: The purpose of this study was to investigate the effect of Sulforaphane on ischemia/ reperfusion (IR) injury of the liver and distant organs resulting from liver blood flow arrest. Materials and methods: Fourty Wistar rats were assigned into four groups, each included 10 rats were used. Group I as only laparatomy, Group II laparatomy and Sulforaphane application, Group III hepatic IR; and Group IV as hepatic IR and Sulforaphane application group. Animals were subjected to liver ischemia for 30 min and then reperfusion is started. 5 mg/kg Sulforaphane was applied via oral lavage 15 minutes before initiating the experimental study. Blood samples were taken from the animals for biochemical analysis at 60th minutes of the experiment in the first and second groups; 30 minutes after beginning reperfusion in the third and forth groups. Simultaneously, liver, lung and kidney tissues were sampled for biochemical and histopathological examinations. Results: The administration of sulforaphane significantly reduced the serum TOA and liver TOA levels, increased the serum TAC and liver TAC levels and also decreased The OSI and liver OSI levels. In the histopathologic examination, the injury was reduced by the administration of sulforaphane. Administration of sulforaphane did not lead to any significant changes in any parameter including histopathological parameters in both the kidney and the lung. Conclusions: Sulforaphane reduced the liver oxidative stress from I/R injury. A histological injury in liver was reduced by sulforaphane administration. However, there were no significant effects of sulforaphane on the remote organ injuries induced by IR. (C) 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.Öğe Factors Affecting the Postsurgical Length of Hospital Stay in Patients with Breast Cancer(Aves, 2015) Gumus, Metehan; Satici, Omer; Ulger, Burak Veli; Oguz, Abdullah; Taskesen, Fatih; Girgin, SadullahObjective: Breast cancer is the most common malignancy and the most common cause of mortality in women worldwide. In addition to the increasing incidence of breast cancer, the length of hospital stay (LOS) after breast cancer surgery has been decreasing. Because LOS is key in determining hospital usage, the decrease in the use of hospital facilities may have implications on healthcare planning. The purpose of this study was to evaluate the factors affecting postoperative LOS in patients with breast cancer. Materials and Methods: Seventy-six in patients with breast cancer, who had been treated between July 2013 and December 2014 in the General Surgery Clinic of Dicle University, were included in the study. The demographic characteristics of the patients, treatment methods, histopathological features of the tumor, concomitant diseases, whether they underwent neoadjuvant chemotherapy or not, and the length of drain remaining time were retrospectively recorded. Results: There was a correlation between drain remaining time, totally removed lymph node, the number of metastatic lymph node, and LOS. LOS of patients treated with neoadjuvant chemotherapy was longer. The patients who underwent breast-conserving surgery had a shorter LOS. Linear regression analysis revealed that the drain remaining time and the number of metastatic lymph nodes were independent risk factors for LOS. Conclusion: Consideration should be given to cancer screening to diagnose the patients before lymph node metastasis occurs. In addition, drains should be avoided unless required and, if used, they should be removed as early as possible for shortening LOS.Öğe Factors effecting mortality in abdominal major vascular injuries(Drunpp-Sarajevo, 2012) Gul, Mesut; Aliosmanoglu, Ibrahim; Oguz, Abdullah; Ulger, Burak Veli; Turkoglu, AhmetBackground and Aim: Despite recent advancements of medical facilities and improvements in surgical techniques, traumatic abdominal major vascular injuries still has high morbidity and mortality rates. Our objective in this study is to investigate the factors effecting mortality in patients who had surgery due to abdominal major vascular injury. Methods: Seventeen patients who had emergent surgery for abdominal major vascular injury were analyzed retrospectively. Age, gender, cause of injury, existence of additional organ injuries, vascular repair technique, blood replacement, mortality and duration of hospital stay are evaluated. Results: The study group consisted of 16 male and 1 female patients. Average age was 28.4 +/- 8.3. Cause of injury was firearms for 15 patients (88.2 %), cutter for 1 patient (5.9 %) and traffic accident in vehicle for 1 patient (5.9 %). Iliac veins, iliac arteries and vena cava inferior were the most injured vessels. Elapsed time between injury and operation was 140.0 +/- 18.2 minutes for patients who have died, 97.3 +/- 16.1 minutes for the other patients (p=0.003). For patients who had additional organ injury accompanying vessel injury, mortality rate was higher (p=0.028). Four patients have died (23,5 %). Conclusion: Successful surgical results in abdominal vascular injuries depend on well knowledge of abdominal vascular anatomy, experience in vascular repair techniques, less additional organ injury and surgical intervention without delay.Öğe Fasciola hepatica infection at a University Clinic in Turkey(J Infection Developing Countries, 2014) Ulger, Burak Veli; Kapan, Murat; Boyuk, Abdullah; Uslukaya, Omer; Oguz, Abdullah; Bozdag, Zubeyir; Girgin, SadullahIntroduction: We aimed to analyze the approaches to the diagnosis and treatment of patients with fascioliasis in light of current literature. Methodology: Thirty-nine patients with fascioliasis admitted to the Surgery Clinic of Dicle Medical Faculty (Turkey) were included in this study. The demographic, clinical, diagnostic, treatment and outcome data were analyzed retrospectively. Results: Abdominal pain (n = 37; 95%) and eosinophilia (n = 31; 79%) were the most common findings. Twenty-seven patients were diagnosed by clinical and radiological findings. Patients were treated with triclabendazole. Thirty-six (92.4%) of the patients improved after medical treatment. Conclusions: The presence of typical clinical, laboratory and radiological findings is sufficient for diagnosis. Triclabendazole administration is often an effective treatment, with improvements occurring over the course of a few months.Öğe Fournier's Gangrene: A Summary of 10 Years of Clinical Experience(Int College Of Surgeons, 2015) Oguz, Abdullah; Gumus, Metehan; Turkoglu, Ahmet; Bozdag, Zubeyir; Ulger, Burak Veli; Agacayak, Elif; Boyuk, AbdullahWe aimed to present our clinical experience with FG treatment. Fournier's gangrene (FG) is a rare but serious disease characterized by progressive necrosis in the genitourinary and perineal region. The retrospective study included 43 patients. Patients were divided into 2 groups as survivors and nonsurvivors. Included in the analysis were data pertaining to demographics, predisposing factors, comorbidities, results of bacteriologic analyses, number of debridements, duration of treatment, FG Severity Index (FGSI) score, fecal diversion methods (trephine ostomy or Flexi-Seal Fecal Management System-FMS), and dressing methods (wet or negative aspiration system). In the nonsurvivor group, urea, WBC, and age were significantly higher, whereas albumin, hematocrit, platelet count, and length of hospital stay (LOHS) were significantly lower compared to the survivor group. Mean FGSI was lower in survivors in comparison with nonsurvivors (5.00 +/- 1.86 and 10.00 +/- 1.27, respectively; P < 0.001). We conclude that FGSI is an important predictor in the prognosis of FG. Vacuum-assisted closure (VAC) should be performed in compliant patients in order to enhance patient comfort by reducing pain and the number of dressings. Fecal diversion should be performed as needed, preferably by using FMS. The trephine ostomy should be the method of choice in cases where an ostomy is necessary.Öğe Gangrenous Cholecystitis: Mortality and Risk Factors(Int College Of Surgeons, 2015) Onder, Akin; Kapan, Murat; Ulger, Burak Veli; Oguz, Abdullah; Turkoglu, Ahmet; Uslukaya, OmerAs a serious complication of cholelithiasis, gangrenous cholecystitis presents greater mortality than noncomplicated cholecystitis. The aim of this study was to specify the risk factors on mortality. 107 consecutive patients who underwent surgery due to gangrenous cholecystitis between January 1997 and October 2011 were investigated retrospectively. The study included 60 (56.1%) females and 47 (43.9%) males, with a mean age of 60.7 6 16.4 (21-88) years. Cardiovascular diseases were the most frequently accompanying medical issues (24.3%). Thirty-six complications (33.6%) developed in 29 patients, and surgical site infection was proven as the most common. Longer delay time prior to hospital admission, low white blood cell count, presence of diabetes mellitus, higher blood levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and total bilirubin, pericholecystic fluid in abdominal ultrasonography, and conversion from laparoscopic surgery to open surgery were identified as risk factors affecting mortality (P < 0.001, P = 0.001, P = 0.044, P = 0.005, P = 0.049, P = 0.009, P = 0.022, P = 0.011, and P = 0.004, respectively). Longer delay time prior to hospital admission and low white blood cell count were determined as independent risk factors affecting mortality.Öğe HEPATOPULMONARY SYNDROME RELATED PORTAL HYPERTENSION(Wiley-Blackwell, 2015) Erbis, Halil; Calli, Iskan; Mutlu, Fatih; Ulger, Burak Veli; Tuna, Yasar; Ozturk, Bunyamin; Yilmaz, Vural Taner[Abstract Not Available]Öğe Institutional experience in the histopathological characteristics and frequency of gallbladder lesions(E-Century Publishing Corp, 2016) Turkcu, Gul; Alabalik, Ulas; Keles, Ayse Nur; Ibiloglu, Ibrahim; Hamidi, Arif; Ulger, Burak Veli; Buyukbayram, HuseyinPurpose: Our aim in this study is to retrospectively examine cases in which cholecystectomy was performed and to determine incidental cancer cases. Materials and methods: We retrospectively examined the pathology reports of 1841 patients who underwent surgeries in the general surgery clinic for the treatment of gallbladder diseases between March 2006 and May 2015 and whose gallbladder materials were examined after surgery. Age, gender, pathological diagnosis and presence of gallbladder stones were recorded. Results: The average age of the 1841 patients (male/female: 585/1256) evaluated in this study was 50.37 +/- 18.81 years (range: 2-97 years). Surgery for gallbladder disease was most commonly performed in the age range of 50-60 years. Chronic cholecystitis was the most common histopathological diagnosis (92.0%), followed by acute cholecystitis (5.1%), non-neoplastic lesions (1.74%), preneoplastic lesions (0.76%), carcinomas (0.33%) and lymphomas (0.1%). One or more gallbladder stones were detected in 955 patients. Of these, 93.4% and 4.1% patients were diagnosed with chronic cholecystitis and acute cholecystitis, respectively. Conclusion: Histopathological examination of gallbladder materials is important for identifying incidental benign and malignant tumours.Öğe Is Ostomy Still Mandatory in Rectal Injuries?(Int College Of Surgeons, 2013) Ulger, Burak Veli; Turkoglu, Ahmet; Oguz, Abdullah; Uslukaya, Omer; Aliosmanoglu, Ibrahim; Gul, MesutThe aim of this study was to compare the outcomes of the treatment methods of ostomy and primary repair in rectal injuries. A total of 63 patients with rectal injury who had been treated at Dicle University Hospital between 2000 and 2011 were retrospectively reviewed. To determine the outcomes of the treatment methods, the patients were divided into 2 groups (ostomy group: patients who underwent ostomy plus primary repair; repair group: patients who only underwent primary repair) and compared. The patients included 51 men and 12 women. A total of 44 patients underwent ostomy, whereas 19 patients underwent primary repair. No morbidity was detected in either group with grade II intraperitoneal rectal injury. The outcomes of the patients with grade II intraperitoneal and extraperitoneal rectal injury were similar. In the treatment of patients with low-grade rectal injuries, primary repair can be preferred to ostomy.Öğe Mean Platelet Volume/Platelet Count Ratio: A New Diagnostic Parameter for Necrosis in Adhesive Small Bowel Obstruction-A Retrospective Cohort Study(Int College Of Surgeons, 2015) Ulger, Burak Veli; Erbis, Halil; Turkoglu, Ahmet; Gumus, Metehan; Gul, Mesut; Arikanoglu, Zulfu; Bozdag, ZubeyirAbdominal adhesions are still one of the most common causes of intestinal obstruction. A major challenge in adhesive small bowel obstruction (SBO) management is to detect ischemia as early as possible to avoid necrosis and resection. Elevated mean platelet volume and decreased platelet count have been associated with worse disease course for various ischemic diseases in many clinical studies. The objective of the current study was to evaluate the predictive value of the mean platelet volume/platelet count ratio for patients with small bowel obstruction. Data for patients with adhesive small bowel obstruction, admitted to the general surgery department of Dicle University Hospital between November 2010 and March 2014, were reviewed retrospectively. Mean platelet volume (MPV)/platelet count (PC) ratio values, demographic data, vital signs, and laboratory blood test results of the patients were analyzed. Mean platelet volume/platelet count ratio was higher in bowel necrosis group, while there were no differences between the groups in terms of mean platelet volume values. Mean platelet volume and mean platelet volume/platelet count ratio was higher in patients who underwent surgical treatment. The cutoff value with the highest sensitivity and specificity for MPV/PC ratio was 0.02855 (sensitivity 68%, specificity 65%) for predicting bowel necrosis in patients with adhesive SBO. Mean platelet volume/platelet count ratio is associated with the failure of the conservative management and the presence of bowel necrosis in patients with adhesive small bowel obstruction.Öğe Mean Platelet Volume: Is It a Predictive Parameter in Diagnosis of Acute Mesenteric Ischemia?(Int College Of Surgeons, 2015) Turkoglu, Ahmet; Gul, Mesut; Oguz, Abdullah; Bozdag, Zubeyir; Ulger, Burak Veli; Yilmaz, Ahmet; Aldemir, MustafaOur objective for this study was to discuss the usability of mean platelet volume, which is associated with numerous vascular pathologies, in the early diagnosis of acute mesenteric ischemia. Acute mesenteric ischemia is an uncommon, life-threatening clinical condition mostly seen in the elderly. Early diagnosis of acute mesenteric ischemia and correction of blood circulation before necrosis occurs are important factors affecting prognosis. A total of 95 patients who underwent emergency surgery for acute mesenteric ischemia and 90 healthy volunteers as control group were included in this study. Age, gender, hemoglobin values, white blood cell counts, mean platelet volume, and platelet counts are recorded for evaluation. The mean platelet volume values were significantly higher in patients with acute mesenteric ischemia than in the controls (9.4 +/- 1.1 fL and 7.4 +/- 1.4 fL, respectively; P < 0.001). Receiver-operating characteristic analysis demonstrated a cutoff value of mean platelet volume as 8.1 fL (area under the curve, 0.862), a sensitivity of 83.2%, and a specificity of 80%. As a result, in the patients who are admitted to the hospital with acute nonspecific abdominal pain and suspected of having acute mesenteric ischemia, high mean platelet volume values in routine hemograms support the diagnosis of acute mesenteric ischemia.Öğe Nebivolol Ameliorates Hepatic Ischemia/Reperfusion Injury on Liver But Not on Distant Organs(Taylor & Francis Inc, 2015) Ulger, Burak Veli; Erbis, Halil; Turkcu, Gul; Ekinci, Aysun; Turkoglu, Mehmet Akif; Ekinci, Cenap; Yilmaz, Vural TanerIntroduction: Hepatic ischemia/reperfusion injury may occur after large tumor resection and liver transplantation procedures. Nitric oxide was shown to have protective effects on ischemia/reperfusion injury. Nebivolol is a compound that has been reported to improve nitric oxide release. We evaluated the effects of nebivolol in a rat liver ischemia/reperfusion model. Methods: A total of 40 rats were randomly divided into four groups (n = 10 each). Group I underwent only laparotomy, Group II was administered nebivolol and then underwent laparotomy, Group III underwent laparotomy and hepatic ischemia/reperfusion, and Group IV was administered nebivolol and then underwent laparotomy and hepatic ischemia/reperfusion. Serum AST, ALT, urea, and creatinine levels, and TAS and TOS levels of liver, lung, and kidney tissues were determined. Histopathological determination was also performed. Results: Nebivolol significantly reduced liver function tests in group IV, but it did not improve renal functions. Oxidative stress and abnormal histopathological findings were found to be reduced in liver tissue in group IV. Although the oxidative stress was increased after hepatic ischemia/reperfusion, nebivolol could not reduce the oxidative stress in kidney tissue. There were no significant differences between group III and group IV in terms of the histopathological changes in kidney tissue. There were no significant differences in lung tissue between the groups. Conclusions: The results of this study suggest that nebivolol has protective effects on liver but not on distant organs in a hepatic ischemia/reperfusion injury model. These experimental findings indicate that nebivolol may be useful in the treatment of hepatic ischemia/reperfusion injury.Öğe New hormones to predict the severity of gallstone-induced acute pancreatitis(Aves, 2014) Ulger, Burak Veli; Gul, Mesut; Uslukaya, Omer; Oguz, Abdullah; Bozdag, Zubeyir; Yuksel, Hatice; Boyuk, AbdullahBackground/Aims: Levels of the hormones ghrelin and leptin in rat models of acute pancreatitis (AP) have been investigated in several experimental studies. However, there are very few clinical studies addressing the connection between hormone levels and AP. A few recent studies investigating the changes in ghrelin and leptin levels in patients with AP have been reported; however, our study is the first clinical study to investigate the change of nesfatin-1 levels in patients with gallstone-induced AP. Materials and Methods: Forty patients were enrolled in this study, eight of which presented with severe AP. Two blood samples were obtained from each study patient. The first blood samples were obtained at patient admission to the hospital and the second was obtained at patient discharge. All samples were collected after at least 6 h of fasting. Plasma nesfatin-1, leptin, and ghrelin levels were measured. Results: In all 40 patients, nesfatin-1 and leptin levels were higher at admission and had decreased at discharge. In contrast, the ghrelin levels at discharge were significantly higher than those at admission. Only the changes in these hormones in the mild AP group were significant. Conclusion: Levels of these hormones were altered during the course of gallstone-induced AP. These changes might be associated with the clinical outcomes of the disease. To clarify whether the magnitude of the change in hormone levels at AP onset can be used as a biomarkers to predict the severity of the disease requires further investigation.Öğe Protective Effect of Caffeic Acid Phenethyl Ester on Antituberculosis Drug-Induced Hepatotoxicity in Rats(Int College Of Surgeons, 2017) Aliosmanoglu, Cigdem; Erbi, Halil; Aliosmanoglu, Ibrahim; Turkoglu, Mehmet Akif; Ulger, Burak Veli; Turkoglu, Ahmet; Yuksel, HaticeIsoniazid and rifampicin are drugs primarily used in antituberculosis treatment. Our aim in this study is to evaluate the effect of caffeic acid phenethyl ester's protective effect on liver function tests and to trace elements in hepatic damage caused by isoniazid and rifampicin on rats. Forty Wistar albino rats were divided into 4 groups. Group 1: Sham, Group 2: caffeic acid phenethyl ester application, Group 3: isoniazid and rifampicin given, Group 4: isoniazid + rifampicin and caffeic acid phenethyl ester application. After 30 days, the rats were sacrificed by taking blood from the heart. Alanine aminotransferase, aspartate aminotransferase, zinc, copper, total antioxidant capacity, total oxidative status, and oxidative stress index levels were evaluated. The rats to which isoniazid + rifampicin + caffeic acid phenethyl ester were given had less oxidative stress and copper levels (P < 0.001, P = 0.019) but have higher zinc levels (P = 0.001) compared to the isoniazid + rifampicin group. Liver enzyme levels were also lower in rats that were given isoniazid + rifampicin + caffeic acid phenethyl ester (P < 0.001). The results of this study suggested that caffeic acid phenethyl ester influences the levels of trace elements (copper and zinc) that are important for the physiologic mechanisms of organisms, reducing liver damage.Öğe The protective role of glutamine against acute induced toxicity in rats(Taylor & Francis Ltd, 2015) Aydin, Mesut; Yildiz, Abdulkadir; Ibiloglu, Ibrahim; Ekinci, Aysun; Ulger, Burak Veli; Yuksel, Murat; Bilik, Mehmet ZihniContext: Deltamethrin (DLM) is an insecticide commonly used to protect agricultural crops against pests. QT prolongation with malignant ventricular arrhythmias are amongst the most common cardiovascular complications. DLM intoxication cause decreased level of antioxidant enzymes. Glutamine is the precursor of glutathione which is an antioxidant and has been demonstrated to improve outcome after several critical illnesses. Objective: We hypothesized that glutamine, by means of antioxidant characteristics, may antagonize the cardiotoxic effects of DLM. Materials and methods: All experiments were performed on 8-week-old male Wistar albino rats. The rats were divided into following groups (n = 10); Group I: control, Group II: L-glutamine, Group III: DLM, Group IV: DLM and after 4 h L-glutamine. Total antioxidant status (TAS), total oxidant status (TOS) and parameter analyses were performed in cardiac tissue. Results: We found that TAS was higher and TOS lower in DLM group. We also found that interstitial edema and inflammatory cell infiltration was significantly more frequent in DLM group and QT and QTc of DLM group were higher than others. Discussion: Recent studies have shown that several special amino acids, such as glutamine, glycine, arginine and taurine, exhibit cytoprotective effect on the cardiocyte, and have established the cardioprotective properties of glutamine. Conclusion: In this study, we showed the protective role of glutamine against cardiotoxic effects of DLM in rats. This protective effect was confirmed by showing both tissue level improvement in oxidative stress markers and improvement in prolonged QT interval.Öğe RECONSTRUCTION OF SEGMENT 5 AND 8 VEINS IN RIGHT LOBE LIVING DONOR LIVER TRANSPLANTATION: AKDENIZ UNIVERSITY EXPERIENCE(Wiley-Blackwell, 2015) Aliosmanoglu, Ibrahim; Ulger, Burak Veli; Erbis, Halil; Tuna, Yasar; Ozturk, Bunyamin; Yilmaz, Vural Taner; Dinckan, Ayhan[Abstract Not Available]Öğe The Reliability of Fine-Needle Aspiration Biopsy in Terms of Malignancy in Patients With Hashimoto Thyroiditis(Int College Of Surgeons, 2015) Kapan, Murat; Onder, Akin; Girgin, Sadullah; Ulger, Burak Veli; Firat, Ugur; Uslukaya, Omer; Oguz, AbdullahThe aim of this study was to analyze the presence of malignancy in patients with Hashimoto's thyroiditis and to investigate the reliability of preoperative fine-needle aspiration biopsy (FNAB). The retrospective study included 44 patients who were operated on for nodular goiter between December 2010 and October 2011. The patients underwent thyroidectomy following a cytologic analysis plus FNAB. Hashimoto's thyroiditis was confirmed on histopathology in all patients. FNAB results were defined as benign in 14 (31.8%), suspicion for malignancy in 17 (38.6%), malignant in 9 (20.5%), and inadequate in 4 (9.1%). Following the thyroidectomy, presence of papillary thyroid carcinoma and follicular variant of papillary thyroid carcinoma were detected in 10 patients (22.7%) and 1 (2.3%) patient, respectively. The FNAB results were interpreted in terms of malignancy, which revealed the sensitivity as 80%; specificity, 40%; false positives, 69.2%; false negatives, 14.3%; positive predictive value, 31.8%; negative predictive value, 85.7%; and diagnostic accuracy, 50%. The coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma is quite common. The FNAB results for such cases are hard to evaluate, and they are likely to increase the number of false positives.
