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    Effects of hepatitis B surface antigen (HBsAg) positivity of donors in HBsAg(+) renal transplant recipients: comparison of outcomes with HBsAg(+) and HBsAg(-) donors
    (Wiley, 2016) Yilmaz, V. T.; Aliosmanoglu, I.; Erbis, H.; Ulger, B. V.; Cetinkaya, R.; Suleymanlar, G.; Kocak, H.
    AimThe aim of this study was to determine the effects of hepatitis B surface antigen (HBsAg) positivity of the donors on graft survival and liver complications in HBsAg(+) renal transplant recipients. Patients and methodA group of 55 patients who underwent renal transplantation (RTx) in our hospital between 2001 and 2012 were included in the study. Patients were divided into 2 groups. Group 1 (n=50) consisted of HBsAg(+) renal transplant recipients (RTR) whose donors were HBsAg(-). In Group 2 (n=5), RTR and donors were both HBsAg(+). Lymphocyte cross matches, number of mismatches, donor types, renal replacement treatment modalities, drugs of induction treatment, and preoperative hepatitis B virus DNA titers of the groups were similar. In Group 1, 42 patients were taking lamivudine, 3 patients were taking entecavir, and 5 patients were taking tenofovir. All of the patients in Group 2 were taking lamivudine. Patient and graft survival rates, graft functions, acute hepatitis rates, acute rejection rates, and other clinical outcomes of the groups were compared. ResultsDemographic data of the groups were similar. Acute rejection rates (P=0.458), graft survival rates (P=0.515), and patient survival rates (P=0.803) were also similar. No significant difference was found between the groups in terms of acute hepatitis rate (P=0.511), glomerular filtration rate (calculated by Modification of Diet in Renal Disease formula) in the last follow-up (P=0.988), alanine aminotransferase levels (P=0.069), or delayed graft function rate (P=0.973). Rates of chronic allograft dysfunction and new onset diabetes mellitus after transplantation were similar. ConclusionOur study revealed that, RTx from HBsAg(+) donors to HBsAg(+) recipients is safe with antiviral treatment.
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    Factors affecting morbidity and mortality in pancreatic injuries
    (Springer Heidelberg, 2016) Bozdag, Z.; Kapan, M.; Ulger, B. V.; Turkoglu, A.; Uslukaya, O.; Oguz, A.; Aldemir, M.
    Difficulties in the detection of pancreatic damage result in morbidity and mortality in cases of pancreatic trauma. This study was performed to determine factors affecting morbidity and mortality in pancreatic trauma. The records of 33 patients who underwent surgery for pancreatic trauma between January 2004 and December 2013 were analyzed retrospectively. The types of injury were penetrating injury and blunt abdominal trauma in 75.8 and 24.2 % of all cases, respectively. Injuries were classified as stage 1 in 6 cases (18.2 %), stage 2 in 18 cases (54.5 %), stage 3 in 5 cases (15.2 %), and stage 4 in 4 cases (12.1 %). The average injury severity scale (ISS) value was 25.70 +/- A 9:33. Six patients (18.2 %) had isolated pancreatic injury, 27 (81.2 %) had additional intraabdominal organ injuries and 10 patients (30.3 %) had extraabdominal organ injuries. The mean length of hospital stay was 13.24 +/- A 9 days. Various complications were observed in eight patients (24.2 %) and mortality occurred in three (9.1 %). Complications were more frequent in patients with high pancreatic damage scores (p = 0.024), additional organ injuries (p = 0.05), and blunt trauma (p = 0.026). Pancreatic injury score was associated with morbidity, while the presence of major vascular injury was associated with mortality. Complications were significantly more common in injuries with higher pancreatic damage scores, additional organ injuries, and blunt abdominal trauma. Pancreatic injury score was associated with morbidity, while the presence of major vascular injury was associated with mortality.
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    The Protective Effect of Ellagic Acid on Lung Damage Caused by Experimental Obstructive Jaundice Model
    (Acta Medical Belgica, 2013) Gul, M.; Aliosmanoglu, I.; Uslukaya, O.; Firat, U.; Yuksel, H.; Gumus, M.; Ulger, B. V.
    Aim : This study aimed to investigate protective effects of ellagic acid on lungs in an experimental obstructive jaundice model. Methods : Four groups were established, each consisting of ten randomly selected rats : Group 1: sham, Group 2: ellagic acid, Group 3 : obstructive jaundice, and Group 4 : obstructive jaundice + ellagic acid. Ellagic acid was administered orally at a dose of 60 mg/kg/day to group 2 and 4. The animals were sacrificed eight days later. The total oxidative status and the total antioxidant capacity in their lung tissue were determined, and malondialdehyde levels in their blood were measured. Histopathological changes in the lungs were examined. Results : In the obstructive jaundice group treated with ellagic acid, there was a decrease in malondialdehyde levels and a reduction in the total oxidative status and the oxidative stress index, whereas the total antioxidant capacity increased (p < 0.001). The histopathological examination showed that neutrophil leukocyte infiltration and edema formation decreased and destruction of lung parenchyma disappeared following the treatment with the ellagic acid (p < 0.05). Conclusion : This study shows that ellagic acid has a protective effect against oxidative damage in lung tissue in obstructive jaundice.
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    A Successful Renal Transplantation Case After Stem Cell Transplantation
    (Elsevier Science Inc, 2015) Yilmaz, V. T.; Koksoy, S.; Ulger, B. V.; Salim, O.; Akbas, H.; Aliosmanoglu, I.; Erbis, H.
    Renal transplantation is the most effective treatment method for end-stage renal disease (ESRD). However, new treatment modalities are being investigated, such as immunotoleration, to avoid the acute and chronic side effects of immunosuppressant drugs. We report a case in which a man had undergone allogenic stem cell transplantation from his brother 16 years ago due to chronic myeloid leukemia, and who then developed ESRD due to arterial hypertension and underwent renal transplantation (Rtx) from the same brother. The patient was followed up without immunosuppression due to full chimerism.