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Öğe Acute biliary pancreatitis in cholecystectomised patients(Aves, 2012) Gul, Mesut; Aliosmanoglu, Ibrahim; Turkoglu, Ahmet; Ucmak, Feyzullah; Ulger, Burak Vel; Oguz, Abdullah; Uslukaya, OmerPurpose: This study aimed to investigate the treatments of patients with acute biliary pancreatitis after cholecystectomy. Materials and Methods: Twenty-two patients who were diagnosed with acute biliary pancreatitis and underwent cholecystectomy were analysed retrospectively. The patients' demographic characteristics, severity of disease, elapsed time since cholecystectomy, whether endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy were performed, surgical intervention, duration of hospital stay, and mortality were recorded. Results: The average age of the 22 patients was 60.14 +/- 16.4 (2186), and the female to male ratio was 14:8. The average elapsed time since cholecystectomy was 81.7 (6-240) months. In 18 patients, stones and mud were detected in the choledoch duct with endoscopic retrograde cholangiopancreatography, with no factors identified in 4 patients. While 14 of these 18 patients were treated successfully with stone extraction and endoscopic sphincterotomy, endoscopic retrograde cholangiopancreatography did not succeed in 4 patients. In 3 of 4 patients, in whom stones were detected but failed to be extracted, choledoch duct exploration was carried out with open surgery. Mortality developed in one patient. Average hospital stay, with the exception of the deceased patient, was 8.5 +/- 3.5 days. Conclusion: Some choledoch duct stones can remain asymptomatic for an extended period after cholecystectomy. However, some cause acute pancreatitis ending in mortality after several months or even years. Endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy are the standard methods of treatment. Patients in whom endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy have failed, can be treated with choledoch duct exploration with open surgery and laparoscopic surgery.Öğe An Adult Choledochocele Case Presented with Acute Pancreatitis: Treatment by Endoscopic Sphincterotomy and Cyst Unroofing(Korean Soc Gastrointestinal Endoscopy, 2015) Bestas, Remzi; Ekin, Nazim; Ucmak, Feyzullah; Kaya, Muhsin[Abstract Not Available]Öğe Assessment of Hand Functions in Patients with Chronic Hepatitis B(Aves, 2014) Oktayoglu, Pelin; Tekin, Recep; Caglayan, Mehmet; Bozkurt, Mehtap; Em, Serda; Yildiz, Mehmet; Ucmak, FeyzullahObjective: Motor dysfunction is an important clinical finding in patients with liver cirrhosis (LC), but there is no study assessing fine motor coordination in patients with chronic hepatitis B (CHB). We aimed to investigate hand functions and fingertip dexterity in patients with CHB. Materials and Methods: A total of 17 female and 15 male patients diagnosed with CHB without histopathological findings of cirrhosis were enrolled to the study; 21 female and 9 male healthy volunteers were included as a control group. Hand grip strength was assessed by Jamar hand dynamometer. Three kinds of pinch strength of fingers were assessed by Jamar pinchmeter. Functional status was evaluated by using the Stanford Health Assessment Questionnaire (HAQ). Duruoz Hand Index (DHI) was used to assess the hand functions. Fingertip dexterity was evaluated by Purdue pegboard test. Results: Bilateral hand grip strength and pinch strength were not statistically different from controls (p>0.05). There was also no significant difference between the categories of the Purdue pegboard test between the groups. HAQ scores of patients were higher than controls (p< 0.05). Conclusion: Hand functions are not influenced in patients with CHB. Disruptions in the functional status of patients with CHB may be due to fatigue and depression, which are usually seen in chronic liver diseases.Öğe BLUE RUBBER BLEB NEVUS SYNDROME: A CASE REPORT(Carbone Editore, 2013) Ucmak, Derya; Ucmak, Feyzullah; Akkurt, Zeynep Meltem; Sula, Bilal; Yakut, YunusBlue Rubber Bleb Nevus Syndrome (BRBNS) is a syndrome that is characterized with cutaneous venous malformations besides visceral involvement. Visceral involvement affects mostly the gastrointestinal (GI) system. As these venous malformations can lead to life-threatening serious GI bleeding, anemia is an important clue to diagnosis. A 18-year-old female presented to the department of internal medicine with complaints of weakness and paleness. Hypochromic microcytic anemia was diagnosed and upper and lower GI screenings were done. On endoscopy, reddish-purple polypoid lesions were detected throughout the GI tract and nodular lesions compatible with venous malformations were observed on both lower extremities. A diagnosis of BRBNS was made. Symptoms of iron deficiency anemia guide patients with BRBNS to general practitioners and internal medicine specialists. If cutaneous findings are present, collaboration with dermatologists at this stage will improve diagnostic accuracy.Öğe Brucellosis as a rare cause of granulomatous hepatitis with hepatic and bone marrow granulomas: A case report(Kare Publ, 2021) Yalcin, Kendal; Tuncel, Elif Tugba; Ucmak, Feyzullah; Bestas, RemziBrucellosis is a zoonotic infection that may involve the liver in a variety of ways, however, data on the histopathology of liver effects in brucellosis are limited. Brucellosis is generally characterized by a high fever, joint or back pain, and hepatosplenomegaly. This report illustrates a case of granulomatous hepatitis with granulomas in the liver and bone marrow in a patient who presented with non-specific symptoms, hepatomegaly, splenomegaly, digital clubbing, and laboratory signs of intrahepatic cholestasis. Granulomas were detected in the bone marrow and hepatic specimens. The diagnosis of brucellosis was based on the isolation of Brucella mellitensis in a blood culture and serum agglutination titers of 1:640. Treatment for brucellosis led to improved laboratory and clinical findings. Brucellosis should be considered in regions where it is endemic in cases of an elevated transaminase level and related clinical findings. Brucellosis should also be considered in the differential diagnosis of intrahepatic cholestasis and/ or granulomas in hepatic and bone marrow biopsies. This case report provides valuable histopathological features and detailed information of liver involvement in a case of brucellosis.Öğe Epidemiological and clinical characteristics of malignant melanoma in Southeast Anatolia in Turkey(African Field Epidemiology Network-Afenet, 2016) Sula, Bilal; Ucmak, Feyzullah; Kaplan, Mehmet Ali; Urakci, Zuhat; Arica, Mustafa; Isikdogan, AbdurrahmanIntroduction: The present study aimed to establish the epidemiological and clinical characteristics of patients who were histopathologically diagnosed with malignant melanoma (MM). Methods: The present study retrospectively analyzed the data of 78 patients who were histopathologically diagnosed with MM in Dicle University Medical Faculty, Dermatology and Medical Oncology departments between 2005 and 2014. Results: The study included 78 patients in total with 44 (56.4%) male and 34 (43.6%) female. Median age of the patients was 62.50 years (range: 27 - 84 years). Of the patients, 78.2% (n=61) had cutaneous melanoma, 8.9% had solid organ melanoma, and 2.5% had ocular and mucosal melanoma. The most common tumor localization among the patients was the lower extremities with 29.4% (n=23). The most common histopathological type was nodular malignant melanoma with 35.8% (n=28). Based on TNM, Clark and Breslow classifications, 26.9% (n=21) of the patients were stage 4, 26.9% (n=21) were Clark stage 4, and 37.1% (n=29) were Breslow stage 4. Median overall survival in all patients was 14.9 months (95% CI 10.9 - 18.8 months). In the multivariate Cox analysis, only stage statistically significantly affecting survival [ odds ratio (OR): 0.54; (95% CI 0.16-1.82, p=0.02)]. Conclusion: Malignant melanoma data are also important for the optimal utilization of effective methods and healthcare resources to prevent the disease. In order to minimize MM mortality and morbidity, not only the society but also physicians from primary and secondary care hospitals should become familiar with melanoma.Öğe Evaluation of Retinal Microvascular Perfusion Changes in Patients with Celiac Disease(Taylor & Francis Inc, 2022) Erdem, Seyfettin; Ucmak, Feyzullah; Karahan, Mine; Ava, Sedat; Dursun, Mehmet Emin; Dursun, Birgul; Hazar, LeylaPurpose We aimed to determine whether there are retinal microvascular changes in patients with celiac disease (CD). Methods A total of 30 patients with CD (group 1) and 30 healthy controls (group 2) were included in this study. AngioVue optical coherence tomography angiography (OCTA) device was used to evaluate the retinal microvascular structure. Results Some of the values of both optic nerve head (ONH) vessel density (VD) and radial peripapillary capillary VDs were found to be significantly lower in group 1 than in group 2. These 2 groups were similar except for one of the parameters of superficial capillary plexus VD (SCP-VD), whereas it was found that deep capillary plexus VD (DCP-VD) was lower in group 1 than in group 2 except for the foveal area. Conclusion It was determined that some VDs obtained from the ONH and DCP-VD obtained from most areas of the macular region were significantly lower.Öğe The frequency of osteoporosis in patients with pemphigus vulgaris on treatment(Wolters Kluwer Medknow Publications, 2013) Ucmak, Derya; Harman, Mehmet; Ucmak, Feyzullah; Akpolat, VeysiBackground: Pemphigus vulgaris was almost fatal before the advent of glucocorticoids. Unfortunately, the high doses and prolonged administration of glucocorticoids, which often needed to control the disease, result in numerous adverse effects many of which are serious. Aims: To evaluate the patients with pemphigus vulgaris on treatment in respect of osteoporosis and to compare the frequency of osteoporosis in these patients with the healthy ones. Methods: The study consisted of 40 patients with pemphigus vulgaris and 34 healthy controls. Bone mineral density measurements were obtained by dual-energy X-ray absorptiometry. Blood serum, bone parameters, and biochemical hormonal measurements were examined in both groups. Results: When the bone mineral density values of patients with pemphigus vulgaris were compared with those of the control group, there was no significant difference between hip bone mineral density values, while lumbar region T and Z scores were found significantly low in the patient group (p = 0.034 and p = 0.006, respectively). Osteoporosis, osteopenia, and normal dual-energy X-ray absorptiometry rates in the patient group were found to be 32.5%, 32.5%, and 35%, respectively. These rates were found to be 18%, 23%, and 59% in control group, respectively. There were more fractures in the patient group and the difference was statistically significant (p = 0.004). Conclusion: An increase in osteoporosis frequency and secondary fracture to osteoporosis in the patients with pemphigus vulgaris was detected.Öğe Gaucher's Disease Presenting with Massive Hepatic Fibrosis and Skeletal Abnormalities: A Case Report with Review of the Literature(Ortadogu Ad Pres & Publ Co, 2011) Yalcin, Kendal; Ucmak, Feyzullah; Bestas, Remzi; Unal, Hakan Umit; Necmioglu, Serdar; Mizrak, BulentThe case presented in this manuscript is a 32-year-old female referred to our clinic with massive hepatosplenomegaly, thrombocytopenia, anemia and avascular necrosis at the head of right femur. Gaucher's disease was diagnosed upon observation of specific blood cells in bone marrow and liver. Homozygote N370S mutation was established in the Gaucher's mutation screening. Glycocerebrosidase enzyme level of the patient was quite low (0.66 nmol/hour/mg). Additionally, histological examination of the liver revealed massive hepatic fibrosis without any clinically significant signs of cirrhosis or portal hypertension. Other significant signs of the patient were severe skeletal involvement with stage V/c avascular necrosis of the femoral head and Erlenmeyer flask paralysis. Glycocerebrosidase enzyme replacement therapy was initiated at 60 units/kg after the diagnosis was established. The case presented here is a female patient with signs of hepatic, bone marrow and skeletal system involvement. This rare non-neuropathic type 1 Gaucher's case with massive hepatic fibrosis and pathogonomic skeletal signs has been evaluated in the light of literature.Öğe Germ cell tumor in duodenum(Turkish Soc Gastroenterology, 2013) Kucukoner, Mehmet; Kaplan, Muhammed Ali; Inal, Ali; Ucmak, Feyzullah; Firat, Ugur; Isikdogan, Abdurrahman[Abstract Not Available]Öğe The Hepatic Phase of Fascioliasis Complicated with Liver Bleeding: Presentation of Three Cases(Iranian Scientific Society Medical Entomology, 2024) Ucmak, Feyzullah; Kaya, MuhsinBleeding is a very rare complication of Fasciola species ( F. hepatica or F. gigantica ) infection. We present here three cases of subcapsular liver bleeding caused by the hepatic phase of Fasciola spp. infection in patients, two of whom were women, aged 22, 66, and 84 years in Diyarbakir Province, southeastern Turkey. They had symptoms of right upper quadrant pain (n = 3), nausea (n = 1), and vomiting (n = 2) for periods ranging from 6 hours to 15 days. All patients with clinical presentations ranging from moderate abdominal pain to hypovolemic shock and ischemic hepatitis were improved with supportive treatment without the need for surgery. They showed complete clinical and laboratory recovery after triclabendazole administration in their follow-up. In conclusion, Fasciola spp . infection should be considered in the etiology of bleeding from liver disease.Öğe Investigation of dermatology life quality index and serum prolactin and serum dehydroepiandrosterone sulphate levels in patients with chronic urticaria(Allergy Immunol Soc Thailand,, 2014) Ucmak, Derya; Akkurt, Meltem; Ucmak, Feyzullah; Toprak, Gulten; Acar, Gurbet; Arica, MustafaBackground: Chronic urticaria (CU) is known to be one of the most disturbing diseases which significantly affect the quality of life. Prolactin (PRL) and DHEA-S (dehydroepiandrosterone sulfate) are stress-associated hormones in chronic urticaria. Objective: In the present study, we measured DHEA-S and prolactin levels of CU patients, compared them with healthy subjects and evaluated the association between disease status and serum levels. Methods: Plasma DHEA-S and serum PRL concentrations were measured in 48 CU patients and 31 healthy subjects. CU activity was assessed with the use of the symptom scores recommended with EAACI/GALEN/EDF guidelines. All the patients participating in this study were evaluated by means of Dermatology Life Quality Index (DLQI). With respect to DLQI and clinical activity scores, plasma DHEA-S and serum prolactin levels were compared. Results: Median plasma concentration of DHEA-S was significantly lower in CU patients as compared with healthy subjects (p = 0.026). DHEA-S levels of females were significantly lower than males (p = 0.001). Mean PRL values of the patients were higher than the controls, but not statistically significant (p = 0.619) and there was a statistically signifcant inverse correlation with DHEA-S levels (p = 0.04, r = -0.298). There was a significant correlation between DLQI and clinical disease activity (p < 0.001, r = 0.748). Conclusions: The exact relation of hormones to CU pathogenesis remains to be determined by further clinical studies. In addition, therapies aiming to increase DHEA-S and decrease PRL may be subject to trial in CU.Öğe Multiple Primary Cutaneous Plasmacytomas: An Unusual Presentation(Sage Publications Inc, 2014) Ucmak, Derya; Akkurt, Zeynep Meltem; Turkcu, Gul; Harman, Mehmet; Dal, Mehmet Sinan; Ucmak, FeyzullahBackground: Extramedullary plasmacytoma of the skin, a rare type of cutaneous B-cell lymphoma, is characterized by clonal proliferation of plasma cells primarily in the skin without evidence of multiple myeloma. Only about 30 cases with extramedullary plasmacytoma of the skin are reported in the literature. Case Report: An 82-year-old male patient presented to our clinic with complaints of asymptomatic red nodular swelling and pain in the anterior chest wall. A dermatologic examination revealed multiple nodular lesions of varying sizes with a hard smooth surface and vivid red color. Serum protein and immunoglobulin electrophoresis, skeletal radiography, and bone marrow biopsy showed normal results in this patient. Here a rare case of multiple primary plasmacytoma localizing in the skin is reported.Öğe Neutrophil-to-Lymphocyte Ratio in the Prediction of Microscopic Colitis(Derman Medical Publ, 2015) Ucmak, Feyzullah; Yilmaz, Ahmet; Ekin, Nazim; Tuncer, Elif Tugba; Firat, Ugur; Palanci, YilmazAim: The aim of this study was to investigate the importance of the neutrophil-to-lymphocyte ratio (NLR) in predicting microscopic colitis (MC) in patients with diarrhea-dominant type irritable bowel syndrome (IBS-D). Material and Method: Between January 1, 2010 and December 31, 2012, 49 patients who fulfilled the Roma III criteria for IBS-D were included in the study. All patients had underwent colonoscopy and colonoscopic biopsy (cecum, ascending, transverse, descending and rectosigmoid sections) to diagnose MC (25 patients with MC). Complete blood count parameters were evaluated in the two groups (IBS-D and MC) using standard methodology. Results: The patients were evaluated in two groups: MC and IBS-D. The groups were similar with respect to age, gender and presence of hypertension. The NLO was significantly higher in the MC group compared to the IBS-D group (2.48 +/- 0.99, 1.92 +/- 0.84; p=0.041, respectively). A cut-off value of 1.86 had a sensitivity of 76% and spesificity of 55% in predicting MC in patients with symptoms of IBS-D. Discussion: A significant association was found between the presence of MC in patients with IBS-D and increased NLR. The NLR may be a useful marker in predicting MC in patients with symptoms of IBS-D.Öğe Polymorphisms in the IL28B gene (rs12979860, rs8099917) and the virological response to pegylated interferon therapy in hepatitis D virus patients(Univ Catholique Louvain-Ucl, 2016) Yilmaz, Bulent; Can, Guray; Ucmak, Feyzullah; Arslan, Ali Osman; Solmaz, Ihsan; Unlu, Ozan; Duzenli, SelmaAim : Few data are available regarding the effects of interleukin 28B (IL28B) polymorphisms in chronic hepatitis D (CHD) patients. This study investigated the relationship between IL28B polymorphisms and the response of patients with CHD infections to pegylated interferon (PEG-IFN) therapy. Materials and methods : A total of 101 CHD patients were selected, 80 of whom (46 males; median age 41 years) satisfied the inclusion criteria and were enrolled in the study. Thirty-seven patients were treated with peg-IFNa for at least 12 months and were followed for a median of 18 months (range, 12-30 months). The primary treatment endpoint was the suppression of HDV replication, as documented by the loss of detectable HDV RNA in serum. Geno-typing was used to analyse the IL28B polymorphisms rs12979860 and rs8099917 according to the virological response. Results : After treatment, a sustained viral response (SVR) was achieved in 19 (51%) of the patients treated with PEG-INF. The IL28B genotypes in the 80 patients were as follows : CC in 36 (45%), CT in 33 (41%) and TT in 11 (14%) for rs12979860, and GG in 4 (5%), GT in 27 (34%) and TT in 49 (61%) for rs8099917. SVR was achieved in 5 (26%), 10 (53%) and 4 (21%) patients with CC, CT and TT at rs12979860, respectively, and one (5%), nine (47%) and nine (47%) patients with GG, GT and TT at rs8099917, respectively. There were differences in the SVR among genotypes (rs12979860 and rs8099917; chi-squared test, p = 0.047). Conclusion : IL28B predicts the PEG-IFN response in patients with CHD infection.Öğe RATE OF MICROSCOPIC COLITIS AND CYTOKINE LEVELS IN PATIENTS WITH IRRITABLE BOWEL SYNDROME(Carbone Editore, 2015) Ucmak, Feyzullah; Goral, Vedat; Firat, Ugur; Mete, NuriyeAims: The aim of this study is to determine the rate of microscopic colitis (MC) among patients diagnosed as Irritable Bowel Syndrome (IBS) in accordance with Roma III criteria and to investigate the correlation of cytokine levels with the type of IBS and presence of MC. Methodology: A total of Eighty-nine patients who were diagnosed with IBS based on Rome Ill diagnostic criteria were included in this study. Biopsies taken from caecum, ascending colon, transverse colon, descending colon and rectosigmoid region during colonoscopy were put in separate tubes and histopathologically examined. In addition, serum TNF-alpha, IL-1 beta and IL-6 levels were determined in peripheral blood samples of patients. Results: The frequency of MC was higher in the study groups compared to the general population (22.5% and 20.4% in IBS-D and IBS-C groups, respectively). Specimens taken from caecum, ascending colon, transverse colon and descending colon were more likely to lead to the diagnosis of MC compared to those taken from rectrosigmoid region (p<0.001). No significant difference was found between presence of MC and IL-1 beta, IL-6 and TNF-alpha levels. In addition, TNF-a levels were significantly higher in the IBS-C group (p= 0.013). Conclusion: Rate of MC in IBS patients is higher than the rate in normal population. In IBS patients, biopsy samples obtained solely from rectosigmoid area is not sufficient to preclude MC diagnosis. No difference exists between IBS patients with and without MC in terms of cytokine levels.Öğe The role of vitamin B1-B2 and plasma lipid profile in intrahepatic cholestasis of pregnancy(Walter De Gruyter Gmbh, 2017) Basaranoglu, Serdar; Agacayak, Elif; Ucmak, Feyzullah; Tunc, Senem Yaman; Deregozu, Aysegul; Akkurt, Zeynep Meltem; Peker, NurullahAim: The present study aimed to determine the levels of total cholesterol, triglycerides (TG), low-density lipoproteins (LDL), high-density lipoproteins (HDL), and vitamins B1 and B2 in intrahepatic cholestasis of pregnancy (ICP) patients, and to evaluate if these were involved in the pathophysiology of the disease. Methods: The prospective randomized study included 35 pregnant patients who were admitted to the Gynecology and Obstetrics Polyclinic, Faculty of Medicine at Dicle University and who were diagnosed with ICP (Group 1), and 40 healthy pregnant women who were admitted in the same period and who had no systemic diseases that might complicate the pregnancy during the pregnancy follow-up (Group 2). Serum lipid levels and vitamins B1 and B2 were determined and compared, and statistical comparisons of the groups were made. Results: There was no difference between the TG levels of the two groups (P=0.631). Total cholesterol, LDL, HDL, and vitamin B1 and B2 levels were higher in Group 1 than in Group 2 (P=0.001, P=0.001, P=0.001, P=0.001, and P=0.032, respectively). Conclusions: Increased levels of vitamins B1 and B2 may indicate a need for increased energy metabolism at the fetus. So we believe that new studies are required, which will be supported by the placental analyses of the pyruvate and lactate levels in maternal blood at delivery and fetal cord blood in order to develop a better understanding on the fetal effects of energy metabolism.Öğe Somatosensory Amplification, Anxiety, and Depression in Patients With Hepatitis B: Impact on Functionality(Lippincott Williams & Wilkins, 2016) Yilmaz, Ahmet; Ucmak, Feyzullah; Donmezdil, Suleyman; Kaya, Mehmet Cemal; Tekin, Recep; Gunes, Mehmet; Arslan, NecmiIn the present study, we aimed to determine the differences in body image along with anxiety and depression levels, and also to evaluate their impact on disability parameters in patients with hepatitis B.Our study comprised 77 patients with hepatitis B (n=41, chronic active patients; n=36, patients with inactive hepatitis B) and 53 healthy individuals (control group). Enrolled patients responded to several questionnaires, including a sociodemographic form, Sheehan Disability Scale (SDS), Hospital Anxiety and Depression Scale (HADS), and Somatosensory Amplification Scale.Patients with chronic active hepatitis B (CAHB) had higher levels of somatosensory perception than patients with inactive hepatitis B (IHB) and control group (P<0.001, P=0.001, respectively). Patients with CAHB had high scores on all the 3 domains of SDS (work/school, P<0.001; social life, P<0.001; and family life, P<0.001). Also, patients with CAHB had a significantly higher HADS total score, HADS anxiety score, and HADS depression score than control group (P<0.001, P<0.001, P<0.001, respectively). No significant difference was noted between patients with CAHB and patients with IHB with regard to HADS depression score; however, HADS anxiety and HADS total scores were significantly higher in the CAHB group (NS, P=0.027, P=0.035, respectively). Moreover, the IHB group exhibited higher scores for the work/school and social life domains of SDS than those of the control group (P=0.008, P=0.047).Although patients with CAHB may present with somatosensory amplification, anxiety, and depression, patients with IHB do not exhibit such symptoms. However, functionality is affected in both carrier and active patient groups. We believe that routine health checks of patients with hepatitis B should include psychiatric evaluation, psychiatric examination, and follow-up.Öğe THE STATUS OF OXIDATIVE STRESS AND ANTIOXIDANT DEFENSE IN PATIENTS WITH CHRONIC HEPATITIS D(Carbone Editore, 2016) Ucmak, Feyzullah; Solmaz, Ihsan; Ekin, Nazim; Kaplan, Ibrahim; Tuncel, Elif Tugba; Senates, Ebubekir; Yalcin, KendalIntroduction: Oxidative stress is increasingly recognized as an important factor in the progression of chronic liver disease of varying etiologies and antioxidants are utilized in the treatment of some of them. Chronic viral hepatitis D continues to be a significant health problem in certain regions of the world. Rates of response to currently proposed treatments are rather low. The aim of this study was to investigate oxidative stress in patients with chronic viral hepatitis D. Materials and methods: A total of 91 patients with chronic hepatitis D virus infection were included in this study (mean age: 42.2 +/- 11.7). In addition, 40 healthy volunteers were included in the study to form the control group. Patients were divided into two main sub-groups as cirrhotic (n=30) and non-cirrhotic (n=61) groups. Blood samples were taken from both patients and control subjects and compared for total oxidant status (TOS), total anti-oxidant status (TAS) and oxidative stress index (OSI). Results: TOS levels were significantly higher in the patients compared to the control sub-jects (p<0.001). Moreover, TOS levels were higher in the cirrhotic patients compared to the non-cirrhotic patients (p=0.006). TAS levels were significantly lower in the patients compared to the control subjects (p=0.003). OSI levels were significantly higher in the patients compared to the control subjects (p<0.001). Moreover, OSI levels were higher in the cirrhotic patients compared to the non-cirrhotic patients (p<0.05). Conclusion: These results are supportive of the role of oxidative stress in the pathogenesis of chronic viral hepatitis D. Antioxidant therapies might be considered in patients with chronic viral hepatitis D considering the presence of oxidative stress in these patients.Öğe Toxic hepatitis case with prolonged jaundice due to Favipiravir(Kare Publ, 2022) Yolacan, Ramazan; Karabulut, Umit; Uzel, Ali; Ucmak, Feyzullah; Kaya, MuhsinFavipiravir (FPV) is an antiviral drug used in the treatment of severe acute respiratory syndrome coronavirus 2 infection. The main side effects of this drug are teratogenicity and hyperuricemia. Limited information is available on other side effects. Here, we aimed to present our toxic hepatitis case with prolonged jaundice after FPV treatment.
