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Öğe COMORBIDITIES IN PSORIATIC ARTHRITIS: COMPARISON WITH RHEUMATOID ARTHRITIS AND PSORIASIS(Clinical & Exper Rheumatology, 2014) Nas, K.; Karkucak, M.; Durmus, B.; Karatay, S.; Capkin, E.; Kaya, A.; Ucmak, D.[Abstract Not Available]Öğe Effects of hyperbaric oxygen therapy on rat facial skin(Sage Publications Ltd, 2016) Sula, B.; Ekinci, C.; Ucak, H.; Ucmak, D.; Akkurt, Z. M.; Aktas, A.; Arica, M.Introduction: We used immunohistochemistry to investigate the histopathologic effects of hyperbaric oxygen (HBO) on the facial skin of rats. Material and methods: Rats in the HBO group (n = 6) were placed in a 20 L HBO chamber at 2.5 atmospheres absolute at 25-26 degrees C with 100% oxygen for 90 min/day for 7 days. Following euthanasia, sections of facial skin were removed for examination. Results: Epidermal hyperplasia and degeneration, basal-cell hypertrophy, subepithelial fibrosis, and increased connective tissue were observed in the HBO group. E-cadherin expression was reduced in the epidermis, hair follicles, and sebaceous glands in HBO-treated rats relative to control animals. HBO treatment was associated with vimentin immunoreactivity in fibroblasts, endothelial cells, and the bulbus pilorum of a subset of hair follicles. It also resulted in increased type IV collagen expression within the connective tissue in the hair follicles and sebaceous glands. Conclusion: The HBO group demonstrated epidermal hyperplasia and degeneration, basal-cell hypertrophy, and subepithelial fibrosis. In addition, HBO decreased E-cadherin expression, which suggests that HBO may impair intracellular adhesion. Expression of vimentin and type IV collagen was also observed in the dermis. Increased connective tissue, hemorrhage, and mononuclear cell infiltration were observed in the dermis of HBO-treated animals. Thus, HBO has effects on the structures of the epidermis and dermis.Öğe Oxidative stress index may play a key role in patients with pemphigus vulgaris(Wiley, 2013) Yesilova, Y.; Ucmak, D.; Selek, S.; Dertlioglu, S. B.; Sula, B.; Bozkus, F.; Turan, E.Background Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, including atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris (PV), lichen planus and alopecia areata. In PV, the increased production of ROS from activated neutrophils reduces the concentrations of antioxidant vitamins and enzymes. Objective The present study aims to determine the oxidative stress index (OSI) by studying serum total oxidant capacity (TOC), lipid hydroperoxide (LOOH) and total antioxidant capacity (TAC) in PV patients. Methods The study included 27 PV patients and a control group consisting of 24 healthy volunteers. Serum TOC, LOOH and TAC levels were examined and OSI was measured in the PV patients and the control group. Results TOC (P=0.001) and LOOH (P=0.001) levels as well as OSI (P=0.001) were found higher in the PV patients, relative to the control group. Serum TAS (P=0.221) did not differ between groups. Serum TOC, LOOH and TAC levels and OSI in PV patients with mucosal involvement were not different than those in mucocutaneous PV patients. Conclusion Serum TOC and LOOH levels and OSI were higher in the PV patients, in comparison with the control group. Serum TAC level was not different.Öğe Seroprevalence of IgG anti-Toxocara canis antibodies and anti-Fasciola sp antibodies in patients with urticaria(Soc Editrice Univ, 2013) Dal, T.; Cicek, M.; Ucmak, D.; Akkurt, M.; Tekin, A.; Dal, M. S.; Tekin, R.Aims. Chronic urticaria (CU) is defined by recurrent episodes occurring at least twice a week for 6 weeks and generally characterized by the rapid appearance of wheals and/or angioedema and may be associated with parasitic infections. We aimed to investigate the seroprevalance of Toxocara canis and Fasciola species in patients with CU. Materials and Methods. We included 55 patients (in age 16-55) with urticaria admitted in study. As a control group we recruited 30 healthy volunteers they had no history of urticaria, rhinitis, asthma, atopic eczema/dermatitis syndrome (AEDS), or other relevant diseases. IgG antibodies to Toxocara canis and Fasciola species were investigated by ELISA method. Results. In a total of 55 patients (mean age: 31.85 +/- 8.92), 8 patients (14.5%) were positive for IgG antibodies to Toxocara canis. Among seropositive patients (mean age: 38.62 +/- 12.46) 6 patients were female. No patient was positive for Fasciola by ELISA. Six of Toxocara canis seropositive cases were frequently visited or lived in rural areas and had contact with pets. Conclusions. Patients with urticaria, should be tested for Toxocara canis and treated with anthelminthic drugs in endemics areas for toxocariasis.Öğe Sexual dysfunction in male patients with Behget's disease(Publisaude-Edicoes Medicas Lda, 2016) Yildiz, M.; Batmaz, I; Sula, B.; Ucmak, D.; Sariyildiz, M. A.; Daggulli, M.; Turkcu, F.Introduction: The purpose of this study was to evaluate sexual dysfunction in male patients with Behget's Disease in comparison to healthy control subjects. Material and Methods: Seventy-two sexually active male patients with Behcet's Disease and 62 healthy control subjects were included in this study. Patients' demographic and clinical characteristics were noted. Sexual function was assessed by means of the International Index of Erectile Function scoring system. In addition, disease-related quality of life was measured by means of the Nottingham Health Profile, and anxiety and depression levels were assessed by means of the Hospital Anxiety and Depression Scale. Results: Patients with Behget's Disease scored significantly lower in each of the 5 parameters of International Index of Erectile Function (p < 0.001) and significantly higher in Hospital Anxiety and Depression Scale compared to healthy control subjects (p < 0.001). International Index of Erectile Function scores correlated with age, duration of disease and Hospital Anxiety and Depression Scale and Nottingham Health Profile scores in patients with Behcet's Disease (p < 0.05). Conclusion: Sexual function is impaired in male patients. With Behcet's Disease, which might be associated by age, duration of disease, psychological status and quality of life.Öğe SLEEP QUALITY IN PATIENTS WITH PSORIATIC ARTHRITIS(Clinical & Exper Rheumatology, 2014) Gezer, O.; Batmaz, I; Sariyildiz, M. A.; Sula, B.; Ucmak, D.; Bozkurt, M.; Nas, K.[Abstract Not Available]
