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    Organic or psychosomatic? A cross-sectional study Organic or psychosomatic?
    (Bayrakol Medical Publisher, 2022) Donmezdil, Suleyman; Arac, Esref; Yesildal, Mahir; Guleken, Mehmet Diyadin; Tuzun, Abidin
    Aim: Symptomatic treatments of psychosomatic symptoms are not successful because they cannot solve true etiological causes. To resolve the disorder, it is first necessary to investigate and diagnose the underlying cause and persuade the patient to use the appropriate drugs. In this study, it was aimed to make suggestions in order to identify patients who may have psychiatric symptoms and to prevent unnecessary invasive procedures by scanning psychosomatic symptoms prior to endoscopy indication. Material and Methods: The Cornell index, Beck depression and Anxiety scales, and the Somatization scale were applied to 140 patients whose EGD procedure was planned. The patients were divided into three groups as normal endoscopic examination, antral gastritis, and other disease diagnoses (erosive gastritis, gastric ulcer, etc.). Beck Depression and Beck Anxiety Inventory scores were statistically lower in other diagnostic groups than in normal endoscopic findings and antral gastritis groups. Also, scores on the somatization scale were significantly higher in normal endoscopic findings and antral gastritis groups compared to other diagnostic groups. Results: In patients who underwent EGD, the process was found to be more likely to cause normal endoscopic examination as the age decreased. In addition, somatization, Cornell index, anxiety and depression scores were higher at a young age. The Cornell Medical Index showed a significantly higher sub-score of the strong neurotic structure in the antral gastritis group compared to the other groups. Similarly, there were significantly higher scores for the subscales of depression, irritability-anxiety, fear-startle, psychosomatic symptoms, hypochondriasis, and gastrointestinal disorders in the antral gastritis group compared to other diagnostic groups Discussion: Our results show that applying the somatization scale or an equivalent screening scale to screen psychiatric symptoms before seeking endoscopic examination, especially in the young population, can provide early treatment and prevent increased treatment costs.
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    Preventive effect of fucoxanthin administration on intra-abdominal adhesion: An experimental animal study
    (Turkish Assoc Trauma Emergency Surgery, 2022) Dalbasi, Erkan; Tuzun, Abidin; Arserim, Neval Berrin; Ozcan, Filiz; Dogan, Elif; Cetin, Alpay
    BACKGROUND: The most common cause of intra-abdominal adhesion (IAA) is previous abdominal surgery and mortality. IAA can cause serious complications such as chronic abdominal pain, ileus, and infertility. Approximately 3% of all laparotomies are related to adhesions. IAA reduces the quality of life of the patient, causes morbidity, and increases health expenditures. In this study, we aimed to investigate the preventive effect of fucoxanthin (Fx) on IAA in the intra-abdominal surgical adhesion model that experimentally created in rats. METHODS: This study used 21 Sprague-Dawley rats divided into three groups. After anesthesia, the abdomen was opened, the cecum and right abdominal wall were damaged with a sterile toothbrush until petechiae bleeding was seen. No additional action was taken to the control group. In the sham group, 5 cc saline solution was released into the peritoneum before the abdomen was closed. In the Fx group, 35 mg/kg Fx was instilled intraperitoneally and the abdomen was closed. On the 21st post-operative day, all subjects were anesthetized with standard anesthesia. Macroscopic adhesions were quantitatively evaluated according to the Mazuji classification. The cecum anterior wall and parietal peritoneum were excised for pathological sampling. A pathologist, unaware of the groups, evaluated inflammation, fibroblastic activity, and vascular proliferation. In addition, serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 levels were measured. RESULTS: No rat was lost during the study period. Congenital adhesion was not observed in any of the subjects at the first laparotomy. Adhesion was significantly less macroscopically in the Fx group compared to the control and sham group (p<0.001 and p<0.001). Fibroblastic activity was found to be significantly less in the Fx group compared to the sham and control groups (p<0.001 and p<0.001). Vascular proliferation was found to be significantly less in the Fx group than in the sham and control groups (p<0.001 and p<0.001). The inflammation score was significantly lower in the Fx group compared to the other two groups (p<0.001 and p<0.001). The inflammation score in the sham group was lower than the control group and was statistically significant (p<0.001). TNF-alpha level was found to be statistically significantly lower in the Fx group compared to the sham and control groups (p<0.001 and p<0.001). CONCLUSION: As a result of experimental study, we can say that Fx is effective in preventing IAAs and decreases the level of TNF-alpha, a pro-inflammatory cytokine.