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    Adult langerhans cell histiocytosis
    (Ortadogu Ad Pres & Publ Co, 2007) Cil, Timucin; Goekalp, Deniz; Tuzcu, Alparslan; Isikdogan, Abdurrahman; Bahceci, Mithat
    Langerhans cell histiocytosis is a group of idiopathic disorders characterized by the abnormal proliferation of specialized bone marrow-derived Langerhans cells. There are one to two cases per million population. Most reports are based only on anecdotal experience in adult patients. Surgical excision, radiotherapy and chemotherapy, either alone or in combination are the main treatment options. In this report, we present a rare case of Langerhans cell histiocytosis in a 32 years-old-woman who developed symptomatic diabetes insipidus and multiple bone and cranial metastases during the disease course. This paper discusses controversial treatment modalities.
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    Ectopic lingual thyroid as a rare cause of primary hypothyroidism - A case report
    (Lippincott Williams & Wilkins, 2008) Pasa, Semir; Beyaz, Coskun; Arikan, Senay; Altintas, Abdullah; Gokalp, Deniz; Cil, Timucin; Tuzcu, Alparslan
    Ectopic lingual thyroid gland is all uncommon abnormality of migration of the thyroid gland. Although it is uncommon, it is often found in the region of the foramen cecum as a lingual thyroid at the base of the tongue in patients whose gland fails to descend. The true incidence of lingual thyroid is unknown. Treatment depends on the presence of symptoms. In this case report, we described a 17-year-old mail who presented with growth retardation due to severe hypothyroidism associated with a lingual thyroid gland. He did not complain of pressure symptoms. We recommended regular follow-up visits to monitor this state of thyroid function and the size and shape of the gland. We wanted to note that ectopic thyroid tissue should be taken into consideration in the differential diagnosis of all lingual and pharyngeal masses, and in the differential diagnosis of hypothyroidism.
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    QUS measurements in dialysis patients
    (Medi+World Int, 2005) Kara, Ismail Hamdi; Yilmaz, Mehmet Emin; Turgutalp, Kenan; Tuzcu, Alparslan; Kadiroglu, Ali Kemal
    Background: It was aimed to evaluate the bone measurements by quantitative heel ultrasound (QUS) in patients undergoing chronic haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD), and healthy controls. It was also aimed to investigate the relationship between weight, body mass index (BMI), smoking and parathyroid hormone (PTH) with QUS parameters. Method: Present study included 25 patients on chronic HD (Group 1), 16 patients treated by CAPD (Group 2) and 32 controls (Group 3). QUS (Hologic, Sahara bone sonometer) measured broadband ultrasound attenuation (BUA; dB/Mhz), quantitative ultrasound index (QUI; g/cm(2)), speed of sound (SOS; m/s). The WHO (1997) classification of BMI was used for weight classification. The smoking criterion was defined as smoker and non-smoker. Results: Mean age of cases was 40.2 +/- 15.5, 36.0 +/- 9.9 and 36.6 +/- 12.4 years, in groups 1, 2 and 3 (p>0.05), and mean dialysis duration time was 31.8 +/- 12.6 and 42.8 +/- 12.8 months, in groups 1 and 2 (p=0.015). Depending on the QUS parameters, both osteoporosis and osteop zenia were diagnosed in five (56%) of women and in 11 (69%) of men in HD vs in two (33%) of women and in four (40%) of men in CAPD, respectively (p=0.584). QUS measurements were not correlated with serum PTH and BMI in both HD and CAPD groups, respectively. In HD group, we found SOS to be lower ( 1526 +/- 27 vs. 1548 +/- 19 m/s, p=0.016) in smokers compared to non- smokers. There were negative correlations between smoking and QUS parameters ( r=-0.34; p=0.044). Conclusion: Our findings suggest that there is an unfavorable influence of HD and smoking on bone mineralization compared to CAPD.