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    Evaluating mean platelet volume as a new indicator for confirming the diagnosis of necrotizing pancreatitis
    (Edizioni Luigi Pozzi, 2015) Erbis, Halil; Aliosmanoglu, Ibrahim; Turkoglu, Mehmet Akif; Ay, Enver; Turkoglu, Ahmet; Ulger, Burak Veil
    BACKGROUND: The aim of the present study is to discuss the possible role of mean platelet volume as a new predictor in the diagnosis of necrotizing pancreatitis. METHODS: Study subjects are arranged in three different groups: Group I; control group (n= 40), Group II; acute pan-creatitis (n= 40), Group III; necrotizing pancreatitis (n= 36). Demographic data and mean platelet volume values are recorded retrospectively. RESULTS: Mean platelet volume of patients in Group II was 7.9 +/- 0.53, while in Group III patients' it was 7.2 +/- 0.52 (p<0.001). When we compared the study groups with ROC analysis, results demonstrated that cut off value of necrotizing pancreatitis patients as 7,8 (area under curve: 0.857), sensitivity as 86.1% and specificity as 72.5%. CONCLUSION: The current study shows that mean platelet volume in necrotizing pancreatitis patients is significantly reduced compared to that of patients in the control and acute pancreatitis group.
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    Nebivolol Ameliorates Hepatic Ischemia/Reperfusion Injury on Liver But Not on Distant Organs
    (Taylor & Francis Inc, 2015) Ulger, Burak Veli; Erbis, Halil; Turkcu, Gul; Ekinci, Aysun; Turkoglu, Mehmet Akif; Ekinci, Cenap; Yilmaz, Vural Taner
    Introduction: Hepatic ischemia/reperfusion injury may occur after large tumor resection and liver transplantation procedures. Nitric oxide was shown to have protective effects on ischemia/reperfusion injury. Nebivolol is a compound that has been reported to improve nitric oxide release. We evaluated the effects of nebivolol in a rat liver ischemia/reperfusion model. Methods: A total of 40 rats were randomly divided into four groups (n = 10 each). Group I underwent only laparotomy, Group II was administered nebivolol and then underwent laparotomy, Group III underwent laparotomy and hepatic ischemia/reperfusion, and Group IV was administered nebivolol and then underwent laparotomy and hepatic ischemia/reperfusion. Serum AST, ALT, urea, and creatinine levels, and TAS and TOS levels of liver, lung, and kidney tissues were determined. Histopathological determination was also performed. Results: Nebivolol significantly reduced liver function tests in group IV, but it did not improve renal functions. Oxidative stress and abnormal histopathological findings were found to be reduced in liver tissue in group IV. Although the oxidative stress was increased after hepatic ischemia/reperfusion, nebivolol could not reduce the oxidative stress in kidney tissue. There were no significant differences between group III and group IV in terms of the histopathological changes in kidney tissue. There were no significant differences in lung tissue between the groups. Conclusions: The results of this study suggest that nebivolol has protective effects on liver but not on distant organs in a hepatic ischemia/reperfusion injury model. These experimental findings indicate that nebivolol may be useful in the treatment of hepatic ischemia/reperfusion injury.
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    Protective Effect of Caffeic Acid Phenethyl Ester on Antituberculosis Drug-Induced Hepatotoxicity in Rats
    (Int College Of Surgeons, 2017) Aliosmanoglu, Cigdem; Erbi, Halil; Aliosmanoglu, Ibrahim; Turkoglu, Mehmet Akif; Ulger, Burak Veli; Turkoglu, Ahmet; Yuksel, Hatice
    Isoniazid and rifampicin are drugs primarily used in antituberculosis treatment. Our aim in this study is to evaluate the effect of caffeic acid phenethyl ester's protective effect on liver function tests and to trace elements in hepatic damage caused by isoniazid and rifampicin on rats. Forty Wistar albino rats were divided into 4 groups. Group 1: Sham, Group 2: caffeic acid phenethyl ester application, Group 3: isoniazid and rifampicin given, Group 4: isoniazid + rifampicin and caffeic acid phenethyl ester application. After 30 days, the rats were sacrificed by taking blood from the heart. Alanine aminotransferase, aspartate aminotransferase, zinc, copper, total antioxidant capacity, total oxidative status, and oxidative stress index levels were evaluated. The rats to which isoniazid + rifampicin + caffeic acid phenethyl ester were given had less oxidative stress and copper levels (P < 0.001, P = 0.019) but have higher zinc levels (P = 0.001) compared to the isoniazid + rifampicin group. Liver enzyme levels were also lower in rats that were given isoniazid + rifampicin + caffeic acid phenethyl ester (P < 0.001). The results of this study suggested that caffeic acid phenethyl ester influences the levels of trace elements (copper and zinc) that are important for the physiologic mechanisms of organisms, reducing liver damage.