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    Serum levels of alpha-1 acid glycoprotein and pentraxin 3 in patients with Behcet's disease and relationship with disease activity
    (Wiley, 2015) Yazmalar, Levent; Batmaz, Ibrahim; Sula, Bilal; Alpayci, Mahmut; Aydin, Fatma; Turkcu, Fatih; Yildiz, Mehmet
    Background To evaluate the relationship between disease activity and levels of alpha 1-acid glycoprotein and pentraxin 3 in patients with Behcet's disease (BD). Methods Forty-eight patients with BD and 29 age-and gender-matched healthy control subjects were included in the study. Serum pentraxin 3 levels were measured using enzyme-linked immunosorbent assay (ng/ml), and alpha 1-acid glycoprotein levels were measured using nephelometry (mg/dl). Disease activity was assessed using the BD Current Activity Form (BDCAF). Results Serum alpha-1 acid glycoprotein levels were significantly higher in patients with BD compared to the control group (P = 0.048). There were no significant differences between two groups in terms of levels of pentraxin 3 (P = 0.697). According to Pearson's analysis, alpha 1-acid levels are significantly positively correlated with erythrocyte sedimentation rate, C-reactive protein, and skin lesions and arthritis of BDCAF scores. Pentraxin 3 levels did not correlate with erythrocyte sedimentation rate, C-reactive protein, or any domains of BDCAF scores. Conclusion The results of the present study demonstrate that serum levels of alpha-1 acid glycoprotein were significantly higher in patients with BD relative to the control group. Alpha-1 acid glycoprotein is greatly associated with skin lesions and arthritis in patients with BD. We did not find high serum levels of PTX3 in patients with BD compared to healthy controls, and pentraxin 3 is not associated with disease activity in BD.
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    Sleep quality in patients with Behcet's disease
    (Wiley, 2017) Yazmalar, Levent; Batmaz, Ibrahim; Sariyildiz, Mustafa A.; Yildiz, Mehmet; Ucmak, Derya; Turkcu, Fatih; Akdeniz, Dicle
    AimThe aim of this study was to evaluate sleep quality and the related variables in patients with Behcet's disease (BD). MethodOne hundred and twelve patients diagnosed with BD and 67 age- and gender-matched healthy controls were enrolled in the study. The Pittsburgh Sleep Quality Index (PSQI) was used for the evaluation of sleep disturbance in all participants. The quality of life (QoL) of all patients were evaluated by Nottingham Health Profile (NHP), and anxiety and depression which were assessed by Hospital Anxiety and Depression Scale (HADS). ResultsThe patients with BD had significantly higher scores in subjective sleep quality, sleep latency, sleep efficiency, sleep disorder, functional disorder in the morning and total PSQI score compared to the healthy control group. According to Pearson's analysis, there was a significantly higher correlation between the anxiety, depression and all components of NHP scores and the total PSQI score. Logistic regression analyses indicated that genital ulcer and arthritis were predictors for poor sleep quality. ConclusionSleep quality is disturbed in patients with BD. The lower quality of sleep is greatly associated with anxiety, depression, QoL, genital ulcers and arthritis.