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    Continuous amnioinfusion via an epidural catheter following spontaneous membrane rupture: A case report
    (Galenos Yayincilik, 2013) Turgut, Abdulkadir; Katar, Selahattin; Sak, Muhammet Erdal; Turgut, Fethiye Gulden; Sahin, Alparslan; Basaranoglu, Serdar; Yalinkaya, Ahmet
    Preterm premature rupture of membranes (PPROM) is seen in 3% of all pregnancies, and is a frequent cause of preterm birth, neonatal mortality and morbidity. The most important complications are maternal and foetal infection, prematurity, umbilical cord compression, hypoxia or asphyxia due to cord prolapse, pulmonary hypoplasia and extremity deformities. The basic approach to PPROM therapy aims to prevent premature birth and the development of foetal distress, and decrease the risk of maternal and foetal infection, and amniotic fluid loss. In compliance with these objectives, alternatives of PPROM therapy demonstrate a wide spectrum, including watchful waiting, amniopatch application, recurrent amnioinfusions and emergency birth. However, repeated amnioinfusions in cases of fluid loss, especially within 6 hours of therapy, provides only minimal benefit. In this case presentation, we attempted to describe a different and cost-effective continuous amnioinfusion technique performed to confer survival benefit for an immature anhydramniotic foetus affected by PPROM at the border of viability.
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    Effect of Estrogen Replacement Treatment on VEGF in Serum and Retina in Rats
    (Modestum Ltd, 2015) Yuksel, Harun; Turgut, Fethiye Gulden; Turkcu, Fatih M.; Ozkurt, Zeynep; Sahin, Muhammed; Yuksel, Hatice; Turkcu, Gul
    Vascular endothelial growth factor (VEGF) is a molecule implicated in the pathogenesis of several eye diseases. In this experimental study, we planned to evaluate the effects of surgical menopause and hormone replacement therapy on VEGF levels. Thus, we studied the effects of treatments involving estrogen, estrogen and progesterone (E/P) in combination, and genistein, which is a selective estrogen modulator, on serum VEGF levels and the expression of VEGF in the retinas of rats with surgical menopause. The rats were randomly divided into five groups. Bilateral ovariectomy (OVX) was performed in all groups except for the sham-operated group. estrogen, E/P, genistein or water (sham and control groups) treatments were given for 8 weeks through the orogastric catheter. Serum VEGF level and immunohistochemical staining of VEGF in retinal tissue were analyzed in each group. Serum VEGF levels were significantly higher in the OVX + estrogen and OVX + genistein groups than in the control and sham groups. It was also higher in the OVX + E/P group than in the sham and control groups; however, in this case, the difference was not statistically significant. The OVX + estrogen, OVX + E/P, and OVX + genistein groups exhibited increased VEGF staining in comparison with the control and sham groups. However, the difference was not statistically significant. The current study demonstrated that estrogen replacement treatment (ERT) leads to an increase in serum VEGF levels and progesterone plays a protective role in this increase. The ERT used in this study had no effect on VEGF expression in the retina.
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    Immunohistochemical and Ultrastructural Examination of Changes in the Retina in Diabetic Rats
    (Sci Printers & Publ Inc, 2016) Turgut, Fethiye Gulden; Ozevren, Huseyin; Irtegun, Sevgi; Deveci, Engin
    OBJECTIVE: To study diabetic retinopathy by the immunohistochemical and ultrastructural examination of changes in the retina in diabetic rats. STUDY DESIGN: We examined the blood-retinal barrier and cell-to-cell connections in diabetic rats by immunohistochemistry and ultrastructural level. Twenty adult male Wistar rats were used in this study. The animals were divided into 2 groups. The control group was fed standard rat chow and drinking water for 8 weeks. Single-dose streptozotocin (55 mg/kg) was dissolved in sodium citrate buffer and administered via intraperitoneal injection to induce diabetes in the diabetes group. The diabetes and control groups were compared for glucose values. RESULTS: The blood glucose concentration in diabetic rats was significantly increased (p< 0.05). Dilation of blood vessels, hemorrhage, and edema were observed in the nerve fibers and ganglion layer. An increase in vascular endothelial growth factor expression was confirmed by Western blot method. E-cadherin-positive cells in the immune junctions between cells in the diabetic retina were observed, weakly staining. CONCLUSION: Ultrastructural analysis of diabetic retinopathy showed that dysfunctionality of photoreceptor cells and vision loss are thought to occur due to mitochondrial degeneration. (Anal Quant Cytopathol Histpathol 2016; 38: 357-363)