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    31. Zeynep Kamil Jinekopatoloji Kongresi Poster Bildiriler P12 Sezeryan sonrasında uterin kavitede unutulmuş plasenta olgusu:case report
    (2013) Özler, Ali; Ağaçayak, Elif; Yaman, Senem Tunç; Turgut, Abdulkadir
    [Abstract Not Available]
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    Alteration of peripheral blood cells in tubal ectopic pregnancy
    (Studio K, 2013) Turgut, Abdulkadir; Sak, Muhammet Erdal; Ozler, Ali; Soydinc, Hatice Ender; Karacor, Talip; Gul, Talip
    Objectives: To investigate whether mean platelet volumes and leukocyte counts are altered significantly in patients with tubal ectopic pregnancy (TEP). Materials and Methods: Retrospective analysis of mean platelet volumes and leukocyte counts of 138 TEP patients, diagnosed between 2005 and 2012, and the control group consisting of 72 pregnants was performed. Patients with TEP were further subdivided into 2 subgroups composed of 72 ruptured and 66 non-ruptured cases. Statistical analysis was performed using the Kruskal-Wallis and the Mann-Whitney U tests. Results: Mean platelet volume was found to be larger in patients with TEP (whether ruptured or non-ruptured) when compared to controls (p=0.007). However, no significant difference could be observed between the ruptured or non-ruptured cases (p=0.89). With respect to leukocytosis, the TEP group with tubal rupture had significantly higher white blood cell numbers when compared to the non-ruptured TEP and the control groups (p=0.022 and p<0.001, respectively). Conclusions: Mean platelet volume seems to be higher in ectopic pregnancy and this finding evokes a possible role of increased platelet activity in the pathophysiology. Leukocytosis may occur more apparently in EP cases with tubal rupture. However, further prospective, controlled and with a larger sample size studies must be conducted to find clues on the correlation between the clinical entities and laboratory findings.
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    Assessment of oxidative stress markers in cord blood of newborns to patients with oxytocin-induced labor
    (Wiley, 2017) Karacor, Talip; Sak, Sibel; Basaranoglu, Serdar; Peker, Nurullah; Agacayak, Elif; Sak, Muhammet Erdal; Turgut, Abdulkadir
    Aim: We aimed to measure the extent of oxidative stress experienced during labor by the neonates of pregnant women undergoing induced or spontaneous birth and to compare the effects of induced labor on fetalwell-being. Methods: Sixty-four healthy pregnant women referring to the Department of Gynecology and Obstetrics, Dicle University Medical Faculty between October 2010 and May 2011 were included in this comparative study. Pregnant women undergoing induced labor by oxytocin were group 1 and those without labor induction were group 2. Post-partum Apgar score was calculated at 1 and 5 min and measurements of weight and height of the neonateswere carried out. After the fetal cordwas clamped, 5 cm(3) blood was drawn into a plain tube without anticoagulant. The samples were centrifuged at 5000 r.p.m. for 5 min. Separated sera were transferred to Eppendorf tubes and were stored at -80 C degrees until the analysis time. Results: The complete blood counts and biochemistry results indicated that there were no statistically significant differences in regards to diseases between the two groups. Nitric oxide and asymmetrical dimethylarginine values of the two groups were not significantly different; however, there were statistically significant differences in the malondialdehyde, paraoxonase, total antioxidative status, and total oxidative status values of the two groups (respectively, P = 0.005, P = 0.006, P = 0.008, and P = 0.007). Conclusion: We observed that oxytocin-induced labor increases stress markers but does not affect Apgar scores. Oxidative stress in pregnant women may trigger antioxidative mechanisms. Prospective studies in larger cohorts are needed to better understand the impact of oxytocin-induced labor on pregnant women and neonates.
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    Bilateral Congenital Diaphragmatic Hernia: A Rare Case Report
    (2014) Özer, Mehmet; Turgut, Abdulkadir; Ağaçayak, Elif; Özler, Ali; Tunç, Senem Yaman
    Konjenital diyafragma hernisi nedeni bilinmeyen, oldukça nadir görülen bir doğumsal anomalidir. Diğer anomaliler ile ilişkisi ve farklı klinik desenleri ile çeşitli nedenleri olabileceğini düşündürmektedir. Konjenital diyafragma hernisi 2.500 canlı doğumda 1 görülür. Olguların% 85'inde defekt [1] sol taraflıdır. Konjenital diyafragma hernisi vakalarının çoğu sporadiktir. Ailesel konjenital diyafragma hernisi, tüm vakaların sadece % 2' sini [2] oluşturur, oldukça nadirdir. Bu konjenital anomali hemen hemen her zaman doğum öncesi ultrasonografik muayene ile tanınabilir. Tedavisi ile sonuçlar herninin derecesine göre değişkenlik gösterir. Bilateral konjenital diyafragma hernisi kötü prognozile, nadir bir doğumsal anomalidir. Biz sağ taraflı konjenital diyafragma hernisi operasyon sırasında keşfedilen bilateral konjenital diyafragma hernisi olgusu sunulmuştur. Diyafragmatik defekt onarıldı ve bir prolen örgü abdominal kompartman sendromu önlemek için karın yara yerleştirildi. Hasta yine de ameliyat sonrası ciddi pulmoner hipertansiyon nedeniyle öldü. Öncelikle olgu sınırlı sayıda olup bilateral konjenital diyafragma hernisi, son derece nadirdir. CDH hasta bakımı yenidoğan ve cerrahlar için çok zordur. Olgumuzu sunmamızın amacı özellikle bilateral konjenital diyafragma hernisi olan hastaların tedavi ve sonuçlarını değerlendirmektir
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    The Biochemical and Histologic Effects of Adnexal Torsion and Early Surgical Intervention to Unwind Detorsion on Ovarian Reserve: An Experimental Study
    (Sage Publications Inc, 2013) Ozler, Ali; Turgut, Abdulkadir; Soydinc, Hatice Ender; Sak, Muhammet Erdal; Evsen, Mehmet Siddik; Alabalik, Ulas; Basarali, Mustafa Kemal
    Objective: The aim of the present study was to determine to what extent ovarian reserves are affected by ischemia-reperfusion injury, evaluating the number of growing follicles and the serum levels of the ovarian hormones. Study Design: Thirty female fertile adult Wistar albino rats, weighing 200 to 220 g, were previously numbered to randomization, and then randomly divided into 3 equal groups (n = 10): sham, torsion, and detorsion groups. In torsion and detorsion groups, bilateral adnexal torsion (3-hour ischemia) was carried out. Bilateral adnexal detorsion (3-hour reperfusion) was performed in the detorsion group. Results: The mean number of preantral and small antral follicles in detorsion group were lower than those of the sham group (P < .01). After torsion, anti-Mullerian hormone (AMH), estradiol, and inhibin B levels decreased significantly compared to the preoperative and postoperative periods (P = .003, P = .032, and P = .014, respectively). In detorsion group, only AMH levels were found to decrease significantly following the 3-hour ischemia and 3-hour reperfusion (P < .05). Conclusion: After adnexal torsion, a significant decrease in ovarian reserve has been detected for the first time in this study. Additionally, the results of this study suggest that conservative surgery alone is insufficient to protect ovarian reserve.
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    BLOOD PRESSURE DIURNAL RHYTHM IS RELATED WITH HEMATOLOGICAL INDICES IN GESTATIONAL DIABETES MELLITUS PATIENTS
    (Carbone Editore, 2013) Soydinc, Serdar; Oylumlu, Mustafa; Yuksel, Murat; Turgut, Abdulkadir; Soydinc, Hatice Ender
    Objective: Gestational diabetes mellitus (GDM) is related with cardiovascular risk factors. Non-dipping blood pressure pattern and high mean platelet volume, which is an indicator of increased platelet activation, are associated with cardiovascular morbidity and inortality. The aim of our study is to determine circadian variation of blood pressure and to study the impact of hematological indices on blood pressure dipping and non-dipping patterns in patient with GDM. Material and methods: A total of 42 patients who were diagnosed with GDM and 33 patients with healthy pregnancies were included into the study. Patients' blood pressures were monitored and were grouped due to their blood pressure circadian pattern. If the blood pressure while sleeping decreased more than 10% from the blood pressure while awake, the patient was classified as a dipper. If the decrease was less than 10%. the patient was classified as a non-dipper. Biochemical and hematological parameters were measured and clinical features were recorded for all study groups. Results: Ambulatory blood pressures monitoring of two groups revealed that average systolic and diastolic blood pressures as well as the day-phase diastolic and night-phase systolic and diastolic blood pressures of GDM patients were significantly increased than those of the control group. Besides, control patients had a more significant decrease in night-phase systolic and diastolic blood pressures than GDM patients (p<0.001). There was no significant difference between hematological indices and dipping status, except for mean platelet volume (MPV). MPV in non-dippers was significantly higher than dippers one (p<0.001). Step-wise multivariate linear regression demonstrated that MPV and GDM can be used as independent predictors of non-dipping status. Conclusion: According to our results the circadian variation of blood pressure is impaired and MPV is increased in GDM patients. Increasing in MPV is associated with non-dipping status of blood pressure. It is possible that non-dipping status and increased MPV levels may be additional risk factors for increased cardiovascular disease events in gestational diabetes patients.
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    Continuous amnioinfusion via an epidural catheter following spontaneous membrane rupture: A case report
    (Galenos Yayincilik, 2013) Turgut, Abdulkadir; Katar, Selahattin; Sak, Muhammet Erdal; Turgut, Fethiye Gulden; Sahin, Alparslan; Basaranoglu, Serdar; Yalinkaya, Ahmet
    Preterm premature rupture of membranes (PPROM) is seen in 3% of all pregnancies, and is a frequent cause of preterm birth, neonatal mortality and morbidity. The most important complications are maternal and foetal infection, prematurity, umbilical cord compression, hypoxia or asphyxia due to cord prolapse, pulmonary hypoplasia and extremity deformities. The basic approach to PPROM therapy aims to prevent premature birth and the development of foetal distress, and decrease the risk of maternal and foetal infection, and amniotic fluid loss. In compliance with these objectives, alternatives of PPROM therapy demonstrate a wide spectrum, including watchful waiting, amniopatch application, recurrent amnioinfusions and emergency birth. However, repeated amnioinfusions in cases of fluid loss, especially within 6 hours of therapy, provides only minimal benefit. In this case presentation, we attempted to describe a different and cost-effective continuous amnioinfusion technique performed to confer survival benefit for an immature anhydramniotic foetus affected by PPROM at the border of viability.
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    Diagnostic Dilemma in Rudimentary Horn Pregnancies: Report of the Eight Cases and a Literature Review
    (2013) Özler, Ali; Görük, Neval Yaman; Turgut, Abdulkadir; Evsen, Mehmet Sıddık; Soydinç, Hatice Ender; Sak, Muhammet Erdal; Yalınkaya, Ahmet
    AMAÇ: Rudimenter horn gebelikleri (RHP) son derece nadir olmasına rağmen, tehlikeli olabilirler. Bu çalışmanın amacı, literatür incelemesi eşliğinde RHP olan 8 hasta ile ilgili klinik deneyimimizi sunmaktır. GEREÇ VE YÖNTEM: Türkiye'nin Güneydoğu bölgesinde tersiyer referans bir hastanede Ocak 2008 ve Aralık 2011 tarihleri arasında tedavi edilen RHP hastaların kayıtları geriye dönük olarak incelendi. Çalışma süresi boyunca RHP'li sekiz olgu tespit edildi. BULGULAR: Hastaların ortalama yaşı 23±3,9 yıldı ve ortalama gebelik haftası 14,8±4,8 hafta idi.Rudimenter horn 8 hastanın 6'sında (%75) sol tarafta lokalize idi. Dört (%50) olgu horn rüptür sonrası diğer hastanelerden kliniğimize sevk edilmişti. İlginç olarak iki olguda malprezentasyon nedeniyle sezaryen öyküsü olmasına rağmen Müllerian anomali varlığı konusunda herhangi bir bilgileri yoktu. Dört olgu masif intra-abdominal kanama ile şok tablosunda dış merkezlerden kliniğimize refere edildi. Maternal mortalite görülmedi. SONUÇ: Unicornuat uterus olgularına, rudimenter horn gebelikleri ve rüptür riski nedeni ile kadın hastalıkları ve doğum eğitiminde daha fazla önem verilmelidir.
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    Effect of Caffeic Acid Phenethyl Ester on Intra-Abdominal Adhesion in Rats
    (Karger, 2013) Turgut, Abdulkadir; Sak, Muhammet Erdal; Turkcu, Gul; Ozler, Ali; Soydinc, Hatice Ender; Evsen, Mehmet Siddik; Evliyaoglu, Osman
    Background: To determine the impact of caffeic acid phenethyl ester (CAPE) on abdominal adhesion formation after laparotomy. Methods: Forty female rats were allocated into four distinct groups on which laparotomy alone; laparotonny with traumatization of the uterine horns; laparotomy, traumatization of the uterine horns and intraperitoneal irrigation with saline, and laparotomy, traumatization of the uterine horns and intraperitoneal irrigation with CAPE were performed. After sacrifying the animals on the 14th postoperative day, histopathological examination and biochemical analysis were conducted to evaluate the formation of abdominal adhesions and antioxidant status. Results: In the CAPE group, total adhesion scores were significantly lower than in the control and saline groups. The CAPE group displayed less inflammation, giant cell formation, fibrosis and fibroblastic activity than the control group. On the other hand, the control group displayed higher total adhesion scores. Conclusion:The results of this study indicate that the administration of CAPE may have beneficial effects for the prevention of abdominal adhesion formation after laparotomy. Further clinical studies are mandatory to explore the actual therapeutic potential of CAPE. Copyright (C) 2013 S. Karger AG, Basel
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    EFFECTS OF GENISTEIN, ESTROGEN AND PROGESTERONE THERAPIES ON BLADDER MORPHOLOGY AND M2, M3 RECEPTOR EXPRESSIONS IN OOPHORECTOMIZED RATS
    (Carbone Editore, 2014) Turgut, Abdulkadir; Goruk, Neval Yaman; Sak, Muhammet Erdal; Deveci, Engin; Akdemir, Fatih; Keles, Ayse Nur; Nergiz, Yusuf
    Aims: Investigating the effects of estrogen, estrogen/progesterone combination and genistein therapy on the expression of M2 and M3 receptors located on bladder walls and comparing the morphological and degenerative changes exerted on bladder walls. Materials and methods: A total of 50 adult Sprague-Dawley female rats were randomly divided into five groups. Rats other than the sham group were ovariectomized. OVX group (control group) received water, OVX+G group received 10 mg/kg genistein, OVX+E group received 0.014 mg/kg 17-beta estradiol, OVX+E+P group received 0.014 mg/kg 17-beta estradiol plus 0.028 mg/kg drospirenone per day. Results: When compared with the sham group, in the OVX group higher collagen fibre (CF): smooth muscle (SM) ratio, relatively increased fibrosis, oedema, space between detrusor smooth muscle fascicles, cytoplasmic vacuoles, and total M2, and M3 expression were observed. Relative to the OVX group, decreased CF: SM ratio and fibrosis in the OVX+G, OVX+E, and OVX+E+P groups, decreased oedema, spaces between detrusor muscle fascicles and cytoplasmic vacuoles in the OVX+G group and lesser total M2, and M3 expression in the OVX+G, OVX+E and OVX+E+P groups were observed. Conclusion: Genistein therapy regresses unfavourable morphological changes effecting postmenopausal bladder and increases in M2 and M3 receptor expression more effectively than estrogen and estrogen/progesterone combination. Besides, genistein therapy almost completely regresses degenerative changes; however, estrogen and estrogen/progesterone combination therapies do not improve these degenerative changes except for fibrosis. We think that genistein will favourably contribute both to the conduction of more comprehensive studies in the future concerning its use in postmenopausal urinary incontinence where estrogen and estrogen/progesterone combination therapies do not provide any improvement and etiopathogenesis of urinary incontinence.
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    Etkisi The Effect of Transport on Mortality and Morbidity in Preterm Infants Less than 32 Weeks of Gestation
    (Galenos Yayincilik, 2014) Katar, Selahattin; Yildiz, Dogan; Turgut, Abdulkadir; Taskesen, Mustafa; Saka, Gunay
    Introduction: The aim of this study was to compare mortality and morbidity rates of premature infants with gestational age of less than 32 weeks who were born in our hospital and those who were transported to our hospital after birth from other centers. Materials and Methods: Patients were divided into two groups; Group 1 included 40 patients who were born before gestational age of 32 weeks in our hospital, and Group 2 included 108 premature patients who were born before gestational age of 32 weeks in other centers and later transferred to our hospital. Morbidity and mortality rates were compared between the two groups (intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), respiratory distress syndrome (RDS), necrotizing enterocolitis (NEC), and bronchopulmonary dysplasia (BPD)). Results: Demographic characteristics, gender, body weight, and gestational age were similar in both groups (p> 0.05). The rate of normal vaginal delivery births was higher in Group 2 (p< 0.001). On admission, hypothermia was detected in 90% of the patients and hypoglycemia was found in 2.7% of patients in Group 2. Mortality was higher in Group 2 than in Group 1, however the difference was not significant (p> 0.05). Although higher rates of IVH, ROP, RDS, NEC, and BPD were found in Group 2, there was no statistically significant difference between the two groups (p> 0.05). Conclusions: Being transferred after birth has a negative effect on morbidity and mortality in premature infants. Thus, the best transport method is intrauterine transport except in state of an emergency, especially for infants with severe prematurity; these patients should be treated in centers with facilities of the highest level.
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    The evaluation of diagnostic and clinical findings in grand multiparous patients with endometrial cancer
    (Dicle Üniversitesi Tıp Fakültesi, 2013) Özler, Ali; Turgut, Abdulkadir; Ağaçayak, Elif; İçen, Mehmet Sait; Alabalık, Ulaş; Başaranoğlu, Serdar; Peker, Nurullah; Gül, Talip
    Amaç: Bu çalışmanın amacı grand multipar, endometrium kanserli hastaların tanısal ve klinik özelliklerini diğer endometrial kanserli hastalar ile karşılaştırarak değerlendirmektir. Yöntemler: Kliniğimizde Ocak 2006-Ağustos 2012 tarihleri arasında endometrium kanseri nedeniyle opere edilen 34 hasta dahil edildi. Hastalar doğum sayısına göre üç gruba ayrıldı; Grup 1 (doğum yapmamış hastalar, n=8), Grup 2 (doğum sayıları 1’den 4’e kadar olan hastalar, n=14), Grup 3 (grand multipar hastalar, n=12). Grand multipar hastaların tanısal, klinik ve histopatolojik verileri diğer gruplardaki hastalar ile karşılaştırıldı. Bulgular: Grup 3 (grand multipar) hastaların yaş ortalaması diğer gruplara göre anlamlı yüksek bulundu. (p<0,05). Tüm gruplar tümörün myometrial invazyon derinliği açısından karşılaştırıldığında ise anlamlı bir farklılık tespit edilmedi (p>0,05). Grup 1, 2 ve 3’ deki Evre 1A tümörlü hastaların oranlarının sırasıyla %75, %64,2 ve %83,3 olduğu bulundu. Ayrıca, bütün grand multipar hastaların evre 1 tümöre sahip oldukları bulunmuştur. Sonuç: Sonuç olarak, grand multipar hastaların tanıları daha geç yaşlarda konmakta, fakat erken evrede ve endometrioid tip endometrial kanser tanılarını almışlardır. Son doğumdan itibaren geçen süre endometrial kanser riski üzerine etkili bir faktör olabilir.
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    Evaluation of fetal ventriculomegaly
    (2013) Turgut, Abdulkadir; Arınkan, Sevcan Arzu; Aydın, Özgür; Dayıcıoğlu, Vedat; Çakmak, Yusuf; Tosun, Öykü; Tarhan, Nazan
    Amaç: Fetal ventrikülomegali tanısı alan olguların prenatal, postnatal dönem takip ve tedavi sonuçlarını değerlendirmektir. Yöntemler: Lateral ventrikül boyutu 10mm ve üzerindeolan olgular çalışmaya dahil edildi. Toplam 69 olgu saptadık ancak bu olgulardan sekizi çalışmamıza katılmayıreddetti. Hastalar ek anomalisi olanlar (kombine ventrikülomegali) ve olmayanlar (izole ventrikülomegali) olarak2 gruba ayrıldı. Her grup lateral ventrikül boyutuna göre;hafif (10-12mm), orta (12,1-14,9 mm), ağır (15 mm veüzeri) ventrikülomegali olarak alt gruplara ayrıldı. Bulgular: İzole ve kombine ventrikülomegalisi olan 10 fetus doğumdan sonra öldü. Onhastaya cerrahi tedavi uygulandı. Hastaların %16.7’sine kromozomal analiz yapıldı. Kombine ventrikülomegalisi olan grupta sezaryen oranı yüksek bulundu(%91.7) ve bu gruptaki hastaların tümü Yenidoğan Yoğun Bakım Ünitesi’ne (YYBÜ) yatış gerektirdi. İzole ventrikülomegalisi olan grupta vaginal doğum daha yüksek bulundu(%45.7). İzole ventrikülomegalisi olan grupta 18 olgu (%78.3) 6. ayda normal nörolojik gelişim gösterirken kombine ventrikülomegalisi olan grupta hiçbir hastada 6. ayda normal nörolojik gelişim izlenmedi. Ağır ventrikülomegalisi olan grupta terminasyon oranı (%64.7) izole ventrikülomegalisi olan gruptan (%11) daha yüksek bulundu. Hafif ventrikü- lomegalisi olan grupta sağ kalım %90 ve ağır ventrikülo- megalisi olan grupta %42.9 olarak saptandı. Sonuç: Ağır ventrikülomegalisi olanlarda terminasyon oranı; hafif ve orta ventrikülomegalisi olan gruplardan daha sık gözlendi. Bunun nedeni ağır ventrikülomegalisi olan hastalarda prognozun çok daha kötü olmasıdır. İntrauterin fetal hafif izole ventrikülomegalisi olan olgularda prognoz oldukça iyi olduğundan terminasyon kararının hasta ile iyice irdelenmesi gerektiğini düşünmekteyiz.
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    Evaluation of postoperative sexual function in patients after trans-obturator-tape operation
    (Aves Press Ltd, 2016) Agacayak, Elif; Basaranoglu, Serdar; Yavuz, Mustafa; Tunc, Senem Yaman; Sak, Sibel; Turgut, Abdulkadir; Deregozu, Aysegul
    Introduction: In this study, we aimed to evaluate postoperative sexual function of patients, who had undergone colporraphy anterior and transobturator tape operation due to cystocele and stress urinary incontinence. Materials and Methods: In our study, 52 patients with cystocele and stress urinary incontinence that were admitted to Dicle University, School of Medicine, Department of Obstetrics arid Gynecology between January 2009 and January 2014, were included in the study. Patients with previous hysterectomy, patients who had rectocele repair during operation, patients in menopause were excluded from the study. Patients completed the Pelvic Organ Prolapse Urinary Incontinence Sexual Questionnaire-12 before and after under going surgery. Results: Mean age of the patients in our study was 42.04 +/- 7.50, average body mass index of the patients was 30.1 +/- 3.7 kg/m(2). Average follow-up time was 31.5 +/- 11.3 months. 22 (42.3%) patients did not completely recovery the postoperative complaints. 2 (3.8%) patients had increased postoperative complaints. The positive correlation between postoperative complaints with dyspareunia was observed (r= 0.355 **p: 0.010). 5 (9.6%) patients developed postoperative complications. These complications, urinary comfortable inability in 2 (%3.8) patients, mesh erosion in 1(%1.9) patient, developed de novo urinary incontinence in 2 (%1.9) patients. The total result according to Pelvic Organ Prolapse Urinary Incontinence Sexual Questionnaire-12 was observed significant improvement in sexual function (p= 0.000). Conclusion: Urinary incontinence negatively affects the sexual life of women. We observed improvement in sexual function of women that had went transobturator tape operation for urinary incontinence.
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    Evaluation of the Protective Effects of CoQ10 on Ovarian I/R Injury: An Experimental Study
    (Karger, 2013) Ozler, Ali; Turgut, Abdulkadir; Goruk, Neval Yaman; Alabalik, Ulas; Basarali, Mustafa Kemal; Akdemir, Fatih
    Background: The aim of this study was to investigate the protective effects of coenzyme Q(10) (CoQ(10)) on ovarian ischemia/reperfusion injury in an experimental rat adnexal torsion model. Methods: 48 female adult Wistar albino rats, weighing 220-250 g, were randomly equally divided into six groups (n = 8): sham, torsion, detorsion, sham+CoQ(10), torsion+CoQ(10), and detorsion+CoQ(10) groups. Bilateral adnexal torsion was performed for 3 h in all groups, except the sham and sham+CoQ(10) groups. Bilateral adnexal detorsion was performed on the detorsion and detorsion+CoQ(10) groups. CoQ(10) was injected intraperitoneally 30 min before the sham operation, torsion, and detorsion. Results: The torsion and detorsion groups had significantly higher histologic evaluation scores, as well as higher MDA levels, TOS values, and oxidative stress index values than the sham group. A strong correlation between total histologic evaluation scores for ischemia/reperfusion injury and the oxidative stress index was found. The mean oxidant marker levels and histopathologic scores for the ovarian tissue significantly decreased after using CoQ(10), which is a potent antioxidant. Conclusions: Conservative surgery (detorsion) was found to provide inadequate protection to ovarian tissue. The results of this study suggest that CoQ(10) could be useful for the protection of ovarian tissue before conservative surgery. (C) 2013 S. Karger AG, Basel
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    Expression of endothelin-1 and Ki-67 in normotensive and severe preeclamptic placentas
    (Universidad de la Frontera, 2018) Ekinci, Aysun; Aktaş, Ayfer; Dönder, Ahmet; Ekinci, Cenap; Turgut, Abdulkadir; Deveci, Şenay; Deveci, Engin
    Severe preeclampsia (HELLP syndrome) is a life-threatening pregnancy complication, usually a severe form of preeclampsia. In this study, we aimed to examine histopathologic changes and Endothelin-1 and KI-67 expression levels by immunohistochemical methods in severe preeclamptic placentas. Severe preeclampsia and obstetric characteristics and biochemical and hematological characteristics of healthy subjects were compared. Placenta sections were stained with hematoxylin-eosin for histopathological examination. In the histopathological examination of severe preeclamptic placenta, degeneration in synaptic and cytotrophoblastic cells, increase in insidious knots, fibrinoid necrosis, degeneration in endothelial cells, calcification and hyaline villous stains were observed. In the severe preeclampsia group, Ki-67 expression increased in decidua cells and inflammatory cells, while endothelial cells in the vessel wall and inflammatory cells in the villus and intervillous spaces increased. It is thought that angiogenetic and cellular proliferation is induced in a co-ordinated manner and significantly influences fetal development.
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    Gebeliğin akut yağlı karaciğer hastalığı ile karışan akut viral Hepatit A olgusu
    (Modestum Ltd., 2013) Turgut, Abdulkadir; Özler, Ali; Görük, Neval Yaman; Tunç, Senem Yaman; Peker, Nurullah; Tekin, Recep
    Gebelikte akut hepatit A enfeksiyonu oldukça nadir görülmektedir. Klinik ve laboratuar bulgularıyla gebelikte oldukça mortal seyredebilen gebeliğin akut yağlı karaciğer hastalığı ile karışabilmektedir. Karaciğer fonksiyon testlerinde yükseklik izlenen her iki durumun ayırıcı tanısı yapılmalı ve bu tabloyla gelen bir hastada hepatit A enfeksiyonu da akla gelmelidir. Kliniğimize başvurusunda, gebeliğin akut yağlı karaciğer hastalığı tanısı sonrasında akut hepatit A tanısı alan, 30 yaşında 35 haftalık gebeliği olan bir olgu sunulmuştur.
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    Gestasyonel Yaşları 32 Haftadan Küçük Doğan Prematürelerde Transportun Mortalite ve Morbiditeye Etkisi The Effect of Transport on Mortality and Morbidity in Preterm
    (2014) Taşkesen, Mustafa; Katar, Selahattin; Turgut, Abdulkadir; Saka, Günay; Yıldız, Doğan
    Özet Giriş: Bu çalışmada amaç, hastanemizde doğan ve gestasyonel yaşları 32 haftadan küçük prematüre bebeklerle dış merkezlerde doğduktan sonra hastanemize transfer edilen gestasyonel yaşları 32 haftadan küçük prematüre bebeklerin mortalite ve morbidite sonuçlarını karşılaştırmaktır. Gereç ve Yöntem: Hastanemizde doğan gestasyonel yaşları 32 haftadan küçük 40 hasta (Grup 1) ile aynı süre içerisinde dış merkezlerde doğup hastanemize transfer edilen ve gestasyonel yaşları 32 haftadan küçük 108 prematüre hasta (Grup 2) araştırmaya alındı. İki grup arasında mortalite ve morbidite (intraventriküler kanama (İVK), prematüre retinopatisi (ROP), respiratuvar distres sendromu (RDS), nekrotizan enterokolit (NEK) ve bronkopulmoner displazi (BPD)) açısından karşılaştırma yapıldı. Bulgular: Her iki grupta demografik özellikler, cinsiyet, vücut ağırlığı ve gestasyonel yaş verileri benzerdi (p>0,05). Grup 2de normal vaginal yol ile doğum daha fazlaydı (p<0,001). Grup 2deki hastaların başvuru anında %90nında hipotermi, %2,7sinde ise hipoglisemi saptandı. Grup 2deki hastaların mortalitesi Grup 1e göre daha yüksek, ancak istatistiksel olarak anlamlı değildi (p>0,05). İVK, ROP, RDS, NEK ve BPD Grup 2de daha yüksek oranda görülmesine rağmen, iki grup arasındaki karşılaştırmada istatistiksel olarak anlamlı farklılık saptanmadı (p>0,05). Sonuç: Sonuç olarak, doğduktan sonra prematürelerin transfer edilmesi mortalite ve morbiditeyi olumsuz yönde etkilemektedir. Bu nedenle acil durumlar dışında en iyi transportun intrauterin transport olduğu, özellikle ileri derecede prematüre doğan hastaların en üst düzeyde imkanları olan merkezlerde tedavi edilmeleri gerektiği unutulmamalıdır. (Gün­cel Pe­di­at­ri 2014;1:16-9)
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    Öğe
    Increased psychological trauma and decreased desire to have children after a complicated pregnancy
    (Galenos Yayincilik, 2013) Tan, Pinar; Evsen, Mehmet Siddik; Soydinc, Hatice Ender; Sak, Muhammet Erdal; Ozler, Ali; Turgut, Abdulkadir; Bez, Yasin
    Objective: Information about fertility desire and psychological sequelae after high-risk pregnancies are scarce in the literature. The aim of the present study is to investigate the psychological effects of high-risk pregnancies. Material and Methods: The patients who had a history of severe preeclampsia, eclampsia or major hemorrhage during the peripartum period were enrolled as the study group and compared with the control subjects with respect to fear about new pregnancy, anxiety/depression and post-traumatic stress disorder (PTSD) scores. The study was carried out by submitting a questionnaire form to the participants. Numbers of planned children before and after the last delivery were evaluated in both groups. Results: Fear about a new pregnancy was found to be significantly higher in the study group compared with the controls. There were no statistically significant difference between the two groups in terms of anxiety and depression. In terms of re-experience and avoidance in PTSD was significantly higher in the study group, however no significant difference was found for hyper-arousal. Conclusion: Fear regarding new pregnancy is high and planning more children is decreased after high-risk pregnancies and PTSD symptom scores were higher after high-risk pregnancies.
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    Öğe
    Jinekolojik kanserli olguların retrospektif analizi: 11 yıllık deneyim
    (Modestum Publishing Ltd., 2012) Turgut, Abdulkadir; Özler, Ali; Sak, Muhammet Erdal; Evsen, Mehmet Sıddık; Soydinç, Hatice Ender; Alabalık, Ulaş; Gül, Talip
    Amaç: Hastanemizde izlenen jinekolojik kanserlerinin epidemiyolojik özellikleri hakkında fikir vermek amacıyla bu çalışmamızı planladık. Gereç ve yöntem: Çalışmamızda Dicle Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniğinde Ocak 2001 ile Kasım 2011 tarihleri arasında jinekolojik kanser ön tanısı ile ameliyat edilen 231 hasta geçmişe yönelik incelendi. Bulgular: 2001-2006 yılı ilk yarısı arası dönemi kapsa- yan ilk grup jinekolojik kanserler arasında en sık tanı ko- nan over kanserleridir. 2006 yılı ikinci yarısından 2011 yılı sonuna kadar olan dönemi kapsayan ikinci grupta ise en sık jinekolojik kanser yine over kanserleridir. Ancak en- dometrium kanseri oranında artış olduğu bulundu. Over kanserli hastaların büyük bölümünü ileri evreli olgular oluştururken, endometrium kanserli olguların büyük bö- lümünün ise evre 1 olgulardan oluştuğu bulundu. Ağrı şikâyeti ile başvuran Endemetrium kanserli 6 olgunun 4’ ünde hastalık ileri evrede tanınmıştır. Tüm dünyada ve özellikle de sosyoekonomik düzeyi düşük toplumlarda en sık jinekolojik kanser olan serviks kanseri bölgemizde sık- lık bakımından endometrium kanserinden sonra 3. sırada yer almıştır. Sonuç: Sonuç olarak, bölgemizde son yıllarda en sık ar- tış gösteren jinekolojik kanser endometrium kanseridir. Kötü beslenme, sosyoekonomik düzeyin yükselmesi gibi nedenlerle artan obezite sıklığı ile endometirum kanseri sıklığı artışı ilişkili olabilir. Özellikle over kanserli olguların erken evre de tanı konulabilmesi için sağlık çalışanları ve halk bilgilendirilmelidir.