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    Effects of Adnexal Torsion on the Fallopian Tube in Rats A Histologic and Immunohistochemical Study
    (Sci Printers & Publ Inc, 2014) Tung, Senem Yaman; Agacayak, Elif; Yaman, Neval S.; Deveci, Engin; Kalkanli, Sevgi; Ozler, Ali
    OBJECTIVE: To investigate histopathological and immunohistochemical changes in the Fallopian tube structure following ovarian torsion. STUDY DESIGN: Thirty fertile, female, adult Wistar albino rats, weighing 200-220 g, were randomly divided into 3 equal groups (n=10): sham, torsion, and detorsion. In the torsion and detorsion groups, bilateral adnexal torsion (3-hour ischemia) was carried out. Bilateral adnexal detorsion (3-hour reperfusion) was performed in the detorsion group. Fallopian tube sections were stained hematoxylin and eosin, periodic acid Schiff, Mallory-Azan and immunohistochernically-stained desmin, a smooth actin, and CD68 antibodies. RESULTS: In the sections of the ischemic group, degeneration of epithelium, loss of cilia, dilation of blood vessels, and hemorrhages were observed. Image analysis of the studied Fallopian section revealed a significant decrease in density of desmin in the torsion group. Moreover, strong positive cytoplasmic CD68 expression was observed in the torsion group. CONCLUSION: The use of effective antiinflammatory treatments may contribute to the conservative surgery in preservation of ovarian reserve and tubal structure.