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Analysis of MR imaging of wrists in female patients with carpal tunnel syndrome and healthy controls
(Soc Chilena Anatomia, 2009) Karabulut, Özlen; Tuncer, Mehmet Cudi; Karabulut, Zülfü; Güzel, Ebru
The objective of this study was to evaluate morphological changes of the median nerve in patients with carpal tunnel syndrome (CTS) and healthy controls, to correlate the MRI findings of wrists. This study compared not only morphological changes of the median nerve and also displayed descriptively structures in carpal tunnel between patients diagnosed with idopathic CTS and healthy controls. Our study involved 60 hand, 30 of hand were evaluated diagnosed with idiopathic CTS and 30 hand as healthy controls bilaterally. Two provocative tests (Phalen's and Tinel's test) were performed on each hand for both the patient group (60 wrist) and the control group (60 wrist). With regard to Phalen and Tinel's test results, 24 and 26 wrists were excluded from patient and control groups respectively. Totally 70 wrists were evaluated, and in terms of cross-sectional area of median nerve at the level of distal radioulnar joint, pisiform bone and the hook of hamate bone by MRI in the patient and control groups. In addition to evaluation of cross-sectional area of median nerve, we determined signal intensity of wrists and different localization of the median nerve in the carpal tunnel. Cross-sectional area of the median nerve measured by wrist magnetic resonance at the level of metacarpal bones and signal intensity of wrists may be considered as a valuable indicator to determine patients referred with idiopathic CTS.
Anatomical surgical approach to lateral ventricle masses and histopathological findings of the brain
(Via Medica, 2024) Ünlü, İlker; Alptekin, Mehmet; Tuncer, Mehmet Cudi
Background: The selection of surgical approach to the lateral ventricular masses includes difficulties due to their deep localisations and close proximity to the vascular and the eloquent brain structures. The most appropriate approach that should be chosen in surgical treatment of lateral ventricular masses is still controversial. In this study, the factors in the choice of surgical approach to the lateral ventricle masses and the results of them were investigated. Materials and methods: In this study, 80 patients who underwent surgery in our clinic due to the lateral ventricular masses were retrospectively analysed between the years 2002 and 2013. All the cases were evaluated in terms of clinical and neuroradiological results pre- and postoperatively. In 24 cases the anterior interhemispheric transcallosal, in 4 cases the posterior interhemispheric transcallosal, in 30 cases the posterior interhemispheric precuneal, in 14 cases the transcortical, and in 8 cases the combined surgical approaches were performed. Results: Gender distribution of the cases were 45 male/35 female, and the mean age of them was 31.7 years (7 month — 73 years). In 64 patients the gross total resection was performed, whereas in 16 patients subtotal resection was performed due to the infiltration of eloquent brain areas. In the histopathological examination 52 neuroepithelial, 8 mixed neuroglial, 3 meningeal, 2 lympho-hematopoietic system, 1 pine blastoma, 1 germ cell, 5 metastatic, and 8 other benign masses were observed. After surgery, additional neurological deficits developed in 9 patients. Mortality was observed in 6 patients postoperatively. The average follow-up time was 13 (1–83) months. Conclusions: The essential factors that affect the results of surgical treatment of lateral ventricular masses are the size of the mass, histopathology, location, extension, and the relationship with the neurovascular structures. The goal of surgery is to provide a histopathological diagnosis, gross total resection, if possible, and to normalise the flow of cerebrospinal fluid by eliminating the mass effect of pressure. © 2024 Via Medica.
Apoptotic effect of thymoquinone on OVCAR3 cells via the P53 and CASP3 activation
(Acta Cirurgica Brasileira, 2024) Karaosmanoglu, Ozge; Kamalak, Zeynep; Ozdemir, Ilhan; Tuncer, Mehmet Cudi; Ozturk, Tamil
Purpose: The limitations in cancer treatment and the inadequacy of classical methods have made it necessary to discover therapeutics in cancer treatment. The cytotoxicity of thymoquinone, which has quite different properties in terms of biological activities, in ovarian cancer cells, and the changes in the expression levels of apoptotic genes (p53/caspase-3 (casp-3)) were investigated. Methods: In the study, thymoquinone (5, 50, 100, 250 and 500 mu M and 24, 48, 72 hours) were applied to ovarian adenocarcinoma cancer cell line (OVCAR3), at different concentrations. Cytotoxic effect of thymoquinone on OVCAR-3 cells were analyzed by MTT method, and apoptotic and pro-apoptotic gene expression levels (p53, Casp-3) of thymoquinone in cancer cells were analyzed by quantitative real-time polymerase chain reaction. Results: Thymoquinone, whose effect has been revealed in many types of cancer, was shown to significantly reduce the viability of OVCAR3 cancer cells depending on the dose and time (p < 0.05). It was also determined that Casp-3 and p53 gene expressions increased in OVCAR3 cells. Conclusion: Considering the in-vitro cytotoxic activity and apoptotic gene expressions of thymoquinone, an important treatment agent, since it is a promising agent for the future of cancer treatment, more comprehensive studies may pave the way for its clinical use.
Audiological evalutation of the cochlear nerve with brainstem evoked response audiometry in patients with COVID-19
(Pisa Univ Press, 2022) Tas, Abdurrahim; Haznedar, Berzan; Tuncer, Mehmet Cudi
Purpose: In this clinical study, it was aimed to prospectively evaluate the cochlear nerve with brainstem evoked response audiometry (BERA) in terms of audiological ailments in patients with COVID-19. Although the relationship of COVID-19 with tinnutus and hearing loss has been investigated since the day this infectious respiratory disease emerged, its relationship with BERA has not been fully demonstrated from a neurological perspective.Methods: It was carried out on a group of patients who had COVID-19 in the last 6 months between February and August 2021 in Diyarbakir Gazi Yasargil Training and Research Hospital. Patients between the ages of 18-50, who applied to the otorhinolaryngology and neurology clinic and had COVID-19 in the last 6 months, were selected. The COVID-19 group of our study consisted of 30 patients, 18 males and 12 females, who had had COVID-19 disease in the last 6 months, and 30 healthy individuals, 16 males and 14 females, as the control group.Results: In patients with COVID-19, the evaluation of the destruction of the cochlear nerve with BERA showed that there was a statistically significant prolongation in I-III and I-V interpeaks at 70, 80 and 90 db nhl.Conclusions: Statistically significant prolongation of especially I-III and I-V Interpeaks in BERA showed that COVID-19 has the potential to cause neuropathy. We believe that the BERA test should be considered in the neurological evaluation of cochlear nerve damage in patients with COVID-19 as a differential diagnosis.
Balo's concentric sclerosis in a patient with spontaneous remission based on magnetic resonance imaging: A case report and review of literature
(Baishideng Publishing Group Co, 2018) Ertuğrul, Özgür; Çiçekçi, Esra; Tuncer, Mehmet Cudi; Aluçlu, Mehmet Ufuk
Balo's concentric sclerosis (BCS) is a rare monophasic demyelinating disease known as multiple sclerosis subtype and seen as a round lesion with variable hyper and hypodetoxification layers. Characteristic appearance can be seen as "bulb eye" or "onion bulb". The initial terminology for this neurological disorder was leukoencephalitis periaxialis concentrica; this is defined as a disease in which the white matter of the brain is destroyed in concentric layers in such a way as to leave the axial cylinders intact. This report presents a case of BCS with spontaneous healing of the patient and a mass lesion with concentric rings adjacent to the left lateral ventricle and the posterior portion of the corpus callosum with peripheral vasogenic edema. The neurological lesion of the patient was similar to the magnetic resonance imaging and clinical findings of the BCS.
Biochanin A restored the blood-brain barrier in cerebral ischemia-reperfusion in rats
(Assoc Medica Brasileira, 2024) Karaaslanli, Abdulmutalip; Asir, Firat; Gursoy, Gorkem Tutal; Tuncer, Mehmet Cudi
OBJECTIVE: Blood-brain barrier is a protective layer that regulates the influx and efflux of biological materials for cerebral tissue. The aim of this study was to investigate the effects of Biochanin A on cerebral histopathology and blood-brain barrier immunohistochemically. METHODS: A total of 24 rats were assigned to three groups: sham, ischemia-reperfusion, and ischemia-reperfusion+Biochanin A. Ischemiareperfusion was performed by occluding the left carotid artery for 2/24 h. Notably, 20 mg/kg Biochanin A was administered to rats for 7 days after ischemia-reperfusion. Blood was collected for malondialdehyde and total oxidant/antioxidant status analysis. Cerebral tissues were processed for histopathology and further for immunohistochemical analysis. RESULTS: Malondialdehyde content with total oxidant status value was significantly increased and total antioxidant status values were significantly decreased in the ischemia-reperfusion group compared with the sham group. Biochanin A treatment significantly improved scores in the ischemiareperfusion+Biochanin A group. The normal histological appearance was recorded in the cerebral sections of the sham group. Degenerated neurons and vascular structures with disrupted integrity of the cerebral cortex were observed after ischemia-reperfusion. Biochanin A alleviated the histopathology in the cerebrum in the ischemia-reperfusion+Biochanin A group. Ischemia-reperfusion injury decreased the expression of blood-brain barrier in the ischemia-reperfusion group compared to the sham group. Administration of Biochanin A upregulated the blood-brain barrier immunoreactivity in the cerebrum by restoring blood-brain barrier. CONCLUSION: Cerebral ischemia-reperfusion caused an increase in oxidative stress and pathological lesions in the cerebrum. Biochanin A treatment restored the adverse effects of ischemia-reperfusion injury by restoring blood-brain barrier.
Can paricalcitol increase the effectiveness of N-acetylcysteine in contrast induced acute kidney prophylaxis in rats? A biochemical and histopathological study
(Universidad de la Frontera, 2022) Yıldırım, Yaşar; Bahadır, Veysi; Aydın, Emre; Aydın, Fatma Yılmaz; Yılmaz, Zülfükar; Ketani, Aydın; Kaplan, İbrahim; Tuncer, Mehmet Cudi; Kadiroǧlu, Ali Kemal; Yılmaz, Mehmet Emin
N-Acetylcysteine (NAC) is used for contrast induced acut kidney injury (CI-AKI) prophylaxis because of its antioxidant effects. Paricalcitol, which has reno-protective effects, is likely to provide a more effective prophylaxis when added to NAC treatment. The study was designed based on this hypothesis. The study was organised to include 4 groups each consisting of 7 rats. Group 1 was the control group, and Group 2 included rats with CI-AKI. Rats in Group 3 were administered NAC at a dose of 100 mg/kg via oral gavage once a day for 5 days. Rats in group 4 were administered paricalcitol at a dose of 0.4 mcg/kg once a day for 5 days in addition to NAC. CI-AKI was induced after the treatments in both groups. The study was terminated on the sixth day. Samples were collected from the rats’ sera and kidney tissues to study oxidant and antioxidant parameters; kidney function tests were also studied. There were significant differences between the contrast nephropathy group (Group 2) and NAC and NAC+paricalcitol groups with respect to serum urea and creatinine levels. When the same groups were compared regarding oxidant (TOS-MDA) and antioxidant (TAC-Paraoxonase) parameters, we observed that the oxidant parameters increased in serum and kidney tissue samples with NAC use, and that effect was strengthened by the addition of paricalcitol to NAC treatment. However, despite increased antioxidant effectiveness, we observed no decrease in urea and creatinine levels when paricalcitol was added for CI-AKI in rats. There was no significant difference between Group 3 and Group 4. Paricalcitol provides a more potent antioxidant effect in both serum and kidney tissue samples when added to NAC treatment in rats with CI-AKI. Despite increased antioxidant parameters, however, paricalcitol does not provide a significant decrease in urea and creatinine levels.
Comparison of ependymomas and medulloblastomas located in the posterior cranial fossa: An anatomical and histopathological study
(Pisa University Press, 2020) Yılmaz, Tevfik; Öztürk, Pınar Aydın; Başar, İbrahim; Turan, Yahya; Aslanoğlu, Barış; Aydın, Kamuran; İbiloğlu, İbrahim; Tuncer, Mehmet Cudi
PURPOSE: Posterior fossa tumors (PFTs) include medulloblastomas, atypical teratoid/rhabdoid tumors, pilocytic astrocytomas, ependymomas, and brainstem gliomas. We evaluated patients with surgery at our clinic, comparing epidemiological, clinical, radiological, and pathological characteristics of medulloblastoma and ependymoma to identify factors that might assist preoperative diagnosis, help to develop treatment algorithms, and have prognostic value after surgery. METHODS: Pediatric patients from 0 to 16 and young adults from 16 to 29 years of age with surgery for pathologically confirmed ependymomas or medulloblastomas between January 2014 and January 2020 were eligible. The study included 19 patients, seven with ependymoma (37%) and 12 with medulloblastoma (63.2%). The ependymoma patients were 5.29 +/- 5.85 years of age, the medulloblastoma patients were 11.58 +/- 8.17 years of age, and 16 patients (84%) were children. RESULTS: Fifteen patients (79%) presented with signs of increased intracranial pressure and four (21%) presented with cerebellar findings. MRI found that 74% (14) of the PSTs were located in the midline, including six of the seven ependymomas (86%) and eight of the 12 medulloblastomas (67%). Enhancement was significantly greater in medulloblastomas compared with ependymomas (p = 0.022). In according to pathology results; synaptophysin, NSE, chromogranin and 50% GFAP positivity were observed in medulloblastoma. Ependymomas were S100 (43%) and vimentin (29%) positive. Ependymoma patients were younger than medulloblastoma patients and more were female. Conclusions: There were no significant differences in the clinical findings, but ependymomas were larger and had greater rates of enhancement and spinal metastasis compared with medulloblastomas.
Comparison of the clinical efficacy of two different types of post systems which were restored with composite restorations
(Baishideng Publishing Group Inc, 2018) Ayna, Buket; Ayna, Emrah; Celenk, Sema; Basaran, Emine Goncu; Yilmaz, Berivan Dundar; Tacir, Ibrahim Halil; Tuncer, Mehmet Cudi
AIM To compare the efficacy of resin composite restorations, retained with either polyethylene or zirconia-rich glass fiber posts. METHODS Sixty-two single rooted maxillary and mandibular central incisor teeth in forty-four patients (15 males and 29 females; age range 15-32 years) were restored either with an ultrahigh molecular weight polyethylene (UHMWP) fiber post (Bondable Reinforcement Ribbon, DENSE, Ribbond, Seattle, WA, United States) or a zircon-rich glass fiber post (Snowpost, Lot H 040; Carbotech, Ganges, France). Then, direct resin composite restoration (Clearfil AP-X, Kuraray) was performed for both post systems in tooth color suitable. Patients were recalled for routine inspections at 6 mo, 1, 2 and 3 years. RESULTS The restorations were assessed during each recall evaluation according to predetermined clinical and radiographic criteria (periapical lesion; marginal leakage and integrity; color stability; surface stain and loss of retention of the post or the composite buildup material). The follow-up data showed no significant difference in these criteria between polyethylene fibre posts and zirconia-rich glass fibre posts. CONCLUSION The efficacy of resin composite restorations, retained with either polyethylene or zirconia-rich glass fiber posts were similar, suggesting that both types of fiber post can be used successfully to help retain resin composite restorations.
Corpus callosum alan ve boyut ölçümlerinin erişkin bireylerde cinsiyet ve el kullanım dominantlığı ile olan ilişkisinin MR ile incelenmesi
(Dicle Üniversitesi, Sağlık Bilimleri Enstitüsü, 2001) Tuncer, Mehmet Cudi; Doğruyol, Şükrü
Corpus callosum alan ve boyut olarak geniş bir spektrumda Magnetik Resonans Görüntüleme (MRG) yöntemi ile izlenebilmektedir. Fakat bu alan ve boyutların sınırları tam olarak belirlenememiştir. Anatomi ve Radyodiagnostik Anabilim dallarında yapılan çalışmalarda farklı yaş gruplarında el kullanım dominantlığı ve cinsiyet faktörü ile corpus callosum boyutları arasında bir ilişki kurulmaya çalışılmıştır. Bu çalışmada, alan ve boyut ölçümleri erişkin bireylerde el kullanım dominantlığı ve cinsiyet faktörü dikkate alınarak corpus callosum morfolojisinde nasıl bir farklılığın olabileceği araştırıldı. İncelemeler spin eko sekanslarıyla elde edilen T1 ağırlıklı görüntülerle cranial midsagittal kesitlerde yapıldı. Olguların tümü, 1 Tesla (T) gücünde SIEMENS EXPERT MR sistemi ile görüntülendi. Gruplar arasındaki parametreler student-t testi ile karşılaştırılmıştır. Sonuç olarak, corpus callosum'a ait uzunluk parametrelerinde tüm gruplarda istatistiksel olarak anlamlı bir sonuç elde edilemedi. Corpus callosum'a ait alan parametrelerinde ise; sol elini kullanan grubun anterior ve posterior corpus callosum gövde alanı ile isthmus alanları sağ elini kullananlara göre daha büyük bulunup farkın anlamlı olduğu saptandı. Sol elini kullanan grup içinde cinsiyet faktörünün önemli olmadığı görüldü. Sağ elini kullanan grup içinde erkeklerin rostrum ve isthmus alanlarının bayanlara oranla daha büyük olduğu tespit edildi. Sol elini kullanan bayanlar ile sağ elini kullanan bayanlar arasındaki parametreler arasında anlamlı bir farkın olmadığı ortaya çıktı. Erkekler arasında aynı parametreler değerlendirildiğinde anterior ve posterior corpus callosum gövde alanlarının sol elini kullanan erkeklerde daha büyük olduğu tespit edildi. El kullanımına bakılmaksızın bayanlar ile erkekler arasındaki parametreler karşılaştırıldığında erkeklerde rostrum alanı ile posterior corpus callosum alanının daha büyük olduğu belirlendi Corpus callosum'un subgrupları üzerine yapılan bu çalışmada el kullanımı ile cinsiyet faktörünün erişkin bireylerde CC alanı ve boyutları üzerinde bir farklılık yarattığı ve bu farklılıkların cinsiyet ve el kullanım tayininde ayırt edici bir özelliğinin olduğu sonucuna varıldı.
Effect of napabucasin and doxorubicin via the Jak2/Stat3 signaling pathway in suppressing the proliferation of neuroblastoma cells
(Acta Cirurgica Brasileira, 2024) Unlu, Ilker; Tuncer, Mehmet Cudi; Ozdemir, Ilhan
Purpose: Napabucasin (NP) is a natural compound that can suppress cancer cell proliferation and cell cycle by inhibition of the signal transducer and activator of transcription 3 (STAT3) gene. We examined the effects of NP on the proliferation and invasion of neuroblastoma cells (SH-SY5Y). Methods: Human neuroblastoma SH-SY5Y cell line was used in this study. NP was administered to groups at the doses of 0.3-1 mu M. Cell viability was analyzed by MTT assay. Real-time quantitative reverse transcription polymerase chain reaction and western blot analysis assessed the expressions of interleukin (IL)-6 dependent Jak2/Stat3 signaling pathway. The MTT cell viability method was applied to determine the antagonistic-synergistic effects and inhibitory concentration (IC50) doses of doxorubicin (DX) and NP. Results: It was determined that 0.3-1 mu M doses of NP killed the cells almost completely after 48 hours, and also that Jak2/Stat3 expressions decreased dose-dependently via IL-6. At the protein level, NP and DX were found to reduce Jak2 and Stat3 levels. Conclusion: NP showed that it suppresses the proliferation of neuroblastoma cells. Due to its inhibitory effect on Jak2 and Stat3, it can be used to prevent invasion of SH-SY5Y cells. NP, which can inactivate Jak2/Stat3, can be used as a treatment agent by combining with DX in proliferation pathway in neuroblastoma.
Effects of Curcumin and Doxorubicin on the Viability of Neuroblastoma Cancer Cell Line
(2024) Ünlü, İlker; Özdemir, İlhan; Öztürk, Şamil; Tuncer, Mehmet Cudi
Aim: Neuroblastoma has a very important place among childhood diseases, and despite all the methods used in treatment, it is very difficult to prevent neuroblastoma invasion. The number of studies showing that curcumin, the most active component of turmeric, is not toxic, is increasing day by day. In this study, the anticancer activities of curcumin (Cur), one of the important active compounds, were demonstrated in the Neuroblastoma cancer cell line (Na2B). Method: Neuroblastoma cell line was used in the study. To determine the IC50 doses of Dox and Cur, Na2B cells line were cultivated with an automatic pipette. MTT analysis was performed to analyze cell survival (viability). Inhibition levels in the cells were determined at 24 and 48 hours. Results: While the IC50 of Na2B cell proliferation was approximately 124.5 uM at the 48th hour in Dox-treated cells, the IC50 value of Cur at the 48th hour was found to be 224.6 uM. Conclusion: These results showed that Cur could be an alternative agent in the treatment of neuroblastoma, and its fewer side effects compared to other chemotherapeutic agents such as Dox would increase its preferability.
Effects of Ischemia/Reperfusion on ? Cells of Pancreas and Protective Effects of Melatonin Treatment
(Soc Chilena Anatomia, 2009) Yildirim, Ayse; Tuncer, Mehmet Cudi; Pamukcu, Oezlem; Aktas, Ayfer; Akkus, Murat
Oxygen free radicals are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia-reperfusion (I/R). In this study, we investigated the putative protective effects of melatonin treatment on pancreatic I/R injury. Sprague Dawley male rats were subjected to 30 min of pancreatic pedicle occlusion followed by 90 min reperfusion. Melatonin (10 mg/kg. s.c) was administrated 30 min prior to ischemia or I/R application. At the end of the reperfusion periods, rats were decapitated. Pancreatic samples were taken for transmission electron microscopy. The results indicated that ischemia created b cell damage as evidenced by dilatation between the nucleus inner and outer membrane and degeneration on islets of Langerhans cells, was reversed by melatonin treatment. As melatonin administration reversed these microscopic damage, it seems likely that melatonin protects pancreatic tissue against oxidative damage.
Effects of ischemia/reperfusion on ß cells of pancreas and protective effects of melatonin treatment
(Universidad de la Frontera, 2009) Yıldırım, Ayşe; Tuncer, Mehmet Cudi; Pamukçu, Özlem; Aktaş, Ayfer; Akkuş, Murat
Oxygen free radicals are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia-reperfusion (I/R). In this study, we investigated the putative protective effects of melatonin treatment on pancreatic I/R injury. Sprague Dawley male rats were subjected to 30 min of pancreatic pedicle occlusion followed by 90 min reperfusion. Melatonin (10 mg/kg. s.c) was administrated 30 min prior to ischemia or I/R application. At the end of the reperfusion periods, rats were decapitated. Pancreatic samples were taken for transmission electron microscopy. The results indicated that ischemia created b cell damage as evidenced by dilatation between the nucleus inner and outer membrane and degeneration on islets of Langerhans cells, was reversed by melatonin treatment. As melatonin administration reversed these microscopic damage, it seems likely that melatonin protects pancreatic tissue against oxidative damage.
The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats
(Springer, 2009) Dokucu, Ali Ihsan; Ozturk, Hulya; Ozturk, Hayrettin; Tuncer, Mehmet Cudi; Yilmaz, Fahri
This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1 alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury. Torsions were created by rotating ipsilateral testes 720A degrees in a clockwise direction for 6 h and 1-h detorsion of the testis was performed. A sham operation was performed in group 1 (control, n = 7). In group 2 (I-R/Untreated, n = 7), following 6 h of unilateral testicular torsion, 1-h detorsion of the testis was performed. No drug was given. In group 3 (I-R/MO), after performing the same surgical procedure as in group 2, a NO donor MO was given at the starting time of reperfusion. In group 4 (I-R/L-NAME), after performing the same surgical procedure as in group 2, L-NAME was given at the starting time of reperfusion. Testes malondialdehyde (MDA) levels were determined as well as examining the testes histologically. Treatment of rats with MO produced a significant reduction in the levels of MDA and histopathological score compared to testes I-R groups. The Sonic hedgehog (Shh) expression in the basement membrane of the tubuli seminiferi, and sertoli and germinal cells in testicular tissue, were greatly increased in the I-R/MO group compared to groups 1, 2 and 4. Additionally, the HIF-1 alpha expression in the interstitial spaces in testicular tissue were greatly increased in the I-R/MO group. The results suggest that MO has a protective effect against ischemia/reperfusion injury in rat testes and may affect Shh and HIF-1 alpha signaling pathway.
The Effects of Valproic Acid on Sciatic Nerve of Fetal Rats and Protective Effects of Folic Acid and Vitamin E
(Soc Chilena Anatomia, 2009) Aluclu, Mehmet Ufuk; Tuncer, Mehmet Cudi; Guzel, Aslan; Aluclu, Mustafa Arif; Akkus, Murat
We aimed to investigate the potential harmful effects of maternal valproic acid (VPA) on fetal sciatic nerve, and the protective effects of vitamin E (Vit E) and folic acid (FA) on fetal rats. Valproic acid (400 mg/kg), folic acid (400 mg/kg) and vitamin E (250 mg/kg) were administered to rats on each of gestation days 8-10. All fetuses were collected on gestation day 20. With thin sections of biopsies, sciatic nerve of fetuses were stained with uranyl acetat and were examined under transmission electron microscope. The fetuses (n:36) were divided into five groups: control, vpa, vpa+fa, vpa+vit e and vpa+fa+vit e groups. In each group; drug procedure, surgical procedure and histological methods were performed. Later, weights and lengths of fetuses in each group were compared and analyzed by One-Way Anova test. Administration of single doses of valproic acid (400 mg/kg) resulted in weight and length loss between control and vpa group. However, length and weight differences between the other groups were not significant. The histopathological findings of control group was normal. In vpa group, it showed extensive degenerative changes especially in myelin coat. In addition, most prominent finding in this group was condensation of collagen fibers in extensively demyelinated samples, while moderately effected areas were relatively normal. Both vpa+fa and vpa+vit e groups exhibited similar ultrastructural changes, reflecting minimal to moderate degenerative changes. In vpa+fa+vit e group had almost the normal structure. Administration of single doses of valproic acid (400 mg/kg) resulted in a deteriorative effect on sciatic nerve at ultrastructural level. Administration of FA and Vit E had a protective effect to prevent the degenerative changes to a certain degree. Combination of FA and Vit E together following VPA administration had a more potent protective effect. The objective of the present study is to analyze histopathologic changes which may occur in a high risk experimental model after the administration of valproic acid. In addition, protective roles of the administration of folic acid and vitamin E are assessed.
Evaluation of Bond Strength of Different Repair Methods Applied in PEEK Infrastructure Restorations
(Sci Printers & Publ Inc, 2021) Yilmaz, Berivan Dundar; Cetinkaya, Numan; Polat, Zelal Seyfioglu; Unal, Server Mutluay; Tuncer, Mehmet Cudi
OBJECTIVE: To evaluate the appropriate intraoral repair procedures in PEEK (polyetheretherketone) restorations when there is a veneer fracture. STUDY DESIGN: The study groups were formed according to the presence or absence of fractured veneer material of PEEK restorations. PEEK specimens (N = 91) were prepared with CAD/CAM in dimensions of 5 x 5.4 x 13 mm and divided into 13 groups including the positive control group. 5000 thermocyclic was applied to the specimens, and then the repair bond strength (RBS) was made at a speed of 0.5 mm/min. The fracture surfaces of the specimens were examined under a stereomicroscope. SEM, EDX, XRD, AFM, and surface contact angle analyses were performed in terms of roughened surfaces of PEEK (N = 16). One-way ANOVA and independent sample t test were used for data analysis (alpha = 0.05). RESULTS: The efficiency of surface treatment, the roughness and wettability of the acid and Co-Jet groups have increased. Acid etching was found to be the most effective surface treatment. The RBS values of the Super-Bond groups in the repair procedures were found to be higher than the Visio.link group and were statistically significant (p = 0.002). When evaluating failure modes, the mode most encountered among all groups was the mixed mode, and least was the cohesive mode. CONCLUSION: The presence or absence of fractured veneer during the repair of PEEK-based restorations does not affect the values of repair bond strength, and RBS values were also not statistically significant.
Evaluation of bond strength of different repair methods applied in PEEK infrastructure restorations
(SCI Printers & Publication INC, 2022) Yılmaz, Berivan Dündar; Çetinkaya, Numan; Polat, Zelal Seyfioğlu; Ünal, Server Mutluay; Tuncer, Mehmet Cudi
OBJECTIVE: To evaluate the appropriate intraoral repair procedures in PEEK (polyetheretherketone) restorations when there is a veneer fracture. STUDY DESIGN: The study groups were formed according to the presence or absence of fractured veneer material of PEEK restorations. PEEK specimens (N = 91) were prepared with CAD/CAM in dimensions of 5 x 5.4 x 13 mm and divided into 13 groups including the positive control group. 5000 thermocyclic was applied to the specimens, and then the repair bond strength (RBS) was made at a speed of 0.5 mm/min. The fracture surfaces of the specimens were examined under a stereomicroscope. SEM, EDX, XRD, AFM, and surface contact angle analyses were performed in terms of roughened surfaces of PEEK (N = 16). One-way ANOVA and independent sample t test were used for data analysis (alpha = 0.05). RESULTS: The efficiency of surface treatment, the roughness and wettability of the acid and Co-Jet groups have increased. Acid etching was found to be the most effective surface treatment. The RBS values of the Super-Bond groups in the repair procedures were found to be higher than the Visio.link group and were statistically significant (p = 0.002). When evaluating failure modes, the mode most encountered among all groups was the mixed mode, and least was the cohesive mode. CONCLUSION: The presence or absence of fractured veneer during the repair of PEEK-based restorations does not affect the values of repair bond strength, and RBS values were also not statistically significant.
Evaluation of the Singh index and Femur Geometry in Osteoporotic Women
(Sciendo, 2010) Karabulut, Ozlen; Tuncer, Mehmet Cudi; Karabulut, Zulfu; Hatipoglu, Eyup Savas; Nazaroglu, Hasan; Akkus, Zeki
We aimed to compare the Singh index with bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA), body mass index (BMI) and femur geometry in the right proximal femur of osteoporotic women, using different statistical tests. Radiographs of each patient were assessed to determine the Singh index by five observers. The observers consisted of a consultant radiologist, physical therapist and anatomists who studied the series of radiographs. They were asked to apply the Singh index by comparing the trabecular bone pattern in the proximal right femur with the reference scale published by Singh et al. [1]. This has a six point scale from grade VI to grade I. We evaluated 47 osteoporotic women in this study. The subjects' mean age, weigth, and height were 63,21 +/- 10,106, 66,72 +/- 12.523, 154,94 +/- 7,026 respectively. We found a significant relationship between the Singh index and BMD. The Singh index correlated significantly with hip axis length, femoral neck diamater and trochanteric width. And, BMD correlated significantly with femoral head and neck diameter, femoral neck cortex width, medial calcar femoral cortex width and femoral shaft cortex width. The evaluation of the Singh index grades in its self, there was a significant relation among them.
Foremen scapulae osseum
(2005) Hatipoğlu, E. Savaş; Tuncer, Mehmet Cudi; Tacar, Orhan
Dicle Üniversitesi Tıp Fakültesi Anatomi Anabilim Dalı'nda bulunan scapula kemiklerinden bir tanesinde foramen scapulae ossesum anomalisi saptadık. Proc.coracoideus'un tabanının medialinde bulunan incisura scapulae'nın, lig.transversum scapula superius'un ossifiye olmasıyla foramen scapulae osseum'a dönüştüğünü gözlemledik. Oluşabilecek dar bir for.scapulae osseum, n.suprascapularis'in periferik kısmına tam bir baskı oluşturabilir (m.supraspinatus ve m.infraspinatus parezisi). Bu anomalinin n.suprascapularis'in parazilerinin değerlendirilmesinde önemli bir yeri vardır.

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