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    Oc ular Surface Findings in Chronic Renal Failure
    (Modestum Ltd, 2014) Turkcu, Fatih Mehmet; Turkcu, Gul; Temiz, Gokhan; Yuksel, Harun; Tas, Mehmet; Tunc, Nurettin
    The purpose of this study was to describe the ocular surface findings in chronic renal failure (CRF). Sixty eyes of 30 patients with CRF group and 70 eyes of 35 healthy subjects were evaluated. Schirmer-I, tear film break-up time tests and conjunctival impression cytology were performed in addition to complete ophthalmologic examination. The presence of dry eye symptoms and conjunctival calcification were noted. The groups were age and gender matched. The mean break-up time was 10.3 +/- 3.1 in group-1 and 11.2 +/- 1.7 seconds in the group-2 (p=0.03). The mean Schirmer score was 11.2 +/- 2.8 mm and 12.0 +/- 1.7 mm in the CRF and control group (p=0.095), respectively. In CRF group, conjunctival impression cytology was revealed as grade-0 findings in 16 eyes, grade 1 findings in 41 eyes and grade 2 findings in 3 eyes, in control group, it was revealed grade-0 findings in 48 eyes, grade 1 findings in 22 eyes and showed no changed in grade 2 (p<0.001). In CRF group, conjunctival calcification was regarded as grade 0 findings in 18 eyes, grade 1 findings in 34 eyes and grade 2 findings in 8 eyes. Grade 0 changes were seen in all subjects in group 2 (p< 0.001). Itching (45%), redness (95%) and foreign body sensation (83%) were observed more frequently in the CRF group and also in all eyes with conjunctival calcification in both groups (p<0.001). Chronic renal failure patients suffer more than normal subjects from ocular surface complaints because of conjunctival calcifications and tear film instability although they have the same tear production with their contemporaries.
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    Öğe
    Serum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarum
    (Wiley-Blackwell, 2016) Tunc, Senem Yaman; Agacayak, Elif; Budak, Sukru; Tunc, Nurettin; Icen, Mehmet Sait; Findik, Fatih Mehmet; Ekinci, Aysun
    Aim: To investigate whether serum levels of neopterin and inflammatory markers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and oxidative status indicators were altered in patients with hyperemesis gravidarum (HG) compared to asymptomatic pregnant women. Methods: This cross-sectional study was performed including 30 pregnant women with HG (mean age: 30.67 +/- 6.68) and 30 asymptomatic pregnant women (mean age: 28.00 +/- 5.30). Demographic features, obstetric history, and the Pregnancy Unique Quantification of Emesis/Nausea (PUQE) index were noted. Complete blood count, serum biochemical assay and measurement of CRP, TNF-alpha, IL-6, total antioxidant status and total oxidative status (TOS) levels were taken and compared between groups. Results: White blood cell count (P = 0.013), platelet count (P = 0.015), TOS (P < 0.001), and PUQE score (P < 0.001) were remarkably higher in HG pregnancies. On the other hand, serum levels of lactate dehydrogenase, (P < 0.001), sodium (P < 0.001), potassium (P < 0.001), chloride (P < 0.001) and TAS (P < 0.001) were higher in the control group. There was no difference in the levels of neopterin, CRP, TNF-alpha and IL-6. In patients with HG, a positive correlation was detected between TOS and serum levels of lactate dehydrogenase, while TNF-alpha, IL-6 and neopterin were positively correlated with hemoglobin levels. Conclusion: Our results demonstrated no association between inflammation and HG. Elucidation of the pathophysiology and complex interaction between various inflammatory processes in HG necessitates further trials on larger series.