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    The Composition and Biologic Actions of Mineral Trioxide Aggregate: A Review
    (Duzce Univ, 2013) Toptanci, Ismet Rezani; Dalli, Mehmet; Colak, Hakan
    Aim: Mineral Trioxide Aggregate (MTA) is widely used in clinical application such as pulp capping, perforation repair, root-end sealing, canal filling at internal and external root resorption and pulpotomies in primary and permanent teeth. In endodontic field when using a material such as MTA the interaction between material and periapical tissue is so important for healing and life time of endodontic therapy. Although it is sealing ability, the interaction with cells or tissues and their replay to this material play major role for endodontic success. Methods: Literature review was performed using electronic and hand-searching methods for the clinical applications, experimental studies and cellular studies of MTA between 2000 and 2010. Results: MTA is a bioactive material when using vital pulpotomies, apical barrier formation for necrotic pulps and open apices. Numerous study and case reports show MTA is more effective material than other materials in these cases. Many studies have shown the effects of MTA on cementoblasts and odontoblasts. Conclusion: This review shows its composition, biologic action when used different endodontic procedure and interaction between cell and tissues.
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    Dental students’ knowledge level regarding the use of antibiotics in endodontic infections in pediatric patients
    (Universitas Airlangga, Faculty of Dental Medicine, 2025) Dogan, Gizem Karagoz; Toptanci, Ismet Rezani
    Background: Endodontic infections frequently occur in children and stand out as dental issues where antibiotics are widely favored. However, the recent overuse of antibiotics has resulted in the development of antimicrobial resistance in children. The awareness and understanding dental students have regarding the application of antibiotics for treating endodontic infections in pediatric patients have been explored in limited studies. Purpose: This study aims to evaluate the understanding of fourth- and fifth-year dentistry students—who are actively involved in patient care during their internships and will soon become medical professionals—about prescribing antibiotics to treat endodontic infections. Methods: This study was conducted using the Google Form electronic survey method on intern students at three different faculties of dentistry who have started their clinical internships. Results: Data were obtained from 468 participants who responded to the survey within the scope of the study. Statistically significant differences were observed in terms of knowledge level between those who were informed and those who were not about general antibiotic knowledge, prescription awareness, pediatric antibiotics dose calculations, and parenteral antibiotic applications, as well as between the places where they were informed; the same difference was observed between those who considered the information they received sufficient and those who did not (p < 0.05). Conclusion: The results of the study indicate that dental students have inadequate knowledge about the use of antibiotics in children with endodontic infections. Nevertheless, the study concludes that the knowledge level of the students can be improved through various training and educational programs. Copyright © 2025 Dental Journal (Majalah Kedokteran Gigi)
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    Evaluation of serum levels in children with delayed eruption
    (Bmc, 2024) Sahin, Meryem; Toptanci, Ismet Rezani
    AimThis study aimed to assess levels of 25-hydroxy vitamin D (25(OH)D-3), calcium (Ca+2), phosphorus (P), and parathyroid hormone (PTH) and to determine delayed tooth eruption by examining their correlations. Material and methodThe study included 101 paediatric patients, aged 6-14 years, who visited the Dicle University Paediatric Dentistry Clinic, had no systemic diseases, and had not received medication in the past three months. Among them, 60 patients exhibited delayed eruption of their permanent central and first molar teeth, while 41 did not. Serum levels of 25(OH)D3, Ca+2, P, and PTH were measured. Statistical analyses were performed using IBM SPSS software, with statistical significance set at p < 0.05. ResultsSerum levels of 25(OH)D3 and Ca+2 were significantly lower in the patient group, whereas PTH levels were significantly lower in the control group (p < 0.05). However, serum P levels did not differ significantly between the groups (p > 0.05). ConclusionsSerum parameters play a significant role in tooth eruption. The significance of vitamin D has increased because of its physiological effects and involvement in metabolic pathways, highlighting the need to examine Ca+2, P, and PTH levels, which contribute to its regulation. Low levels of vitamin D and Ca+2, along with elevated PTH levels, have been identified as potential factors contributing to delayed tooth eruption, whereas P levels do not appear to have a significant impact. In view of the ongoing growth and development in this patient group, regular monitoring of vitamin D, Ca+2, and PTH levels, along with timely interventions, is essential. Trial registrationTCTR identification number: TCTR20240729001; registered on 29 July 2024. The trial was registered retrospectively.
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    A microbiological assessment of the oral hygiene of 24-72-month-old kindergarten children and disinfection of their toothbrushes
    (Biomed Central Ltd, 2014) Celepkolu, Tahsin; Toptanci, Ismet Rezani; Bucaktepe, Pakize Gamze Erten; Sen, Velat; Dogan, Mehmet Sinan; Kars, Veysel; Aslanhan, Hamza
    Background: The objective of this study is to assess the index of decayed, missing and filled teeth (DMF-T), habit of brushing teeth, and the microbiological agents accumulating on the children's toothbrushes for 4 weeks and response of these agents to disinfection via a chlorhexidine solution, then compare those results with the education and income levels of the children's parents. Method: Included in the study were 187 children (96 in the control group and 91 in the experiment group - chlorhexidine) chosen randomly from 600 kindergarten children whose ages ranged from 24 months to 72 months. The children selected had not taken any antibiotics, antimicotics for three months and dental treatments during this trial. The distribution of these children to the groups was also done randomly. After performing a survey for the education, occupation, and income status of the parents, the children were examined and the number of decayed teeth was recorded. The children were given toothbrushes, toothpaste (with fluroide), and the solutions (including distilled water and chlorhexidine) for four weeks under the condition that toothbrushes were returned at the end of each week. The 14 different microbiological agents observed as a result of the assessment of the samples taken in the first week were also included in the assessments of the samples taken over the four-week period. Results: The decrease in the DMF-T index was found to be meaningful according to the differences in education, income, and occupation status of the parents. Of all the samples taken from the toothbrushes, the bacteria with the greatest rate of reproduction included Streptococcus mutans, Escherichia Coli, Pseudomonas aeuroginosa, Enterococcus spp, Staphylococcus epidermidis and Candida albicans. Except for Candida albicans, the other microorganisms taken as samples from the toothbrushes reproduced less overall. In the group using the solution with chlorhexidine, a meaningful decrease in bacterial reproduction was discovered compared to the control group. Conclusion: The findings of this study show that the education, occupation, and socioeconomic situations of the parents should be considered when discussing children's oral and dental health. Moreover, the study shows that disinfection of toothbrushes in order to prevent reinfection and contamination oral flora with the bacteria again is important in terms of preventive medicine and family-children health.
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    Novel FGF10 mutation in autosomal dominant aplasia of lacrimal and salivary glands
    (Springer Heidelberg, 2017) Seymen, Figen; Koruyucu, Mine; Toptanci, Ismet Rezani; Balsak, Selahattin; Dedeoglu, Serkan; Celepkolu, Tahsin; Shin, Teo Jeon
    Aplasia of lacrimal and salivary glands (ALSG) is a rare autosomal dominant inherited disease, characterized by aplasia, atresia, or hypoplasia of the lacrimal and salivary systems with variable expressivity. The purpose of this study was to identify genetic etiology of an ALSG family. We recruited a Turkish family with ALSG and performed a mutational analysis, based on the candidate gene approach, to clarify the molecular genetic etiology. The candidate gene sequencing of the FGF10 gene identified a novel heterozygous nonsense mutation (c.237G > A, p.Trp79*) in the exon 1. The identified novel mutation would result in a haploinsufficiency of the FGF10, because of nonsense-mediated mRNA decay caused by a premature stop codon. This report further confirms that ALSG is caused by the haploinsufficiency of functional FGF10. Identification of the genetic etiology of the ALSG will help both the family members and dentist understand the nature of the disorder. Therefore, it will positively motivate oral health care to avoid further destruction of the tooth due to the lack of salivary production.