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Öğe Assessment of Bone Conduction Thresholds After Surgical Treatment in Patients with Labyrinthine Fistula(Galenos Yayincilik, 2018) Baylan, Muzeyyen Yildirim; Yilmaz, Umit; Akkus, Zeki; Topcu, IsmailObjective: This study aimed to analyze the bone conduction thresholds before and after surgery in chronic otitis media patients with cholesteatoma who had labyrinthine fistula and whose cholesteatoma matrix had been completely cleaned. Methods: The study was performed between 2013 to 2017 with 23 chronic otitis media patients who had labyrinthine fistula with cholesteatoma and who were operated at the Department of Otorhinolaryngology of Dicle University School of Medicine. Patients were assessed by anamnesis and examination and when necessary, by temporal computerized tomography and diffusion magnetic resonance imaging. Bone conduction thresholds at frequencies of 500, 1000, 2000, and 4000 Hz were determined by audiometric examination and they were compared before and after surgery. Results: Of the 23 patients, 12 were female and 11 were male; their age range was 10-55 (26.04 +/- 14.13) years. In the post-operative period, it was possible to conduct audiological follow-up on 20 patients. In these follow-ups, 16 patients showed no change in bone conduction thresholds, two patients showed worsening, and two showed improvement. When pre-and post-operative bone conduction thresholds at each frequency were compared separately, no significant difference was found (p=0.937). No statistically significant difference was found between the pre-and post-operative means at the four frequencies (p=0.712). Conclusion: In this study, we found that to reduce complications relating to cholesteatoma, it might be necessary to completely remove the matrix especially in the case of type 1 and 2 labyrinthine fistulas.Öğe Audiological Findings in Acromegaly Patients(Mediterranean Soc Otology & Audiology, 2011) Baylan, Muzeyyen Yildirim; Gokalp, Deniz; Celik, Yusuf; Tuzcu, Alpaslan; Meric, Faruk; Topcu, IsmailObjective: The aim of this study was to evaluate otologic problems in patients with acromegaly. Materials and Methods: This retrospective study was performed on 26 patients with acromegaly and 27 age-matched healthy controls. Otoscopic examination, pure tone odiometry, tympanometry, otoacoustic emissions, and stapes reflex were performed in all cases. Hearing thresholds of air and bone conduction (AC and BC), middle ear function, cochlear function, tympanic membrane compliance, gradient, peak pressure, and external ear canal volume were researched in patients with acromegaly. Results: The hearing thresholds for all frequencies except Right-AC 4000 frequencies were found to be significantly higher in patients with acromegaly as compared to the control group (p<0.05). Also significant correlation coefficients were calculated among disease duration, hearing thresholds, and tympanometric variables (p<0.05). There was a significant difference in tympanometry results between the two groups in regard to external ear canal volumes of the right and left ears (p <= 0.05). No differences were observed between the two groups in their type of tympanometry, stapes reflex, and otoacoustic emissions (OAE) (p>0.05). Conclusions: We have determined that patients with acromegaly have lower levels of hearing in both bone and air conduction compared with the normal population. This may be ascribed to deformation of hearing physiology related to hypertrophy in the temporal bone.Öğe Bilateral symptomatic petrous apex effusion(Springer, 2010) Yildirim, Muzeyyen; Senturk, Senem; Guzel, Ebru; Guzel, Aslan; Topcu, IsmailPetrous apex effusions can present with aural fullness, hearing loss and dizziness. Although they can be followed-up when asymptomatic, clinical management of symptomatic patients is controversial. In this study, we present clinical and radiological findings of a 24-year-old patient with bilateral petrous apex effusion. She had been complaining of bilateral aural fullness and dizziness for 2 years. Radiological examinations revealed bilateral petrous apex effusion. After medical treatment, her symptoms gradually disappeared. In all previous published studies, unilateral petrous apex effusions were reported. To our best knowledge, this is the first patient with trapped fluid in bilateral petrous apex.Öğe Congenital os vomer agenesis: Case report and literature review(Vendome Group Llc, 2012) Yorgancilar, Ediz; Yildirim, Muzeyyen; Gun, Ramazan; Meric, Faruk; Topcu, IsmailDefects of the nasal septum occur as a result of a variety of causes, including tuberculosis, irritation, neoplasia, trauma, infection, and chronic inflammatory diseases. Congenital os vomer agenesis as a cause is very rare. We report the case of a 28-year-old man with a defect in the posteroinferior part of the nasal septum that was discovered incidentally during a routine endoscopic examination. The patient was diagnosed with congenital os vomer agenesis, and the diagnosis was confirmed by computed tomography We discuss the features of this case and review the literature on this rare anomaly.Öğe Cultural adaptation of an olfactory test: the odour in bottle test (vol 52, pg 172, 2014)(Int Rhinologic Soc, 2014) Gul, Aylin; Akdag, Mehmet; Ozkurt, Fazil Emre; Yilmaz, Beyhan; Sengul, Engin; Bakir, Salih; Topcu, Ismail[Abstract Not Available]Öğe Culturally modified olfactory test adapted to East-Turkey: A comparison with Sniffin' Sticks(Wiley, 2021) Demir, Songul; Sizer, Bilal; Gul, Aylin; Topcu, IsmailBackground Although the Sniffin' Sticks test (SST) is a widely used odor test, aplicability of odor tests is limited because of the high cost of the test and the regional-cultural differentiation of odor recognition. We aimed to evaluate our regional odor norms by applying the SST with a Modified odor test (MOT) we created for this study, and to develop a test similar to the SST, which was less expensive and probably had a higher odor definition for our region. Methods This study includes 201 healthy volunteers: 91 men and 110 women over the age of 18 were included in the study. Tests were compared by applying the SST and MOT to all volunteers. Results In all subjects, for the SST: the mean Threshold score (TS), Discrimination score (DS), and Identification score (IS) were, respectively, 10.73 +/- 2.35, 11.11 +/- 11.94 and 11.32 +/- 2.15. TheTDI mean score was found to be 33.11 +/- 5.9. In the TDI score, the 10th percentile value was found to be 26. For the MOT, the mean TS(mTS), DS(mDS), and IS(mIS) were 10.88 +/- 2.31, 12 +/- 2.06, and 11.95 +/- 2.07, respectively, the modified test TDI(mTDI) mean was 34.68 +/- 6.47. The mTDI 10th percentile value was found to be 26. In all volunteers, there was no statistically significant difference between the two tests for the mean threshold score, while the difference in the mean discrimination score, the average identification score, and the average TDI (thresold, discrimination, sum of identification scores) score was statistically significant (P < .01). Conclusion This study is the first study to compare the SST and the MOT in our region. Making low-cost modifications by adding more probable smells to the smell tests and using them in studies involving more participants will be more meaningful in evaluating normative odor scores and will result in more widespread use.Öğe Does usage of a room air freshener affect the nasal mucosa?(Sage Publications Inc, 2014) Akdag, Mehmet; Bakir, Salih; Alabalik, Ulas; Ozkurt, Fazil Emre; Topcu, IsmailBackground: Effects of chemicals emitted from the room air freshener sprays (RAFSs) on nasal mucosa are still unclear. The purpose of this study was to investigate effects of RAFSs on the nasal mucosa of rats for different time intervals. Methods: Twenty-eight rats were randomly divided into four experimental groups: group 1 (n = 7) was the control group and not exposed to RAFS or other chemicals, group 2 (n = 7) was exposed to RAFS for 1 month, group 3 (n = 7) was exposed to RAFS for 2 months, and group 4 (n = 7) was exposed to RAFS for 3 months. Samples from the nasal septum were stained using hematoxylin and eosin solution, examined by a pathologist using a light microscope, and analyzed with Fisher's exact test. Results: We observed that distinct histopathological differences in the nasal mucosa of exposed rats depends on different time intervals (p < 0.05). Increased congestion was found after the 1st month of exposure (group 2). Although edema and mild inflammatory cell infiltration, including some eosinophils, was seen after the 2nd month (group 3), squamous metaplasia, numerous eosinophils, and intense inflammatory cell infiltration began after 3 months of exposure (group 4). Conclusion: Our results showed that continuous use of RAFS can cause inflammation and eosinophilic infiltration in rats, which begins after 2 months of exposure and may lead to metaplasia after 3 months. Because of differences in body size, geometry, and physiological responses of rats, the extrapolation of these results to humans is not straightforward. However, any such comparison should be made with caution. Finally, more performance is necessary to clarify this subject.Öğe THE EFFECTS OF FACE MASK USE DURING COVID-19 ON SPEECH COMPREHENSION IN GERIATRIC PATIENTS WITH HEARING LOSS WHO USE LIP-READING FOR COMMUNICATION: A PROSPECTIVE CROSS-SECTIONAL STUDY(Gunes Kitabevi Ltd Sti, 2022) Sizer, Bilal; Demir, Songul; Yilmaz, Umit; Yeniceli, Nurelis; Budak, Yakup; Yorgancilar, Argun Ediz; Topcu, IsmailObjective: Communication difficulties are considered the most significant consequence of hearing loss. This study aimed to determine whether surgical face masks, which have been mandatory throughout the COVID-19 pandemic, have an effect on speech comprehension scores in geriatric lip-reading patients with hearing loss and to raise awareness of the need for solutions to this problem. Materials and Method: Patients with moderate and higher sensorineural or mixed bilateral symmetrical hearing loss who stated that they lip-read to better understand during communication were included in the study. The patients' speech comprehension scores were gathered while the audiologist wore a surgical mask and then a transparent mask, respectively. Results: Twelve (33,3%) of the patients were female, and 24 (66.7%) were male. The mean age of the patients was 66.64 +/- 1.53 years. The mean speech comprehension scores of the patients when the audiologist was wearing a surgical mask (38.25 +/- 14.33) and a transparent mask (67.81 +/- 14.30), respectively, were compared. The surgical mask significantly affected speech comprehension scores, and the Cohen d value of the effect size was 2.06. As such, the surgical face mask had a great effect on these patients' speech comprehension scores. Conclusions: In elderly lip-reading patients who suffer from hearing loss, seeing the lip movements of the speaker, especially in hospital applications, promotes more effective communication. Transparent face masks can be considered a solution.Öğe The effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study(Canadian Soc Clinical Investigation, 2014) Akdag, Mehmet; Akkurt, Zeynep M.; Gul, Aylin; Ucmak, Derya; Yilmaz, Beyhan; Sengul, Engin; Topcu, IsmailPurpose: The purpose of this study was to investigate the effect of oral isotretinoin, a drug used in the treatment of acne vulgaris, on hearing function determined by serial audiology examinations. Methods: Forty patients with acne vulgaris were included in this study. Nine patients were excluded from the study because of inconsistent follow-up. The hearing of each participant was tested with pure tone audiometry and transient evoked autoacoustic emissions before and two and four weeks after treatment with isotretinoin (0.3-0.6 mg/kg/day) in the remaining 31 patients (62 ears). Results: Th e di ff erences between the mean values of the pre- treatment and post-treatment pure tone hearing thresholds at 1000, 2000, 4000 and 6000 Hz frequencies were statistically signi fi cant (p< 0.05), but there was no signi fi cant di ff erence between the pretreatment and post- treatment values at 250 and 500 Hz frequencies (p> 0.05). The difference between the pre-treatment and post-treatment signal-noise ratio values of the transient evoked autoacoustic emissions was not significantly different (p> 0.05). Conclusion: Our results suggest that the use of isotretinoin may cause bilateral hearing threshold changes. Further animal and human studies are required to investigate and characterize isotretinoin- induced neurophysiological alterations in hearing.Öğe Evaluation of Hearing and Outer Hair Cell Function of Cochlea in Patients With Psoriatic Arthritis(Korean Soc Otorhinolaryngol, 2015) Akdag, Mehmet; Ucmak, Derya; Ozkurt, Fazil Emre; Bozkurt, Mehtap; Akkurt, Zeynep Meltem; Topcu, IsmailObjectives. The aim of this study was to investigate hearing and outer cells function in patients with psoriatic arthritis. Our investigation was a prospective case control study. Methods. A total of 31 psoriatic arthritis patients (62 ears) and 31 healthy control subjects (62 ears) were enrolled in the study. We investigated hearing changes of patients and controls via pure tone audiometry, speech discrimination scores, tympanometry, acoustic reflex, and transient product otoacoustic emission. Results. The mean age of psoriatic arthritis patients was 36.1 +/- 8.5 years (range, 14 to 62 years). The average age of the control group was 37.9 +/- 8.1 years (range, 16 to 62 years). There were statistically significant differences between pure tone audiometry in all frequencies and right and left emission at the 4.0 and 1.0 in psoriatic arthritis patients versus controls (P < 0.05). This difference was evident, especially at high frequencies. There was no statistically significant difference between the ages and genders of the patient and control groups (P > 0.05). Both audiological and otoacoustic emissions were not significantly different between right and left ear (P > 0.05). Conclusion. Based on the audiological and otoacoustic findings; it is likely that the cochlear outer hair cells become subtly damaged in psoriatic arthritis patients, consequently leading to changes in hearing thresholds. These data suggest that it is important to screen psoriatic arthritis patients for hearing changes with otoacoustic emissions and audiologic tests regularly.Öğe An Evaluation of Preoperative Computed Tomography on Patients with Chronic Otitis Media(Springer, 2012) Yildirim-Baylan, Muzeyyen; Ozmen, Cihan Akgul; Gun, Ramazan; Yorgancilar, Ediz; Akkus, Zeki; Topcu, IsmailThis study aimed to compare the veracity of computed tomography findings on patients undergoing surgery for chronic otitis media (COM) with the surgical findings, and to determine to what extent the preoperative computerized tomography (CT) findings are useful to the surgeon. A series of 56 patients with COM undergoing preoperative CT scanning followed by surgical exploration of the middle ear and mastoid. Operative notes were recorded and data collected on the nature of soft tissue masses, the status of the ossicles, presence or absence of facial canal dehiscence and semicircular canal (SCC) dehiscence and the presence or absence of dural plate erosion, and sigmoid sinus thrombosis. Fifty-six patients were recruited in the study, 30 males and 26 females. The age range was from 16 to 67 years with a mean of 26.51 +/- A 1.4 years. The preoperative CT scan imaging in cases of cholesteatoma, ossicular chain erosion and SCC dehiscence have good correlation with the intraoperative findings. The specificity of preoperative CT scan in detecting facial canal dehiscence, dural plate erosion and sigmoid sinus thrombosis in patient of COM were weak. Preoperative computed tomography evaluation is fairly useful especially in cases of cholesteatoma. According to the results of this study, CT is of value particularly in the definition of cholesteatoma, and in determining ossicular chain erosion and semicircular canal fistula.Öğe THE HISTOMORPHOLOGIC EFFECTS OF HYPERBARIC OXYGEN THERAPY ON SUBMANDIBULAR, THYROID GLANDS AND TRACHEA(Diagnosis Press Ltd, 2013) Akdag, Mehmet; Gul, Aylin; Bakir, Salih; Ozkurt, Fazil Emre; Alabalik, Ulas; Topcu, IsmailThe aim of this experimental study was to investigate the efficacy of hyperbaric oxygen (HBO) therapy in the neck region of rats based on morphologic changes induced in the exocrine and endocrine glands and trachea. Samples of submandibular glands, thyroid gland and trachea were collected following sacrifice and neck dissection of the animals. The samples were processed for light microscopy and morphometric analysis. HBO administered rats were placed into a large pressure chamber and received 100 % oxygen at 253.3125 kPa (2.5 ata) for 60 min per day for a period of seven days. HBO-treated rats showed no statistically significant differences from the control group, according to the analysis of the histopathological scores (p = 0.930). HBO could probably be considered as neither helpful, nor harmless, on the submandibular glands, thyroid glands and trachea in rats.Öğe Is Preeclampsia a New Risk Factor for Cochlear Damage and Hearing Loss?(Lippincott Williams & Wilkins, 2010) Baylan, Muzeyyen Yildirim; Kuyumcuoglu, Umur; Kale, Ahmet; Celik, Yusuf; Topcu, IsmailObjective: We investigated whether preeclampsia is a risk factor for cochlear damage and permanent hearing loss. Study Design: Prospective case-control study design. Setting: Academic tertiary medical center. Patients: Subjects included 40 patients with preeclampsia and 30 healthy pregnant women. Interventions: Otoscopic examinations and pure-tone audiometry, tympanometry, otoacoustic emissions (OAEs), and stapedial reflex tests were conducted for all subjects. Negative audiologic tests were reevaluated after the postpartum period. Statistical analyses were performed using chi(2) and binary logistic regression testing. Main Outcome Measures: We searched for signs of middle ear ventilation, damage of cochlea, and sensorineural hearing loss. Results: Eight patients from the preeclampsia group had 1 or more otological problems. Two patients from the control group were determined as having otological problems. Otoacoustic emissions of the right and left ears (p = 0.029, p = 0.044), hearing levels of right and left ear bone conduction (BC) at the 500-Hz frequency (right and left-BC 500), and left ear at the 2,000-Hz frequency (left-BC 2000) differed significantly between the preeclampsia and control groups (p = 0.040, p = 0.003, and p = 0.003). There was no significant difference in the OAEs between the right and left ears in the preeclampsia group (p < 0.05). The variables BC 500-left, BC 500-right, OAE-right, and OAE-left differed significantly between groups based on binary logistic testing. The odds ratio and 95% confidence intervals (95% CI) for these 4 risk variables were as follows: BC 500-left, 1.167 (1.044-1.306); BC 500-right, 1.117 (1.002-1.244); OAE-right, 0.642 (0.505-0.815); and OAE-left, 0.576 (0.475-0.698), respectively. Conclusion: Preeclampsia is a risk factor for cochlear damage and permanent hearing loss. Even if preeclampsia resolves after delivery, cochlear damage and permanent hearing loss remain unchanged in patients with preeclampsia.Öğe The Protective Effect of Intratympanic Dexamethasone on Streptomycin Ototoxicity in Rats(Sage Publications Inc, 2017) Gul, Aylin; Sengul, Engin; Yilmaz, Beyhan; Ozkurt, Fazil Emre; Akdag, Mehmet; Keles, Aysenur; Topcu, IsmailThe purpose of this experimental study was to investigate the protective role of intratympanically administered dexamethasone on the inner ears of rats that were exposed to streptomycin ototoxicity. Twenty-four adult Wistar albino rats were separated into 4 groups: Group 1 (only streptomycin), Group 2 (only intratympanic dexamethasone), Group 3 (streptomycin and intratympanic dexamethasone), and Group 4 (streptomycin and intratympanic saline). All rats were evaluated with distortion product otoacoustic emissions (DPOAE) tests before the start of treatment and on the day it ended. On the 45th day, after the final DPOAE tests, animals of all groups were sacrificed under general anesthesia. The differences between the amplitudes of DPOAE results were determined, and hearing results were statistically analyzed. Also, the cochleas of each rat were histopathologically evaluated under a light microscope with hematoxylin and eosin staining. In the intratympanic dexamethasone group it was observed that cochlear hair cells were mostly protected. No significant difference was seen between the DPOAE results before and after treatment (p > 0.05). On the other hand, loss was observed in the hearing functions and hair cells of the rats that received streptomycin and streptomycin plus intratympanic saline (p < 0.05). In the streptomycin plus intratympanic dexamethasone group, the cochlear hair cells were partially protected. A significant difference was observed when the DPOAE results (DP-grams) of the streptomycin plus intratypmanic dexamethasone group were compared to those of the streptomycin plus intratympanic saline group (p < 0.05). After the experimental study, ototoxic effects of the administration of streptomycin and intratympanic dexamethasone were observed on the rats' cochlear hair cells. We conclude that intratympanic dexamethasone has protective effects against this cochlear damage in rats.Öğe Rare Head and Neck Trauma due to Construction Nail: Case Report(Aves, 2014) Aguloglu, Bulent; Gul, Aylin; Ozbay, Musa; Ozkurt, Fazil Emre; Cetin, Muzeyyen; Topcu, IsmailIntroduction: Oropharyngeal penetrating trauma is encountered more often in children under the age of 5 due to lack of their selfprotection. Case Report: In this paper, a 2-year-old girl who had penetrating oropharyngeal trauma after falling on a construction nail was presented. As a consequence of the physical examination and radiological examination applied to the patient, it was seen that the foreign body reached the clivus in the base of the skull, through the nasopharynx, passing by the hard and soft palate junction. In the status of the patient, who was operated on, no additional clinical aspects or neurological or lack of visual activity was observed in the post-operative period. As there was no complication during the follow-ups, the patient was discharged with recommendations. Conclusion: Oropharyngeal penetrating trauma should be careful in terms of mortality and morbidity due to the proximity to vital organs.Öğe A rare sublingual cyst in an infant: oral heterotopic gastrointestinal cyst(Turkish J Pediatrics, 2014) Kinis, Vefa; Alabalik, Ulas; Aguloglu, Bulent; Ozbay, Musa; Yilmaz, Beyhan; Topcu, IsmailOral heterotopic gastrointestinal cyst is rarely seen in the oral cavity. The tongue and floor of the mouth are the most commonly affected sites. These cysts may cause feeding and respiration problems, especially in newborns and infants. A benign mass was considered according to the physical examination and ultrasonography findings. We treated the patient with simple excision. We present a three-month-old female infant who was referred to us with a cystic mass in the sublingual region.Öğe The relationship between pneumatized middle turbinate and the anterior ethmoid roof dimensions: a radiologic study(Springer, 2013) Gun, Ramazan; Yorgancilar, Ediz; Bakir, Salih; Ekici, Faysal; Akkus, Zeki; Ari, Seyhmus; Topcu, IsmailThe development of pneumatized middle turbinate may affect anterior ethmoid roof formation. The aim of this study was to investigate the relationship between the pneumatized middle turbinate and the dimensions of the anterior skull base structures using computed tomography scans. The coronal reconstructed images of the computed tomography scans were evaluated retrospectively. The lateral and medial ethmoid roof points, the width of the cribriform plate (CP), and the anterior ethmoid roof were identified at the first coronal cut, which was determined by the infraorbital nerve. The pneumatized middle turbinates were measured on the axial, vertical, and sagittal planes. The images of 101 patients were evaluated. The mean axial diameters of the pneumatized middle turbinate on the right and left sides were between 6.93 and 4.95 mm, respectively. The correlation between the axial diameters of the pneumatized middle turbinate and the width of the anterior ethmoid roof (termed AER width) was significant for both sides and gender (p < 0.05). There was a higher correlation on the right side where the pneumatized middle turbinate was observed more frequently (r = 0.357). The relationship between CP width and the diameters of the pneumatized middle turbinate was not significant (p > 0.05) for both sides. Iatrogenic lesions of the skull base occur predominantly in the lateral lamella of the CP. The risk of this complication may decrease with increasing of the AER width. Pneumatized middle turbinate may cause an increase in the width of the anterior ethmoid roof and provide more reliable endoscopic intervention of the anterior skull base and frontal sinus.Öğe Thyroid Nodule Demonstrating Itself as Calcified Lung Lesion(Derman Medical Publ, 2010) Yorgancilar, Ediz; Yildirim, Muzeyyen; Gun, Ramazan; Meric, Faruk; Topcu, IsmailMultinodular goiter (MNG) is the most prevalent thyroid pathology. Thyroid gland enlarge as a result of MNG, the initial extension is typically outward. After this cervical enlargement, expansion may extend in to the mediastinum. As substernal goiters enlarge within the mediastinum, vascular and visceral structures may slowly became compressed. The most common symptoms of substernal goiter result from compression of the trachea and/ or esophagus and include dyspnea, choking sensation, cough, and dysphagia. Progressive hoarseness and superior vena cava syndrome are less common symptoms. Substernal goiters can remain asymptomatic for many years and it may be diagnosed incidentally. For example, routine chest radiography may reveal a mediastinal mass or tracheal deviation. Many authors have advocated surgical removal of all substernal goiters, even when these goiters are asymptomatic. In this article, we report a case of substernal MNG which demonstrating itself as a nodular calcification on chest X-Ray radiography.Öğe Two Otolaryngologic Cases of Munchausen's Syndrome(Ortadogu Ad Pres & Publ Co, 2012) Yorgancilar, Ediz; Demir, Basaran; Ak, Sertac; Topcu, Ismail; Sennaroglu, LeventMunchausen's Syndrome is characterized by repeated attempts to be hospitalized following an extremely credible and dramatic representation of physical symptoms. This syndrome is commonly known as a factitious disorder. People with factitious disorders act this way not to achieve a concrete benefit, such as financial gain. Munchausen's Syndrome is often diagnosed after hospitalization. Early diagnosis is crucial for preventing high healthcare costs and facing ethical and legal problems. We believe that Munchausen's Syndrome related to otolaryngologic diseases is under-recognized and under-reported. In this article, two cases of Munchausen's Syndrome, genuine by their ear and nose factitious signs, are presented.
