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Öğe Determination of trigeminocardiac reflex during rhinoplasty(Churchill Livingstone, 2012) Yorgancilar, E.; Gun, R.; Yildirim, M.; Bakir, S.; Akkus, Z.; Topcu, I.In most rhinoplasty procedures, osteotomies are usually required. The osteotomy areas are innervated by sensory branches of the trigeminal nerve. The trigeminocardiac reflex (TCR) is clinically defined as the sudden onset of parasympathetic activity during stimulation of the trigeminal nerve. When an osteotomy is performed or external pressure is applied over the nasal bone, the infraorbital nerve may send signals via this nerve. The aim of this prospective study is to determine the blood pressure changes and occurrence of TCR during rhinoplasty. one hundred and eight patients were enrolled into the study. Lidocaine and adrenaline combination (LAC) was injected only into the left lateral osteotomy sites. All patients underwent median, right-side, then left-side lateral osteotomies and nasal pyramid infracture. The haemodynamic changes were recorded. A 10% or more decrease in the heart rate from baseline was considered a TCR. TCR was detected in nine patients following lateral osteotomies and nasal pyramid infracture procedures (8.3%). The authors determined that LAC injection prior to osteotomy did not prevent TCR. Manipulation at or near the infraorbital nerve during rhinoplasty may cause TCR, even if local anaesthetic infiltration is used.Öğe Effects of caffeic acid phenethyl ester on cisplatin ototoxicity(Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2016) Ozbay, M.; Sengul, E.; Kinis, V.; Alabalik, U.; Yilmaz, B.; Topcu, I.Purpose: To report histological and electrophysiological data in rats treated with cisplatin and caffeic acid phenethyl ester. Methods: We randomly divided 28 Wistar rats into four groups of seven, to be treated as follows: control (saline), cisplatin, CAPE and cisplatin-CAPE. Distortion product otoacoustic emission (DPOAE) measurements were performed on day one (before drug administration) and day five under anaesthesia. All animals were killed under general anaesthesia on day five after the DPOAE measurement. The cochleae of each rat were histopathologically and immunohistochemically evaluated. Results: The outer hair cells were mostly preserved in the control and CAPE groups. Moderate -to -severe and mild -to moderate hair cell losses were detected in the cisplatin and cisplatin-CAPE groups, respectively. DPOAE assessments revealed significant deterioration in the cisplatin group (P < 0.05). The difference between the cisplatin and cisplatin-CAPE groups was statistically significant (P < 0.05). Conclusion: CAPE prevents cisplatin ototoxicityÖğe Effects of lidocaine and adrenaline combination on postoperative edema and ecchymosis in rhinoplasty(Churchill Livingstone, 2011) Gun, R.; Yorgancilar, E.; Yildirim, M.; Bakir, S.; Topcu, I.; Akkus, Z.Nasal osteotomies are the most important cause of periorbital edema and ecchymosis. Injection of lidocaine and adrenaline is recommended to reduce bleeding. Whilst the lidocaine and adrenaline combination (LAC) is claimed to reduce postoperative ecchymosis and edema, this effect remains to be proven conclusively. This study, on 48 patients, was designed to investigate the effects of LAC injection on postoperative edema/ecchymosis in rhinoplasty. LAC was applied at a random side prior to the lateral osteotomy. The opposite side was used as a control. The relationship between edema/ecchymosis and the degree of LAC on the injected and uninjected sides was evaluated on the first, third and seventh day, postoperatively. The relationships between edema and ecchymosis with operation time and intraoperative systolic blood pressure were also evaluated. Bleeding was reduced on the side treated with LAC (p = 0.050). The degrees of edema/ecchymosis increased with increases in the duration of operation and the systolic blood pressure on the first postoperative day for the LAC-applied side (p < 0.05). This correlation was not observed on the opposite side (p > 0.05). Application of LAC reduces bleeding during rhinoplasty and pain control postoperatively but reduced edema and ecchymosis should not be expected following LAC application.Öğe Isolated hemifacial hypertrophy: a case with upper airway obstruction and sensorineural hearing loss(Headley Brothers Ltd, 2006) Oktay, M. F.; Topcu, I.; McKinney, A.; Turunz, V.; Aras, O.Hemifacial hypertrophy is an uncommon developmental disorder characterized by facial asymmetry that involves abnormal bone development and facial enlargement. Many cases of hemihypertrophy have been reported since the first case was reported by Wagner in 1839. We identified a child diagnosed with hemifacial hypertrophy and sensorineural hearing loss who presented with upper airway obstruction and cyanosis. We discuss treatment selection and review the associated head and neck symptoms.Öğe The reconstruction of thyroid cartilage defect due to penetrating laryngeal trauma using a autogenous septal cartilage graft(Galenos Yayincilik, 2011) Yorgancilar, E.; Yildirim, M.; Gun, R.; Bakir, S.; Topcu, I.Laryngeal trauma is a rare but potentially lethal injuries. Depending on the amount of force and the degree of ossification of the larynx, this may result in a variety of injury patterns. These injuries may range from simple cartilaginous fracture of thyroid cartilage with cartilaginous displacement, cartilaginous defect, endolaryngeal disruption, or laryngotracheal separation. The clinician should have a high suspicion for laryngeal injury in any patient who has neck trauma. When evaluating the patient with suspected laryngeal trauma, the stability of the airway must first be established. Management of laryngeal trauma may include medical or surgical treatment. In surgical treatment, correction of loss of skeletal support may be performed with alloplastic stents, miniplate and screw fixation and autogenous cartilage grafts. In this report we presented a case of thyroid cartilage defect due to penetrating laryngeal trauma who reconstructed by autogenous septal cartilage graft.Öğe REVEAL BY BIOTECHNOLOGICAL EQUIPMENT TO THE BILATERAL NONFUNCTIONAL SUBMANDIBULAR GLANDS IN ECTODERMAL DYSPLASIA(Taylor & Francis Ltd, 2008) Yildirim, M.; Oktay, M. F.; Ozmen, C.; Yavuz, I.; Topcu, I.We reported a different presentation of ectodermal dysplasia in which bilateral submandibulary glands were nonfunctional. We also reviewed the literature about the ectodermal dysplasia and related submandibular gland abnormalities. In this case report a 22-years-old female with ectodermal dysplasia is presented, complaining of dryness of her mouth, difficulty of chewing, dysphagia and recurrent upper respiratory tract infections. Further investigations consisted of an ultrasound scan fit and small size submandibular salivary glands. Computed tomography confirmed that showed normal left and right parotid glands and small that both submandibular glands were hypoblastic. A 99mTc-pertechnetate scintigraphy showed normal uptake in the parotid glands. However, no functioning submandibular, glands were shown. Although the submandibular gland abnormalities can be rarely seen in ectodermal dysplasia, to our knowledge, this is the first report which presents nonfunctioning submandibular glands in an ectodermal dysplasia case.Öğe Schwannoma of the nasal tip: case report and short review of literature(Galenos Yayincilik, 2009) Yildirim, M.; Yorgancilar, E.; Bulut, F.; Meric, F.; Topcu, I.A case of nasal tip Schwannoma is presented in this paper. Schwannoma is usually a benign neoplasm which is composed of Schwann cells. A 14-year-old boy had suffered from progressive swelling of the nasal tip over 4 months. Computed tomography showed a large soft tissue density in the nasal tip. The mass was resected using an external rhinoplasty approach, and the pathologic diagnosis was Schwannoma. Here, we present this case and discuss the clinical and pathological aspects of Schwannoma arising in the nasal tip.
