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    Probable preventive effects of placenta from oxidative stress; Evaluation of total antioxidant status, total oxidant status and oxidative stress index in fetal cord blood during the delivery
    (Elsevier Ireland Ltd, 2016) Camkurt, Mehmet Akif; Findikh, Ebru; Tolun, Fatma Inanc; Bakacak, Murat; Bal, Nilay Gul; Sakalh, Hilal; Gunes, Mehmet
    Depression in pregnancy may have negative effects on birth outcomes. It may also effect the intrauterine environment of the fetus. The umbilical cord is the conduit between the fetus and placenta, and functions in the transport between fetus and mother. Investigating biochemical parameters in fetal cord blood (FCB) during delivery may be helpful to understanding to what the fetus is exposed to, at least in the last trimester. In this study, we aimed to investigate total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) in the FCB of depressed mothers and healthy controls during delivery. Our study included 33 depressed mothers and 37 healthy controls. TAS, TOS, and OSI were measured according to Erel's method. We found that TAS, TOS, and OSI levels were similar in patients and healthy controls; however, the birth weights of depressed patients were significantly lower than those of healthy controls. Our results suggest that the placental barrier may prevent from oxidative stress. Future studies should include blood samples collected simultaneously from mothers during delivery. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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    Protective Effects of Zofenopril on Testicular Torsion and Detorsion Injury in Rats
    (Urol & Nephrol Res Ctr-Unrc, 2011) Altunoluk, Bulent; Soylemez, Haluk; Bakan, Vedat; Ciralik, Harun; Tolun, Fatma Inanc
    Purpose: To investigate the protective effect of zofenopril on torsion/detorsion-induced biochemical and histopathological changes in experimental testicular ischemia or reperfusion injury in rats. Materials and Methods: A total of 35 prepubertal male Wistar-Albino rats were divided into five groups, including 7 rats in each group: Group I (sham, S), sham operation; group II (torsion/detorsion-early orchiectomy, T/D-E), 2 hours ischemia and 4 hours reperfusion; group III (torsion/detorsion-late orchiectomy), T/D-L), 2 hours ischemia and 5 days reperfusion; group IV (zofenopril-early orchiectomy, Z-E), 2 hours ischemia, 4 hours reperfusion, and a single dose of zofenopril; and group V (zofenopril-late orchiectomy, Z-L), 2 hours ischemia, 5 days reperfusion, and 5 doses of zofenopril. We determined the tissue levels of malondialdehyde, nitric oxide, glutathione peroxidase, and superoxide dismutase enzyme activities. Histopathologically, mean seminiferous tubule diameter measurements were used. Results: Malondialdehyde (3.490 +/- 0.89 versus 1.729 +/- 0.25 in early period; 3.837 +/- 1.694 versus 1.694 +/- 0.47 in late period) and nitric oxide levels (3.507 +/- 0.44 versus 2.853 +/- 0.54 in early period; 4.010 +/- 0.72 versus 2.446 +/- 0.29 in late period) significantly reduced and glutathione peroxidase (0.012 +/- 0.001 versus 0.017 +/- 0.001 in early period; 0.013 +/- 0.002 versus 0.018 +/- 0.001 in late period) and superoxide dismutase enzyme activities (58.030 +/- 5.97 versus 70.773 +/- 3.85 in early period; 57.421 +/- 7.81 versus 76.329 +/- 4.09 in late period) significantly increased in the testis tissue in zofenopril pretreated groups compared to group T/D both in early and late period (P < .05). The mean seminiferous tubule diameter was significantly better in pretreated group (210.33 +/- 17.32) than group T/D (185.02 +/- 22.45) only in late period (P < .05), but not in early period (209.38 +/- 30.40 versus 208.21 +/- 13.57; P > .05). Conclusion: Treatment with zofenopril decreased damage in ipsilateral testis caused by ischemia/reperfusion, and clinical application of zofenopril might be a new approach for the treatment of testicular torsion in addition to conventional detorsion.