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    Chronic Myeloid Leukemia In a Pregnant Woman: A Case Report
    (Cukurova Univ, Fac Medicine, 2015) Tokmak, Aytekin; Guzel, Ali Irfan; Yalinkaya, Ahmet
    Chronic myeloid leukemia (CML) is a rare disease in pregnancy. Our aim is to present a 37 weeks of pregnant woman with chronic myelogenous leukemia. A 27 Years in multigravi (gravida 5, parity: 4), at 37 weeks gestation was admitted with the diagnosis of painful pregnancy and CML. Physical examination findings were normal, complete blood count and peripheral blood smear results were consistent with CML. The patient was diagnosed CML in the 30th week of pregnancy and were treated with hydroxyurea and interferon. Treatment depends on the mother and the fetus did not develop any side effects. Our patient with CML is interesting due to lack of perinatal effects and take the diagnosis at an early age. CML diagnosed during pregnancy requires a multidisciplinary approach and hydroxyurea and interferon treatment on the mother and fetus are at low risk of inducing adverse effects.
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    Evaluation of dietary intake of various vitamins in menopausal women with hot flashes
    (Derman Medical Publishing, 2016) Tokmak, Aytekin; Öztürkkan, Demet; Güzel, Ali İrfan; Çınar, Mehmet; Çelik, Fatma; Uğur, Mustafa
    Aim: Menopausal hot flashes affect the majority of women. Hormone replacement therapy to reduce the severity of hot flashes is the most effective method. Today, however, due to a number of side effects of hormone therapy more women are seeking alternative treatments such as vitamin pills and herbal products. Previously, various vitamins, minerals and trace elements were studied for this purpose. In this study, our aim was to determine the level of dietary intake of various vitamins in women with hot flashes and to compare them with women who had no complaints. Material and Method: One hundred and seven consecutive women who attended the menopause clinic of our hospital for routine follow up were included in this study. All of the participants were asked about the occurrence of specific menopausal symptoms and completed 92-itm antioxidant nutrient questionnaire developed by Satia. The main parameters recorded for each woman were; age, obstetrical characteristics, body mass index, smoking status, educational level, type of menopause (surgical or natural), duration of menopause, menopausal symptoms, and number and duration of hot flashes. According to the computerized analysis of questionnaire, dietary intake of water-soluble vitamins; B complex and vitamin C, and fat-soluble vitamins; vitamin, A D, E, K were calculated. Results: Patients were divided into two groups with regard to presence of hot flashes, those with hot flashes constituted the study groups (n:75), and others without hot flashes constituted the control group (n:32). The mean age of patients was statistically significantly lower in the study group (p<0,001). The mean duration of menopause was also lower in this group (p<0,001). There were no statistically significant differences between groups in terms of obstetrical characteristics, body mass index, smoking status, educational level, type of menopause (p>0,05). Night sweats and sleep disorders were more common in women with hot flashes. There were no statistically significant differences between the groups regarding the mean levels of dietary intake of evaluated vitamins. Discussion: Although the mean levels of all studied vitamins were lower in women with hot flashes, the differences were statistically insignificant. Supplementation with vitamins should not be recommended in postmenopausal women suffering hot flashes currently. Further investigations are required to determine the role of vitamin supplements for hot flashes.
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    Öğe
    Gebelikte Kronik Miyeloid Lösemi: Olgu Sunumu
    (2015) Güzel, Ali İrfan; Yalınkaya, Ahmet; Tokmak, Aytekin
    Kronik miyeloid lösemili (KML) gebelikte çok nadir görülen bir hastalıktır. Amacımız 37 haftalık gebeliği olan kronik miyeloid lösemili olgunun sunulmasıdır. Bir 27 yaşında multigravida (gravida :5, parite:4), 37. gebelik haftasında sancılı gebelik ve KML tanılarıyla kabul edildi. Fizik muayene bulguları normal olan hastanın tam kan sayımı ve periferik yayma sonuçları KML ile uyumluydu. Gebeliğinin 30. haftasında KML tanısı alan hastaya hidroksiüre ve interferon tedavisi uygulandı. Tedaviye bağlı anne ve fetüste herhangi bir yan etki gelişmedi. Olgumuz KML tanısını erken yaşta alması ve perinatal etkilerinin olmaması nedeniyle ilginçtir. ebelik sırasında tanı konulan KML multidisipliner bir yaklaşım gerektirir ve hidroksiüre ve interferon tedavisinin anne ve fetüs üzerinde olumsuz etkiler oluşturma riski düşüktür