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Öğe Demographical characteristics of the patients with leukemia in Diyarbakir(2003) Işikdo?an A.; Ayyildiz O.; Tiftik N.; Altintaş A.; Müftüo?lu E.The distrubition of leukemias showed variation in various parts of the world. Chronic lymphocytic leukemia is the most common form of leukemia (31% of all leukemias) in western countries, but is rare in Japan. Acute myeloblastic leukemia consist of 80% of adult acute leukemias, whereas acute lymphoblastic leukemia is 20 percent. In this report we analyzed all leukemias according to types, age, sex and peak age. For this reason we analysed 497 leukemia cases followed in our clinic between January 1993-December 1999.Öğe Öğe Large granular lymphocytic leukemia(2000) Işikakdo?an A.; Ayyildiz M.O.; Tiftik N.; Müftüo?lu E.LGL-L is a rare disorder characterized by clonal proliferation of cells with large granular lymphocytes. LGL-L can be divided into two major lineage: T(CD3 +) and NK (CD3 -) which have distinct clinical and prognostic features. T-LGL-L represents 80-85% of the all LGL-L. The disease may occur both in men and women, and mostly affects elderly people. Clinical features of T-LGL-L is characterized by recurrent infection related to neutropenia, hepatosplenomegaly and rheumatoid arthritis. Laboratory findings include positive rheumatoid factor and antinuclear antibody. The clinical presentation of NK-LGL leukemia is more acute than T-LGL leukemia, with B symptoms, massive hepatosplenomegaly, involvement of the gastrointestinal tract, and coagulopathy in most cases. Patients are younger and usually have an aggressive course with multiorgan failure and death within a few months of diagnosis despite multiagent chemotherapy. Occasional patients have a chronic NK-LGL leukemia with a more indolent course similar to T-LGL leukemia.