Yazar "Tekes, Selahaddin" seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Effects of Atorvastatin on Smoking-Induced Alveolar Injury in Rat Lungs(Elsevier, 2009) Yildiz, Tekin; Tasdemir, Serhan; Tunik, Selcuk; Ates, Gungor; Tekes, Selahaddin; Kaplanoglu, Iskender; Topcu, FusunBACKGROUND: Smoking is one of the most serious health care issues worldwide, as one third to one half of all people who smoke eventually use tobacco habitually. Chronic smoke exposure causes airway and lung parenchymal inflammation and the destruction of alveolar cell walls. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage associated with smoking. OBJECTIVE: The aim of this study was to investigate whether atorvastatin protects against smoking-induced inflammation in alveolar epithelial type I (ATI) and type II (ATII) cells in the lungs of rats. METHODS: Adult male albino Wistar rats (200-250 g) were randomly divided into 3 groups and exposed to cigarette smoke 8 hours per day for 15 days. During that 15-day period, the 2 treatment groups received atorvastatin 0.5 or 1.0 mg/kg/d in 2 mL of methyl cellulose solution and the control group received 2 mL of methyl cellulose solution alone, all via nasogastric catheter. After the 15 days, the lungs were excised and the tissues were examined by transmission electron microscopy. RESULTS: Thirty rats were divided into 3 groups of 10 rats each. All rats survived the 15 days. In the atorvastatin 0.5-mg group, no changes were found in the ATI cells or in the blood-air barrier. In the atorvastatin 1.0-mg group, we observed hyperplasia in the common basal membranes. Hypertrophy, mitochondrial crystolysis (MC), and intracytoplasmic edema (ICE) were detected in the ATI cells in the 1.0-mg group, while chromatin condensation, atrophic appearance, cell shrinkage, and cytoplasmic vacuolization were observed in the ATII cells. The rough endoplasmic reticulum (rER) tubules of the ATII cells appeared spiral-shaped. In the control group, minimal ICE was detected in the ATI cells. However, microvillus deformation, pseudopod formation, edema, mitochondrial swelling, and MC were observed in the ATII cells. We also observed MC, several pinocytic vesicles, and normal rER tubules in the endothelial cells of the control group. CONCLUSIONS: The administration of atorvastatin 0.5 mg/kg/d was associated with some attenuation of lung injury caused by smoke inhalation in these rat lungs. However, atorvastatin 1.0 mg/kg/d was associated with lung damage. Future studies are needed to evaluate the dose-response relationship of atorvastatin to smoking-induced alveolar damage. (Curr Ther Res Clin Exp. 2009;70:366-376) (C) 2009 Excerpta Medica Inc.Öğe GENETIC ANALYSIS IN PREGNANCY WITH FETAL PATHOLOGIC ULTRASOUND FINDINGS(Diagnosis Press Ltd, 2013) Simsek, Selda; Turkyilmaz, Aysegul; Oral, Diclehan; Yalinkaya, Ahmet; Tekes, Selahaddin; Akbas, Halit; Budak, TurgayThe aim of this study was to investigate the relationship between fetal abnormal karyotype and fetal abnormal ultrasound examination in pregnancy A total of 191 women were analyzed for karyotyping after detection of a soft marker or of major malformations at the routine antenatal USG, for the period 2007-2011. A total of 191 amniotic fluid samples were analyzed for chromosome aberrations and the fetal karyotype was abnormal in 24.6 % (47/191) of all cases. Among them, 13 cases were with trisomy 21; 5 cases with trisomy 18; 1 case with trisomy 13; 2 cases with triploidy; 7 cases with karyotype of 45,X; 1 case with karyotype 47,XXY; and 18 cases with other abnormal chromosome structures. One hundred and fifty-two karyotyping procedures were done due to the finding of a single sonographic marker Within this group, 17.1 % of the karyotypes were abnormal. Thirty-nine karyotyping procedures were done due to the finding of a multiple sonographic marker In this group, 53.8 % of the karyotypes were abnormal. The overall termination rate was 61.7 % (29/47) in cases with a fetus affected by chromosomal abnormalities. Ultrasound examination is important in prenatal diagnosis. We suggest that karyotype analysis should be advised to pregnant women with an abnormal fetus in the ultrasound examination.Öğe POLYMORPHISM OF P53 GENE EXON 4 IN PATIENTS WITH CORONARY ARTERY DISEASE(John Wiley & Sons Inc, 2009) Tekes, Selahaddin; Cakir, Dilek; Yokus, Beran; Iltumur, Kenan; Simsek, Selda[Abstract Not Available]Öğe SINGLE NUCLEOTIDE POLYMORPHISMS OF THE FOLLICLE-STIMULATING HORMONE RECEPTOR GENE IN FERTILE AND INFERTILE MALES(John Wiley & Sons Inc, 2009) Balkan, Mahmut; Gedik, Abdullah; Tekes, Selahaddin; Simsek, Selda; Turkyilmaz, Aysegul; Oral, Diclehan; Budak, Turgay[Abstract Not Available]
