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Öğe Cystic meningiomas: Report of three cases(Turkish Neurosurgical Society, 2006) Tatli M.; Güzel A.; Göksel H.M.Although intracranial meningiomas are usually solid and firm tumours, some are associated with diagnostically confusing cysts. In this article, we present our experience from three of our patients with cystic meningiomas and discuss the characteristics of these lesions. We detected type two cysts in our first and third cases, and a type one cyst in the second case, according to the Nauta classification. Contrast enhancement of the cyst wall was detected in our third case and an atypical meningioma was diagnosed histopathologically. We conclude that the contrast enhancement of the cyst wall might be a predictive factor for a malignant meningioma. The cyst wall should be completely removed in these patients to prevent tumour recurrences.Öğe An experimental Staphylococcus aureus meningitis model for investigating induced leptomeningeal and subpial inflammation in rats: A transmission electron microscopy study(Maghira and Maas Publications, 2007) Guzel A.; Er U.; Tatli M.; Aluclu U.; Ozekinci T.; Nergiz Y.; Ahishali B.Objective: To evaluate leptomeningeal and subpial inflammatory responses of experimental Staphylococcus aureus bacteriemia following intraperitoneal and intravenous applications and to compare the inflammatory reactions in different regions of central nervous-system. Material and Methods: Forty anesthetized rats were divided into four groups equal in number. The rats in group-I were given 1 ml suspension of Staphylococcus aureus intraperitoneally. Group-II was the control group of group I; it was administrated 1 ml 0.9% NaCl in water intraperitoneally. The rats in group-III were given the same amount of bacteria intravenously. Group IV was the control group of the group-III; it was administrated 1 ml 0.9% NaCl solution intravenously. The rats were sacrificed on the 21st day. Inflammatory changes of different regions of the central nervous system were examined under transmission electron microscopy. Statistical analysis was done by using variance analysis, Bonferroni, Tamhane post hoc, Student's t and univariate tests. Results: Thoracic and occipital regions were the most vulnerable zones. Increasing of collagen tissue was the most detected inflammatory change. Conclusion: This experimental model can be used for inducing subpial and leptomeningeal inflammations and it may be developed for investigations of pathogenesis of leptomeningitis during systemic infections. © 2007 Neuroendocrinology Letters.Öğe Intradiploic meningioma with inward and outward extensions in a rheumatoid arthritis patient(2010) Er U.; Güzel A.; Tatli M.; Ceviz A.; Sav A.Background: Meningiomas usually arise from clusters of arachnoidal cap cells. Originating of a meningioma in an intraosseous region is rare condition. There are several theories about occurrence of these types of meningiomas. Here we report a case of an intradiploic meningioma in a rheumatoid arthritis patient and discuss the mechanism of developing intraosseous meningiomas, differential diagnosis of intraosseous lesions of calvarium, relations of rheumatoid arthritis and extensions of meningioma outside the diploe. Case description: A sixty three-year-old female patient who had been under the treatment for rheumatoid arthritis was admitted to the hospital with a swelling around her right eye. Bony window of preoperative CT showed an expansile right sphenoid bone lesion. The mass was excised with internal and external tables of the temporal bone by craniectomy. Conclusion: We advocate a wide resection, followed by cranioplasty with acrylic. If the subtotal resection is possible, residual lesion should be followed for adjuvant radiation therapy.Öğe Pediatric orbital multifocal cavernous hemangiomas associated with bilateral arachnoid cysts of the middle cranial fossa. Case report and review of the literature(2005) Tatli M.; Guzel A.; Keklikci U.; Guzel E.Cavernous hemangiomas of the orbit are benign vascular growths that commonly occur in adults and account for 6% of all intraorbital tumors. Multifocal intraorbital cavernous hemangiomas are quite rare. The reported incidence of arachnoid cysts accounts for only 1% of lesions that occupy intracranial space, and they are nearly always sporadic and single. So far, the authors have not encountered any study reporting the coexistence of bilateral arachnoid cysts of the middle cranial fossa and orbital multifocal cavernous hemangiomas. In this report, they describe a 10-year-old boy with such a hemangioma that included the eyelid, conjunctiva, and retrobulbar space. His was the first case of a surgically treated pediatric orbital multifocal cavernous hemangioma associated with bilateral arachnoid cysts of the middle cranial fossa. An association between arachnoid cysts, intracranial cavernous malformations, and bilateral arachnoid cysts and metabolic disorders has been reported. The authors report on the coexistence of orbital multifocal cavernous hemangiomas and bilateral arachnoid cysts of the middle cranial fossa. Based on these observations, they believe that all patients with bilateral temporal arachnoid cysts should be screened for genetic disorders. In addition, the possibility of orbital cavernous malformations should be kept in mind for the follow-up period, and patients should be evaluated for possible symptoms of this condition.Öğe Simultaneous choriocarcinoma metastases to brain, spine and lung(2007) Güzel A.; Tatli M.; Zileli M.Cerebral metastasis of choriocarcinoma is well documented. However, multifocal metastasis of choriocarcinoma is an extremely rare event. A 20-year-old married woman was admitted through A & E presented with spastic paraplegia and sensory deficit below T4 level. She was not having any obstetric or gynaecological problems. Magnetic resonance imaging revealed bilateral multiple lesions in the lungs and an extradural mass of T2-T3 vertebrae, along with metastatic haemorrhagic cerebral lesions. The patient was operated and histopathology revealed choriocarcinoma. She died on the 5th postoperative day in intensive care unit due to massive haemoptysis. Lung and brain haemorrhages of metastatic choriocarcinoma are indicators of a poor outcome in gestational trophoblastic neoplasia. To our knowledge, this is the first reported case of multifocal choriocarcinoma metastases in brain, thoracic spine and lungs.
