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    Enteric Adenovirus Antigens in Children with Gastroenteritis
    (Turkish Soc Immunology, 2014) Kandemir, Idris; Atalay, Mustafa Altay; Delice, Safiye; Tas, Sevgi Kalkanli; Gokahmetoglu, Selma
    Objectives: This study aims to investigate the age and seasonal distribution of enteric adenovirus gastroenteritis in childhood. Patients and methods: The records of stool specimens of a total of 2,422 patients (968 females, 1454 males; mean age 3.6 years; range 0 to 16 years) admitted to our hospital with the complaint of acute gastroenteritis between January 2009 and December 2012 were retrospectively analyzed. Adenovirus serotype 40-41 antigens in the stool specimens were investigated through the immunochromatographic test. Results: Of a total of 2,422 stool specimens, 170 were found to have viral antigens. Most of the patients were between 0 and 2 years old (n=106; 62%). Enteric adenovirus infection was mostly seen during spring (8%) and it reached peak during August (11.2%). Conclusion: The detection of adenoviruses in acute gastroenteritis is important to prevent unnecessary antibiotic usage and to reduce the development of antibacterial resistance.
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    The Prophylactic Effects of Folic Acid and Vitamin E against Valproic Acid During Fetal Thymus Development: an Ultrastructural Study
    (Soc Chilena Anatomia, 2011) Baran, Ozlem Pamukcu; Tunik, Selcuk; Akkoc, Hasan; Devieci, Engin; Ayaz, Ercan; Soker, Sevda; Tas, Sevgi Kalkanli
    To evaluate histopathologic differences in the thymus of Wistar Albino rat fetuses prenatally exposed to valproic acid (VPA), folic acid (FA) and vitamin E (Vit-E). VPA (400 mg/kg), FA (400 mcg/kg) and Vit -E (250 mg/kg) were administered to rats on each of gestation days 8,9 and 10. The fetuses (n:24) were divided into four groups: control, VPA, VPA+Vit-E and VPA+FA groups. On the 20th day of gestation, all pregnant rats were sacrificed and the fetuses were extracted. Thin sections from thymus of live fetuses were stained with uranyl acetate-lead citrate and were examined under transmission electron microscope. The histopathological findings of control group was normal. In VPA group, it showed extensive degenerative changes by VPA were on all tissue compartments when compared to controls. In VPA-FA group, vacuoles, mitochondrial cristalysis and swelling were decreased in cytoplasm. In VPA-Vit-E group, lipid storage and vacuolization were observed. Mitochondrial cristalysis decreased. Our aim in the present study is to analyze histopathological changes which may occur in a high risk experimental model after giving of VPA. In addition, protective roles of the administration of FA and Vit-E are assessed.