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Öğe Analysis of cancer cases from Dicle University Hospital; ten years' experience Analysis of cancer cases(Derman Medical Publ, 2018) Arslan, Necmi; Yilmaz, Ahmet; Firat, Ugur; Tanriverdi, Mehmet HalisAim: Cancer is the most common mortality and morbidity reason in the world. In Turkey cancer prevalence is high, and the treatment is expensive. The most important step in preventing and treating cancer is an early diagnosis. We aimed to contribute to the literature by specifying the common cancer types and etiological factors present in Diyarbakir region. Material and Method: Archived biopsy reports of patients diagnosed with malignant cancers after histopathological evaluation were studied retrospectively. The cases were dated between 2001 and 2010 and were all taken from the Dicle University Medical Faculty Hospital. Results: In total, 3624 cases were examined according to age, gender, year, location, and pathological diagnosis. Of the patients, 41.7% of the cases were female, and 58.3% were male. The average age of the patients was 54.8 years, and the most frequent age of cancer occurring were between 51-60 years (26.7%). In the pathological results distribution, the years that had the most cancer cases were 2006 and 2007. In general, the most frequent cancer location was lung (11.9%). In terms of specific types of cancers, the most frequent type was adenocarcinoma (24.1 %). Discussion: The most common type in both genders was adenocarcinoma, and it was found that the most common cancer location was the lung. Our study found that cancer was common in older age groups. We tried to determine the most frequent cancer types in the area by using data from Diyarbakir region.Öğe Clinical and laboratory characteristics of 48 patients with miliary tuberculosis(Academic Journals, 2011) Abakay, Ozlem; Abakay, Abdurrahman; Tanriverdi, Mehmet Halis; Sen, Hadice S.; Sezgi, Cengizhan; Kaya, Halide; Tanrikulu, Abdullah CetinMiliary tuberculosis (TB) is a progressive form of TB, indicating disseminated hematogenous spread. Data were collected by scanning the Dicle University Hospital records between January 1990 and December 2010. Forty eight adult patients which were diagnosed miliary TB and followed by hospitalization were enrolled in this study. The mean age was 41.2 +/- 14.1 years. Twenty-four patients (50%) had history of contact with TB patients; six patients (12.5%) had a history of previous TB disease. The most common presenting symptoms were loss of appetite (77.1%), cough (70.8%) and weight loss (64.5%), respectively. Typical miliary pattern were diagnosed radiologically on chest radiographs of all patients. There was cavity at Thoracic tomography in six of 31 patients (12.5%). The most common laboratory finding was elevated erythrocyte sedimentation rate (83.3%). The patients were diagnosed by microbiological (10%), histological (29%) and clinical-radiological (61%) methods. 10 patients (20.8%) had a history of an additional disease accompanying TB. Five patients (10.4%) died during hospitalization. As a result, miliary TB is a form of TB that is more frequent and severe in risk groups with co morbid disease. After clinical suspicion, the use of microbiological and histopathological methods up to radiological methods thought to be useful for fast and accurate diagnosis.Öğe Effects of enuresis nocturna on parents of affected children: Case-control study(Wiley, 2014) Tanriverdi, Mehmet Halis; Palanci, Yilmaz; Yilmaz, Ahmet; Penbegül, Necmettin; Bez, Yasin; Daggulli, MansurBackgroundEnuresis nocturna (EN) is a chronic medical disorder that may cause a parent to question their parenting ability and contribute to an inability to perform the parental role. The aim of the study was to investigate the effects of EN on the relationship between parents, and the effect of mood changes in the couples on the children. MethodsForty children with EN (group 1) were enrolled in the study, and 44 consecutive healthy children (group 2) were randomly selected from the same school. The clinical diagnosis for the patient group was based on a careful history. Spielberg's State-Trait Anxiety Inventory (STAI), Beck Depression Inventory (BDI), and Dyadic Adjustment Scale (DAS) were applied to all parents, and the answers were recorded. ResultsSTAI scores differed between the mothers in the two groups in terms of trait anxiety, while significant differences between the fathers in terms of both state and trait anxiety were observed. The BDI scores were similar between the two groups. The scores of dyadic consensus were lower in the mothers, while the affectional expression scores were lower in the EN study group fathers compared with controls. The total DAS scores were significantly lower in the parents of the children with EN. ConclusionThe parents of children with EN seem to experience increased levels of anxiety. Their desire to continue the marital relationship, the overall quality of their marital relationship and their comfort as a family may also be negatively affected by having a child with EN.Öğe THE EVALUATION OF NEPHROPATHY RISK FACTORS IN TYPE 2 DIABETES(Carbone Editore, 2014) Celepkolu, Tahsin; Tanriverdi, Mehmet Halis; Celk, Sercan Bulut; Bucaktepe, Pakize Gamze Erten; Can, Huseyin; Aslan, Ilknur; Kibrisli, ErkanIntroduction: The prevalence of diabetes has been increasing at an alarming rate worldwide. Thus, the complications of diabetes are increasingly prevalent and each year three million people die as a result of its chronic complications. In our study, we aimed to compare nephropathic and non neplzropathic patients according to socio-denzographic features, biochemical parameters, and proteinuria characteristics. Methods: Data of 923 type 2 diabetic patients, who were admitted to our Department between January 2000 and December 2008, were analysed retrospectively. The records of 378 patients were included in the study and classified as normoalbuminuric, microalbuminuric and macroalbumhzuric. These groups were compared in terms of demographic, clinical and laboratory findings to investigate the risk factors related to nephropathy. Results: Of the 378 patients, 224 were female (59%) and 154 were male (41%). The mean age was 58.9 +/- 9.7 years. A total of 100 patients (265%) with micro and macroalbuminuria were identified as nephropathic. In the nephropathic group, the levels of FBG (Fasting Blood Glucose), PBG (Postprandial Blood Glucose), HbAl c (Hemoglobin Al c= glycosylated hemoglobin), urea, and creatinine, and the duration of known diabetes were significantly increased when compared with the non-nephropathic group. Diastolic blood pressure and urea levels were significantly higher and creatinine clearance was significantly lower in the macroalbuminuric group. Conclusion: We found a significant relationship between nephropathy and HbAl c, an important indicator of blood glucose control. Therefore, it is essential to provide aggressive blood pressure management and long-term glycaeinic control in order to reduce cardiovascular risk, prevent the development of diabetic nephropathy and ESRF (End Stage Renal Failure), and reduce overall mortality and morbidity. Education of diabetic patients about the risks and complications of elevated blood pressure and poor glycaemic control is a critical component of clinical practice.Öğe Evaluation of post-graduate training effect on smoking cessation practice and attitudes of family physicians towards tobacco control(E-Century Publishing Corp, 2014) Turker, Yasemin; Aydin, Leyla Yilmaz; Baltaci, Davut; Erdem, Ozgur; Tanriverdi, Mehmet Halis; Sariguzel, Yunus; Alasan, FatihObjective: Family physicians (FPs) are cornerstone for tobacco control. It was aimed to compare the effect of training on their smoking cessation practice, knowledge level and attitudes towards smoking and tobacco control. Methods and materials: The cross-sectional and multi-centered study was carried out using structured survey modified WHO based questionnaire. It was delivered to 1500 FPs randomly selected among approximately 23000 family physicians across the country. The study survey was self-reported by FPs, assessing their knowledge, attitudes, status of post-graduate training, and practice about tobacco control. Participants were assigned into two groups as non-trainee groups (Group 1) and post-graduate trainee (Group 2). Results: The mean age was 38.4 +/- 7.1 years-old. The percentage of male and female FPs in the study was 53.1% and 46.9%. The ratio of family physicians who participated in training program Group 2) was 26.5% (n = 327). The ratio of female FPs who participated the SCP training course was significantly higher than that of male FPs (27.3% versus 22.5%, p = 0.035). There was no significant difference for smoking status between groups (p = 0.686). When the number FPs whose consulted by the smokers over = 5 a week was compared, the ratio of FPs was significantly higher in group 2 than group 1 (p < 0.001), but overall ratio of FPs (2.8%) who consulted within a week smokers was considerably lower Statements of Competence and confidence items stated by all FPs were 24.2% and 32.2%, respectively. Physicians who had attended post-graduate training on SCP were more competent and confident, compared to non-trained FPs (p = 0.002 and p = 0.001). Conclusion: Post-graduate training on tobacco control improved self-confidence and competence of FPs. With post-graduate training, significant improvement was seen in practical skills of physicians. A continuing training program should be introduced to FPs, to engage them for smoking cessation practice.Öğe Investigation of Mean Platelet Volume and Platelet Count in the Blood of Patients with Migraine(Turkish Neurological Soc, 2013) Varol, Sefer; Akil, Esref; Cevik, Mehmet Ugur; Celepkolu, Tahsin; Yucel, Yavuz; Tanriverdi, Mehmet Halis; Aluclu, Mehmet UfukObjective: Mean platelet volume (MPV) is an indicator for platelet function and activation. Studies researching MPV and platelet level on the patients with migraine are insufficient. In this study, we aimed to find a difference in MPV and platelet count in individuals with migraine compared to healthy controls, which are indicators for platelet activation. Material and Method: We recruited 193 patients (female/male: 128/65, average age: 31.66 +/- 9.01) who are referred to the Neurology Clinic of Dicle University, Faculty of Medicine between January 2010 and January 2012 and have been diagnosed with migraine according to 2004 diagnostic criteria of International Headache Society (IHS) and 119 healthy individuals (female/male: 73/46, averge age: 32.27 +/- 9.88) who are referred to the Family Practice Clinic and Blood Bank. We compared MPV and platelet counts between the patients with migraine and healthy controls. Both groups were similar in terms of age and gender. Results: A statistically insignificant increase was found in MPV in patients with migraine (7.98 +/- 1.34 fL) when compared to the control group (7.85 +/- 0.96 fL) (p=0.34). Platelet levels were significantly lower in patients with migraine (367.6 +/- 74.2) than the platelet levels of the control group (286.9 +/- 68.3) (p=0.02). Discussion: We found lower platelet levels in the patients with migraine compared to the control group. There was also statistically insignificant increase in MPV in patients with migraine, suggesting that these findings may indicate an insignificant platelet activation in patients with migraine. New prospective studies are needed on this subject.Öğe Investigation of Mean Platelet Volume in Patients with Multiple Sclerosis(Turkish Neurological Soc, 2011) Uzar, Ertugrul; Arikanoglu, Adalet; Yucel, Yavuz; Aydin, Birsen; Tanriverdi, Mehmet Halis; Tasdemir, NebahatObjective: Alterations in platelet function have been observed in patients with multiple sclerosis. Mean platelet volume is a marker of the platelet activity and is reported to be increased in vascular diseases. The aim of this retrospective study was to investigate the correlation between mean platelet volume and multiple sclerosis. Materials and Methods: The patient group consisted of 46 multiple sclerosis patients who were presented with multiple sclerosis attacks (males/females: 10/36, mean age: 34.3 +/- 9.4 year). In the multiple sclerosis patients, mean platelet volume values during the attack were compared with the mean platelet volume value after attack. Mean platelet volume values of patients were also compared with those of 38 age/sex-matched healthy individuals (males/females: 14/24, mean age: 36.4 +/- 10.4). Results: No difference was found in mean platelet volume values during the multiple sclerosis attack (8.0 +/- 1.2) versus after the multiple sclerosis attack (7.9 +/- 1.2), and no relation was found between mean platelet volume and Expanded Disability Status Scale (EDSS) parameters (p> 0.05). No difference was found in mean platelet volume values between the multiple sclerosis group (8.1 +/- 1.3) and control group (8.1 +/- 1.1) (p> 0.05). Conclusion: No significant change in mean platelet volume values was seen during the multiple sclerosis attack versus after the multiple sclerosis attack. This finding supports that platelet activation does not play an important role in the multiple sclerosis pathogenesis. However, the relation between multiple sclerosis and mean platelet volume should be investigated prospectively.Öğe Low fetuin-A level in migraine: a case-control study(Springer-Verlag Italia Srl, 2014) Tanriverdi, Mehmet Halis; Varol, Sefer; Arikanoglu, Adalet; Bucaktepe, Pakize Gamze Erten; Celepkolu, Tahsin; Akil, Esref; Yuksel, HaticeMigraine is a type of primary headache which is caused by the alterations in trigeminovascular system. Migraine attacks are associated with neurovascular inflammation of the cerebral and extracerebral vessels, but its pathophysiological mechanisms have not still been fully delineated. Also, migraine has been found to be associated with higher risks for various metabolic disorders. Thus, we aimed to investigate the matrix metalloproteinases (MMP), fetuin-A, ghrelin, and omentin levels which have important roles in metabolic disorders and inflammation, and to examine their relationship with migraine subtypes and attack frequency. Forty-nine migraine patients and 30 age- and sex-matched healthy control subjects were enrolled. Migraine diagnosis was confirmed according to the International Classification of Headache Disorders-II diagnostic criteria. Analyses of MMP9,MMP3, ghrelin, omentin, and fetuin-A were performed by the ELISA method. Fetuin-A, MMP-9, and MMP-3 levels were significantly lower in migraine than controls (p < 0.05). There were no significant differences between groups with respect to omentin and ghrelin (p > 0.05). In migraine patients, serum fetuin-A levels were positively correlated with MMP-9 and negatively correlated with MMP-3. MMP-3, MMP-9, fetuin-A, omentin and ghrelin levels did not correlate with age, disease duration, or frequency of migraine headache (p > 0.05). Migraine patients have lower fetuin-A, MMP-3 and MMP-9 levels than healthy individuals. Migraine patients have low fetuin-A levels, which may be related to the pathogenesis of migraine. The importance and impact of our findings on the pathogenesis, characteristics, and treatment of migraine needs to be investigated in further detailed studies.Öğe The potential role of BMI, plasma leptin, nesfatin-1 and ghrelin levels in the early detection of pancreatic necrosis and severe acute pancreatitis: A prospective cohort study(Elsevier Science Bv, 2014) Turkoglu, Ahmet; Boyuk, Abdullah; Tanriverdi, Mehmet Halis; Gunduz, Ercan; Dusak, Abdurrahim; Kaplan, Ibrahim; Gumus, MetehanBackground: Early prediction of disease severity in acute pancreatitis (AP) is crucial. The aim of this study was to investigate the body-mass index (BMI), plasma leptin, nesfatin-1 and ghrelin levels as potential markers predicting peripancreatic necrosis and severity in acute pancreatitis. Methods: In the study period, 97 consecutive patients with AP were prospectively analysed. Severe AP was defined according to the Atlanta Criteria. BMI was also calculated. To measure plasma Leptin, Nesfatin-1 and Ghrelin concentrations, the blood samples were obtained from patients within 24 hours of admission. Results: Out of 97 patients, 92(70 females, 22 males) were considered eligible for analysis. Of the 92 patients, 30 patients (32.6%) were assessed as severe pancreatitis. BMI and leptin levels were significantly higher in patients with severe pancreatitis. The pooled sensitivity and specificity of BMI as a predictor for the development of pancreatic necrosis were 0.90(95% CI = 0.56-0.99) and 0.70(95% CI = 0.58-0.79), respectively; with an overall area under curve value of 0.78. The pooled sensitivity and specificity of leptin levels as a predictor for development of pancreatic necrosis were 1(95% CI = 0.69-1) and 0.73(95% CI = 0.62-0.82), respectively; with an overall area under curve value of 0.82. Nesfatin-1 and ghrelin levels showed no significant difference in patients with mild pancreatitis (6.97 +/- 0.84 ng/ml and 2.3(1.0-9.9); respectively) and severe pancreatitis (6.74 +/- 0.65 ng/ml and 2.0(1.9-9.9); respectively) (p = 0.1923 and 0.8531; respectively). Conclusion: BMI and plasma leptin levels both were correlated with the severity of pancreatitis. Leptin levels showed better area under the curve, sensitivity and specificity values compared to BMI in prediction of pancreatic necrosis. Nesfatin-1 and ghrelin levels were not found to be predictors of the severity of disease. (C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.Öğe Protective Effects of Beta Glucan and Gliclazide on Brain Tissue and Sciatic Nerve of Diabetic Rats Induced by Streptozosin(Hindawi Ltd, 2012) Alp, Harun; Varol, Sefer; Celik, Muhammet Murat; Altas, Murat; Evliyaoglu, Osman; Tokgoz, Orhan; Tanriverdi, Mehmet HalisThere have not been yet enough studies about effects of beta glucan and gliclazide on oxidative stress created by streptozotocin in the brain and sciatic nerve of diabetic rats. The aim of this paper was to investigate the antioxidant effects of gliclazide and beta glucan on oxidative stress and lipid peroxidation created by streptozotosin in brain and sciatic nerve. Total of 42 rats were divided into 6 groups including control, diabetic untreated (DM) (only STZ, diabetic), STZ (DM) + beta glucan, STZ (DM) + gliclazide, only beta glucan treated (no diabetic), and only gliclazide treated (no diabetic). The brain and sciatic nerve tissue samples were analyzed for malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON-1) levels. We found a significant increase in MDA, TOS, and OSI along with a reduction in TAS level, catalase, and PON-1 activities in brain and sciatic nerve of streptozotocin-induced diabetic rats. Also, this study shows that in terms of these parameters both gliclazide and beta glucan have a neuroprotective effect on the brain and sciatic nerve of the streptozotocin-induced diabetic rat. Our conclusion was that gliclazide and beta glucan have antioxidant effects on the brain and sciatic nerve of the streptozotocin-induced diabetic rat.Öğe Smoking cessation practice in male versus female family physicians in Turkey(European Respiratory Soc Journals Ltd, 2013) Aydin, Leyla Yilmaz; Baltaci, Davut; Alasan, Fatih; Tanriverdi, Mehmet Halis; Deler, Harun[Abstract Not Available]
