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    Increased fibrinogen, D-dimer and galectin-3 levels in patients with migraine
    (Springer-Verlag Italia Srl, 2014) Yucel, Yavuz; Tanriverdi, Halis; Arikanoglu, Adalet; Varol, Sefer; Kaplan, Ibrahim; Akil, Esref; Celepkolu, Tahsin
    There are limited studies evaluating the fibrinogen levels in patients with migraine. It remains unknown whether the levels of the haematological marker of thromboembolism, d-dimer, and the levels of galectin-3, which plays an important role in inflammation as a proinflammatory mediator, change during the attacks in patients with migraine. The present study aims to compare galectin-3, fibrinogen and d-dimer levels in patients with migraine during the attacks and interictal periods, and to compare galectin-3, fibrinogen and d-dimer levels between patients with migraine and healthy controls to investigate the role of these parameters in the pathogenesis of migraine. Fifty-nine patients with migraine and 30 age-gender matched healthy control subjects were enrolled in the study. Blood galectin-3, fibrinogen and d-dimer levels were measured in patients with migraine. Patients with migraine had higher levels of galectin-3, fibrinogen and d-dimer compared to the healthy controls (p < 0.05). No statistically significant difference was found between galectin-3 and fibrinogen levels during the attacks and interictal period in the migraine group (p > 0.05). Migraine patients had higher d-dimer levels during the attacks compared to the patients in the interictal period in the migraine group (p = 0.05). In conclusion, we found increased levels of fibrinogen, d-dimer and galectin-3 in patients with migraine compared to the healthy control group. Furthermore, we showed increased galectin-3 levels in patients with migraine, and higher d-dimer levels during migraine attacks compared to the interictal periods for the first time. These findings may be associated with the hypercoagulability and neurogenic inflammation during migraine headaches.
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    The relationship between high incidence of deep neck infection and toothbrushing frequency
    (Academic Journals, 2012) Bakir, Salih; Gunay, Ahmet; Tanriverdi, Halis; Gun, Ramazan; Atilgan, Serhat; Palanci, Yilmaz; Ozbay, Musa
    This study aimed to investigate and compare the frequency of toothbrushing and dental health status between deep neck space infection (DNSI) patients with dental origin and healthy population. 64 participants were included in this study in the form of two groups. The first group consisted of 34 DNSI patients with dental onset, and the second group consisted of 30 participants (control group). Study was carried out in two separate categories: the frequency of toothbrushing and assessment of dental health status. Toothbrushing frequency was evaluated with a questionnaire. Dental health status was assessed for periodontal and dental disease by periodontist according to the some widely used indicators; Decayed Missing Filled Teeth (DMFT) scores, Plaque Index score, Gingival Index score and Sulcus Bleeding Index score. Present study showed that the majority had brushed their teeth occasionally. In DNSI group, the percentage of never toothbrushing was very high and regular toothbrushing rate was so low. DNI group has higher scores than the control group and this indicates poor oral hygiene. Our results showed that, oral health was impaired and regular toothbrushing seems to have been neglected in DNSI group. In our opinion, this negligence is a very important contributory factor towards the more occurrence of deep neck abscess.
  • [ X ]
    Öğe
    The relationship between high incidence of deep neck infection and toothbrushing frequency
    (Academic Journals, 2012) Bakir, Salih; Gunay, Ahmet; Tanriverdi, Halis; Gun, Ramazan; Atilgan, Serhat; Palanci, Yilmaz; Ozbay, Musa
    This study aimed to investigate and compare the frequency of toothbrushing and dental health status between Deep neck space infection (DNSI) patients with dental origin and healthy population. 64 participants were included in this study in the form of two groups. The first group consisted of 34 DNSI patients with dental onset, and the second group consisted of 30 participants (control group). Study was carried out in two separate categories: the frequency of toothbrushing and assessment of dental health status. Toothbrushing frequency was evaluated with a questionnaire. Dental health status was assessed for periodontal and dental disease by periodontist according to the some widely used indicators; DMFT scores, Plaque Index score, Gingival Index score and Sulcus Bleeding Index score. Present study showed that the majority had brushed their teeth occasionally. In DNSI group, the percentage of never toothbrushing was very high and regular toothbrushing rate was so low. DNI group has higher scores than the control group and this indicates poor oral hygiene. Our results showed that, oral health was impaired and regular toothbrushing seems to have been neglected in DNSI group. In our opinion, this negligence is a very important contributory factor towards the more occurrence of deep neck abscess.
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    Öğe
    Toxic Effects of Isoniazid and Rifampicin on Rat Brain Tissue: The Preventive Role of Caffeic Acid Phenethyl Ester
    (Asian Network Scientific Information-Ansinet, 2012) Cevik, Mehmet Ugur; Acar, Abdullah; Tanriverdi, Halis; Varol, Sefer; Arikanoglu, Adalet; Yucel, Yavuz; Akil, Esref
    To the best of present knowledge, the possible protective effects of Caffeic Acid Phenethyl Ester (CAPE), on possible Isoniazid (INH) and Rifampicin (RIF) induced neurotoxic effects in brain tissue have not been investigated yet. As such, the purpose of this experimental study was to investigate the effects of CAPE, on INH and RIF induced neurotoxicity in rat brain tissue. We measured Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD) activities, Malondialdehyde (MDA) and nitric oxide (NO) levels in the brain tissue of rats. Male Sprague-Dawley rats were divided into eight experimental groups, with ten animals in each group. These groups are consist of control group, INH-treated group, RIF-treated group, INH+RIF treated group, INH+CAPE treated group, RIF+CAPE treated group, INH+RIF+CAPE treated group and CAPE treated group. MDA and SOD levels in brain tissue were significantly higher and TAC levels were lower in the INH, RIF and INH+RIF treated groups (p<0.05) and TAC levels were lower in the INH, RIF and INH+RIF groups than in the control group (p<0.05). CAPE plus INH and/or RIF treatment caused a significant decrease in MDA levels in brain tissue (p<0.05). In addition, CAPE plus INH and/or RIF treatment caused a significant increase in TAC levels (p<0.05). In conclusion, we have shown that administration of INH and RIF is accompanied by increased lipid peroxidation and oxidants in rat brain tissue. CAPE may protect against INH and RIF-induced neurotoxicity. Therefore, CAPE supplementation may be used as a potential neuroprotective drug for antituberculosis therapy with INH and/or RIF.