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Öğe An approach based on probabilistic neural network for diagnosis of Mesothelioma's disease(Pergamon-Elsevier Science Ltd, 2012) Er, Orhan; Tanrikulu, Abdullah Cetin; Abakay, Abdurrahman; Temurtas, FeyzullahMalignant mesothelioma (MM) is an aggressive progress tumor that results from mesotel cells and pleura usually incurs. The two important causes, in MM etiologies are known as asbestos and erionite, both mineral fibers. Environmental asbestos exposure and MM are one of the major public health problems of Turkey. In this study, two different probabilistic neural network (PNN) structures were used for MM's disease diagnosis. The PNN results were compared with the results of the multilayer and learning vector quantization neural networks focusing on MM's disease diagnosis and using same database. It was observed the PNN is the best classification with 96.30% accuracy obtained via 3-fold cross-validation. The MM disease dataset were prepared from a faculty of medicine's database using new patient's hospital reports from south east region of Turkey. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.Öğe Cigarette use frequency and the affecting factors in primary and high school students in Diyarbakir(Turkish Assoc Tuberculosis & Thorax, 2009) Palanci, Yilmaz; Saka, Gunay; Tanrikulu, Abdullah Cetin; Acemoglu, HamitCigarette, alcohol and substance use is a worldwide threat which especially affects young people and a preventable public health problem. Aim of the study is to investigate the prevalence of substance use and the factors affecting this prevalence among the students of primary and high school students in Diyarbakir. 62% of the students were males, and 38% were females. The age range was from 11 to 20 and the mean age was 15.2 + 2.0. The smoking prevalence was a total of 14.8% (6.0% in females and 20.2% in males), 5.8% in primary school students, 23.7% in high school students. The mean first-smoking age was found as 12.6 + 2.3 years. Smoking were more common among male students than girls. Close friends and teachers were source of imitation to smoke cigarettes. Other associated factors were age, buying cigarettes from the corner shops for parents, usage of other addictive substances. Cigarette use among students attending to schools in Diyarbakir is significant health problem and preventive interventions should be employed without delay. Interventions which will be implemented in this context not only should comprise the young, but also the all society. Families, teachers and primary school students are the groups which are of priority for intervention. The law about cigarette smoking should be fully enforced.Öğe Clinical and laboratory characteristics of 48 patients with miliary tuberculosis(Academic Journals, 2011) Abakay, Ozlem; Abakay, Abdurrahman; Tanriverdi, Mehmet Halis; Sen, Hadice S.; Sezgi, Cengizhan; Kaya, Halide; Tanrikulu, Abdullah CetinMiliary tuberculosis (TB) is a progressive form of TB, indicating disseminated hematogenous spread. Data were collected by scanning the Dicle University Hospital records between January 1990 and December 2010. Forty eight adult patients which were diagnosed miliary TB and followed by hospitalization were enrolled in this study. The mean age was 41.2 +/- 14.1 years. Twenty-four patients (50%) had history of contact with TB patients; six patients (12.5%) had a history of previous TB disease. The most common presenting symptoms were loss of appetite (77.1%), cough (70.8%) and weight loss (64.5%), respectively. Typical miliary pattern were diagnosed radiologically on chest radiographs of all patients. There was cavity at Thoracic tomography in six of 31 patients (12.5%). The most common laboratory finding was elevated erythrocyte sedimentation rate (83.3%). The patients were diagnosed by microbiological (10%), histological (29%) and clinical-radiological (61%) methods. 10 patients (20.8%) had a history of an additional disease accompanying TB. Five patients (10.4%) died during hospitalization. As a result, miliary TB is a form of TB that is more frequent and severe in risk groups with co morbid disease. After clinical suspicion, the use of microbiological and histopathological methods up to radiological methods thought to be useful for fast and accurate diagnosis.Öğe Clinical Characteristics of Patients with Mesothelioma: A University Hospital of 2011 Data(Derman Medical Publ, 2013) Tanrikulu, Abdullah Cetin; Abakay, Abdurrahman; Abakay, Ozlem; Sezgi, Cengizhan; Sen, Hadice Selimoglu; Onder, Omer Faruk; Senyigit, AbdurrahmanAim: Malignant mesothelioma (MM) in the etiology of environmental and occupational asbestos exposure is usually to be responsible. The fibrous zeolite erionite was accused. MM due to environmental asbestos exposure is a common disease in our region. Material and Method: University Hospital in 2011 followed up a total of 28 patients with MM was evaluated retrospectively. Clinical radiological and histopathological features were investigated. Results: Fifteen patients were female and thirteen male. The mean age was 59.9 +/- 12.4 (36-81) years. In nine patients Ergani four patients Cermik district appealed. Fifteen patients (53.6%) were positive for asbestos exposure and mean asbestos exposure time was 24.7 years. Fourteen patients (50%) were diagnosed biopsy. In twelve patients left sides were involved. Seventeen patients had epithelial type. Pleural fluid cytology was positive in only four patients. The most frequent clinical symptom dyspnea. Patients with alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) values were higher. Discussion: People living in dense region are the theme of environmental asbestos MM appropriate should be considered in patients with symptoms and signs. For the prevention of disease in our region for the abandonment of the use of asbestos in environmental studies will be useful to do.Öğe Clinical characteristics, treatment and survival outcomes in malignant pleural mesothelioma: An institutional experience in Turkey(Imprimatur Publications, 2014) Kucukoner, Mehmet; Kaplan, Mehmet Ali; Inal, Ali; Urakci, Zuhat; Abakay, Ozlem; Tanrikulu, Abdullah Cetin; Abakay, AbdurrahmanPurpose: To compare treatment modalities and investigate potential prognostic factors for survival in patients with malignant pleural mesothelioma (MPM). Methods: The present study has investigated the data of 150 patients with MPM who were examined and treated in our center from 2005 to 2012. Results: The study included 87 male (58%) and 63 female (42%) patients. Surgical resection (pleurectomy/decortications (P/D), and extrapleural pneumonectomy (EPP)) was performed in 32 (36.7%) patients; 87 patients (58%) received chemotherapy alone and 16 (10.7%) had surgery, chemotherapy and radiotherapy (trimodal treatment). The median progression free and overall survival (PFS and OS) for all patients were 10.6 and 14.8 months, respectively. No statistically significant difference was observed between the patients who received pemetrexed/cisplatin (N=54) and gemcitabine/cisplatin (N=28) in terms of PFS and OS (p=0.145, p=0.244, respectively). Also, no statistically significant difference was registered between operated and non operated patients (PFS and OS, p=0.416, p=0.095, respectively). There was no difference in both PFS and OS rates between patients who had P/D or EPP (p=0.87, p=0.652, respectively). Log rank analysis: Eastern Cooperative Oncology Group performance status (ECOG PS)(p=0.018), histology (p < 0.001), stage (p < 0.001) and leukocytosis (p=0.005) were found to be significant prognostic factors of OS. At multivariate analysis, ECOG PS (p=0.016) and stage (p < 0.001) were independent prognostic factors for OS. Conclusion: Median OS was approximately 1 year. ECOG PS, histological type, stage and presence of leukocytosis were prognostic factors that affected both PFS and OS. EPP or P/D surgical options did not provide difference in terms of survival. Survival rates in patients who received a combination of platinum analogues with pemetrexed or gemcitabine as front-line chemotherapy were similar.Öğe A Clinical, Radiographic and Laboratory Evaluation of Prognostic Factors in 363 Patients with Malignant Pleural Mesothelioma(Karger, 2010) Tanrikulu, Abdullah Cetin; Abakay, Abdurrahman; Kaplan, Mehmet Ali; Kucukoner, Mehmet; Palanci, Yilmaz; Evliyaoglu, Osman; Sezgi, CengizhanBackground: Malignant pleural mesothelioma (MPM) has a poor prognosis. Objectives: Only few studies in literature investigated the presence of pleural fluid and radiographic findings for the prognosis of MPM. Methods: We retrospectively investigated the hospital charts of 363 MPM patients who were diagnosed from January 1989 to March 2010. Survival time was calculated by the Kaplan-Meier method. Pretreatment clinical, laboratory and radiographic features of each patient at the time of diagnosis were obtained from patients' charts. Results: The mean age of 363 patients (217 men, 146 women) was 50.6 +/- 11.2 years (range 19-85) and the mean survival time was 11.7 +/- 8.6 months (range 1-53). Histological types of MPM were epithelial (71.2%), mixed (15.9%) and sarcomatous type (4.9%). The frequency of disease stages were 31.4% for stage 1, 24.2% for stage 2, 28.6% for stage 3 and 15.8% for stage 4. The most frequent symptoms were dyspnea (82.1%), chest pain (68.3%) and weight loss (58.9%). Results of univariate and multivariate analyses revealed that a Karnofsky performance score <= 60, a pleural fluid glucose level <= 40 mg/dl, a C-reactive protein level > 50 mg/l, a serum lactate dehydrogenase level > 500 U/l, the presence of pleural fluid, pleural thickening > 1 cm and a platelet count of > 420 x 10(3)/mu l were found to be associated with poor prognosis in MPM. Conclusions: Our data suggest that low pleural fluid glucose and high C-reactive protein, the presence of pleural fluid and pleural thickening were associated with poor MPM prognosis. Further prospective studies are needed to highlight prognostic factors more clearly. Copyright (C) 2010 S. Karger AG, BaselÖğe Coenzyme Q10, Copper, Zinc, and Lipid Peroxidation Levels in Serum of Patients with Chronic Obstructive Pulmonary Disease(Humana Press Inc, 2011) Tanrikulu, Abdullah Cetin; Abakay, Abdurrahman; Evliyaoglu, Osman; Palanci, YilmazSeverity of chronic obstructive pulmonary disease (COPD) exacerbation is associated with increased level of copper (Cu), zinc (Zn), and lipid peroxidation (malodialdehyde, MDA). The aim of this study was to investigate the levels of lipid peroxidation, Coenzyme Q10 (CoQ10), Zn, and Cu in the COPD exacerbations. Forty-five patients with COPD acute exacerbation and 45 healthy smokers as control group were used in the study. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were lower in exacerbation group than in control. C- reactive protein levels, white blood cell count, and sedimentation rate were significantly (p < 0.001) higher in patients than in control. CoQ10 level and Cu/Zn ratio was significantly (p < 0.05) lower in patients than in control, although MDA, Cu, and Zn levels were significantly (p < 0.05) higher in patients than in control. Negative correlations were found among MDA, Cu, Zn, FEV1, and FVC values in exacerbation and control subjects (p < 0.05). In conclusion, we observed that oxidative stress in the exacerbation period of COPD patients was increased. The decrease in CoQ10 level and Cu/Zn ratio and elevation in Cu and Zn levels observed in the patients probably result from the defense response of organism and are mediated by inflammatory-like substances.Öğe A Department of Chest Diseases: 2011 Data of Tuberculosis(Derman Medical Publ, 2013) Tanrikulu, Abdullah Cetin; Cakirca, Seher; Abakay, Abdurrahman; Sezgi, Cengizhan; Sen, Hadice Selimoglu; Onder, Omer Faruk; Abakay, OzlemAim: Tuberculosis (TB) is transmitted through inhalation, is a disease that can involve all the tissues and organs. The most common location was the lung involvement. In this study we aimed to discuss the clinical and demographic data of TB patients who were followed in the University of Chest Diseases Clinic in 2011. Material and Method: TB is still an important public health problem: order to analyze our data about the disease patients file retrospectively studied who followed clinical university hospital in 2011. During the study period 56 TB patients file were examined. Results: A total of 24 patients female were and 32 were male. The mean age of female patients was 28.8 and male was 32.5 years. A total of 28 patients were smear-positive pulmonary tuberculosis (11 female, 17 male). In smear-positive cases 25 sputum smear-positive and 3 cases gastric juice smear-positive. Three patients were diagnosed with smear-negative, while a positive in culture. In total, four patients had relapsed pulmonary TB. Six patients were diagnosed with TB pleurisy and four of the six patients diagnosed with pleural biopsy and two diagnosed pleural fluid adenosine deaminase levels. A total of 22 patients with pulmonary tuberculosis were diagnosed radiologically and clinically. In two of 56 patients developed hepatotoxicity. Discussion: TB is a disease affecting the young population that seriousness of continued. Early diagnosis and treatment is particularly important for transmission of TB.Öğe Determination of environmental exposure to asbestos (tremolite) and mesothelioma risks in the southeastern region of Turkey(Heldref Publications, 2004) Senyigit, Abdurrahman; Dalgic, Abdurrahman; Kavak, Orhan; Tanrikulu, Abdullah CetinIn this study, the authors examined the concentrations and mineralogical analyses of asbestos, and investigated mesothelioma risk in southeastern Anatolia, Turkey. They used a gravimetric dust sampler to collect samples from 2 villages and 2 asbestos mines (1 active). Samples were then evaluated by an X-ray diffractometer and an electron microscope. The authors found high concentrations of asbestos in an active mine (4.9 fibers[f]/cm(3)) and at a house that was plastered with asbestos (1.24 f/cm(3)) and had a very active population. They found a low concentration (0.0042 f/cm(3)) in indoor measurements taken in Armutova village, and an even lower concentration (0.000081 f/cm(3)) in the inactive mine environment. Outdoor measurements included a low concentration of 0.007 f/cm(3) in the village environment, and a high concentration of 1.17 f/cm(3) on the mine road during the passing of a sheep herd. The people in the region are continuously exposed to asbestos during normal activities. This cumulative exposure to asbestos carries sufficient risks for mesothelioma development.Öğe Factors affecting incidence of tuberculosis in Diyarbakir(Turkish Assoc Tuberculosis & Thorax, 2007) Tanrikulu, Abdullah Cetin; Abakay, Abdurrahman; Abakay, Ozlem; Alp, AdilLast decade, there have been important improvements about tuberculosis (Tbc) in the world. Today, 32% of world populations are infected by Tbc basil's, every year about 9 million people have been catching Tbc. We have purposed to determine the incidence of Tbc and the factors affect it, using rate of bacteriology in diagnosis, rate of treatment completion and to constitute an idea for innovation. Diyarbakir, standard monthly data forms used for informing of Tbc in tuberculosis control dispensary are investigated retrospectively among 1996-2004. The mean incidence of yearly Tbc is 37.77/100.000 and pulmonary Tbc is 30.11/100.000. In this period have been determined 3724 new Tbc patient; 2969 (79.7%) are pulmonary Tbc and 755 (20.3%) extrapulmonary Tbc. 842 patient (22.6%) of pulmonary Tbc are smear positive. Tbc pleurisy is the most common type of extrapulmonary Tbc in our series. 3354 (90.1%) of whole patients and 2624 (88.4%) with pulmonary Tbc had completed treatment. There is no data about the rate of cure. This is the most common problem Tbc control system. In 2005, cure rates will have been determined by the way of new form. 162 (4.4%) patient had abandoned treatment. Incidence of Tbc is higher than the incidence of Turkey. It was considered that at the first place highly growing population, the crowded family pattern sharing the same house and bad socioeconomic factors have been playing a major role. Furthermore, it was found that the rate of bacteriological diagnosis was low. In order to increasing of this rates should be carried out necessary studies, should be tried to diagnose all patients with bacteriological methods. End of the treatment cure should be tried to demonstrate by way of examination of sputum. The treatment process should be pursued by directly observed treatment strategy.Öğe High Social Anxiety and Poor Quality of Life in Patients With Pulmonary Tuberculosis(Lippincott Williams & Wilkins, 2015) Kibrisli, Erkan; Bez, Yasin; Yilmaz, Ahmet; Aslanhan, Hamza; Taylan, Mahsuk; Kaya, Halide; Tanrikulu, Abdullah CetinPulmonary tuberculosis (PT) has been previously related with various psychosocial adverse consequences including stigmatization and social isolation. Social anxiety is a psychiatric condition that may be associated with social isolation and fear of social exclusion. To date no study has investigated social anxiety and its impact on quality of life (QoL) among patients with PT. Therefore, we aimed to determine the severity of social anxiety in a group of patients with PT. Among patients who were recently discharged from hospital with the diagnosis of PT 94 patients and 99 healthy control subjects who had similar demographical features have been included in the study. A psychiatrist interviewed all participants and a semistructured interview form, which was prepared by the authors, Liebowitz Social Anxiety Scale (LSAS), and Short Form-36 were administered to them. Patients with PT showed higher levels of performance avoidance and social avoidance than healthy control subjects. They reported lower QoL scores across all dimensions. Among patients women showed higher levels of LSAS subscale scores and total score. Fear of social exclusion was predicted by perceived illness severity and emotional role difficulty. On the other hand, perceived illness severity was predicted by fear of exclusion and sedimentation level. PT patients seem to experience higher levels of social anxiety and associated fear of social exclusion that add to their worse QoL during the earlier months of their disease. Among them fear of social exclusion is related with perceived illness severity.Öğe High-risk mesothelioma relation to meteorological and geological condition and distance from naturally occurring asbestos(Springer, 2016) Abakay, Abdurrahman; Tanrikulu, Abdullah Cetin; Ayhan, Mustafa; Imamoglu, Mehmet Sefik; Taylan, Mahsuk; Kaplan, Muhammet Ali; Abakay, OzlemVery few studies have investigated the incidence and risk of malignant mesothelioma (MM) associated with distinct sources of asbestos exposure, especially exposure to naturally occurring asbestos (NOA). Subjects were MM, lung, and breast cancer patients who were diagnosed and followed in Diyarbakir Province between 2008 and 2013. The birthplaces of patients were displayed on a geologic map. Geological and meteorological effects on MM were analyzed by logistic regression. A total of 180 MM, 368 breast, and 406 lung cancer patients were included. The median distance from birthplace to ophiolites was 6.26 km for MM, 31.06 km for lung, and 34.31 km for breast cancer (p < 0.001). The majority of MM cases were seen within 20 km from NOA areas. The MM incidence inside of NOA was 1059/100.000, and out of NOA was 397/100.000; this difference was significant (p = 0.014). The largest concentration of MM residential areas was within +/- 30A degrees (34 residential areas 36.6 %) of the dominant wind direction. Most MM patients were found in or near the dominant wind direction, especially in the acute angle defined by the dominant wind direction. MM incidence was directly proportional to {[area of NOA (km(2))] * [cosine alpha of wind direction angle]} and was inversely proportional to the square of the distance (R = 0.291, p = 0.023). MM was higher near NOA and in the downwind direction. MM incidence and risk were affected by geological and meteorological factors.Öğe High-risk mesothelioma relation to meteorological and geological condition and distance from naturally occurring asbestos (vol 21, pg 82, 2016)(Springer, 2016) Abakay, Abdurrahman; Tanrikulu, Abdullah Cetin; Imamoglu, Mehmet Sefik; Ayhan, Mustafa; Taylan, Mahsuk; Kaplan, Muhammet Ali; Abakay, Ozlem[Abstract Not Available]Öğe Interstitial Lung Disease in Coppersmiths in High Serum Copper Levels(Humana Press Inc, 2010) Dagli, Canan Eren; Tanrikulu, Abdullah Cetin; Koksal, Nurhan; Abakay, Abdurrahman; Gelen, Mehmet Emin; Demirpolat, Gulen; Yuksel, MurvetCoppersmith is a worker who uses copper most commonly for the production of kitchen appliances in Turkey. This is an ancient occupation practiced for centuries in Turkey. Our objective was to investigate the prevalence of parenchymal lung diseases among coppersmiths in Kahramanmaras city in Turkey. Thirty coppersmiths were included to the study, and they all signed an informed consent. Demographics, spirometric test results and high-resolution computed tomography (HRCT) scans, and blood samples were obtained. Laboratory analysis of the serum samples showed that serum copper levels of the subjects were 0.93 +/- 0.14 mg/L. Serum copper level in control group was found as 0.70 +/- 0.14 mg/L, and it was significantly different between the two groups (p < 0.05). Of 30 coppersmiths, 17 HRCT findings are abnormal and seen with diffuse parenchymal interstitial lung disease pattern-ten (58.8%) respiratory bronchiolitis interstitial lung disease, five (29.4%) nonspecific interstitial pneumonia, and two (11.8%) usual interstitial pneumonia. The most prevalent HRCT pattern was micronodular pattern in workers. This is the first field study reporting the radiologic findings of coppersmiths and effect of the occupation on lung diseases.Öğe Is a complete blood cell count useful in determining the prognosis of pulmonary embolism?(Springer Wien, 2014) Sen, Hadice Selimoglu; Abakay, Ozlem; Tanrikulu, Abdullah Cetin; Sezgi, Cengizhan; Taylan, Mahsuk; Abakay, Abdurrahman; Kaya, HalidePulmonary embolism (PE) is the third cardiovascular cause of hospital admission, following acute coronary syndrome and stroke. Despite high-tech diagnostic methods and new treatment modalities, PEs continue to have a high mortality rate within the first 3 months. This study was designed to assess the additional prognostic value of a complete blood cell count, renal function markers, C-reactive protein, and simplified pulmonary embolism severity index (sPESI) scoring system in PE 100-day mortality. The study retrospectively enrolled 208 consecutive patients who were hospitalized with the diagnosis of an acute PE. The patients' demographic characteristics and clinical and laboratory parameters were recorded from the hospital electronic database and patient's case notes. The primary end point of the study was an adverse 100-day outcome, defined as death from any cause. The all-cause mortality in the first 100 days was 14.42 %. The mean age was 57.87 +/- 18.17 (range: 16-93) years. We included 79 (38 %) male and 129 (62 %) female individuals. Red cell distribution width (RDW) and sPESI were found to be statistically significant predictors of PE mortality by multivariate regression analysis. On multivariate regression analysis, RDW was associated with a 4.08-fold (95 % confidence interval: 1.229-13.335, P = 0.021) increase in PE mortality. The results of this study demonstrated that RDW and sPESI may be a useful guide in predicting 100-day mortality. The elevated RDW may alert physicians to possible poor prognosis.Öğe AN OVERVIEW OF THROMBOLYTIC TREATMENT FOR PULMONARY EMBOLISM: A SINGLE CENTRE EXPERIENCE(Carbone Editore, 2014) Sen, Hadice Selimoglu; Abakay, Ozlem; Sezgi, Cengizhan; Yilmaz, Sureyya; Taylan, Mahsuk; Kaya, Halide; Tanrikulu, Abdullah CetinIntroduction: A massive pulmonary embolism (MPE) has a poor prognosis and high mortality. Thrombolytic therapy is preferred in patients with life-threatening symptoms such as hypotension, cardiogenic shock, and right ventricular failure due to the risk of severe bleeding. Materials and methods: This is a retrospective analysis of patients who were hospitalized with the diagnosis of pulmonary embolism (PE) and given thrombolytic therapy in the chest diseases clinic of a tertiary university hospital between January 2008 and November 2013. Results: The subjects' mean age was 59.54 +/- 13.76 years. Fourteen of 39 patients who were treated with thrombolytic therapy were male (35.89%) and 25 (64.10%) were female. The symptoms experienced by the patients included dyspnea in 39 patients, chest pain in 35 patients, hemoptysis in 6 patients, syncope in 13 patients and cough in 10 patients. Risk factors were advanced age (> 60 years) in 19, immobilization in 19, malignancy in 3, major surgery in 11 patients. The in-hospital mortality analysis showed that 32 patients were discharged and 7 patients died. Four patients died from their pulmonary embolism and 3 patients died because of a major bleeding complication. Conclusions: Pulmonary embolism is a disease that may lead to death within hours secondary to acute right heart failure. Early diagnosis and treatment can be life saving. Thrombolytic therapy has been shown to improve hemodynamic parameters in the early period post-PE. An increased risk of bleeding is one of the most important drawbacks of thrombolytic therapy. Nonetheless, it can be a life-saving therapy in properly selected patients.Öğe Relationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndrome(Springer Heidelberg, 2015) Abakay, Ozlem; Abakay, Abdurrahman; Palanci, Yilmaz; Yuksel, Hatice; Sen, Hadice Selimoglu; Evliyaoglu, Osman; Tanrikulu, Abdullah CetinThis study was aimed to assess potential correlations between periodic leg movement (PLM) index, hepcidin levels, and iron status in patients with obstructive sleep apnea syndrome (OSAS). Forty-four newly diagnosed OSAS patients and 49 non-apneic controls were enrolled in this study. All patients underwent polysomnographic evaluation. The hepcidin, iron, ferritin, total iron binding capacity, and C-reactive protein levels were measured. The mean age was 47.4 +/- 7.2 years (18-68) in the OSAS group and 44.9 +/- 11.1 years (23-65) in the control group. There were no differences in age, gender, and smoking between OSAS patients and controls. Mean apnea-hypopnea index (AHI) was 25.1 events/h. Mean serum hepcidin levels were significantly higher in OSAS subjects (725.9 ng/ml) than in control subjects (646.0 ng/ml) (p < 0.001). Serum iron levels were significantly lower in the OSAS and PLM disorder groups than in control subjects (p < 0.001). Serum hepcidin levels were significantly correlated with AHI (r = 0.453) and PLM index (r = 0.114). Serum iron levels were significantly negatively correlated with AHI (r = -0.169) and PLM index (r = -0.180). In our study, the level of hepcidin was increased in patients with OSAS. Our study indicates that levels of hepcidin correlate with the AHI and PLM index severity of OSAS.Öğe Risk factors for multidrug-resistant tuberculosis in Diyarbakir, Turkey(Int Scientific Information, Inc, 2010) Tanrikulu, Abdullah Cetin; Abakay, Abdurrahman; Abakay, OzlemBackground: Multidrug-resistant (MDR) tuberculosis (TB) is a serious public health problem. This study aimed to investigate probable risk factors for developing MDR in the patients treated for TB at Tuberculosis Control Dispensaries (TCD). Matreial/Method: The records of 34 patients with MDR-TB and 70 patients with TB sensitive to all first-line drugs (DS), who were treated at TCD between January 2002 and December 2008, were reviewed retrospectively in Diyarbakir, Turkey. Results: The mean age was 34.47 +/- 16.99 (32.35 +/- 14.21 in MDR group and 35.50 +/- 18.19 in control group) with the range from 2 to 76 years. Of the patients, 63 were male and 41 were female. When risk factors for MDR were evaluated with univariate analysis methods, low socio-economic status, the presence of accompanying disease, previous TB history, previously administered TB treatment, inappropriate TB treatment, and noncompliance with TB treatment were all found to be significant risk factors. When these risk factors were analyzed with logistic regression analysis, regardless of other risk factors, MDR risk was significantly increased with previous TB history by 22.31, with previously taking TB medication by 13.19, and with low socio-economic status by 6.03. Conclusions: Socio-economic factors also play an important role in this issue. To minimize the effect of patients' risk factors, health workers should be able to reach all patients, and therapies must be given under direct observation.Öğe Skin Ulcers: A Sign of Disseminated Tuberculosis(Daedalus Enterprises Inc, 2011) Tekbas, Guven; Abakay, Abdurrahman; Tanrikulu, Abdullah Cetin; Firat, Ugur; Ekici, Faysal; Dostbil, Zeki; Sula, Bilal[Abstract Not Available]Öğe Tuberculosis as an occupational disease: based on health care centers in Turkey(Drunpp-Sarajevo, 2011) Abakay, Abdurrahman; Tanrikulu, Abdullah Cetin; Abakay, Ozlem; Sen, Hadice SelimogluBackground: Health care workers (HCWs) are at high risk of contamination. Preventive measures simultaneously implemented in hospitals have reduced the risk of nosocomial transmission of M. tuberculosis. It was aimed to determine the tuberculosis (TB) risk of HCWs working in hospitals and Tuberculosis Control Dispensaries (TCDs). Material and Methods: The records of HCWs worked in five hospitals and four TCDs in Diyarbakir were reviewed retrospectively. Clinical data belong to HCWs diagnosed TB were recorded. Results: TB was determined in 36 HCWs. Disease rate was a mean of 74/100.000 and relative risk was 2.5 times higher than population. In health care centers (HCCs) providing smear positive pulmonary TB treatment, disease rate was 176/100.000 and relative risk was 6 times higher; in HCCs not providing smear positive pulmonary TB treatment, disease rate was 66/100.000 and relative risk was 2.2 times higher. It was determined that most of the precautions that should be implemented for preventing transmission was missed in HCCs providing smear positive pulmonary TB. Conclusion: It was determined that TB risk of HCWs working in HCCs included in the study especially in the centers providing smear positive pulmonary TB treatment was increased. It was suggested that a steady educational program for HCWs and implementing the other preventive measures could be effective to decrease the increased risk.
