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    The protective effect of ellagic acid against renal ischemia-reperfusion injury in male rats
    (Veteriner Fakultesi Dergisi, 2012) Bozkurt Y.; Firat U.; Atar M.; Sancaktutar, Ahmet Ali; Pembegul N.; Soylemez H.; Yuksel H.
    The aim of this study was to evaluate the possible protective effect of ellagic acid (EA) on rats following renal ischemia-reperfusion (I/R) injury. Twenty-four Wistar rats were divided into three groups. Sham group underwent laparotomy then waited for 45 min without ischemia. I/R group were subjected to left renal ischemia for 45 minutes followed by 60 min of reperfusion. I/R+EA group were subjected to the same renal ischemia/reperfusion as the I/R group, were also given 85 mg/kg EA perorally 30 min prior to the ischemia. Malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were determined on the blood samples and kidney tissues. Histopathological analyses were conducted on the kidney tissues. I/R damage significantly increased serum MDA levels in the I/R group when compared with Sham group. Serum TAC level was significantly lower in I/R group than I/R+EA group. A significantly increase on OSI levels and decrease on TAC levels was found in the kidneys in I/R group. In I/R + EA group, EA reversed the negative effects of I/R injury. EA pretreatment was effective in decreasing tubular necrosis score. In conclusion; EA pretreatment ameliorated the oxidative damage and histopathological changes occurring following renal I/R injury.
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    Tubularized incised plate repair in circumcised adults
    (2013) Hatipoglu N.K.; Bodakci M.N.; Soylemez H.; Sancaktutar, Ahmet Ali; Atar M.; Penbegul N.; Cakmakci S.
    Aim In this study, the experience of tubularized incised plate repair in circumcised adults in terms of functional, cosmetic, and satisfactory results is reported. Methods Tubularized incised plate repair urethroplasty (TIPU) was performed to 27 circumcised adult patients between 2008- 2010; 19 (70.4%) had distal penile hypospadias and eight (29.6%) had midshaft hypospadias. All patients were operated by a single surgeon and were asked to fill out a questionnaire to asses functional and cosmetic results of the surgery. Results The mean age of patients was 22.0 years. All patients were controlled in urology office seven days after the removal of urethral catheter. They were controlled in the 3rd, 6th, and 12th month after the operation and they filled out the questionnaire in the 6th month after the operation in the TIP. The mean follow up was 13 months. Three (11.1%) patients had meatus stenosis and two (7.4%) urethral fistula as a complication. Twenty-four (88.8%) patients reported that they were satisfied about penile length, 26 (96.2%) about the appearance of the meatus, 25 (92.5%) about the appearance of the glans penis, 22 (81.4%) about the appearance of the foreskin, 23 (85.1%) about the straightness of the penis with erection, and 24 (88.8%) about the overall appearance of the penis. All patients were satisfied about the urinary flow and seven (100%) patients who were sexually active reported that they were satisfied with vaginal penetration and sexual satisfaction. Conclusion Tubularized incised plate repair technique reveals good functional and cosmetic results even in adults who were circumcised.