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Phytochemical Analysis and Assessment of Antioxidant and Enzyme Inhibitory Activity of Alchemilla pseudocartalinica Juz.
(Wiley-V C H Verlag Gmbh, 2024) Uzunkaya, Cagla; Gokkaya, Icim; Akkaya, Didem; Soral, Michal; Seyhan, Gokce; Barut, Burak; Yilmaz, Mustafa Abdullah
This study aimed to evaluate and compare the antioxidant capacity and enzyme inhibitory activity of extracts, sub-extracts, and fractions prepared from the aerial parts and roots of A. pseudocartalinica. The phytochemical content of the active extracts was also analyzed. According to the results, ellagic acid (38.42 mg/g) was the major compound in the aerial part methanol extract and catechin (185.30 mg/g) in the root methanol extract. The DPPH inhibition activity of all fractions was monitored, with the most active one (Fr B) reaching an IC50 value of (4.92 +/- 0.59 mu g/mL). All the fractions prepared from the aerial parts' water sub-extract showed higher a-glucosidase inhibitory activity than the positive control acarbose. In the tyrosinase assay, Fr B (58.81 +/- 7.50 mu g/mL) exhibited the highest inhibitory actions among all fractions. The structure of the major substances of the most active fraction were elucidated as quercetin 7-O-beta-glucopyranosyl-3-O-beta-glucuronopyranoside- (1), and alpha-[(2-formyl-5-hydroxymethyl)pyrrol-1-yl]aspartic acid (2).