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    Association Between the Rh Blood Group and the Covid-19 Susceptibility
    (Akad Doktorlar Yayinevi, 2020) Arac, Esref; Solmaz, Ihsan; Akkoc, Hasan; Donmezdil, Suleyman; Karahan, Zulkuf; Kaya, Safak; Mertsoy, Yilmaz
    We aimed to investigate whether there is a predisposition to COVID-19 with ABO and Rh blood group systems. This study was a retrospective study that investigate the patients admitted to our hospital between March 16 -May 20 due to Covid-19 pandemic and conducted with data revealed from the hospital Information Management System A total of 392 patients were included in this study, including 227 PCR test positive patients with blood group information in the system and 165 possible patients with CT findings in favor of Covid-19. Data from a blood group study conducted with 127091 people in our province in 2019 were used as a control group. In our study, a significant increase was observed in the blood group A in patients diagnosed with Covid-19, and a decrease was found in the blood groups B, AB and especially O. However, statistical analysis showed no significant difference between Covid-19 patients and healthy individuals in terms of ABO blood group system. When analyzed in terms of Rh blood group system, it was found that Rh positivity was statistically significantly higher in patients with Covid-19 (p= 0.000). Our study suggests that the Rh (-) blood group is protective and the Rh (+) blood group is predisposed to Covid 19 significantly. We think that it is valuable because it is the first study to reveal the relationship between Covid-19 and blood type in our country and the only one to reveal the relationship between Covid-19 and Rh (+) in the world literature.
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    Nasal septum perforation in the patients with advanced breast cancer due to the treatment of lapatinib+capecitabine
    (Kare Publ, 2015) Oruc, Zeynep; Kucukoner, Mehmet; Urakci, Zuhat; Kaplan, M. Ali; Solmaz, Ihsan; Isikdogan, Abdurrahman
    Nasal septum perforation is a rare complication that can occur due to certain antineoplastic agents, especially antiangiogenic agents such as bevacizumab. There has been no case of nasal perforation case due to the treatment of lapatinib+capecitabine so far. Our case is nasal septum perforation occuring with the 38-year-old patient diagnosed with premenopausal advanced breast cancer during the treatment of lapatinib+capecitabine. It occured as epistaxis in the 30th month of patient's treatment. In the anterior rhinoscopy, nasal septum perforation was diagnosed. The patient had no nasal irritant or cocaine, or no trauma story. Although it is a rare complication, perforation due to lapatinib+capecitabine should be considered in the advanced breast cancer patients with the treatment of lapatinib+capecitabine when nasal symptoms (epistaxis, nasal congestion, local pain, irritation, rhinorrhea) occur.
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    Polymorphisms in the IL28B gene (rs12979860, rs8099917) and the virological response to pegylated interferon therapy in hepatitis D virus patients
    (Univ Catholique Louvain-Ucl, 2016) Yilmaz, Bulent; Can, Guray; Ucmak, Feyzullah; Arslan, Ali Osman; Solmaz, Ihsan; Unlu, Ozan; Duzenli, Selma
    Aim : Few data are available regarding the effects of interleukin 28B (IL28B) polymorphisms in chronic hepatitis D (CHD) patients. This study investigated the relationship between IL28B polymorphisms and the response of patients with CHD infections to pegylated interferon (PEG-IFN) therapy. Materials and methods : A total of 101 CHD patients were selected, 80 of whom (46 males; median age 41 years) satisfied the inclusion criteria and were enrolled in the study. Thirty-seven patients were treated with peg-IFNa for at least 12 months and were followed for a median of 18 months (range, 12-30 months). The primary treatment endpoint was the suppression of HDV replication, as documented by the loss of detectable HDV RNA in serum. Geno-typing was used to analyse the IL28B polymorphisms rs12979860 and rs8099917 according to the virological response. Results : After treatment, a sustained viral response (SVR) was achieved in 19 (51%) of the patients treated with PEG-INF. The IL28B genotypes in the 80 patients were as follows : CC in 36 (45%), CT in 33 (41%) and TT in 11 (14%) for rs12979860, and GG in 4 (5%), GT in 27 (34%) and TT in 49 (61%) for rs8099917. SVR was achieved in 5 (26%), 10 (53%) and 4 (21%) patients with CC, CT and TT at rs12979860, respectively, and one (5%), nine (47%) and nine (47%) patients with GG, GT and TT at rs8099917, respectively. There were differences in the SVR among genotypes (rs12979860 and rs8099917; chi-squared test, p = 0.047). Conclusion : IL28B predicts the PEG-IFN response in patients with CHD infection.
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    THE STATUS OF OXIDATIVE STRESS AND ANTIOXIDANT DEFENSE IN PATIENTS WITH CHRONIC HEPATITIS D
    (Carbone Editore, 2016) Ucmak, Feyzullah; Solmaz, Ihsan; Ekin, Nazim; Kaplan, Ibrahim; Tuncel, Elif Tugba; Senates, Ebubekir; Yalcin, Kendal
    Introduction: Oxidative stress is increasingly recognized as an important factor in the progression of chronic liver disease of varying etiologies and antioxidants are utilized in the treatment of some of them. Chronic viral hepatitis D continues to be a significant health problem in certain regions of the world. Rates of response to currently proposed treatments are rather low. The aim of this study was to investigate oxidative stress in patients with chronic viral hepatitis D. Materials and methods: A total of 91 patients with chronic hepatitis D virus infection were included in this study (mean age: 42.2 +/- 11.7). In addition, 40 healthy volunteers were included in the study to form the control group. Patients were divided into two main sub-groups as cirrhotic (n=30) and non-cirrhotic (n=61) groups. Blood samples were taken from both patients and control subjects and compared for total oxidant status (TOS), total anti-oxidant status (TAS) and oxidative stress index (OSI). Results: TOS levels were significantly higher in the patients compared to the control sub-jects (p<0.001). Moreover, TOS levels were higher in the cirrhotic patients compared to the non-cirrhotic patients (p=0.006). TAS levels were significantly lower in the patients compared to the control subjects (p=0.003). OSI levels were significantly higher in the patients compared to the control subjects (p<0.001). Moreover, OSI levels were higher in the cirrhotic patients compared to the non-cirrhotic patients (p<0.05). Conclusion: These results are supportive of the role of oxidative stress in the pathogenesis of chronic viral hepatitis D. Antioxidant therapies might be considered in patients with chronic viral hepatitis D considering the presence of oxidative stress in these patients.