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  • [ X ]
    Öğe
    The prevalence of hepatocellular carcinoma in patients with liver cirrhosis in Southeastern Turkey
    (1998) Degertekin H.; Sit D.
    In this study, the prevalence of hepatocellular carcinoma (HCC) in patients liver cirrhosis in Southeastern Turkey was been investigated. Median age was 47.9 years and female/male ratio was 1/2.2. Ultrasonography (USG), alkalene phasphatose (ALP), alpha fetoprotein (AFP) and ferritin were studied in all cases; CT was performed in suspected cases and HCC was diagnosed by liver biopsy. HCC was found in eight out of 156 patients with liver cirrhosis (5.1%). One of the HCC cases was in Child B, and the others in Child C. Levels of ALP, AFP and ferritin were significantly high (p<0.001). All cases were male and the average age was 56.2. HBsAg was positive in all cases. In addition anti-HCV and anti-HDV were positive in two patients. HCC was located in the right lobe in all cases. It was localized type (2 to 7 cm) in seven cases and diffuse type in one case. In conclusion, the prevalence of HCC seems to be lower than expected (5.1%) in our region in spite of the high frequency of liver cirrhosis. The short survival period, severity of complications and genetic properties of viral agents may be important. The levels of ALP, AFP and ferritin and examination of USG are important in follow up of patients. Hepatitis B virus is the most important factor not only in liver cirrhosis, but also in HCC cases in our region.
  • [ X ]
    Öğe
    Venlafaxine HCl in the treatment of painful peripheral uremic neuropathy: A case report
    (2006) Kadiroglu A.K.; Sit D.; Kayabasi H.; Yilmaz E.; Isikoglu B.
    Background: It is well known that uremia may lead symmetric sensorimotor polyneuropathy that tends to affect the lower limbs compared to upper limbs. It typically involves the legs than the arms. Clinical manifestations include paresthesia, painful dysesthesia, weakness in the legs and arms. The traditional tricyclic antidepressants (TCA) are commonly used in the treatment of painful peripheral polyneuropathy. Venlafaxine is a serotonin-noradrenaline reuptake inhibitor that may have analgesic effect on painful peripheral polyneuropathy. Case Report: Venlafaxine extended release capsule (Effexor 75mg XR, Wyeth) was administered to a 49 years old female patient who has been under hemodialysis therapy for 7 years. She complained of bilateral numbness, pain, pin-pricking and burning in her feet that increasing in the evening. She was also suffered from insomnia for two months. The patient's symptoms were resolved in two weeks after beginning to the therapy but the intensity of pain continued minimaly and the patients demonstrated effective improvements at her insomnia in this period. Venlafaxine was well tolerated and there were no side effects such as nasuea, elevated blood pressure and dizziness. Conclusions: Venlafaxine relieved the symptoms of the uremic polyneuropathy and it was effective in insomnia.