Yazar "Sir, A" seçeneğine göre listele
Listeleniyor 1 - 10 / 10
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Comparative efficacy of sertraline and venlafaxine-XR in major depression(Cambridge Univ Press, 2004) D'Souza, R; Sir, A; de Felice, N; George, T; Uguz, S; Martin, A; Lamb, W[Abstract Not Available]Öğe Comparative efficacy of sertraline versus venlafaxine-XR in severe depression(Elsevier Science Bv, 2004) George, T; Uguz, S; Hopwood, M; Souza, RD; Sir, A; Malouf, E; Burt, T[Abstract Not Available]Öğe Comparative efficacy of sertraline versus venlafaxine-XR in severe depression(Cambridge Univ Press, 2004) George, T; Uguz, S; Hopwood, M; D'Souza, R; Sir, A; Malouf, E; Burt, T[Abstract Not Available]Öğe Frequency of PTSD in a group of search and rescue workers two months after 2003 Bingol (Turkey) earthquake(Lippincott Williams & Wilkins, 2004) Ozen, S; Sir, AThis study aimed to determine the frequency of posttraumatic stress disorder (PTSD) in a group of search and rescue workers 2 months after the May 2003 Bingol earthquake. Forty-four of 55 workers were interviewed. The Personal Information Form, the Clinician Administered Posttraumatic Stress Disorder Scale, the State Anxiety Inventory, the Trait Anxiety Inventory, the Beck Depression Inventory, the Quality of Life Enjoyment and Satisfaction Questionnaire, and the Endicott Work Productivity Scale were used. PTSD was diagnosed in 25% of the subjects. In subjects with PTSD, all scale scores were significantly higher. A positive correlation was determined between Clinician Administered Posttraumatic Stress Disorder Scale score and State Anxiety Inventory, Trait Anxiety Inventory, Beck Depression Inventory, Endicott Work Productivity Scale scores (r = 0.712, p = .000; r = 0.429, p = .004; r = 381, p = .011; r = 0.720, p = .000, respectively). The high scores of all scales showed that PTSD may also have comorbidity with other psychiatric disorders. Rescue workers who give first-level service in disasters should receive psychiatric support in specific time frames.Öğe Nicotine dependency of a girl at the age of 18 months(Carfax Publ Co, 1998) Sir, A; Ozkan, MThis case report describes severe nicotine dependency developing at the age of 18 months. Familial, genetic, biological aspects of the case and the therapeutic strategy are discussed.Öğe One-year follow-up study of posttraumatic stress disorder among earthquake survivors in Turkey(W B Saunders Co, 2005) Altindag, A; Ozen, S; Sir, AEarthquakes and their consequences present a major global public health problem. In 1998, a major earthquake struck Southern Turkey. The aims of this study were to describe longitudinally the severity and the course of posttraumatic stress disorder (PTSD) and depression among earthquake survivors in Turkey and to explore risk factors associated with psychiatric disorders. The sample of this study consists of 105 consecutive subjects who used our psychiatric service, via either outpatient clinic or home visit. PTSD was assessed by the Clinician-Administered PTSD Scale for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The severity of depression was assessed using Beck Depression Inventory. The rates of earthquake-related Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition PTSD were 42% within 1 month and 23% within 13 months. The diagnosis of PTSD was significantly related to the presence of injury and to less social support in the initial assessment. In the follow-up assessment, although the mean total Clinician-Administered PTSD Scale severity score improved significantly, the mean Beck Depression Inventory score did not change significantly. The decrease in posttraumatic stress symptoms 13 months after the earthquake may be related to relatively good living conditions and adequate social and health services. Early mental health intervention may serve to prevent the chronicity of posttraumatic stress reactions among earthquake victims. (c) 2005 Elsevier Inc. All rights reserved.Öğe Predisposing factors for delirium in the surgical intensive care unit(Biomed Central Ltd, 2001) Aldemir, M; Özen, S; Kara, IH; Sir, A; Baç, BBackground Delirium is a sign of deterioration in the homeostasis and physical status of the patient. The objective of our study was to investigate the predisposing factors for delirium in a surgical intensive care unit (ICU) setting. Method Between January 1996 and 1997, we screened prospectively 818 patients who were consecutive applicants to the general surgery service of Dicle-University Hospital and had been kept in the ICU for delirium. All patients were hospitalized either for elective or emergency services and were treated either with medication and/or surgery. Suspected cases of delirium were identified during daily interviews. The patients who had changes in the status of consciousness (n=150) were consulted with an experienced consultation-liaison psychiatrist. The diagnosis of delirium was based on Diagnostic and Statistical Manual of Mental Disorders (revised third edition) criteria and established through psychiatric interviews. Patients were divided into two groups: the 'delirious group' (DG) (n=90) and the 'nondelirious group' (NDG) (n=728). During delirium, all abnormal findings related to physical conditions, laboratory features, and additional diseases were evaluated as probable risk factors of delirium. Results Of 818 patients, 386 (47.2%) were male and 432 (52.8%) were female. Delirium developed in 90 of 818 patients (11%). The cases of delirium in the DG were more frequent among male patients (63.3%) than female patients (36.7%) (chi (2) = 10.5, P=0.001). The mean age was 48.9 +/- 18.1 and 38.5 +/- 13.8 years in the DG and NDG, respectively (t=6.4, P=0.000). Frequency of delirium is higher in the patients admitted to the Emergency Department (chi (2) = 43.6, P=0.000). The rate of postoperative delirium was 10.9%, but there was no statistical difference related to operations between the DG and NDG (chi (2) = 013, P=0.71). The length of stay in the ICU was 10.7 +/- 13.9 and 5.6 +/-2.9 days in the DG and NDG, respectively (t=0.11, P=0.000). The length of stay in hospital was 15.6 +/- 16.5 and 8.1 +/-2.7 days in the DG and NDG, respectively (t=11.08, P=0.000). Logistic regression was used to explore the associations between probable risk factors and delirium. Delirium was not correlated with conditions such as hypertension, hypo/hyperpotassemia, hypernatremia, hypoalbuminemia, hypo/hyperglycemia, cardiac disease, emergency admission, age, length of stay in the ICU, length of stay in hospital, and gender. It was determined that conditions such as respiratory diseases (odds ratio [OR] = 30.6, 95% confidence interval [CI] = 9.5-98.4), infections (OR = 18.0, 95% CI = 3.5-90.8), fever (OR = 14.3, 95% CI = 4.1-49.3), anemia (OR = 5.4, 95% CI = 1.6-17.8), hypotension (OR 19.8, 95% CI = 5.3-74.3), hypocalcemia (OR = 30.9, 95% CI = 5.8-163.2), hyponatremia (OR 8.2, 95% CI = 2.5-26.4), azotemia (OR = 4.6, 95% CI = 1.4-15.6), elevated liver enzymes (OR 6.3, 95% CI = 1.2-32.2), hyperamylasemia (OR = 43.4, 95% CI = 4.2-442.7), hyperbilirubinemia (OR = 8.7, 95% CI = 2.0-37.7) and metabolic acidosis (OR = 4.5, 95% CI = 1.1-17.7) were predicting factors for delirium. Conclusion We determined that conditions such as respiratory diseases, infections, fever, anemia, hypotension, hypocalcemia, hyponatremia, azotemia, elevated liver enzymes, hyperamylasemia, hyperbilirubinemia and metabolic acidosis were predicting factors for delirium.Öğe Randomized trial of sertraline versus venlafaxine XR in major depression: Efficacy and discontinuation symptoms(Physicians Postgraduate Press, 2005) Sir, A; D'Souza, RF; Uguz, S; George, T; Vahip, S; Hopwood, M; Martin, AJBackground: The comparative efficacy of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepmephrine reuptake inhibitors (SNRIs) was recently debated. Meta-analyses, based mainly on fluoxetine comparator data, suggest that the SNRI venlafaxine has superior efficacy to SSRIs in treatment of major depression. Objective: To compare quality of life (QOL), efficacy, safety, and tolerability associated with sertraline and venlafaxine extended release (XR) for treatment of DSM-IV major depression. Method: This was an 8-week, double-blind, randomized study of sertraline (50-150 mg/day) versus venlafaxine XR (75-225 mg/day), followed by a 2-week taper period. Subjects were recruited from 7 sites in Turkey and 6 sites in Australia between October 2002 and July 2003. The primary outcome measure was the Quality of Life Enjoyment and Satisfaction Questionnaire. Secondary outcome measures included measures of depression (including response and remission), anxiety, pain, safety (e.g., blood pressure), and tolerability (e.g., discontinuation symptoms). Results: A total of 163 subjects received study treatment (women, 69%; mean age, 37.0 [SD = 12.9] years). No significant differences in QOL or efficacy were noted between treatments on the primary or secondary endpoints for the total study population or the anxious depression and severe depression subgroups. A priori analyses of symptoms associated with treatment discontinuation demonstrated no difference between treatment groups. However, in post hoc analyses, sertraline was associated with less burden of moderate to severe discontinuation symptoms. Venlafaxine XR was associated with a relative increase in mean blood pressure (supine diastolic blood pressure, -4.4 mm Hg difference at week 8/last observation carried forward). Conclusion: Sertraline and venlataxine XR demonstrated comparable effects on QOL and efficacy in treatment of major depression, although sertraline may be associated with a lower symptom burden during treatment discontinuation and a reduced risk of blood pressure increase.Öğe Saturation mapping of bipolar affective disorder (BPAD) susceptibility locus on chromosome 20p11.2-q11.2.(Univ Chicago Press, 2002) Akarsu, AN; Kara-Ozer, S; Yuncu, Z; Girgin, B; Okur, H; Sir, A; Herken, H[Abstract Not Available]Öğe Tolerability and discontinuation effects for sertraline versus venlafaxine-XR in depression(Cambridge Univ Press, 2004) Sir, A; D'Souza, R; de Felice, N; Uguz, S; George, T; McIlroy, F; Lamb, W[Abstract Not Available]
