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    The association of endothelial nitric oxide synthase gene G894T polymorphism and serum nitric oxide concentration with microalbuminuria in patients with gestational diabetes
    (Dustri-Verlag Dr Karl Feistle, 2014) Atay, Ahmet Engin; Akbas, Halit; Tumer, Cemil; Sakar, Mehmet Nafi; Esen, Bennur; Incebiyik, Adnan; Simsek, Selda
    Aim: Gestational diabetes mellitus (GDM) is a glucose intolerant condition that affects 14% of all pregnancies. Diabetes mellitus (DM) occurs in 30 - 70% of patients with GDM after delivery. DM and GDM are associated with structural and functional deterioration of the renovascular system. Our aim is to investigate the association Glu-298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene with serum nitric oxide levels and microalbuminuria in patients with GDM and healthy pregnancies. Material and methods: Serum nitric oxide (NO) levels, urinary excretion of albumin and Glu298Asp polymorphism of the eNOS gene were analyzed in 68 patients with GDM and 73 healthy controls. High performance liquid chromatography (HPLC-Griess) method was used to analyze serum NO levels. Microalbuminuria was evaluated by rate nephelometry method. The Glu298Asp polymorphism of the eNOS gene was determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: Nitric oxide, glucose, creatinine, and microalbuminuria were significantly different between the patients and the control subjects (p = 0.001, p = 0.001, p = 0.002, and p = 0.005, respectively). There was a significant difference between groups in terms of the ratio of GG/GT+TT of eNOS gene Glu298Asp (p = 0.02). The patients with GT+TT genotype had significantly higher microalbuminuria levels and lower NO concentrations (22.16 vs. 9.51, p = 0.005, and 10.56 vs. 12.73, p = 0.021, respectively). The presence of T allele of eNOS gene is an independent predictor of microalbuminuria (OR: 2.346, 95% confidence interval: 1.247 - 5.238, p = 0.02) as well as serum glucose and NO concentration. Conclusion: The G894T polymorphism of eNOS gene and decreased NO concentration seem to be independent predictors of increased urinary excretion of albumin in patients with GDM. Determining the frequency of eNOS gene G894T polymorphism may help to identify pregnancies at increased risk of microalbuminuria.
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    AN AZOOSPERMIC CASE WITH Y ISOCHROMOSOME
    (John Wiley & Sons Inc, 2009) Turkyilmaz, Aysegul; Oral, Diclehan; Simsek, Selda; Isi, Hilmi
    [Abstract Not Available]
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    The Effects of Pegylated Interferon Alpha-2a and Alpha-2b Therapy on Chromosomal Aberrations and Mitotic Index in Patients with Chronic Hepatitis B
    (Ortadogu Ad Pres & Publ Co, 2012) Akbas, Halit; Yalcin, Kendal; Isi, Hilmi; Simsek, Selda; Atay, Ahmet Engin; Budak, Turgay
    Objective: We aimed to prospectively evaluate the effects of pegylated interferon alpha-2a and alpha-2b therapy on chromosomal aberrations and mitotic index in patients with chronic hepatitis B. Material and Methods: Fifty patients with chronic hepatitis B who underwent pegylated interferon alpha-2a or 2b therapy were evaluated for chromosomal aberrations and mitotic index before the treatment and at the end of 6 months of therapy. Results: Cytogenetic examinations revealed out that there was no significant difference between pre- and post-treatment frequencies of mitotic index and chromosomal aberrations. Conclusion: Interferon alpha-2a and alpha-2b therapy which is associated with common hematologic adverse effects has no significant cytogenetic effect.
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    Ethyl Pyruvate Prevents Ischemia Reperfusion Injury in Isolated Perfused Rat Heart
    (Colegio Farmaceuticos Provincia De Buenos Aires, 2013) Akkoc, Hasan; Tunik, Selcuk; Kelle, Ilker; Gurkan, Ahmet; Erdogmus, Zeynep; Simsek, Selda; Erdinc, Meral
    The aim of the present study was to investigate the protective effect of ethyl pyruvate (EP) against ischemia reperfusion (I/R) injury in isolated rat heart. Male Sprague-Dawley rats were divided into three groups (n = 8); Group 1: Control group, Group 2: I/R, Group 3: I/R+EP. Ischemia was produced for 30 min by blocking the perfusion with Krebs Henseleit solution and it was followed by reperfusion for 60 min. In group 3, EP (2 mmol/L) was added into Krebs Henseleit solution after stabilization period. EP did not change the number of a-smooth muscle actin positive vessels and expression of Bcl-2 and desmin. Treatment with EP significantly reduced I/R induced extension in infarct size (p < 0.001) and release of lactate dehidrogenase (p < 0.001) and creatine phosphokinase (p < 0.05). Myocardial I/R injury significantly increased oxidative stress index and malondialdehyde, total oxidant status levels and significantly decreased paraoxonase actvity and total antioxidant status (p < 0.05). On the other hand, alterations in these biochemical indices due to I/R injury were attenuated by EP treatment (p < 0.01). These results show that ethyl pyruvate prevents ischemia reperfusion injury in isolated perfused rat heart.
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    GENETIC ANALYSIS IN PREGNANCY WITH FETAL PATHOLOGIC ULTRASOUND FINDINGS
    (Diagnosis Press Ltd, 2013) Simsek, Selda; Turkyilmaz, Aysegul; Oral, Diclehan; Yalinkaya, Ahmet; Tekes, Selahaddin; Akbas, Halit; Budak, Turgay
    The aim of this study was to investigate the relationship between fetal abnormal karyotype and fetal abnormal ultrasound examination in pregnancy A total of 191 women were analyzed for karyotyping after detection of a soft marker or of major malformations at the routine antenatal USG, for the period 2007-2011. A total of 191 amniotic fluid samples were analyzed for chromosome aberrations and the fetal karyotype was abnormal in 24.6 % (47/191) of all cases. Among them, 13 cases were with trisomy 21; 5 cases with trisomy 18; 1 case with trisomy 13; 2 cases with triploidy; 7 cases with karyotype of 45,X; 1 case with karyotype 47,XXY; and 18 cases with other abnormal chromosome structures. One hundred and fifty-two karyotyping procedures were done due to the finding of a single sonographic marker Within this group, 17.1 % of the karyotypes were abnormal. Thirty-nine karyotyping procedures were done due to the finding of a multiple sonographic marker In this group, 53.8 % of the karyotypes were abnormal. The overall termination rate was 61.7 % (29/47) in cases with a fetus affected by chromosomal abnormalities. Ultrasound examination is important in prenatal diagnosis. We suggest that karyotype analysis should be advised to pregnant women with an abnormal fetus in the ultrasound examination.
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    p53 CODON 72 POLYMORPHISM ASSOCIATED WITH HEPATITIS B
    (John Wiley & Sons Inc, 2009) Akbas, Halit; Isi, Hilmi; Yalcin, Kendal; Tekes, Selahallin; Simsek, Selda; Budak, Turgay
    [Abstract Not Available]
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    POLYMORPHISM OF P53 GENE EXON 4 IN PATIENTS WITH CORONARY ARTERY DISEASE
    (John Wiley & Sons Inc, 2009) Tekes, Selahaddin; Cakir, Dilek; Yokus, Beran; Iltumur, Kenan; Simsek, Selda
    [Abstract Not Available]
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    PRENATAL DIAGNOSTIC RESULTS OF 241 CASES WITH HIGH RISK IN SCREENING TESTS
    (John Wiley & Sons Inc, 2009) Simsek, Selda; Turkyilmaz, Aysegul; Akbas, Halit; Tekes, Selahattin; Balkan, Mahmut; Budak, Turgay
    [Abstract Not Available]
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    SINGLE NUCLEOTIDE POLYMORPHISMS OF THE FOLLICLE-STIMULATING HORMONE RECEPTOR GENE IN FERTILE AND INFERTILE MALES
    (John Wiley & Sons Inc, 2009) Balkan, Mahmut; Gedik, Abdullah; Tekes, Selahaddin; Simsek, Selda; Turkyilmaz, Aysegul; Oral, Diclehan; Budak, Turgay
    [Abstract Not Available]
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    TURNER- DOWN SYNDROME: A CASE REPORT
    (John Wiley & Sons Inc, 2009) Oral, Diclehan; Simsek, Selda; Turkyilmaz, Aysegul; Balkan, Mahmut
    [Abstract Not Available]