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    Effects of caffeic acid phenethyl ester on cisplatin ototoxicity
    (Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2016) Ozbay, M.; Sengul, E.; Kinis, V.; Alabalik, U.; Yilmaz, B.; Topcu, I.
    Purpose: To report histological and electrophysiological data in rats treated with cisplatin and caffeic acid phenethyl ester. Methods: We randomly divided 28 Wistar rats into four groups of seven, to be treated as follows: control (saline), cisplatin, CAPE and cisplatin-CAPE. Distortion product otoacoustic emission (DPOAE) measurements were performed on day one (before drug administration) and day five under anaesthesia. All animals were killed under general anaesthesia on day five after the DPOAE measurement. The cochleae of each rat were histopathologically and immunohistochemically evaluated. Results: The outer hair cells were mostly preserved in the control and CAPE groups. Moderate -to -severe and mild -to moderate hair cell losses were detected in the cisplatin and cisplatin-CAPE groups, respectively. DPOAE assessments revealed significant deterioration in the cisplatin group (P < 0.05). The difference between the cisplatin and cisplatin-CAPE groups was statistically significant (P < 0.05). Conclusion: CAPE prevents cisplatin ototoxicity
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    Öğe
    Type D personality, anxiety, depression and personality traits in patients with isolated itching of the external auditory canal
    (Cambridge Univ Press, 2016) Yilmaz, B.; Canan, F.; Sengul, E.; Ozkurt, F. E.; Tuna, S. F.; Yildirim, H.
    Objective: This study evaluated type D personality, anxiety, depression and personality traits in patients with isolated itching of the external auditory canal. Method: A hundred consecutive out-patients with isolated itching of the external auditory canal and 100 controls were enrolled in the study. The Type D Scale, the abbreviated form of the Eysenck Personality Questionnaire Revised and the Hospital Anxiety and Depression Scale were used for data collection. Patients were also evaluated using the Modified Itch Severity Scale. Results: In all, 43 per cent of patients and 15 per cent of controls met the criteria for a type D personality. Patients with a type D personality had higher anxiety and itching severity but lower extraversion compared with those without a type D personality. Multiple linear regression analysis showed that extraversion and type D personality were independently associated with itch severity. Conclusion: These data suggest that clinicians should consider psychological and personality features when evaluating and treating patients with isolated itching of the external auditory canal.