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Öğe Barriers to Timely Diagnosis of Cystic Fibrosis Via Newborn Screening in Turkey(Amer Thoracic Soc, 2019) Gokdemir, Y.; Emiralioglu, N.; Sismanlar, T.; Er, B.; Pekcan, S.; Ergenekon, A.; Sen, V.[Abstract Not Available]Öğe Does atopy affect the course of viral pneumonia?(Elsevier Espana Slu, 2018) Erdem, S. B.; Can, D.; Girit, S.; Catal, F.; Sen, V.; Pekcan, S.; Yuksel, H.Background: The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia. Methods: Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Patients were classified into two groups as mild-moderate and severe according to the course of pneumonia. Presence of atopy was evaluated with skin prick tests. Groups were compared to evaluate the risk factors associated with severe viral pneumonia. Results: A total of 280 patients from nine centres were included in the study. Of these patients, 163 (58.2%) were male. Respiratory syncytial virus (29.7%), Influenza A (20.5%), rhinovirus (18.9%), adenovirus (10%), human metapneumovirus (8%), parainfluenza (5.2%), coronavirus (6%), and bocavirus (1.6%) were isolated from respiratory samples. Eighty-five (30.4%) children had severe pneumonia. Atopic sensitisation was found in 21.4% of the patients. Ever wheezing (RR: 1.6, 95% CI: 1.1-2.4), parental asthma (RR: 1.5, 95% CI: 1.1-2.2), other allergic diseases in the family (RR: 1.8, 95% CI: 1.2-2.9) and environmental tobacco smoke (RR: 1.6, 95% CI: 1.1-3.5) were more common in the severe pneumonia group. Conclusions: When patients with mild-moderate pneumonia were compared to patients with severe pneumonia, frequency of atopy was not different between the two groups. However, parental asthma, ever wheezing and environmental tobacco smoke exposure are risk factors for severe viral pneumonia in children. (C) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Does the imbalance between agonistic and antagonistic IL-1 play a role in progression of febrile convulsions?(Verduci Publisher, 2016) Ozen, F.; Kocak, N.; Yildirim, I. Halil; Hacimuto, G.; Sen, V.OBJECTIVE: Inflammation may play an important role in the etiopathology of febrile convulsions (FC). IL-1 beta is an important mediator of inflammation and fever is also important information of FCs. It is suggested that there may be a relationship between polymorphisms of IL-1 beta and FC. The aim of the present study is to investigate the polymorphic stituation of promoter region of IL-1 beta in two sites (-31 and -511) and assess the IL-1 RA VNTR polymorphisms in FC patients in comparison with healthy control groups. MATERIALS AND METHODS: Fifty FC patients and 50 healthy controls (HC) were included in the study. DNA extraction was performed by QIAamp DNA Mini Kit from peripheral blood lymphocytes of all subjects. IL-1 beta promoter polymorphisms were analyzed by PCR-RFLP, IL-1 RA VNTR polymorphisms were analyzed by PCR-agarose gel electrophoresis. RESULTS: Genotype distribution of IL-1 beta promoter region in position -31 was statistically different between FC patients and control groups. Allele I and allele II of IL-1 RA distribution were also statistically different in FC patients and healthy controls. CONCLUSIONS: We have found a significant association between IL-1 RA allele distribution and FC and a poor correlation of T/C substitution at the -31 position of IL-1 beta promoter in FC. Further studies are needed to investigate the gene expression levels and polymorphic situation in same samples.Öğe An evaluation of cases of pneumonia that occurred secondary to hydrocarbon exposure in children(Verduci Publisher, 2013) Sen, V.; Kelekci, S.; Sen, H. Selimoglu; Yolbas, I.; Gunes, A.; Abakay, O.; Gurkan, M. FuatOBJECTIVE: Hydrocarbon pneumonia is distinct among the types of childhood pneumonia in that it has a different pathogenesis and treatment and is preventable. In this study, the cases of 54 children with hydrocarbon pneumonia admitted to the Dicle University Medical Faculty Pediatric Chest Diseases Unit between the years 2006 and 2010 were analyzed retrospectively. PATIENTS AND METHODS: The medical records of 54 patients diagnosed with pneumonia after ingesting/inhaling hydrocarbons were analyzed retrospectively. Age, sex, presenting symptoms, clinical status, radiological and laboratory findings and response to treatment and prognosis were noted. RESULTS: 35 (64.8%) of the patients were male, 19 (35.2%) were female and the ages of the patients ranged from 1 to 5 with an average of 2.49 +/- 0.80. The etiologies of the pneumonia were thinner (33%), naphta (3.7%) and kerosene. In 49 of the patients (90.7%), the symptoms started to occur the day the patient was exposed to hydrocarbons. The average length of hospital stay was 4.0 +/- 2.3 days. Six patients were treated in the intensive care unit (ICU), and one patient with hydrocarbon pneumonia due to kerosene ingestion died. Inhaled corticosteroids were administered to 18 patients who were progressively deteriorating and inhaled salbutamol was given to 16 patients with bronchospasm. Patients with radiological findings on their chest X-rays and auscultatory findings were found to have longer hospital stays (p < 0.05). CONCLUSIONS: To prevent chemical pneumonia, precautions must be taken to stop children under 5 years of age from using/abusing chemical substances. Although some cases of chemical pneumonia lead to death, with diligent care and treatment, the outcomes are promising. The patients in this study group responded well to treatment with inhaled corticosteroids and salbutamol.Öğe FeNO levels in children with asthma and other diseases of the lung(Verduci Publisher, 2013) Kelekci, S.; Sen, V.; Yolbas, I.; Uluca, U.; Tan, I.; Gurkan, M. F.BACKGROUND: Prolonged cough in children is one of the major complaints seen in hospitals. It is difficult to make a proper diagnosis and start the appropriate treatment. Fraction of exhaled nitric oxide (FeNO) measurement is a valuable non-invasive diagnostic tool in determining the cause of prolonged cough in children. Although there are several studies on asthma and COPD, there is a lack of them on other lung diseases such as tuberculosis, bronchiectasia, bronchiolitis obliterans (BO), and pneumonia. PATIENTS AND METHODS: In this study, pretreatment FeNO levels of patients with various lung diseases were measured and results from the sick patient groups were compared with the results from the control group. RESULTS: Pre-treatment FeNO levels in BO, asthma, and tuberculosis patient groups were higher than in the control group (p < 0.001). There was no significant difference between the acute bacterial pneumonia and bronchiectasia groups, and the control group (p > 0.05). CONCLUSIONS: FeNO measurement is a highly important guiding tool in diagnosis and treatment of various lung diseases.Öğe The relationships between clinical outcome and the levels of total antioxidant capacity (TAC) and coenzyme Q (CoQ10) in children with pandemic influenza (H1N1) and seasonal flu(Verduci Publisher, 2012) Kelekci, S.; Evliyaoglu, O.; Sen, V.; Yolbas, I.; Uluca, U.; Tan, I.; Gurkan, M. F.BACKGROUND AND AIM, This study was planned to evaluate the relationships between the levels of total antioxidant capacity (TAC) and Coenzyme 0 (Coal 0) and clinical outcome in hospitalized children with pandemic influenza (H1N1). Serum copper (Cu) and zinc (Zn) levels were also determined to evaluate the changings of oxidative stress's enzyme activities depending on their cofactor concentrations. PATIENTS AND METHODS, Children with suspected H1N1 virus infection were hospitalized and nasal swabs were sent to laboratory for confirmation of H1N1 by rRT-PCR assay. Age and sex matched 31 healthy children were included as Control Group. Total antioxidant capacity and CoQ10 were determined by spectrophotometry and HPLC, respectively, and Cu and Zn were determined using atomic absorption spectrometer. RESULTS, Totally 28 children had H1N1 and 37 children had seasonal influenza (SI). TAC, CoQ10 and Zn levels were found to be significantly decreased in H1N1 patients (1.01 +/- 0.19, 752.2 +/- 163, 69 +/- 27, respectively) compared to Control Group (1.64 +/- 0.36, 934 +/- 21, 92 +/- 4, respectively). Seasonal Influenza group had significantly decreased TAC and Zn levels (1.31 +/- 0.27, 78 +/- 34 respectively) compared with control group (1.64 +/- 0.36, 92 +/- 41, respectively). CoQ10 levels were also found as decreased in H1N1 compared to seasonal influenza (752.2 +/- 163 vs 1022 +/- 199, p = 0.003). There was a significant correlation between CoQ10 levels of sera and chest radiographic findings of patients with H1N1 pneumonia. No significant differences were found in serum Cu levels between patients with H1N1 and SI or control group (150 +/- 45 vs 127 +/- 37, p = 0.215). CONCLUSIONS, Pandemic influenza infection had increased oxidative stress compared to the seasonal influenza.Öğe Renal Growth in Children with Growth Hormone Deficiency(Springer, 2010) Ece, A.; Cetinkaya, S.; Eksioglu, S.; Senel, S.; Ozkasap, S.; Ginis, T.; Sen, V.[Abstract Not Available]Öğe THE ROLE OF FLT3-ITD AND CEBPA MUTATIONS ON PROGNOSIS OF ACUTE LYMPHOBLASTIC LEUKEMIA IN TURKISH PATIENTS(Pergamon-Elsevier Science Ltd, 2014) Uluca, I.; Soker, M.; Ayyildiz, M.; Yurt, M.; Sen, V.; Yel, S.; Coskun, S.[Abstract Not Available]Öğe URINARY EARLY KIDNEY INJURY MOLECULES IN CHILDREN WITH BETA-THALASSEMIA MAJOR(Pergamon-Elsevier Science Ltd, 2014) Sen, V.; Ece, A.; Uluca, I.; Soker, M.; Gunes, A.; Kaplan, O.; Tan, I.[Abstract Not Available]
