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Öğe Adult Diagnosis of Swyer-James-Macleod Syndrome: Retrospective Analysis of Four Cases(Daedalus Enterprises Inc, 2014) Sen, Hadice Selimoglu; Taylan, Mahsuk; Abakay, Ozlem; Sezgi, Cengizhan; Cetincakmak, Mehmet GuliSwyer-James-Macleod syndrome (SJMS) is a rare constrictive bronchiolitis with air-flow obstruction and a decreased number and diameter of ipsilateral peripheral pulmonary vessels. This syndrome is characterized by unilateral hyperlucency on chest radiography. Computed tomography provides useful additional information. The diagnosis is usually made in childhood but sometimes occurs in adulthood. The disease often presents with dyspnea, decreased exercise tolerance, cough, hemoptysis, and recurrent pulmonary infections. SJMS may be confused with asthma or pulmonary embolism due to similar symptoms and may result in inappropriate therapy. This case series examined the clinical and imaging spectrum of four patients who were diagnosed with SJMS in adulthood.Öğe Adult diagnosis of Swyer-James-MacLeod syndrome: Retrospective analysis of four cases(European Respiratory Soc Journals Ltd, 2013) Sen, Hadice Selimoglu; Taylan, Mahsuk; Abakay, Ozlem; Sezgi, Cengizhan; Cetincakmak, Mehmet Guli[Abstract Not Available]Öğe Alterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit(Wiley, 2015) Sezgi, Cengizhan; Taylan, Mahsuk; Kaya, Halide; Sen, Hadice Selimoglu; Abakay, Ozlem; Demir, Melike; Abakay, AbdurrrahmanIntroductionThrombocytopenia is associated with increased mortality in intensive care unit (ICU) patients. Mean platelet volume (MPV) reflects platelet function and activation. Elevated MPV is associated with poor outcomes and increased mortality rate in diseases that are commonly encountered in the respiratory ICU. MethodsWe retrospectively enrolled 95 patients who died in the ICU (dead group), 80 patients who improved and were transferred from the ICU (survived group), and 80 healthy individuals as controls. Laboratory parameters including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), albumin, and complete blood count (CBC) were recorded within 24h on admission and transfered from the ICU or died. White blood cell (WBC) count, hemoglobin (Hb), red cell distribution width, MPV, platelet distribution width (PDW), and platelet count (PC) were obtained from the CBC. ResultsAdmission PC and MPV levels were not different in the survived and dead groups. But in the survived group, admission WBC, MPV and PDW levels decreased, while PC increased when compared with admission levels. In the dead group, admission MPV and PDW levels increased, while PC decreased with respect to admission levels. The admission mean PC of the dead group was 182103, which was above the thrombocytopenia limit. The ratio of admission thrombocytopenia was 45.3% in the dead group, which was significantly higher than that of the survived group (13.8%) (P<0.001) ConclusionsIncreasing MPV and decreasing platelet count may alert intensivists to the worse course of disease in patients who had normal platelet counts at ICU admission. The development of thrombocytopenia may also be essential to assessing the outcome of ICU patientsÖğe Alterations of the neutrophil-lymphocyte ratio during the period of stable and acute exacerbation of chronic obstructive pulmonary disease patients(Wiley, 2017) Taylan, Mahsuk; Demir, Melike; Kaya, Halide; Sen, Hadice Selimoglu; Abakay, Ozlem; Carkanat, Ali Ihsan; Abakay, AbdurrrahmanObjectivesWe aimed to investigate the importance of neutrophil-lymphocyte ratio (NLR) in patients with chronic obstructive pulmonary disease (COPD) for identifying the severity of inflammation and recognition of acute exacerbation. MethodsWe retrospectively enrolled 100 patients with a diagnosis of COPD exacerbation who were admitted to our clinic. Complete blood count (CBC), measurement of C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were determined within 2 h of hospital admission. Three months after an acute exacerbation, these measurements were obtained from the same patients during the stable period of COPD. The control group included 80 healthy subjects. NLR was calculated from CBC. ResultsNLR and other inflammatory markers, such as WBC, CRP and ESR were found to be significantly elevated in exacerbated COPD compared to stable COPD and control participants. There was a significant correlation of NLR with CRP (r=0.415, P<0.001), WBC (r=0.304, P=0.002) and ESR (r=0.275, P=0.035). For an NLR cutoff of 3.29, sensitivity for detecting exacerbation of COPD was 80.8% and specificity was 77.7% (AUC 0.894, P=0.001). Some patients presenting with acute exacerbation of COPD and CRP, WBC or ESR levels lower than the optimal cut-off value had high NLR values. ConclusionsElevated NLR can be used as a marker similar to CRP, WBC and ESR, in the determination of increased inflammation in acutely exacerbated COPD. NLR could be beneficial for the early detection of potential acute exacerbations in patients with COPD who have normal levels of traditional markers.Öğe Apnea-hypopnea duration may be a better choice rather than apnea-hypopnea index for forecasting complications in OSAS(Taylor & Francis Ltd, 2024) Sen, Hadice Selimoglu; Yilmaz, Sureyya Cetin; Tekin, Veysi; Kaya, Sueheyla; Kilic, Tarik; Isik, SehmusObjective: Mean apnea-hypopnea duration (AHD) is the mean duration of apnea-hypopneas experienced during sleep and was found as an indicator of blood oxygenation. The aim of this study was to compare and define the differences in clinical, demographic and polysomnographic characteristics of obstructive sleep apnea (OSA) patients in long and short AHD groups and investigate the relationship between apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and sleepiness. Methods: The cross-sectional analysis included 511 OSA patients who were >18 years and followed up between June 2019 and December 2019 in the Sleep Center of university hospital. The consecutive polysomnography reports and patient data were recorded retrospectively. Results: Polysomnographic evaluation of different AHD groups showed obvious differences. Although there were no statistically significant differences in the overall AHI values. The Epworth measurements, ODI, time that saturation is below 90%, and N1 and N2 sleep were higher in the long AHD group. On the contrary, sleep efficiency, total sleep time, N3 and REM sleep, average oxygen saturation (AOS), and lowest oxygen saturation (LOS) were lower in the long AHD group. Conclusions: The findings of this study showed that the AHD is a useful indicator of blood oxygenation and, therefore, tissue oxygenation, independent of the AHI. OSA patients with longer AHD have more vascular complications such as diabetes and hypertension. We suggest that the severity of OSA should be monitored with AHD for preventing potential complications of OSA.Öğe Clinical and demographic characteristics of tracheobronchial variations(Medknow Publications & Media Pvt Ltd, 2011) Abakay, Abdurrahman; Tanrikulu, Abdullah C.; Sen, Hadice Selimoglu; Abakay, Ozlem; Aydin, Ayse; Carkanat, Ali I.; Senyigit, AbdurrahmanBackground: There are various anatomic variations in tracheobronchial system (tracheal bronchus, ectopic bronchus, and accessory bronchus). We aimed to investigate the bronchoscopic findings of the patients with tracheobronchial variations (TBVs) during bronchoscopy and to describe their clinical characteristics. Materials and Methods: A total of 3322 records of bronchoscopic examinations in university hospital and 1560 in chest disease hospital total 4882 were retrospectively analyzed and 198 (134 male, 64 female) patients were diagnosed as TBV. Results: Mean age of patients was 48.5 +/- 17.8 (range, 15-78) years. Most of the tracheobronchial variations (n = 68, 33.1%) were localized at the right upper lobe bronchus. The most common type of TBVs at this region was right upper lobe with two segments. Symptoms were found in 21 (10.2%) patients with TBVs (7 accessory cardiac bronchus, 5 tracheal bronchus, 5 accessory segmental bronchus in left main bronchus and 4 accessory segmental bronchus in right main bronchus). Their symptoms cough, hemoptysis and recurrent pneumonia with unknown etiologies were thought as related to TBVs. No other potential causes leading these symptoms were found in these patients. Conclusion: According to our best of knowledge our study population is one of the largest series of bronchoscopy for investigate of TBVs. Although TBVs were usually reported as asymptomatic, nearly 10% of our patients with TBVs had symptoms such as recurrent pneumonia, cough and hemoptysis. TBVs should be taken into consideration in symptomatic patients before fiber-optic bronchoscopic examination.Öğe Clinical Characteristics of Patients with Mesothelioma: A University Hospital of 2011 Data(Derman Medical Publ, 2013) Tanrikulu, Abdullah Cetin; Abakay, Abdurrahman; Abakay, Ozlem; Sezgi, Cengizhan; Sen, Hadice Selimoglu; Onder, Omer Faruk; Senyigit, AbdurrahmanAim: Malignant mesothelioma (MM) in the etiology of environmental and occupational asbestos exposure is usually to be responsible. The fibrous zeolite erionite was accused. MM due to environmental asbestos exposure is a common disease in our region. Material and Method: University Hospital in 2011 followed up a total of 28 patients with MM was evaluated retrospectively. Clinical radiological and histopathological features were investigated. Results: Fifteen patients were female and thirteen male. The mean age was 59.9 +/- 12.4 (36-81) years. In nine patients Ergani four patients Cermik district appealed. Fifteen patients (53.6%) were positive for asbestos exposure and mean asbestos exposure time was 24.7 years. Fourteen patients (50%) were diagnosed biopsy. In twelve patients left sides were involved. Seventeen patients had epithelial type. Pleural fluid cytology was positive in only four patients. The most frequent clinical symptom dyspnea. Patients with alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) values were higher. Discussion: People living in dense region are the theme of environmental asbestos MM appropriate should be considered in patients with symptoms and signs. For the prevention of disease in our region for the abandonment of the use of asbestos in environmental studies will be useful to do.Öğe Comparison of clinical features of cystic fibrosis patients eligible but not on CFTR modulators to ineligible for CFTR modulators(Wiley, 2024) Buyuksahin, Halime Nayir; Emiralioglu, Nagehan; Yalcin, Ebru; Sen, Velat; Sen, Hadice Selimoglu; Arslan, Huseyin; Baskan, Azer KilicIntroduction: Cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs target the underlying defect and improve CFTR function. They are a part of standard care in many countries, but not all patients are eligible for these drugs due to age and genotype. Here, we aimed to determine the characteristics of non-eligible patients for CFTR modulators in the CF registry of Turkey (CFRT) to highlight their clinical needs. Methods: This retrospective cohort study included CF patient data from the CFRT in 2021. The decision of eligibility for the CFTR modulator was determined according to the 'Vertex treatment-Finder' on the Vertex (R) website. Demographic and clinical characteristics of patients were compared between eligible (group 1) and ineligible (group 2) groups for CFTR modulators. Results: Among the study population (N = 1527), 873 (57.2%) were in group 1 and 654 (42.8%) were in group 2. There was no statistical difference between groups regarding sex, meconium ileus history, diagnoses via newborn screening, FEV1 z-score, CF-associated complications, organ transplant history, and death. Patients in group 2 had a higher incidence of pancreatic insufficiency (87.7% vs. 83.2%, p = .010), lower median height z-scores (-0.87 vs. -0.55, p < .001), lower median body mass index z-scores (-0.65 vs. -0.50, p < .001), longer days receiving antibiotics due to pulmonary exacerbation (0 [interquartile range, IQR: 0-2] vs. 0 [IQR: 0-7], p = 0.001), and more non-invasive ventilation support (2.6% vs. 0.9%, p = 0.008) than patients in group 1. Conclusion: The ineligible group had worse clinical outcomes than the eligible group. This highlights their need for life-changing drugs to improve clinical outcomes.Öğe Congenital tuberculosis: presentation of a rare case(Soc Argentina Pediatria, 2015) Sen, Velat; Sen, Hadice Selimoglu; Aktar, Fesih; Uluca, Unal; Karabel, Musemma; Gurkan, Mehmet FuatCongenital tuberculosis is a rare disease with a high mortality rate. Congenital tuberculosis is considered the result of mother-to-child transmission from the placenta to the fetus, through the ingestion of the amniotic fluid, or via transplacental transmission through the umbilical vein. Given the non-specific clinical signs of tuberculosis, it is usually difficult to diagnose it. The case of a 48-day-old male infant hospitalized due to weight loss, fever, cough, hemoptysis, and respiratory distress for the past 20 days, is presented. In this period, he had received broad spectrum antibiotics but with no improvement. A chest x-ray showed the presence of consolidation and a cavitary lesion in the upper and middle left lung fields. Mycobacterium tuberculosis was detected by polymerase chain reaction in a bronchoalveolar lavage specimen. Congenital tuberculosis was diagnosed based on this finding; hence, a tuberculostatic regimen was started accordingly. The patient died 13 days after treatment initiation. Congenital tuberculosis should be considered in infants with weight loss, fever, cough, hemoptysis and respiratory distress.Öğe A Department of Chest Diseases: 2011 Data of Tuberculosis(Derman Medical Publ, 2013) Tanrikulu, Abdullah Cetin; Cakirca, Seher; Abakay, Abdurrahman; Sezgi, Cengizhan; Sen, Hadice Selimoglu; Onder, Omer Faruk; Abakay, OzlemAim: Tuberculosis (TB) is transmitted through inhalation, is a disease that can involve all the tissues and organs. The most common location was the lung involvement. In this study we aimed to discuss the clinical and demographic data of TB patients who were followed in the University of Chest Diseases Clinic in 2011. Material and Method: TB is still an important public health problem: order to analyze our data about the disease patients file retrospectively studied who followed clinical university hospital in 2011. During the study period 56 TB patients file were examined. Results: A total of 24 patients female were and 32 were male. The mean age of female patients was 28.8 and male was 32.5 years. A total of 28 patients were smear-positive pulmonary tuberculosis (11 female, 17 male). In smear-positive cases 25 sputum smear-positive and 3 cases gastric juice smear-positive. Three patients were diagnosed with smear-negative, while a positive in culture. In total, four patients had relapsed pulmonary TB. Six patients were diagnosed with TB pleurisy and four of the six patients diagnosed with pleural biopsy and two diagnosed pleural fluid adenosine deaminase levels. A total of 22 patients with pulmonary tuberculosis were diagnosed radiologically and clinically. In two of 56 patients developed hepatotoxicity. Discussion: TB is a disease affecting the young population that seriousness of continued. Early diagnosis and treatment is particularly important for transmission of TB.Öğe Effect of human development index parameters on tuberculosis incidence in Turkish provinces(J Infection Developing Countries, 2016) Taylan, Mahsuk; Demir, Melike; Yilmaz, Sureyya; Kaya, Halide; Sen, Hadice Selimoglu; Oruc, Menduh; Icer, MustafaIntroduction: A country's development level is measured with a quantitative parameter called the human development index (HDI). The present study researched the effects of HDI parameters (such as healthcare standards, income, and education level) on the incidence of tuberculosis. Methodology: HDI data of 36 provinces of Turkey and the tuberculosis surveillance data were obtained from the Ministry of Development and the Ministry of Health, respectively. The associations between the incidence of tuberculosis and other HDI parameters were analyzed. Results: Higher population density (n/km(2)) (CI = 0.05 to 0.40) and higher relapse rate of tuberculosis (CI = 0.36 to 1.48) were identified to be independent predicting factors that increased the incidence of tuberculosis, whereas higher gross national product (CI =- 0.06 to 0.00), the population that holds a green Medicare card(CI=-0.58 to -0.04), increased general practitioners per 100,000 people (CI=-0.66 to -0.01), female population (CI = -0.70 to -0.06), married population (CI = -1.34 to -0.03), were found to be significant negative predicting factors that were relevant to the incidence (protective against tuberculosis). Conclusions: Tuberculosis is a disease that is affected by multiple factors, including the components of HDI. Improvement of income level, facilitation of access to health services via health insurance, urbanization with lower population density strategy, and provision of enough general practitioners may be useful in reducing the incidence of TB' in provinces of developing countries such as Turkey.Öğe Evaluation of children and adolescent with cystic fibrosis by pancreatic elastography(Wiley, 2022) Yilmaz, Kamil; Hattapoglu, Salih; Sen, Velat; Karabel, Musemma; Kan, Ahmet; Yilmaz, Engin Deniz; Sen, Hadice SelimogluBackground Cystic fibrosis (CF) is an autosomal recessively inherited disease. Clinical findings vary by age of the patient, the organ systems involved, and the severity of the CFTR gene mutation. Pancreatic and liver involvement is prominent and exocrine pancreatic insufficiency is observed in the majority of patients. Point shear wave elastography (pSWE) is a non-invasive method that can quantitatively determine tissue elasticity and stiffness. In this study, the morphological evaluation of the pancreas was performed using the pSWE technique in pediatric patients diagnosed with CF. The effectiveness of this method for the early detection of pancreatic insufficiency was investigated. Methods Fifty-five patients with CF (24 girls, 31 boys) and 60 healthy children (29 girls, 31 boys) without any chronic diseases and who were suitable for the pSWE examination were included in the study. Results The mean value of pSWE was 1.12 +/- 0.16 in the healthy group and 0.97 +/- 0.16 in the patients with cystic fibrosis. There was a statistically significant difference between the two groups (P < 0.001). Significant negative correlations were found between pSWE and age (r = -0.319; P = 0.018), height (r = -0.293; P = 0.03), serum glucose (r = -0.346; P = 0.01), HbA1C (r = -0.592; P = 0.02), and duration of the disease (r = -0.806; P < 0.001). Conclusions Investigating pancreatic elasticity and detecting pancreatic insufficiency using pSWE (a simple, inexpensive, and non-invasive method) in the early period before overt laboratory and clinical symptoms of EPI appear can contribute positively to long-term results in young patients with CF.Öğe Evaluation of social determinants of health in people with cystic fibrosis living at the affected areas of devastating earthquake in Turkey: multicenter-study(European Respiratory Soc Journals Ltd, 2024) Karabulut, Seyda; Sen, Velat; Ozsezen, Beste; Ozdemir, Ali; Savas, Suat; Sen, Hadice Selimoglu; Inal, GayeÖğe FACTORS ASSOCIATED WITH MORTALITY AMONG TUBERCULOSIS PATIENTS IN SOUTHEAST TURKEY(Carbone Editore, 2015) Yilmaz, Sureyya; Taylan, Mahsuk; Sen, Hadice Selimoglu; Abakay, Ozlem; Demir, Melike; Kaya, Halide; Yilmaz, ZulfukarIntroduction: Tuberculosis (TB) is a disease caused by bacillus mycobacterium tuberculosis. Tuberculosis is a preventable and treatable disease that, despite the rapid advances in active therapy, continues to cause global mortality. In this study, we investigated the risk factors associated with mortality in patients undergoing treatment for TB. Materials and methods: Records of 2,450 tuberculosis patients who were followed-up with in tuberculosis dispensaries in the city of Diyarbakir, southeast Turkey, between January 2005 and December 2011 were reviewed retrospectively. Case definitions and treatment outcomes were classified according to WHO criteria. Results: Of the 2,450 registered TB patients, 1,339 were male (54.7%) and 1,111 were female (45.3%). Their mean age was 32.15 +/- 17.87 years, and 51 (2.1%) of them died. Mortality rates were higher in pulmonary TB (PTB) patients, males, relapse patients, category 2 patients, those >65 years old, TB meningitis patients, and patients who self-administered their therapy. According to Kaplan-Meier analysis, the mortality rates were significantly higher in patients aged >65 years, in those with Category II and in those TB meningitis. The significant independent risk factors for mortality during anti-TB treatment were advanced age, TB meningitis and gastrointestinal TB. Conclusion: Mortality was increased in the elderly, males, those with relapse, and in category II and extrapulmonary TB patients. Based on these data, we suggest that tuberculosis control programs should pay more attention to the high-risk groups determined in the current and previous studies. Treatment regimens for these risk groups should be considered for revision.Öğe Flexible bronchoscopy findings in lung amoebiasis: a case report(Drunpp-Sarajevo, 2012) Kelekci, Selvi; Sen, Velat; Tuncel, Tuba; Sen, Hadice Selimoglu; Cicek, Muttalip; Erge, Duygu; Gurkan, M. FuatThe protozoon Entamoeba histolytica is an agent of human amoebiasis. Amoebiasis is common around the world, especially in tropical and subtropical regions. About 90% of infections are asymptomatic, while the remaining 10% are characterized by dysentery and abscesses observable in the liver or other organs. The liver is the organ most commonly affected by extraintestinal amoebiasis. Pulmonary and invasive amoebiasis is seen in 2-3% of patients, but isolated pulmonary amoebiasis is rarely seen in the pediatric age group. In this study, a 14 year old male patient diagnosed with isolated pulmonary amoebiasis is presented. Diagnosis was based on the detection of trophozoites through direct examination of bronchoalveolar lavage fluid obtained by flexible bronchoscopy, and the presence of amoebic IgG in the blood. Three weeks of metronidazole combined with antimicrobial treatment significantly improved the patient's clinical and radiologic findings. The aim of this report was to present a rare case of childhood pulmonary amoebiasis without liver or other organ involvement and to demonstrate the efficacy of flexible bronchoscopy for diagnosis.Öğe Is a complete blood cell count useful in determining the prognosis of pulmonary embolism?(Springer Wien, 2014) Sen, Hadice Selimoglu; Abakay, Ozlem; Tanrikulu, Abdullah Cetin; Sezgi, Cengizhan; Taylan, Mahsuk; Abakay, Abdurrahman; Kaya, HalidePulmonary embolism (PE) is the third cardiovascular cause of hospital admission, following acute coronary syndrome and stroke. Despite high-tech diagnostic methods and new treatment modalities, PEs continue to have a high mortality rate within the first 3 months. This study was designed to assess the additional prognostic value of a complete blood cell count, renal function markers, C-reactive protein, and simplified pulmonary embolism severity index (sPESI) scoring system in PE 100-day mortality. The study retrospectively enrolled 208 consecutive patients who were hospitalized with the diagnosis of an acute PE. The patients' demographic characteristics and clinical and laboratory parameters were recorded from the hospital electronic database and patient's case notes. The primary end point of the study was an adverse 100-day outcome, defined as death from any cause. The all-cause mortality in the first 100 days was 14.42 %. The mean age was 57.87 +/- 18.17 (range: 16-93) years. We included 79 (38 %) male and 129 (62 %) female individuals. Red cell distribution width (RDW) and sPESI were found to be statistically significant predictors of PE mortality by multivariate regression analysis. On multivariate regression analysis, RDW was associated with a 4.08-fold (95 % confidence interval: 1.229-13.335, P = 0.021) increase in PE mortality. The results of this study demonstrated that RDW and sPESI may be a useful guide in predicting 100-day mortality. The elevated RDW may alert physicians to possible poor prognosis.Öğe AN OVERVIEW OF THROMBOLYTIC TREATMENT FOR PULMONARY EMBOLISM: A SINGLE CENTRE EXPERIENCE(Carbone Editore, 2014) Sen, Hadice Selimoglu; Abakay, Ozlem; Sezgi, Cengizhan; Yilmaz, Sureyya; Taylan, Mahsuk; Kaya, Halide; Tanrikulu, Abdullah CetinIntroduction: A massive pulmonary embolism (MPE) has a poor prognosis and high mortality. Thrombolytic therapy is preferred in patients with life-threatening symptoms such as hypotension, cardiogenic shock, and right ventricular failure due to the risk of severe bleeding. Materials and methods: This is a retrospective analysis of patients who were hospitalized with the diagnosis of pulmonary embolism (PE) and given thrombolytic therapy in the chest diseases clinic of a tertiary university hospital between January 2008 and November 2013. Results: The subjects' mean age was 59.54 +/- 13.76 years. Fourteen of 39 patients who were treated with thrombolytic therapy were male (35.89%) and 25 (64.10%) were female. The symptoms experienced by the patients included dyspnea in 39 patients, chest pain in 35 patients, hemoptysis in 6 patients, syncope in 13 patients and cough in 10 patients. Risk factors were advanced age (> 60 years) in 19, immobilization in 19, malignancy in 3, major surgery in 11 patients. The in-hospital mortality analysis showed that 32 patients were discharged and 7 patients died. Four patients died from their pulmonary embolism and 3 patients died because of a major bleeding complication. Conclusions: Pulmonary embolism is a disease that may lead to death within hours secondary to acute right heart failure. Early diagnosis and treatment can be life saving. Thrombolytic therapy has been shown to improve hemodynamic parameters in the early period post-PE. An increased risk of bleeding is one of the most important drawbacks of thrombolytic therapy. Nonetheless, it can be a life-saving therapy in properly selected patients.Öğe Oxidative Status and Acute Phase Reactants in Patients with Environmental Asbestos Exposure and Mesothelioma(Hindawi Publishing Corporation, 2014) Sezgi, Cengizhan; Taylan, Mahsuk; Sen, Hadice Selimoglu; Evliyaoglu, Osman; Kaya, Halide; Abakay, Ozlem; Abakay, AbdurrahmanBackground and Objectives. The aim of this study was to investigate inflammatory indicators and oxidative status in patients with asbestos exposure with and without mesothelioma and to compare results with data from healthy subjects. Methods. Eighty people with exposure to environmental asbestos and without any disease, 46 mesothelioma patients, and a control group of 50 people without exposure to environmental asbestos were enrolled in this prospective study. Serum total oxidant level (TOL), total antioxidant capacity (TAC), and oxidative stress index (OSI), CRP, transferrin, ceruloplasmin, alpha-1 antitrypsin, ferritin, and copper levels were measured. Results. Mesothelioma group exhibited higher TOL, OSI, alpha 1-antitrypsin, ferritin and copper levels as compared to the other groups (P < 0.001, P = 0.007, P < 0.0001, P < 0.001, and P < 0.001, resp.). Transferrin was lower in the mesothelioma group than in the other two groups (P < 0.001). The asbestos group had higher TOL, TAC, alpha 1-antitrypsin, and transferrin levels (P < 0.001, P < 0.001, P < 0.001, and P < 0.001, resp.), as well as lower OSI and ferritin levels as compared to the control group (P < 0.001 and P < 0.001). Conclusions. We believe that elevated acute phase reactants and oxidative stress markers (TOL and OSI) in the mesothelioma group can be used as predictive markers for the development of asbestos-related malignancy.Öğe The Predictive Value Of CRP, CEA, IL-6, IL-8, And TNF? In The Diagnosis Of Malignant Pleural Effusions(Drunpp-Sarajevo, 2012) Sen, Hadice Selimoglu; Abakay, Ozlem; Dalli, Ayse; Sezgi, Cengizhan; Abakay, Abdurrahman; Coskunsel, MehmetAim: In this study, we investigated the potential utility of some simple, rapid, biochemical tests that detect the tumor markers interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor alpha (TNF alpha), C reactive protein (CRP), and carcinoembryonic antigen (CEA) in diagnosing malignant pleural effusions (MPEs) in exudative pleural fluids. Material and Methods: The study included 70 patients who had exudative PEs. The presence of CRP, CEA, IL-6, IL-8, and TNF alpha were investigated in the patients' pleural fluids. The cases were grouped into a malignant pleural effusion (PE) group (n = 27) and a benign PE group (n = 43) according to their etiological diagnosis, and the median levels of CRP, CEA, IL-6, IL-8, and TNF alpha in the two groups were compared. Results: The levels of pleural fluid CEA and IL-6 were significantly higher in the malignant PE group compared with the benign PE group (p<0.01 and p = 0.002, respectively). A meaningful difference was not found between the median value of the pleural fluid CRP IL-8 and TNF alpha levels in the two groups (p>0.05). We used Roc curve analysis to determine the sensitivity and specificity of CEA as a marker of malignant pleural effusion. When the CEA cut-off point was 1 ng/ml, the sensitivity was found to be 85%, and the specificity was found to be 51%. When the CEA cutoff point was 17 ng/ml, the sensitivity was 29%, and the specificity was 97%. Conclusion: Although the number of cases in the study is low, our findings suggested that CEA and IL-6 may be useful in distinguishing whether exudative PEs are malignant or benign.Öğe Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury(Hindawi Ltd, 2014) Sen, Velat; Guzel, Abdulmenap; Sen, Hadice Selimoglu; Ece, Aydin; Uluca, Unal; Soker, Sevda; Dogan, ErdalThe aim of this study was to examine whether dexmedetomidine improves acute liver injury in a rat model. Twenty-eight male Wistar albino rats weighing 300-350 g were allocated randomly to four groups. In group 1, normal saline (NS) was injected into the lungs and rats were allowed to breathe spontaneously. In group 2, rats received standard ventilation (SV) in addition to NS. In group 3, hydrochloric acid was injected into the lungs and rats received SV. In group 4, rats received SV and 100 mu g/kg intraperitoneal dexmedetomidine before intratracheal HCl instillation. Blood samples and liver tissue specimens were examined by biochemical, histopathological, and immunohistochemical methods. Acute lung injury (ALI) was found to be associated with increased malondialdehyde (MDA), total oxidant activity (TOA), oxidative stress index (OSI), and decreased total antioxidant capacity (TAC). Significantly decreased MDA, TOA, and OSI levels and significantly increased TAC levels were found with dexmedetomidine injection in group 4 (P < 0.05). The highest histologic injury scores were detected in group 3. Enhanced hepatic vascular endothelial growth factor (VEGF) expression and reduced CD68 expression were found in dexmedetomidine group compared with the group 3. In conclusion, the presented data provide the first evidence that dexmedetomidine has a protective effect on experimental liver injury induced by ALI.
