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    Protective Role of Lycopene on Aflatoxin B1 Induced Changes Sperm Characteristics and Testicular Damages in Rats
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2010) Tas, Muzaffer; Saruhan, Berna Gueney; Kurt, Dogan; Yokus, Beran; Denli, Muzaffer
    The aim of this study was to investigate if lycopene could diminish the adverse effects of aflatoxin B-1 (AFB(1)) on sperm characteristics, the testes, epididymis and oxidative stress in rats. A total of 28 adult male Wistar-Albino rats (8 weeks old weighing 180-220 g) were divided into four groups; Controls, lycopene treated rats (10 mg/kg BW, daily by gavage), AFB(1) treated rats (2.5 mg/kg BW, single dose intra peritonal) and lycopene (10 mg/kg BW, daily by gavage) + AFB(1) (2.5 mg/kg BW, single dose intra peritonal) treated rats. Traits of reproductive organs (testes and sperm characteristics, testicular histological findings and the testicular tissue oxidative status) were determined after 15 days of treatment. The sperm motility was significantly decreased while the rate of total abnormal sperms was significantly increased in rats treated with AFB(1) alone compared to their levels in controls (P<0.001). The level of testes malondialdehyde (MDA) in rats treated with AFB(1) was significantly higher than its level in controls (P<0.001). Treatment with AFB(1) significantly decreased testes diameter and seminifer epithelium thickness (P<0.0001) when compared with the others. Similarly, the thickness of the germinative cell layer at seminifer tubul (ST) in rats treated with AFB(1) was significantly smaller than controls. Treatment with lycopene significantly increased sperm motility (P<0.001) and alleviated the many negative effects of AFB(1) on sperm characteristic and testicular damage in rats. In conclusion our results showed that consumption of 10 mg of lycopene/BW given by gavage protected the rats to the toxicity of AFB(1) when it is administrated as a single dose intraperitoneally.