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Öğe Autologous blood injections in the treatment of lateral epicondylitis: A review of the literature(2011) Ulu M.A.; Karakoç M.; Sariyildiz M.A.; Nas K.Lateral epicondylitis is a common overuse syndrome of the upper extremity. Various factors including chronic microtraumas and local ischemia have been implicated in its etiology. The lack of evidence concerning its pathophysiology has resulted in the exploration of numerous treatment strategies. However, there is still no treatment which is based on a high level of evidence and on which a consensus has been reached. Histopathological examinations revealed that the disease is a degenerative process accompanied by angiofibroblastic hyperplasia rather than an inflammatory condition, and new treatment modalities have been introduced based on this finding. The injection of autologous blood into the painful tendon area is one of these modalities. Herein, the role of autologous blood injection in the treatment of lateral epicondylitis was reviewed in the light of the literature. Copyright © 2011 by Türk Tibbi Rehabilitasyon Kurumu Derneği.Öğe Carvacrol prevents methotrexateinduced renal oxidative injury and renal damage in rats(2014) Bozkurt M.; Em S.; Oktayoglu P.; Turkcu G.; Yuksel H.; Sariyildiz M.A.; Caglayan M.Purpose: The purpose of this study was to investigate the effect of carvacrol (CAR) on methotrexate (MTX)-induced renal damage in rats. Methods: Twenty-four male rats were equally divided into three groups: group I, control treatment; group II, MTX-treated; and group III, MTX+CAR-treated. A single dose of CAR (73 mg/kg) was administered intraperitoneally to group III on the First day of the experiment and a single dose of MTX (20 mg/kg) was administered intraperitoneally to groups II and III on the second day of the experiment. Blood samples and kidney tissue were obtained from each animal on day 8 for the measurement of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Light microscopy was used for histopathological examination of kidney specimens. Results: MDA, TOS and OSI levels were significantly greater in the group receiving MTX alone relative to the control animals, while the TAS level was significantly reduced in the MTX group compared with the control group. The administration of CAR was associated with significantly decreased MDA, TOS, and OSI levels and increased TAS levels relative to the rats treated with MTX alone. Animals treated with CAR exhibited decreased tubular degeneration and architectural impairment relative to animals treated with MTX alone; however, the difference in histological scores did not meet the threshold of statistical significance. Conclusions: MTX treatment results in oxidative damage to the rat kidney; damage which is partially abrogated by the administration of CAR. © 2014 CIM.Öğe Radiological damage in rheumatoid arthritis: Relationship between the duration of morning stiffness, depressive symptoms, and disease duration(Acta Medica Mediterranea, 2015) Celepkolu T.; Sariyildiz M.A.; Yazmalar L.; Gamze Erten Bucaktepe P.; Çetinçakmak M.G.; Satici O.Aims: The aim of this study was to evaluate radiological damage and disease-related variables in patients with rheumatoid arthritis (RA). Material and methods: Ninety patients diagnosed with RA were enrolled in this cross-sectional and descriptive study. All of the patients were assessed using the Rheumatoid Arthritis Quality of Life and Health Assessment Questionnaire scales and the Beck Depression Inventory. The Disease Activity Score 28 scale was used to assess disease activity, and antibodies against mutated citrullinated vimentin (Anti MCV) were identified with an Enzyme-Linked Immuno Sorbent Assay. Radiological damage was calculated with the modified Larsen method. Results: According to the suggested cut-off point for the Larsen score (scores ? 28), 35.5% (n=32) of the patients with RA had an erosive score. The patients with erosive RA had significantly higher Anti MCV, disease duration and Beck depression scores than did the non-erosive RA group. Multivariate regression analyses indicated that the Beck depression score, disease duration and duration of morning stiffness were independently associated with the radiological score. Conclusion: Radiological damage in RA patients is a result of multifactorial origins and is associated with disease-related variables such as disease duration, duration of morning stiffness, Anti- Cyclic citrullinated peptide levels and depressive symptoms.Öğe Serum osteocalcin, bone alkaline phosphatase and cathepsin k levels of patients with postmenopausal ra: Correlation with disease activity and joint damage(Acta Medica Mediterranea, 2014) Batmaz I.; Çakirca G.; Sariyildiz M.A.; Dilek B.; Mete N.; Hamidi C.; Bozkurt M.Objective: To investigate serum levels of osteocalcin (OC), bone alkaline phosphatase (BALP) and cathepsin K in patients with postmenopausal rheumatoid arthritis (RA) and to evaluate the relationship between these markers and disease activity and radiological joint damage. Material and methods: Forty six postmenopausal women diagnosed with RA according to the criteria of American College of Rheumatology and 42 postmenopausal healthy women who have similar age range with the patient group were involved into the study. Disease activity was measured with Disease Activity Score (DAS 28). Furthermore, Larsen score was used to evaluate radiological damage. Results: OC and BALP levels were not different between postmenopausal patients with RA and control group (p >0.05). However, levels of cathepsin K were elevated in serum of the patients with postmenopausal RA when compared with that of the healthy control group (p<0.05). In addition, the elevated serum levels of cathepsin K were positively correlated with disease activity and joint destruction (p<0.05). No significant relationship was observed between OC and BALP levels and disease activity and joint destruction (p >0.05). Conclusions: Cathepsin K may be a valuable parameter to assess disease prognosis in postmenopausal RA.Öğe Serum prolidase enzyme activity and oxidative status in patients with scleroderma(Acta Medica Mediterranea, 2014) Bozkurt M.; Dağ Ş.; Oktayoglu P.; Em S.; Yüksel H.; Çağlayan M.; Sariyildiz M.A.Objective: To assess serum prolidase enzyme activity and oxidative stress in patients with scleroderma (also known as systemic sclerosis, or SSc) and determine its relationship with serum oxidative status. Methods: The study population consisted of SSc patients (n = 21) and healthy participants (n =29). Serum prolidase enzyme activity, total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and paraoxonase-1 (PON-1) levels were compared betweeen the two groups. Results: The mean duration of SSc involvement was 5 years; and the mean modified Rodnan skin score was 16. No statistically significant differences existed between the SSc groups and the control participants in terms of age, gender, TAS, PON-1, and haematocrit levels. Serum prolidase activity, OSI, and TOS levels were statistically significantly higher in SSc patients in comparison with controls participants. Also serum prolidase activity was statistically higher in Raynaud's phenomenon positive patients than Raynaud's phenomenon negative patients. But no correlation emerged between the serum prolidase activity and modified Rodnan Skin Score (P=0.235, r=0.304). Conclusion: High prolidase activity may indicate critical biological activities relevant to pathological events in SSc, and this activity may be a biological indicator of disease. Further studies are needed to verify these findings.Öğe Sexual dysfunction in male patients with Behçet's disease(Sociedade Portuguesa de Reumatologia, 2016) Yildiz M.; Batmaz Í.; Sula B.; Uçmak D.; Sariyildiz M.A.; Dàggülli M.; Türkçü F.Introduction: The purpose of this study was to evaluate sexual dysfunction in male patients with Behçet's Disease in comparison to healthy control subjects. Material and Methods: Seventy-two sexually active male patients with Behçet's Disease and 62 healthy control subjects were included in this study. Patients' demographic and clinical characteristics were noted. Sexual function was assessed by means of the International Index of Erectile Function scoring system. In addition, disease-related quality of life was measured by means of the Nottingham Health Profile, and anxiety and depression levels were assessed by means of the Hospital Anxiety and Depression Scale. Results: Patients with Behçet's Disease scored significantly lower in each of the 5 parameters of International Index of Erectile Function (p < 0.001) and significantly higher in Hospital Anxiety and Depression Scale compared to healthy control subjects (p < 0.001). International Index of Erectile Function scores correlated with age, duration of disease and Hospital Anxiety and Depression Scale and Nottingham Health Profile scores in patients with Behçet's Disease (p < 0.05). Conclusion: Sexual function is impaired in male patients with Behçet's Disease, which might be associated by age, duration of disease, psychological status and quality of life.
