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Öğe Comparison of microsuturing to the use of tissue adhesives in anastomosing sciatic nerve cuts in rats(Walter De Gruyter & Co, 1997) Inaloz, SS; Ak, HE; Vayla, V; Akin, M; Aslan, A; Sari, I; Celik, YThe purpose of this study was to investigate and to compare the effects of microsuturing to that of tissue adhesives (Tissee(R)) on the healing of anastomosing peripheral nerve incisions. Forty-five Wistar-Albino rats were placed in special cages and separated into three groups (n = 15). In the control group, biliteral sciatic nerves were explored but no incision was made. In the first experimental group, bilateral sciatic nerves were incised and end-to-end anastomosing was performed by microsuturing the epineurium. In the second experimental group, tissue adhesive (Tisseel(R)) was used alone in anastomosing the sciatic nerve cuts. Assessments of the healing processes were demonstrated by 1. electromyography (EMG), 2. measuring the electrical responses of the anastomosed nerves after electrical stimuli, 3. histopathological examination. Statistical analysis of the EMG findings showed that the Tisseel group was the closest in the healing process to the control group. After applying electrical stimuli to the dissected nerves, the resistance value of the Tisseel group was nearest to those of the control group. The histopathological examinations showed highly degenerative nerve bundles and prominent foreign body granuloma at the anastomosed sites of the microsutured group. The granulomatous inflammation was observed to be much less in the Tisseel group. We conclude that the healing effect of Tisseel was found to be superior to that of microsuturing as demonstrated by the findings of EMG, electrical responses of the anastomosed nerves, and histopathological examination.Öğe Effect of granulocyte-macrophage colony-stimulating factor on treatment of acute osteomyelitis - An experimental investigation in rats(Springer-Verlag, 2001) Subasi, M; Kapukaya, A; Kesemenli, C; Kaya, H; Sari, IGranulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that affects the various developmental steps of hematopoietic cells and enhances the phagocytic activity of these cells. The effect of GM-CSF on acute osteomyelitis, developed in rats, was investigated. For this purpose, osteomyelitis was firstly developed through the direct inoculation of Staphylococcus aureus into rat tibial metaphysis. Twenty-four rats in which diagnosis of osteomyelitis was histopathologically established were divided into two groups. Antibiotic only was given to the first group, and antibiotic as well as CM-CSF to the second roup. Rats were followed up for 3 months with plain radiographs and scintigraphic methods using (67)Gacitrate. Material obtained from the rats that had been killed at the end of the 3rd month were histopathologicalIy investigated. One rat in the first group died. In another rat, chronic osteomyelitis developed and fracture was observed. In 12 rats of the second group, physical examination, plain radiographs, and histopathologic findings were normal. In scintigraphic studies with Ga-67-citrate, when the pre- and posttreatment values of the same groups were evaluated by the Mann-Whitney U-test, the mean values at 48 h after treatment were found to be significant (P < 0.05), indicating a decrease in the 2nd group (experimental group). In conclusion, the antibiotics were effective in the elimination of infection only together with neutrophils. In this manner, infections may be eliminated by strengthening the host's defense mechanism as well as by administering antibiotics. We believe that an adequate number of long-term studies will shed light on this issue. Besides we consider that this factor will be more important in the study of chronic osteomyelitis.Öğe Effects of nimodipine and ofloxacin on staphylococcal brain abscesses in rats(Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1997) Ceviz, A; Inalöz, SS; Çiçek, R; Sari, I; Gül, K; Sanli, AThe therapeutic effects of nimodipine (GAS 66085-59-4) and ofloxacin (GAS 82419-36-1) were investigated against experimental brain abscess formation in rats. Nimodipine, a 1,4-dihydropyridine derivative, is chemically related to nifedipine but the smooth muscle relaxant effect preferentially acts on cerebral arteries. Ofloxacin is a member of 4-Quinolone broad spectrum antibiotics. Ninety-six male Sprague-Dawley rats were inoculated intracortically with Staphylococcus aureus and then different groups were treated with either saline. ofloxacin or the combination of ofloxacin and nimodipine. The rate of brain abscess formation and mortality were considerably decreased by nimodipine and ofloxacin therapy. Combination therapy was found histologically to be considerably more effective than ofloxacin alone against brain abscess formation in rats.Öğe Effects of supplemental L-arginine on the intestinal adaptive response after massive small-bowel resection in rats(Springer, 2002) Özturk, H; Dokucu, AI; Yagmur, Y; Sari, ITo evaluate whether L-arginine methyl ester (L-Arg) can improve the structure of the small intestine and enhance adaptation in an experimental model of short-bowel syndrome (SBS), 40 Sprague-Dawley rats were divided randomly into four groups of 10 each. In one group only a laparotomy was performed (G1). The remaining 30 rats underwent 90% small-bowel resection (SBR) and formed the three experimental groups: the SBR/untreated group (G2), the SBR/L-NAME-treated group (W), and the SBR/ L-Arg-treated group (G4). Rats in G2 received no therapeutic treatment. Rats in the SBR/L-NAME and SBR/L-Arg treated groups received N-G-nitro-L-arginine-methyl ester (L-NAME) and L-Arg intraperitoneally for 3 weeks, respectively. The animals were weighed daily. All rats underwent a relaparotomy on day 21 of the experiment. Remnant small bowel was excised and evaluated for villus height and crypt cell mitoses. After the 90% SBR, all animals had from diarrhea and weight loss between the 1st and 6th postoperative days (POD). The body weight of the SBR/L-Arg group showed significant increases at POD 10 and 21 in comparison to the SBR/untreated and SBR/L-NAME groups (P < 0.001). The rats treated with L-Arg had significantly greater villus height and crypt-cell mitoses compared to the other groups (P < 0.0001, P < 0.001). These observations suggest that L-Arg treatment increases villus height and crypt-cell mitoses after massive SBR and may play a considerable role in the mucosal adaptive response in SBS in rats.Öğe Lumbar epidural brucellar abscess causing nerve root compression(Stockton Press, 1999) Ozates, M; Özkan, Ü; Bükte, Y; Ceviz, A; Sari, I; Simsek, MObjectives: To evaluate the usefulness of MR sequences for the differential diagnosis of spinal brucellar abscesses which mimic lumbar disc herniation. Methods: We analyzed six patients with brucellar abscesses. who had symptoms mimicking lumbar disc herniation. The study group consisted of three women. and three men who were 15 - 67 (mean = 37) years old. Patients were imaged in the axial and sagittal planes with a I.0-T MR scanner using a spine coil. Results: The level of abscesses were accurate in 100% (six of six)of patients with MR imaging. MRI examinations revealed an extradural soft tissue mass which were iso- to hypointense compared to spinal cord on T1WI and hyperintense on T2-weighted images. By contrast study, diffuse homogeneous or slightly heterogeneous enhancements were seen. Conclusion: Lumbar extradural brucellar abscess can have lumbar disc disease symptoms. MRI may non-invasively and rapidly reveal the presence of spinal abscess and degree of extension to the spinal canal. Extradural brucellar abscess should be included in the differential diagnosis of radicular symptoms caused by disc herniation.Öğe Non-squamous papilloma of the bronchus(Med Assoc S Africa, 2000) Sari, I; Uzunlar, AK; Büyükbayram, H; Ozçelik, C; Yilmaz, F; Özaydin, M[Abstract Not Available]Öğe Omeprazole, nitrendipine, famotidine and stress-induced ulcers(Assoc Soc Scientifique Med Belges, 1997) Inaloz, SS; Goral, V; Sari, I; Canberk, Y; Ulak, GBackground: Omeprazole inhibits gastric acid secretion bq blocking the proton pump of the gastric parietal cell, Nitrendipine is a derivative of the dihydropyridine group of calcium channel blockers and administrated for angina and hypertension, Famotidine is one of the newer histamine H-2-receptor antagonists and heals gastric and duodenal ulcers by reducing gastric acid output, Objectives: The healing effects of omeprazole, nitrendipine and famotidine on stress-induced gastric ulcers were investigated in rats, Methods: Forty male Wistar-albino rats were separated into five groups (n = 8), a control (non-stress) and four experimental (stress) groups, Experimental rats were treated with omeprazole, nitrendipine, famotidine or a placebo after the stresses of starvation and coId-restraint, Result: Macroscopically, the mean area of the affected lesional mucosa was 1/4 of the total gastric mucosa in the famotidine treated group and 1/5 of the total gastric mucosa in the nitrendipine treated group. A considerably decrease was observed in the omeprazole treated group in which the mean area of the lesional mucosa was only in 1/8 of the total gastric mucosa, On microscopic examination, congestive vessels and chronic inflammatory cell infiltrates were significantly reduced in the omeprazole treated group, Tissue regeneration was more prominent in the omeprazole group than the other groups, Conclusion: Omeprazole was found to Ire superior in terms of the effect on the healing process to nitrendipine and famotidine. Although therapeutic effects of nitrendipine and famotidine were observed, those were less than omeprazole.Öğe Omeprazole, nitrendipine, famotidine and stress-induced ulcers(Pacini Editore, 1997) Inaloz, SS; Goral, V; Sari, I[Abstract Not Available]Öğe A pericardial hydatid cyst extending to the left lobe of the liver: the diagnostic value of MRI(Springer-Verlag, 2000) Ozates, M; Sari, I[Abstract Not Available]Öğe Spinal subdural tuberculous abscess(Stockton Press, 2000) Özates, M; Özkan, Ü; Kemaloglu, S; Hosoglu, S; Sari, IObjectives: Spinal subdural abscess Is rare and only 45 cases have been described to date. In this report, we present an additional spinal subdural tuberculous abscess. Method: Tuberculous meningitis was diagnosed with clinical and laboratory findings in a 45-year-old man. A spinal subdural abscess was demonstrated using MRI. Presence of the abscess was revealed by surgical intervention. The diagnosis was confirmed by pathological examination. Results: The patient had been treated for tuberculous meningitis 2 years previously. The disease recurred when anti-tuberculous therapy was prematurely discontinued, During the second treatment, the patient also underwent a ventriculo-peritoneal shunt operation for hydrocephalus. Dizziness and weakness of both legs developed after the postoperative period. Spinal MRI showed a. spinal subdural abscess as a iso-intense mass with spinal cord in the T1 and T2 weighted images, ring like enhancement and compression on the spinal cord at T3-T4 level. The patient underwent surgery and the abscess was drained. Conclusion: Tuberculosis may cause a spinal subdural abscess and although it is a rare disorder, when encountered MRI is very useful in the diagnosis.Öğe Whole-body microwave exposure emitted by cellular phones and testicular function of rats(Springer, 1999) Dasdag, S; Ketani, MA; Akdag, Z; Ersay, AR; Sari, I; Demirtas, ÖC; Celik, MSThis study investigated whether there are adverse effects due to microwave exposure emitted by cellular phones in male rats. Eighteen Wistar Albino rats were separated into three groups, a sham group and two experimental groups. The rats were confined in Plexiglas cages and cellular phones were placed 0.5 cm under the cages. In the first experimental group, cellular phones were in standby position for 2 h. In the second experimental group. phones were turned to the speech position three times each for 1 min duration over 2 h. Rats in the first and second experimental groups were exposed to microwaves emitted by phones for 2 h/day for a duration of 1 month. After the last exposure the rats were killed. Brain, eyes, ears, liver, heart, lungs, stomach, kidneys, testes. small and large intestines and skill of the rats were observed histologically. The decrease of epididymal sperm counts in the speech groups were not found to be significant (P > 0.05). Differences in terms of normal and abnormal sperm forms were not observed (P > 0.05). Histological changes ut ru especially observed in the testes of rats of the speech groups. Seminiferous tubular diameter of rat testes in the standby and speech groups was found to be lower than the sham group (P < 0.05). Rectal temperatures of rats in the speech group were found to be higher than the sham and standby groups (P < 0.05). The rectal temperatures of rats before and after exposure were also found to be significantly higher in the speech group (P < 0.05). Specific absorption rate (SAR) was determined as 0.141 W/kg.Öğe Zenker's diverticulum in childhood(Georg Thieme Verlag Kg, 2000) Dokucu, AI; Fabre, M; Otçu, S; Sari, I; Önen, A; Öztürk, H; Bükte, YZenker's diverticulum (ZD) is a very rare pathology in childhood and to date only few pediatric cases have been reported in literature. Herein we report on a case of ZD with cervical abscess formation and oral purulent drainage in a 6-year old girl with severe malnutrition. Diverticulectomy was performed as surgical treatment. The patient is free of symptoms after two years' follow-up.
