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    Arthropathy, quality of life, depression, and anxiety in Behcet's disease: relationship between arthritis and these factors
    (Springer London Ltd, 2006) Gur, Ali; Sarac, Aysegul Jale; Burkan, Yahya Kemal; Nas, Kemal; Cevik, Remzi
    We aimed to determine arthritis frequency, quality of life (QoL), anxiety, and depression levels in Behcet's disease (BD) and thereby the effect of joint involvement on QoL, anxiety, and depression. Sixty-three patients diagnosed with BD according to the International Study Group Diagnostic Criteria and 45 healthy subjects as control were included in the study. All patients were evaluated in terms of clinical findings, the number and site of the joints involved, sacroiliac joint involvement, pain intensity, QoL, anxiety, and depression scale. The instruments used were Beck Depression Inventory (BDI) for depression, State-Trait Anxiety Inventory (STAI-T) for anxiety, and Health Assessment Questionnaire (HAQ) and Nottingham Health Profile (NHP) for health status and QoL. Joint involvement was seen in 41.3% of the patients. The most characteristic form was asymmetric oligoarthritis, which was seen in 65.3% of the patients. The joints most commonly involved were found to be in the wrist (53.8%) and knee (50%). Sacroiliitis was found at a rate of 38.1%. In BD patients without arthritis, rates of men (p=0.004) and genital ulcer (p=0.001) were higher, and rates of erythema nodosum (p=0.001) and human leukocyte antigen B5 positivity (p=0.023) were less than those of BD patients with arthritis. Pain intensity (p=0.000), NHP (p=0.004), and HAQ (p=0.003) scores were significantly higher in BD patients with arthritis than those without arthritis. Pain intensity, NHP, BDI, and STAI-T scores were significantly higher in BD patients without arthritis than in healthy controls, while pain intensity, NHP, HAQ, BDI, and STAI-T scores were significantly higher in BD patients with arthritis than in healthy controls (p=0.000). In conclusion, our study establishes that arthropathy is one of the common manifestations of BD. Arthritis in BD affects considerably patients' pain levels and QoL. A multistep approach is required for these patients. We are of the opinion that this approach may also improve the QoL of these patients and prevent the activation of the disease.
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    THE ASSESMENT OF CARDIAC SEMPATOVAGAL ACTIVITY BY HEART RATE VARIABILITY IN PATIENTS WITH RHEUMATOID ARTHRITIS
    (Oxford Univ Press, 2011) Cevik, Figen Ceylan; Yazici, Selma; Cil, Habib; Cevik, Remzi; Sarac, Aysegul Jale; Nas, Kemal
    [Abstract Not Available]
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    METABOLIC SYNDROME IN PATIENTS WITH ANKYLOSING SPONDYLITIS
    (Oxford Univ Press, 2011) Batmaz, Ibrahim; Karakoc, Mehmet; Yazici, Selma; Cevik, Remzi; Nas, Kemal; Sarac, Aysegul Jale; Atilgan, Zuhal
    [Abstract Not Available]
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    Psychological status is associated with health related quality of life in patients with rheumatoid arthritis
    (Ios Press, 2011) Nas, Kemal; Sarac, Aysegul Jale; Gur, Ali; Cevik, Remzi; Altay, Zuhal; Erdal, Akin; Ersoy, Yuksel
    Objective: Rheumatoid arthritis (RA) is a chronic and disabling disease frequently effects physical and psychological well being. The aim of the present study was to determine the impact of psychological status on health related quality of life in patients with RA and also to assess which quality of life (QoL) instrument - disease specific and generic - is more prone to this effect. Methods: A total of 421 patients with RA recruited from joint database of five tertiary centers. Depression and anxiety risks were assessed by the Hospital Anxiety and Depression Scale (HADS); and quality of life assessed by Rheumatoid Arthritis Quality of Life (RAQoL), Nottingham Health Profile (NHP) and The Short Form 36 (SF 36) questionnaire. Results: Patients with higher risk for depression or anxiety had poorer quality of life compared to the patients without risk for depression or anxiety. Depression and anxiety scores significantly correlated with quality of life questionnaires. There was significant association between anxiety and depression with worsening in both disease specific and generic health related quality of life. However, RAQoL showed more association with depression and anxiety levels. Conclusion: Higher depression and anxiety risks showed increased deterioration in quality of life. Compared to generic QoL scales, RAQoL scale, a disease specific QoL instrument, is much more influenced by depression and anxiety.
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    Relationship Between Clinical Findings, Quality of Life and Functional Disability Related to Disease Activity in Patients with Ankylosing Spondylitis
    (Turkish League Against Rheumatism, 2011) Nas, Kemal; Cevik, Remzi; Bozkurt, Mehtap; Gur, Ali; Sarac, Aysegul Jale
    Objectives: In this study we evaluated the relationships between clinical findings, quality of life and functional disability related to disease activity in patients with ankylosing spondylitis (AS). Patients and methods: Seventy-three patients diagnosed with AS (62 males, 11 females; mean age 33.3 +/- 9.5 years; range 17 to 60 years) who fulfilled the modified New York criteria were included in this study. The mean age for female patients was 29.2 +/- 7.3 years and for males 34.0 +/- 9.7 years. The demographic data of the patients were recorded. The disease activity was assessed using the Bath ankylosing spondylitis disease activity index (BASDAI). The functional disability was evaluated using the Bath ankylosing spondylitis functional index (BASFI). The clinical status was evaluated with the Bath ankylosing spondylitis metrology index (BASMI) and the quality of life was assessed with the Short Form 36 (SF-36). Results: The patients were divided into two groups: patients having a BASDAI score of less than four (BASDAI < 4) with mildly active disease (n=34) and patients having a BASDAI score of four or higher (BASDAI >= 4) with moderate-severe disease activity (n=39). The BASFI and BASMI scores were higher in patients with high disease activity (p < 0.05), and a significant correlation was found between the BASDAI total score and the BASFI and BASMI scores (p < 0.05). Patients with a BASDAI score of < 4 had a lower finger floor distance, a higher cervical rotation and modified Schober's measurement values compared with patients with a BASDAI score of >= 4. There was a significant correlation between the BASDAI score and SF-36 subscores of physical function, physical role, bodily pain and emotional role (p < 0.05). Conclusion: Clinical findings, functional disability, metrological measurements and quality of life are adversely affected by disease activity in AS. The subgroups of SF-36 subscores related to physical health show a more significant relationship with the disease activity in AS.