Yazar "Sakar, Mehmet Nafi" seçeneğine göre listele

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    The association of endothelial nitric oxide synthase gene G894T polymorphism and serum nitric oxide concentration with microalbuminuria in patients with gestational diabetes
    (Dustri-Verlag Dr Karl Feistle, 2014) Atay, Ahmet Engin; Akbas, Halit; Tumer, Cemil; Sakar, Mehmet Nafi; Esen, Bennur; Incebiyik, Adnan; Simsek, Selda
    Aim: Gestational diabetes mellitus (GDM) is a glucose intolerant condition that affects 14% of all pregnancies. Diabetes mellitus (DM) occurs in 30 - 70% of patients with GDM after delivery. DM and GDM are associated with structural and functional deterioration of the renovascular system. Our aim is to investigate the association Glu-298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene with serum nitric oxide levels and microalbuminuria in patients with GDM and healthy pregnancies. Material and methods: Serum nitric oxide (NO) levels, urinary excretion of albumin and Glu298Asp polymorphism of the eNOS gene were analyzed in 68 patients with GDM and 73 healthy controls. High performance liquid chromatography (HPLC-Griess) method was used to analyze serum NO levels. Microalbuminuria was evaluated by rate nephelometry method. The Glu298Asp polymorphism of the eNOS gene was determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: Nitric oxide, glucose, creatinine, and microalbuminuria were significantly different between the patients and the control subjects (p = 0.001, p = 0.001, p = 0.002, and p = 0.005, respectively). There was a significant difference between groups in terms of the ratio of GG/GT+TT of eNOS gene Glu298Asp (p = 0.02). The patients with GT+TT genotype had significantly higher microalbuminuria levels and lower NO concentrations (22.16 vs. 9.51, p = 0.005, and 10.56 vs. 12.73, p = 0.021, respectively). The presence of T allele of eNOS gene is an independent predictor of microalbuminuria (OR: 2.346, 95% confidence interval: 1.247 - 5.238, p = 0.02) as well as serum glucose and NO concentration. Conclusion: The G894T polymorphism of eNOS gene and decreased NO concentration seem to be independent predictors of increased urinary excretion of albumin in patients with GDM. Determining the frequency of eNOS gene G894T polymorphism may help to identify pregnancies at increased risk of microalbuminuria.
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    Öğe
    Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility
    (2020) Oğlak, Süleyman Cemil; Ege, Serhat; Otçu, Serap Mutlu Özçelik; Obut, Mehmet; Kahveci, Bekir; Yıldız, İsmail; Sakar, Mehmet Nafi
    This study aimed to determine the outcomes of combined treatment of letrozole (LTZ) with recombinant follicle -stimulating hormone (rFSH) in comparison with rFSH alone in intrauterine insemination (IUI) cycles.This study consisted of 86 patients who experienced 106 IUI cycle s. Patients were classified into two treatment groups:group I underwent a combination of LTZ plus rFSH, and group II received rFSH alone. Ovulation was triggered withhuman chorionic gonadotropin (hCG), and IUI performed 36 hours later. The number of follicles ?18 mm, endometrialthickness, required dose of FSH, duration of ovulation induction (OI), clinical pregnancy rates, multiple pregnancy rates,spontaneous abortion rates, and live birth rates were evaluated.The total required rFSH dose during the OI was significantly lower in the LTZ-rFSH combination group than the rFSHalone group (401.2±177.1 IU and 770.1±345.8 IU, respectively, p<0.001). The days of stimulation with rFSH were alsolower in the LTZ co-treatment group than the rFSH-alone group (5.2±1.3 days and 10.1±3.0 days, respectively, p<0.001).Clinical pregnancy rate was 17.0% in LTZ-rFSH group, and 15.2% in rFSH group (p>0.05).The combined use of LTZ with rFSH resulted in a lower required dose of rFSH, a similar and ac ceptable endometrialthickness at the day of hCG administration, and comparable pregnancy rate compared with rFSH alone
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    Öğe
    THE EVALUATION OF PARAOXONASE 1 ACTIVITY IN PATIENTS WITH GESTATIONAL DIABETES
    (Carbone Editore, 2013) Atay, Ahmet Engin; Sakar, Mehmet Nafi; Culcu, Nurdagul Serife Nurani; Simsek, Hakki; Akbas, Halit; Acar, Murat; Isik, Birgul
    Material and methods: Sixty five patients with GDM and 66 healthy pregnants were enrolled. Paraoxonase activity, insulin levels, HOMA-IR, demographic features and anthropometric measurements were evaluated. Results: The mean paraoxonase activity was significantly diminished in patients with GDM (p:0,004). Insulin level and HOMA-IR were significantly higher in GDM patients (p:0,004 and p:0,001; respectively). The mean interval between present and previous pregnancy was significantly shorter in patients group (p:0,004). There was a significant correlation between PON1 activity and serum LDL, HDL levels and weight gained during pregnancy (p:0,001,p<0,001 and p:0,002; respectively) but not with weight and parity. However HOMA-IR was significantly correlated with weight and parity (p:0,001 and p:0,002; respectively). Discussion: Diminished PON1 activity and enhanced oxidative stress accompany to insulin resistance in the pathogenesis of GDM. Oxidative stress is associated with weight gained during first 2 trimesters of pregnancy rather than obesity.
  • Küçük Resim
    Öğe
    İnfertil olgularda pelvik patolojilerin laparoskopik değerlendirilmesi ve laparoskopi ile histerosalpingografinin tanısal değerlerinin karşılaştırılması
    (2017) Sakar, Mehmet Nafi; Gül, Talip
    Bu çalışmada Mart 2004-Nisan 2006 tarihleri arasında Dicle Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniği'nde laparoskopi uygulanan 82 infertil olgunun tetkik sonuçlan retrospektif olarak incelendi. Laparoskopik işlem sonucunda olguların %34.14'ünde normal genital bulgu, %40.24'ünde tubal patoloji, %1. 21 'inde ovarian patoloji, %4.87'sinde uterin patoloji, %10.97'sinde endometriozis, %6.09'unda mikst patoloji bulundu. Laparoskopik bulgular, HSG bulguları ile karşılaştırıldı aradaki fark anlamlı bulundu (pO.001). Pelvik adezyonlar (%37.80) ve endometriozis (%10.97) AFS klasifıkasyonuna göre skorlandı ve primer ile sekonder infertil olgulardaki dağılım oranlan saptandı. Toplam adneksial adezyon sayısı 31 idi. Elli üç primer infertil olgunun 18'inde (%33.96), 29 sekonder infertil olgunun 13'ünde (%44.82) adneksial adezyon saptandı. Minimal ve hafif adezyon oranı %77.41 idi. Orta ile ciddi adezyon oranı %22.57 olup, ağırlıklı olarak sekonder infertil olgularda saptandı. İnfertilite süresi ile adneksial adezyonun şiddeti arasında anlamlı bir ilişki saptanmadı. Dokuz endometriozis olgusunun 4'ünde (%44.44) minimal, 4'ünde (%44.44) hafif ve l'inde (%11.11) orta düzeyde endometriozis saptandı. Primer infertil olguların 6'sında(%11.32), sekonder infertil olgulann 3'ünde (%10.34) endometriozis tespit edildi. Çalışmaya konu olan olguların %2.43'üne laparotomi uygulandı. Böylece laparoskopik işlem ile %100'e yakın kesin tam konuldu. Bu uygulamalar sırasında majör komplikasyon oluşmadı. Laparoskopinin kadın infertilitesinde diagnostik alanda, diğer teşhis metodlarından daha üstün ve değerli bir metod olduğu tespit edildi.
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    Öğe
    The role of hysterosalpingography in the evaluation of infertile women without risk factors for tubal pathology
    (2016) Gül, Talip; Özler, Ali; Küllahçıoğlu, Mehmet İrfan; Balsak, Deniz; Sakar, Mehmet Nafi
    Amaç: Kadın infertilite tanısında tubal açıklığın değerlendirilmesi önemli rol oynar. Histerosalpingografi ve kromopertubasyonlu laparoskopi, tubal açıklığın değerlendirilmesinde geleneksel olarak kullanılmaktadır. Risk faktörü değerlendirilmesine göre tubal faktör olabileceğini düşündüğümüz infertil kadınlarda doğrulama açısından histerosalpingografinin gerekli olup olmadığını belirlemeyi amaçladık.Gereç ve yöntem: Bu prospektif vaka-kontrol çalışmasına infertilite polikliniğine çocuk sahibi olamama şikayetiyle başvuran 174 infertil olgu dahil edildi. Hastaların yaşı, evlilik süresi, cinsel ilişki durumu, reprodüktif öyküsü kaydedildi. Hastalar tubal faktör infertilitesine neden olabilecek risk faktörleri açısından sorgulandı ve mevcut risk faktörleri kaydedildi. Tubal risk faktörü taşıyıp taşımamalarına göre hastalar 2 gruba ayrıldı. Grup 1 risk faktörü taşıyanlar, Grup 2 ise risk faktörü taşımayanlardı. Bulgular: Olgularda abdominal cerrahi öyküsü en sık (%82.97) bulunan risk faktörüydü. Grup1'de 47 olgunun 35 (%74.46)'inde herhangi bir tubada geçiş varken, Grup 2'de 127 olgunun 118 (%92.91)'inde herhangi bir tubada geçiş vardır. Grup 1'de 47 olgunun 12 (%25.53)'sinde, Grup 2'de ise 127 olgunun 9 (%7.08)'unda bilateral tubal tıkanıklık tespit edildi. Her iki grup arasında bulunan fark anlamlıdır (p=0.001). Sonuç: Histerosalpingografi, tubal patoloji için risk faktörü taşımayan infertil kadın değerlendirmesinde yapılmayabilir. Böylece herhangi bir tubal risk faktörü taşımayan olgular, anlamlı katkıyı sağlamayan, ağrılı ve radyasyon tehlikesi göz ardı edilemeyen histerosalpingografi işleminden korunmuş olacaktır. Bu veriyi doğrulayacak daha geniş ölçekli çalışmalara ihtiyaç vardır.
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    Öğe
    Separation of Line Widths of HOD Peaks of Healthy and Diseased Blood and Urine Groups Using 400 MHz NMR
    (Springer, 2025) Sakar, Mehmet Nafi; Yilmaz, Utku Nezih; Koylu, Mehmet Zafer
    Line width studies of high field nuclear magnetic resonance (NMR) peaks have been seen more frequently in the recent literature. This study aims to compare the NMR line widths of HOD peaks of healthy and diseased blood, and densely bloody cysts taken from the jaw. Comparisons of HOD peak line widths in healthy and diseased urine were also made. For this purpose, the blood, serum, and urine of 29 cancer patients, 17 diabetic patients, 28 healthy volunteers, and 20 intensely bloody samples from jaw cysts were collected. Mixtures were prepared by adding the 0.02-mL sample to 0.98 mL D2O. Single-pulse proton NMR measurements were performed at 400 MHz, and line widths were obtained from the half-height of the blood HOD peak. Statistical evaluations show that the line width of cancerous blood is different from normal blood (P = 0.032), while the line width of diabetic blood is not different (p = 0.072), whereas other groups and bloody jaw cysts are completely different (p < 0.05). Similar results were found for urine groups. Line widths show a moderate correlation with each of the albumin and total protein groups (R around 0,56). Present data suggest that a comparison of healthy and diseased body fluids can be made by line width measurements of the HOD peak in the high NMR field. Data also suggest that the relaxivities of albumin (Ser-Alb), total protein (Ser-TP) are potential diagnostic indicators for cancerous blood.