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Öğe Apert's Syndrome: Ophthalmic Importance and Clinical Findings(Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2009) Caca, Ihsan; Caca, Fatma Nur; Sakalar, Yildirim Bayezit; Erdem, Seyfettin; Alakus, Fuat; Ciftci, Suleyman; Dogan, EyuepApert's syndrome is a rare form of craniosynostosis that exhibits with many ocular manifestations. We present two cases of Apert's syndrome. Our first case is a 10-year-old girl admitted with exotropia, V pattern and proptosis on examination. Investigations revealed coronal craniosynostosis, cleft palate, vaginal atresia and syndactyly of the hands and feet. The second case is a 5-year-old boy presented with hypertelorism, exotropia, dissociated vertical deviation and proptosis. Investigations revealed coronal craniosynostosis, bifid uvula and syndactyly of the hands and feetÖğe Bilateral Cataract Extraction With Posterior Chamber Intraocular Lens Implantation Simultaneous in Pediatric Cataracts(Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2008) Caca, Ihsan; Sakalar, Yildirim Bayezit; Ari, Seyhmus; Alakus, Fuat; Dogan, EyuepWe evaluated the results of simultaneous bilateral cataract extraction with intraocular lens (IOL) inplantation 32 pediatric cataract patients. Simultaneous cataract extraction and posterior capsulotomy with anterior vitrectomy and IOL implantation is an effective and safe procedure in bilateral pediatric cataracts treatment.Öğe Comparison of Different Methods for Measurement of Intraocular Pressure and Evaluation of Effect of Central Corneal Thickness on Measurement Results(Turkish Ophthalmological Soc, 2010) Sakalar, Yildirim Bayezit; Keklikci, Ugur; Balsak, Selahattin; Dogan, Eyyup; Unlu, KaanPurpose: To compare measurements of intraocular pressure (IOP) by Goldmann applanation tonometer ( GAT), tonopen and non-contact tonometer (NCT) in normal eyes, and determine the relationship between the results of IOP measurement and central corneal thickness (CCT). Material and Method: Seventy-nine eyes of 41 patients, whose ophthalmologic examination and visual field test revealed no glaucoma, were included into the study. IOP was measured by GAT, NCT and tonopen. CCT was measured with an ultrasonic pachymeter. Results: The mean IOP measured by GAT was 12.63 +/- 2.94 mmHg, by tonopen - 8.51 +/- 2.66 mmHg and by NCT - 13.34 +/- 3.88 mmHg. In terms of measurement results, there was a statistically significant difference between the three methods (p<0.05). Although the correlation between tonopen and CCT was insignificant (p>0.05), there was a significant correlation between GAT and CCT, as well as between NCT and CCT (p<0.05). Discussion: There was a significant difference between measurements of IOP by GAT, NCT and tonopen in normal eyes. Tonopen may not be affected by CCT in normal eyes, while a significant correlation existed between CCT and GAT or NCT in normal eyes.Öğe Comparison of Mitomycin C and Limbal-Conjunctival Autograft in the Prevention of Pterygial Recurrence in Turkish Patients: A One-Year, Randomized, Assessor-Masked, Controlled Trial(Elsevier, 2009) Ari, Seyhmus; Caca, Ihsan; Yildiz, Zennure Oezdemir; Sakalar, Yildirim Bayezit; Dogan, EyuepBACKGROUND: A pterygium is a fibrovascular overgrowth of degenerative bulbar conjunctival tissue that grows over the limbus onto the cornea. Although various approaches have been proposed for the treatment of pterygium, the common problem after these treatments is recurrence. OBJECTIVES: The goals of this study were to compare the efficacy of mitomycin C (MMC) and limbal-conjunctival autograft (LCAU) in preventing recurrence of primary pterygia and to monitor long-term adverse effects (AEs). METHODS: Patients undergoing pterygium surgery between February 2006 and May 2007 were assessed prospectively and randomly divided into 2 groups using a random number table. The MMC group underwent pterygium excision and received 0.02%, MMC intraoperatively for 2 minutes. The LCAU group under-went pterygium excision and LCAU. Recurrence and AE rates of the 2 treatments were compared during the 1-year follow-up period. Assessors for pterygial recurrence were masked to treatment group. RESULTS: One hundred thirteen eyes (57 patients in the MMC group and 56 patients in the LCAU group) were included in the study. Thirteen of the patients (7 in the MMC group and 6 in the LCAU group) were withdrawn due to irregular attendance at follow-up visits or lack of sufficient dose and duration for postoperative topical antibiotic and steroid administration; their data were excluded from analysis. Fifty patients (MMC group: 26 men, 24 women; mean [SD] age, 48.0 [12.3] years; age range, 30-73 years; LCAU group: 27 men, 23 women; mean age, 49.0 [12.6] years; age range, 28-71 years) in each group completed the study. The mean (SD) length of the pterygium across the limbus was similar in the MMC group and the LCAU group (4.18 [1.27] vs 4.07 [1.24] mm). The mean follow-up period was also similar in the 2 groups (16.0 [1.9] vs 15.0 [1.7] months). The rate of recurrence was significantly greater in the MMC group than in the LCAU group (10 [20.0%] vs 2 [4.0%] patients; P = 0.035). Seven patients (14.0%) In the MMC group experienced AEs: conjunctival cyst (3 patients), symblepharon (2), conjunctival granuloma (1), and dellen (1). In the LCAU group, 1 patient (2.0%; P = 0.032 vs MMC group) experienced permanent graft edema. All patients in the LCAU group experienced transient graft edema, with recovery occurring in 3 to 4 weeks. There were no intraoperative complications and there was no graft rejection. CONCLUSIONS: Recurrence and postoperative AEs were less frequently observed in primary excision with LCAU than with MMC in these Turkish patients who completed the study. This study found that pterygium excision with LCAU was well tolerated and effective in these patients. (Curr Ther Res Clin Exp. 2009;70:274-281) (C) 2009 Excerpta Medica Inc.Öğe Comparison of Vertical C/D Ratio Obtained by Assistant of Ophthalmology with Results of Optical Cohorence Tomography(Turkish Ophthalmological Soc, 2008) Sakalar, Yildirim Bayezit; Unlu, Kaan; Keklikci, Selahattin Ugur; Caca, Ihsan; Ari, Seyhmus; Balsak, Selahattin; Akkus, ZekiPurpose: To compare vertical C/D ratio that measured with ophthalmoscopic examination of second, third and fourth year assistant of ophthalmology with vertical C/D ratio obtained by optical cohorence tomography. Materials and Methods: One hundred and ten eyes of 72 glaucoma patients which are followed in glaucoma unit were included to study. Each assistant examined vertical C/D ratio by Goldman tree mirror lens and results were recorded independently from results of the other assistants. The measurements of vertical C/D ratio were obtained by optic nerve head analyses of Stratus Optical Cohorence Tomography after pupillary dilatation and vertical C/D ratio were enlisted. All measurements of vertical C/D ratio were compared each other. Results: Thirty patients were male and 42 patients were female, mean age was 51.43 +/- 19.2. Mean vertical C/D ratio measured by second year asisstant was 0.556 +/- 0.246, mean vertical C/D ratio measured by third year assistant was 0.534 +/- 0.251, mean vertical C/D ratio measured by fourth year assistant was 0.529 +/- 0.250. Mean vertical C/D ratio obtained by optical cohorence tomography was 0.651 +/- 0.223. There was no statistically signicant differences among vertical C/D ratio measured by assistants (p>0.05). The mean vertical C/D ratio that measured by each assistant was statistically lower than obtained by optical cohorence tomography (p<0.05). Conclusions: The vertical C/D ratio that measured with ophthalmoscopic examination by assistant of ophthalmology will be different from vertical C/D ratio obtained by optic nerve head analyses of optical cohorence tomography.Öğe Distribution of Central Corneal Thickness and Intraocular Pressure in a Large Population of Turkish School Children(Informa Healthcare, 2012) Sakalar, Yildirim Bayezit; Keklikci, Ugur; Unlu, Kaan; Alakus, Mehmet Fuat; Yildirim, Mine; Dag, UmutPurpose: To determine the distribution of central corneal thickness (CCT) and intraocular pressure (IOP) in a population of Turkish school children and to evaluate the relationships between these values and both age and gender. Methods: A total of 30,320 eyes from 15,160 healthy school children aged 5-18 years were examined. CCT and IOP were measured using an ultrasonic pachymeter and a non-contact tonometer, respectively. Measurements were compared with age, gender, and parental consanguinity of subjects. Results: The mean age of the school children was 10.43 +/- 2.54 years. For right eyes, mean CCT was 557.91 +/- 34.26 mu m and mean IOP was 14.15 +/- 2.87 mmHg. Mean CCT was significantly thicker in males compared to females (P < 0.0001). Mean IOP was significantly higher in females compared to males (P < 0.0001). CCT in children aged 14 years and older was significantly thinner than that in the younger age groups (P < 0.0001). There was a significant difference among the age groups for IOP (P < 0.05). No significant differences were observed in CCT or IOP related to parental consanguinity (P = 0.538, P = 0.319, respectively). Conclusion: Mean CCT in Turkish school children is of comparable thickness to that in Western school children. CCT reached adult values around 14 years of age in our children. Furthermore, males had thicker CCT than females. IOP was lower in males than females, and increased with age.Öğe The Effect of Mitomycin-C on Trabeculectomy in Primary Glaucoma Cases(Turkish Ophthalmological Soc, 2005) Caca, Ihsan; Unlu, Kaan; Sakalar, Yildirim Bayezit; Ari, SeyhmusPurpose: The aim of this study was to determine the effect of mitomycin-C (MMC) treatment on the accomplishments and complications of trabeculectomy. Materials and Methods: 75 eyes of 59 (group 1) primary glaucoma cases that were treated with trabeculectomy operation together with 0.2 mg/ml 2 minutes intraoperative MMC and 22 eyes of 16 (group 2) glaucoma cases to whom only trabeculectomy operation were evaluated. Results: Cases in the group 1 were followed up 10.87 +/- 2.88 months meanly and cases in the group 2 were followed up 9.55 +/- 2.56 months meanly. In all of group 1 and 82% of group 2, intraocular pressure was found postoperatively to . be below 21mmHg. In the postoperative short-term, the most common complications for groupl were anterior chamber shallowness in 22 cases (30%), temporary ocular hypotonia in 21 cases (28%), conjunctival leakage in 8 cases (11 %), while for group 2 the most complications were intraocular pressure rise in 5 cases (23%), anterior chamber shallowness in 3 cases (14%) and temporary ocularhypotonia in 2 cases (9%). The complications appeared in the postoperative long-term for group 1 were endophthalmitis in 1 case (1.3%) and cataract formation in 7 cases (9%) whereas for group 2 were steady high intraocular pressure in 4 cases (18%) and cataract formation in 2 cases (9%). Conclusion: 0.2 mg/ml 2 minutes intraoperative MMC increases considerably the success rate of trabeculectomy in primary glaucoma cases. Nevertheless, postoperative short-term complications should be followed at close range and treated.Öğe Effects of Photodynamic Therapy With Verteporfin for the Treatment of Chronic Central Serous Chorioretinopathy: An Uncontrolled, Open-Label, Observational Study(Elsevier, 2010) Sakalar, Yildirim Bayezit; Keklikci, Ugur; Unlu, Kaan; Alakus, Mehmet Fuat; Kara, Ismail HamdiBACKGROUND: Central serous chorioretinopathy is an idiopathic disorder that leads to serous neurosensory retinal detachment. The disorder is usually self-limited and resolves spontaneously; however, sometimes neurosensory retinal detachment persists. This form of the disorder is called chronic central serous chorioretinopathy (CCSC). OBJECTIVE: The aim of this study was to assess the effects of photodynamic therapy (PDT) on visual acuity with full-dose verteporfin for CCSC. METHODS: The eyes of patients with CCSC were included in the study. Ophthalmic examination including best-corrected visual acuity (BCVA), fundus examination, fluorescein angiography, and optical coherence tomography was performed before treatment and at 1, 3, 6, 9, and 12 months. PDT with full-dose verteporfin (6 mg/m(2) of body surface area) was applied only to areas of active leakage. BCVA was converted to a log of the minimum angle of resolution (logMAR) equivalent for statistical analysis. Central foveal thickness and BCVA between baseline and follow-up were compared. RESULTS: Seventeen eyes of 16 patients (13 males, 3 females; mean [SD] age, 39.75 [7.51] years; mean duration of follow-up, 13.06 [1.82] months) were used in the study. The mean (SEM) logMAR BCVA was 0.26 (0.07) at baseline and 0.04 (0.02) at 12 months. Mean logMAR BCVA values at baseline (0.259) and after treatment (0.112, 0.053, 0.047, 0.041, and 0.041 at 1, 3, 6, 9, and 12 months, respectively) differed significantly (P = 0.006, P = 0.005, P = 0.005, P = 0.005, and P = 0.005). There was a significant difference in the mean central foveal thickness at the final visit (169 pm) compared with the baseline value (383 pm; P < 0.001). BCVA decreased in one eye (20/20 vs 20/25) and persisted during follow-up; in the other 16 eyes, BCVA either increased (n = 10) or remained stable (n = 6). CONCLUSIONS: In this small, open-label study, patients with CCSC treated with a single course of PDT with full-dose verteporfin had significant improvement from baseline in BCVA and resolution of subretinal fluid accumulation and active leakage. Treatment was generally well tolerated, but one patient had worsening in BCVA. (Curr Thor Res Clin Exp. 2010;71:173-185) (C) 2010 Excerpta Medica Inc.Öğe The Importance of the Family Factory in Perforating Eye Injuries(Turkish Ophthalmological Soc, 2007) Keklikci, Ugur; Sakalar, Yildirim Bayezit; Unlu, Kaan; Bozarslan, Berivan Senol; Dag, UmutBackground: To evaluate epidemiologic properties of infants applying to our clinic due to perforating eye injury, as well as the educational level of their parents, and socioeconomic status of their families. Methods: A total of 172 patients aged between 0-15 years and applying to our clinic due to perforating eye injury between March 2005 - March 2007, were included into the study. The cases were prospectively evaluated in terms of age, sex, material causing injury, cause of injury and social environtment where it occured, education levels and professions of parents, the number of siblings, socioeconomic and environmental conditions. Results: Of the cases, 117 (68%) were male, and 55 (32%) were female: the mean age of the patients was 7.8 +/- 5.6 (1-15 years old). The mothers of 118 cases (68.6%) and fathers of 52 cases (30.2%) were determined to be illiterate. Eye injuries occured mostly (53.5%) during playing activites. In 79.6% of the cases, the montly income per capita was less than 150 Yeni Turk Lirasi (YTL.), and 65% of the families had five or more siblings. In addition, 102 (59.3%) of our cases were living in rural areas. Conclusion: There was a significant relationship between perforating eye injuries and parents'educational level and socioeconomic status. It was concluded that this kind of injuries could be prevented through education of parents and improvent of socioeconomic conditions of families.Öğe Intravitreal bevacizumab combined with panretinal photocoagulation in the treatment of open angle neovascular glaucoma(Sage Publications Ltd, 2009) Ciftci, Suleyman; Sakalar, Yildirim Bayezit; Unlu, Kaan; Keklikci, Ugur; Caca, Ihsan; Dogan, EyupPURPOSE. To evaluate the clinical efficacy of intravitreal bevacizumab (IVB) combined with panretinal photocoagulation in patients with open angle neovascular glaucoma (NVG). METHODS. Nine patients (9 eyes) with NVG participated in this study. Patients received IVB (1.25 mg) as the initial treatment for NVG and were followed up for at least 4 months. IVB was offered as the first treatment of choice to patients with NVG. Panretinal photocoagulation was performed as soon as feasible after the second week and completed in all patients the fourth week after IVB. The main outcome measures are resolution of INV, inhibition of peripheral anterior synechia (PAS), and controllability of intraocular pressure (IOP). RESULTS. The mean follow-up period was 5.6 +/- 1.4 months (range, 4-9 months). The mean IOP before treatment was 35.1 +/- 9.7 mmHg (range, 24-56) under medication before IVB treatment. After IVB and after combined treatment, the mean IOP was reduced to 22.8 +/- 8.1 mmHg (range, 9-33) and 13.0 +/- 4.0 mmHg (range, 7-20), respectively. The mean referral INV was 3.6 +/- 0.4 grade (range, 3-4) and reduced to 1.6 +/- 0.4 (range 1-2) grade after IVB and 0.6 +/- 0.8 (range 0-2) grade after combined therapy. By IVB, combined panretinal photocoagulation recurrence of INV was not observed. CONCLUSIONS. In NVG, IVB treatment can reduce iris and angle neovascularization and inhibits further PAS formation temporarily. Panretinal photocoagulation inhibits neovascularization constantly. Therefore, management of open angle NVG is more feasible with bevacizumab combined with panretinal photocoagulation. (Eur J Ophthalmol 2009; 1028-33)Öğe Is it necessary to accompany probing with endoscopy in cases of congenital nasolacrimal canal obstruction?(Elsevier Ireland Ltd, 2010) Cakmak, Sevin Soker; Yildirim, Muzeyyen; Sakalar, Yildirim Bayezit; Keklikci, Ugur; Alakus, FuatObjective To compare the results of probing with and without endoscopy in cases of congenital nasolacrimal duct obstruction who had previously not undergone probing Methods Fifty-one children with congenital nasolacrimal duct obstruction who underwent surgical intervention between June 2007 and April 2009 in our hospital were included in the study Patients who had had previous probings were excluded from the study. Conventional probing was performed in 37 eyes of 25 patients, and probing with intranasal endoscopic visualization in 36 eyes of 26 patients. Diagnosis was based on history of epiphora since birth or shortly after, and fluorescein dye disappearance test. Results Thirty-two of 37 eyes (86.48%) were cured by probing Of the 5 cases with complaints. I had lacrimal sac fistula. Thirty-four of 36 eyes (94.44%) were cured by probing guided by endoscope observation. Thirty-two cases had stenosis at the lower end of the nasolacrimal duct which required probing. In two cases the probe passed submucosally to the floor of the nose In two cases a false passage was made at the upper end of the inferior meatus In these cases, the operation was continued by repeating the process until the distal end of the nasolacrimal canal was seen to have been passed Conclusion Probing with endoscopy may be excessive in primary cases but in cases which have undergone unsuccessful probing, it is useful for visualization of anomalies in the lower nasolacrimal canal and to obtain the correct anatomic position for the probe (C) 2010 Elsevier Ireland Ltd All rights reserved.Öğe MASP1 Mutations in Patients with Facial, Umbilical, Coccygeal, and Auditory Findings of Carnevale, Malpuech, OSA, and Michels Syndromes(Cell Press, 2010) Sirmaci, Asli; Walsh, Tom; Akay, Hatice; Spiliopoulos, Michail; Sakalar, Yildirim Bayezit; Hasanefendioglu-Bayrak, Aylin; Duman, DuyguDistinctive facial features consisting of hypertelorism, telecanthus, blepharophimosis blepharoptosis, epicanthus inversus, periumbil seal defects, and skeletal anomalies are seen in autosomal recessive Carnevale, Malpuech, Michels, and oculo skeletal abdominal (OSA) syndromes The gene or genes responsible for these syndromes were heretofore unknown We report on three individuals from two consanguineous Turkish families with findings characteristic of these syndromes including facial dysmorphism periumbilical depression mixed hearing loss, radioulnar synostosis and coccygeal appendage Homozygosity mapping yielded an autozygous region on chromosome 3q27 in both families In one family, whole exome sequencing revealed a missense mutation, MASP1 c 2059G>A (p G687R) that cosegregated with the phenotype In the second family, Sanger sequencing of MASP1 revealed a nonsense mutation, MASP1 c 870G>A (p W290X) that also cosegregated with the phenotype Neither mutation was found in 192 Turkish controls or 1200 controls of various other ancestries MASP1 encodes mannan binding lectin senne protease 1 The two mutations occur in a MASP1 isoform that has been reported to process IGFBP 5 thereby playing a critical role in insulin growth factor availability during craniofacial and muscle development These results implicate mutations of MASP1 as the cause of a human malformation syndrome and demonstrate the involvement of MASP1 in facial, umbilical, and ear development during the embryonic periodÖğe Persistent Triamcinolone Acetonide Particles on the Posterior Lens Capsule After Intravitreal Injection(Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2008) Sakalar, Yildirim Bayezit; Unlu, Kaan; Keklikci, Ugur; Caca, Ihsan; Senol, Berivan BozarslanWe report a rare case in which triamcinolone acetonide particles gathered on posterior lens capsule after injection of intravitreal triamcinolone acetonide. Intravitreal injection of triamcinolone acetonide is useful in the treatment of macular edema; however, accumulation of triamcinolone acetonide particles on the posterior lens capsule may decrease visual acuity and requires surgical treatment.Öğe Retinal Nerve Fiber Layer Thickness and Features of the Optic Disc in Patients with Nonocular Behcet's Disease(Turkish Ophthalmological Soc, 2010) Sakalar, Yildirim Bayezit; Keklikci, Ugur; Cakmak, Sevin Soker; An, Seyhmus; Erdem, Seyfettin; Unlu, KaanPurpose: To evaluate the retinal nerve fiber layer (RNFL) thickness and optic disc measurements in patients with nonocular Behcet's disease. Material and Method: Forty-six eyes of 23 patients with nonocular Beh double dagger et's disease (Group 1) and 30 eyes of 15 healthy subjects (Group 2) were included in the study. A detailed ophthalmologic examination was performed, and the RNFL thickness and optic disc measurements were made by optical coherence tomography (OCT) in all cases. Thinning was considered when the RNFL thickness values were below 5%. Results: The mean RNFL thickness was 104.08 +/- 8.27 mm and 106.98 +/- 9.14 mm in group 1 and group 2, respectively. No significant difference was found between the two groups in terms of mean RNFL thickness (p>0.05). In group 1, the thinning of RNFL was detected in: one segment-13 eyes (28%), two segments-10 eyes (22%), three segments-2 eyes (4.3%), one quadrant - 8 eyes (17.4%), and two quadrants - 1 eye (2.2%). In group 2, the thinning of RNFL was observed in one segment - 7 eyes (25%) and in three segments - 2 eyes (7%). No thinning was detected in any quadrants in group 2. The thinning of RNFL in both segments and quadrants between the two groups was found to be significantly different (p<0.05). No significant difference existed between the two groups for optic disc measurements (p>0.05). Discussion: Thinning of RNFL may be seen in patients with nonocular Behcet's disease. The OCT can be used as an ancillary examination method in these patients.Öğe Trabeculectomy with Mitomycin-C in Neovascular Galucoma Patients(Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2008) Caca, Ihsan; Ari, Seyhmus; Sakalar, Yildirim Bayezit; Unlu, Kaan; Dogan, EyuepWe sought to determine the effectiveness of trabeculectomy with mitomycin-C (MMC) in neovascular glaucoma (NVG) patients. Trabeculectomy with MMC in NVG patients is a method that has high rate of short-term success.Öğe Treatment of Experimental Bacillus cereus Endophthalmitis Using Intravitreal Moxifloxacin With or Without Dexamethasone(Mary Ann Liebert, Inc, 2011) Sakalar, Yildirim Bayezit; Ozekinci, Selver; Celen, Mustafa KemalPurpose: To evaluate the effects of intravitreal moxifloxacin with or without dexamethasone on experimental Bacillus cereus endophthalmitis. Methods: The right eyes of 21 New Zealand albino rabbits weighing 2-3 kg were used in this study. Each eye was inoculated with 1 x 10(6) colony-forming units of B. cereus microorganisms via intravitreal injection into the vitreous cavity, and an experimental model of B. cereus endophthalmitis was formed. The rabbits were separated into 3 groups: Group 1 was given 0.1 mL of balanced saline solution intravitreally, group 2 was given 50 mu g of moxifloxacin, and group 3 was given 50 mu g of moxifloxacin plus 400 mu g of dexamethasone 24 h after the inoculation. Vitreous aspirates were taken for microbiological examination on the 3rd day. Clinical inflammation scores were evaluated on days 1, 7, and 14. The rabbits were killed on the 14th day, and the eyes were enucleated for histopathological examination. Results: On the 7th day, only the vitreous scores of the treatment groups were significantly low compared with those of the control group (P < 0.05). On day 14, the clinical scores of vitreous inflammation were 2.43 +/- 0.79, 1.43 +/- 0.53, and 1.29 +/- 0.49 in Groups 1, 2, and 3, respectively. The clinical scores of the treatment groups were significantly lower compared with those of the control group on day 14 (P < 0.05). Histopathological scores were 2.43 +/- 0.79, 1.43 +/- 0.53, and 1.43 +/- 0.79 for the iris and 2.14 +/- 0.69, 1.57 +/- 0.53, and 1.14 +/- 0.38 for the vitreous in Groups 1, 2, and 3, respectively. Apart from the conjunctiva, the histopathological scores of the other tissues in the treatment groups were significantly lower compared with those of the control group (P < 0.05). No significant differences were found in the histopathological or clinical scores among the treatment groups (P > 0.05). Microbiological scores at day 14 were 151 +/- 6.43, 125.43 +/- 13.44, and 131.14 +/- 16.99 for Groups 1, 2, and 3, respectively. The microbiological scores of the treatment groups were significantly lower compared with those of the control group (P < 0.05). Conclusions: Intravitreal moxifloxacin injection is effective in experimental B. cereus endophthalmitis. The addition of intravitreal dexamethasone may not significantly affect treatment efficacy.Öğe Two Different Cases with Melanocytoma of the Optic Disc(Ortadogu Ad Pres & Publ Co, 2010) Sakalar, Yildirim Bayezit; Keklikci, Ugur; Unlu, Kaan; Caca, Ihsan; Alakus, Mehmet FuatA 45-year-old woman (Case 1) applied for control examination to learn whether there was any growth or not on tumoral lesion in her left eye. Melanocytoma of the optic disc involving the adjacent choroid in the left eye was seen on ophthalmoscopic examination. The appearence of the patient was consistent with achondroplasia. Case 2, a 29-year-old woman, applied with headache complaint. Bilateral optic disc hypoplasia and melanocytoma of the optic disc in the right eye was found on the fundus examination and magnetic resonance imaging revealed an arachnoid cyst in the left temporal fossa. Although melanocytoma of the optic disc has not been proven to have any systemic associations, it is likely to be associated with some of the systemic diseases and other ocular pathologies. Optic disc hypoplasia associated with melanocytoma of the optic disc has been reported previously, however, associations of achondroplasia or arachnoid cyst with melanocytoma of the optic disc have nor yet been reported.
